Beaver Run Resort Floorplan

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This meeting took place in 2017



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Kinases: Next-Generation Insights and Approaches (C4)


Organizer(s) Reid M. Huber, John Kuriyan and Ruth H. Palmer
March 5—9, 2017
Beaver Run Resort • Breckenridge, Colorado USA
Discounted Abstract Deadline: Nov 3, 2016
Abstract Deadline: Dec 7, 2016
Scholarship Deadline: Nov 3, 2016
Discounted Registration Deadline: Jan 11, 2017

Sponsored by Genentech, Inc. and Incyte Corporation

Summary of Meeting:
Decades of both basic and applied research have unequivocally established the importance of the kinase family of phosphotransferase enzymes in virtually every aspect of organismal homeostasis. From the initial characterization of ATP-dependent phosphorylation in the liver by Gene Kennedy in 1954, our understanding of the family has grown from the diverse perspectives of enzymology, biochemistry, biophysics, structural biology, genetics, cellular biology, pharmacology and physiology. Importantly, these advancements have yielded transformative therapeutic approaches to disease, most notably in the field of cancer where kinase inhibition is helping to fulfill the promise of precision medicine. Yet even today, our perspectives on the complexity of this class of enzymes continues to evolve, and many of the most exciting advancements in the field are being made by applying modern-day insights and technological approaches to the diverse roles the enzymes can play in health and human disease. This meeting is devoted to exploring this innovative leading edge of kinase research, and will bring together leading researchers from academic, clinical and pharmaceutical settings to explore and define the new horizons in the field of kinase biology.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, March 5 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 9 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, March 10 in order to fully experience the meeting.

SUNDAY, MARCH 5

16:00—20:00
Arrival and Registration

Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Foyer

MONDAY, MARCH 6

07:00—08:00
Breakfast

Summit Gallery
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Reid M. Huber, Incyte Corporation, USA

* John Kuriyan, University of California, Berkeley, USA

* Ruth H. Palmer, University of Gothenburg, Sweden

Richard M. Marais, Cancer Research UK Manchester Institute, UK
How Far Are We from Implementing Precision Medicine in Melanoma?

09:00—11:15
Pathways of Kinase Function
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* René H. Medema, Netherlands Cancer Institute, Netherlands

Tony Hunter, The Salk Institute for Biological Studies, USA
pHisphorylation in Cell Signaling

Coffee Break

Susan S. Taylor, University of California, San Diego, USA
Lessons Learned from PKA: from Motifs to the Dynamic Assembly of Isoform-specific Macromolecular Switches

Ruth H. Palmer, University of Gothenburg, Sweden
Regulation of Anaplastic Lymphoma Kinase Signaling during Development and in Neuroblastoma

Kazuki Hattori, University of Tokyo, Japan
Short Talk: ASK1 Signaling Regulates Brown Adipocyte Maturation

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Peaks 1-3
13:00—22:00
Poster Viewing

Peaks 1-3
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Kinases In Cancer Development and Progression
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Ruth H. Palmer, University of Gothenburg, Sweden

Charles A C Williams, University of Dundee, UK
Short Talk: Erk5 is a Key Regulator of ES Cell Pluripotency: Identification of Klf2 as a Novel Erk5 Substrate

René H. Medema, Netherlands Cancer Institute, Netherlands
Mitotic Checkpoint Kinases in Cancer Development and Treatment

Nicolas Tapon, Francis Crick Institute, UK
Hippo Kinase Pathway in Tissue Growth Regulation

Roger J. Daly, Monash University, Australia
Short Talk: Homo- and Heterotypic Association Regulates Signalling by the SgK269/PEAK1 and SgK223 Pseudokinases

Oliver Hantschel, Swiss Federal Institute of Technology Lausanne, Switzerland
Short Talk: Differential Signaling Networks of Bcr-Abl p210 and p190 Kinases in Leukemia Cells Defined by Functional Proteomics

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Peaks 1-3
19:30—22:00
Poster Session 1

Peaks 1-3

TUESDAY, MARCH 7

07:00—08:00
Breakfast

Summit Gallery
08:00—11:00
Franchise Targets in Drug Discovery
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Dorothee Kern, Brandeis University, HHMI, USA

Reid M. Huber, Incyte Corporation, USA
Janus Activated Kinases – Past, Present and Future

Andrew Wylie, Novartis Institutes for BioMedical Research, USA
Targeting an Old Dog with New Tricks – BCR-ABL1 and ABL001

Coffee Break

Pasi A. Jänne, Harvard Medical School, USA
EGFR – Third-Generation Approaches to Drug Discovery

Shiva Malek, Genentech, Inc., USA
Kinases as Molecular Switches: Catalytic and Non-Catalytic Functions of RAF Reveal Novel Insights into Oncogenic Activation

Tamer Ahmed, Icahn School of Medicine at Mount Sinai, USA
Short Talk: Mechanism-Based Strategies to Overcome Intrinsic and Acquired RAF Inhibitor Resistance in BRAF-Mutant Tumors

11:00—17:00
On Own for Lunch

11:00—13:00
Poster Setup

Peaks 1-3
13:00—22:00
Poster Viewing

Peaks 1-3
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Emerging Pathways in Kinase Inhibitor Discovery
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Christoph Lengauer, Blueprint Medicines, USA

Giordano M. Caponigro, Novartis Institutes for BioMedical Research, USA
CDK4/6

Michael Rothenberg, Loxo Oncology, USA
Developing Inhibitors Against Uncommon Oncogenic Kinases

Shohei Koide, New York University Langone Medical Center, USA
Developing Novel Inhibition Strategies using Monobodies

Vitaliy V. Bondar, Baylor College of Medicine, USA
Short Talk: p21-Activated Kinases Modulate ATXN1 Levels Providing Potential Therapeutic Entry Point for Spinocerebellar Ataxia Type 1

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Peaks 1-3
19:30—22:00
Poster Session 2

Peaks 1-3

WEDNESDAY, MARCH 8

07:00—08:00
Breakfast

Summit Gallery
08:00—11:00
Next-Generation Approaches to Kinase Inhibition
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Reid M. Huber, Incyte Corporation, USA

Christoph Lengauer, Blueprint Medicines, USA
Crafting Highly Selective Kinase Inhibitors - From Impossible to the Clinic

Dorothee Kern, Brandeis University, HHMI, USA
Ancient Origins of Allosteric Activation in Kinases – Exploitation for Novel Cancer Drugs

Coffee Break

Soumya S. Ray, Schrödinger, USA
Short Talk: Role of Active Site Water Molecules in Designing Potent Selective Kinase Inhibitors

David E. Puleo, Yale University, USA
Short Talk: Identification and Characterization of Small Molecule Binders of the JAK2 Pseudokinase Domain

Johanna Elisabeth Mayrhofer, University of Innsbruck, Austria
Short Talk: Recording of RAF Kinase:Drug Interactions in vivo

11:00—14:30
On Own for Lunch

11:00—13:00
Poster Setup

Peaks 1-3
13:00—22:00
Poster Viewing

Peaks 1-3
14:30—16:30
Workshop: Emerging Methodological Approaches to Kinase Research

Peaks 4-5
* Shiva Malek, Genentech, Inc., USA

Tarjani M. Thaker, University of California, San Francisco, USA
Defining the HER2 Interactome by Proximity-Based Extracellular Tagging

Katelyn B. Connell, Biodesy, USA
A High-Throughput Method for Inhibitor-Induced Conformational Changes in kinases

Rodrigo Maillard, Georgetown University, USA
Investigating the Conformational Landscape of Protein Kinase A with Optical Tweezers

Khalil A. Davis, Francis Crick Institute, UK
Genetically Encoded Photocrosslinking Amino Acids for In-Cell Kinase Substrate Identification

Joshua M. Lubner, University of Connecticut, USA
Using Bacteria to Characterize and Engineer Protein Kinase Specificity

Michael Z. Lin, Stanford University School of Medicine, USA
Quantitative Control of Cell Signaling by Single-Chain Photoswitchable Kinases

Matthew Robers, Promega Corporation, USA
Kinome-Wide Profiling of Target Engagement and Residence Time in Living Cells Using NanoBRET

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Kinase Inhibitor Resistance
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Natalia Jura, University of California, San Francisco, USA

Rani E. George, Dana-Farber Cancer Institute, USA
Differential Mechanisms of ALK Inhibitor Resistance

Matthew A. Smith, Moffitt Cancer Center, USA
Using Proximity Ligation Assays to Interrogate RTK Activity in Cancers

Ethan Ahler, University of Washington, USA
Short Talk: High-Throughput Mutagenesis Reveals Novel Mechanisms of Drug Resistance in the Oncogene Src Kinase

James Duncan, Fox Chase Cancer Center, USA
Short Talk: Exploring the "Dark" Kinome Using Chemical Proteomics

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Peaks 1-3
19:30—22:00
Poster Session 3

Peaks 1-3

THURSDAY, MARCH 9

07:00—08:00
Breakfast

Summit Gallery
08:00—11:15
Kinase Signaling and Subcellular Context
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Susan S. Taylor, University of California, San Diego, USA

John Kuriyan, University of California, Berkeley, USA
Specificity in Kinase Pathways Downstream of the T Cell Receptor

John D. Scott, University of Washington, USA
Guiding Signals through Anchored Enzyme Complexes

Coffee Break

Natalia Jura, University of California, San Francisco, USA
New Insights into Control of HER3 Receptor Pseudokinase Signaling

Benjamin E. Turk, Yale University, USA
Deciphering Mechanisms of Protein Kinase Substrate Targeting

Chris Phillips, AstraZeneca, UK
Short Talk: Mechanistic Insights into ATM Activation from Cryo-Electron Microscopy: Open and Closed Dimers

Andrei V. Karginov, University of Illinois at Chicago, USA
Short Talk: Mimicking Transient Activation of Protein Kinases in Living Cells

11:15—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Foyer
17:00—18:45
Systems and Synthetic Biology of Kinases
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* John Kuriyan, University of California, Berkeley, USA

Forest M. White, Massachusetts Institute of Technology, USA
High Temporal Resolution Analysis of Phosphorylation Mediated Signaling Networks

James E. Ferrell Jr., Stanford University, USA
A Second Bistable Switch in Mitosis

Emily F. Ruff, University of Minnesota, USA
Short Talk: Novel Allosteric FRET Assays for Mechanistic Studies and Inhibitor Screening of Aurora A Kinase

Zhong Yao, University of Toronto, Canada
Short Talk: A Global Analysis of The Receptor Tyrosine Kinase - Protein Phosphatase Interactome

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Peaks 1-3
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Peaks 1-3

FRIDAY, MARCH 10

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Genentech, Inc. Incyte Corporation

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13CA216983-01

"Funding for this conference was made possible (in part) by CA216983-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government."


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Blueprint Medicines


Incyte Corporation


Loxo Oncology


Novartis Institutes for BioMedical Research


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676