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This meeting took place in 2018
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Mobile Genetic Elements and Genome Plasticity (B7)
Organizer(s) Marlene Belfort, Evan E. Eichler, Henry L. Levin and Lynne E. Maquat
February 11—15, 2018
Eldorado Hotel & Spa • Santa Fe, New Mexico USA
Discounted Abstract Deadline: Oct 12, 2017
Abstract Deadline: Nov 14, 2017
Scholarship Deadline: Oct 12, 2017
Discounted Registration Deadline: Dec 14, 2017
Supported by the Directors' Fund
Summary of Meeting:
Transposable elements are potent sources of genetic variation that also regulate the expression of large gene networks. They constitute the majority of genomic DNA in many eukaryotes, and they dramatically shape genetic content by causing insertions, deletions, rearrangements and sequence duplications. Of increasing significance is the link of these mobile elements to diseases such as cancer and neurodegeneration. Sequencing of human populations demonstrates that active transposable elements are substantially more prevalent than previously appreciated. The aims of this conference are to: 1) Apply recent innovations in high-throughput sequencing and genome analysis to the study of transposon biology and genome dynamics; 2) Discuss the discovery of cellular systems that inhibit transposon activity as examples of the evolutionary arms race between mobile DNA and their hosts; 3) Describe active transposition during neurogenesis and in tumor cells and raise questions about the role of mobile DNA in brain development and cancer; and 4) Discern mechanistic aspects of element mobility from bacteria to humans. This symposium is designed to foster ties between leaders in the field of transposon function and biology with the pioneers of genome analysis, a link that is still tenuous and nascent. Discussions of transposon activity and genome dynamics will focus on mechanistic models. Methods applied to these problems will include molecular structures, biochemistry, expression studies and bioinformatic analyses. The transposons and hosts represented in this conference include diverse examples from eubacteria, archaea, protists, plants and mammals.
View Scholarships/Awards
Transposable elements are potent sources of genetic variation that also regulate the expression of large gene networks. They constitute the majority of genomic DNA in many eukaryotes, and they dramatically shape genetic content by causing insertions, deletions, rearrangements and sequence duplications. Of increasing significance is the link of these mobile elements to diseases such as cancer and neurodegeneration. Sequencing of human populations demonstrates that active transposable elements are substantially more prevalent than previously appreciated. The aims of this conference are to: 1) Apply recent innovations in high-throughput sequencing and genome analysis to the study of transposon biology and genome dynamics; 2) Discuss the discovery of cellular systems that inhibit transposon activity as examples of the evolutionary arms race between mobile DNA and their hosts; 3) Describe active transposition during neurogenesis and in tumor cells and raise questions about the role of mobile DNA in brain development and cancer; and 4) Discern mechanistic aspects of element mobility from bacteria to humans. This symposium is designed to foster ties between leaders in the field of transposon function and biology with the pioneers of genome analysis, a link that is still tenuous and nascent. Discussions of transposon activity and genome dynamics will focus on mechanistic models. Methods applied to these problems will include molecular structures, biochemistry, expression studies and bioinformatic analyses. The transposons and hosts represented in this conference include diverse examples from eubacteria, archaea, protists, plants and mammals.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, February 11 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 15 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, February 16 in order to fully experience the meeting.
SUNDAY, FEBRUARY 11
MONDAY, FEBRUARY 12
TUESDAY, FEBRUARY 13
WEDNESDAY, FEBRUARY 14
THURSDAY, FEBRUARY 15
FRIDAY, FEBRUARY 16
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, February 11 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 15 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, February 16 in order to fully experience the meeting.
SUNDAY, FEBRUARY 11
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.
*
Henry L. Levin,
National Institutes of Health, USA
*
Marlene Belfort,
University of Albany, SUNY, USA
Feng Zhang,
Broad Institute of MIT and Harvard University, USA
Mining Microbial Diversity for Genome Editing
Mining Microbial Diversity for Genome Editing
09:00—11:30
Mechanisms and Results of Genome Editing
Meeting has ended...abstracts no longer viewable online.
Mitchell R. O'Connell,
University of Rochester Medical Center, USA
Targeting RNA using CRISPR-Cas Enzymes
Targeting RNA using CRISPR-Cas Enzymes
John A. Schiel,
Horizon Discovery, USA
Short Talk: Comparison of Different Repair Templates’ HDR Efficiency using CRISPR-Cas9 and Synthetic Guide RNAs
Short Talk: Comparison of Different Repair Templates’ HDR Efficiency using CRISPR-Cas9 and Synthetic Guide RNAs
Coffee Break
Zoltan Ivics,
Paul Ehrlich Institute, Germany
Short Talk: Transposase and Host Factor Determinants of Target Site Selection by DNA Transposons
Short Talk: Transposase and Host Factor Determinants of Target Site Selection by DNA Transposons
Josh T. Dubnau,
Stony Brook University, USA
Retrotransposon Activation Contributes to Non-Cell Autonomous Neurodegeneration in a Drosophila TDP-43 Model of ALS
Retrotransposon Activation Contributes to Non-Cell Autonomous Neurodegeneration in a Drosophila TDP-43 Model of ALS
*
Laura Landweber,
Columbia University, USA
RNA-Programmed Genome Rearrangements in the Ciliate Oxytricha
RNA-Programmed Genome Rearrangements in the Ciliate Oxytricha
14:30—16:30
Workshop 1: Evolutionary Mechanisms of Transposition
Hyo Won Ahn,
University of Georgia, USA
Ribosome Biogenesis Modulates Ty1 Copy Number Control in Saccharomyces Cerevisiae
Ribosome Biogenesis Modulates Ty1 Copy Number Control in Saccharomyces Cerevisiae
*
Irina Arkhipova,
Marine Biological Laboratory, USA
Non-Canonical Base Modifications of Bacterial Origin in a Eukaryotic Genome
Non-Canonical Base Modifications of Bacterial Origin in a Eukaryotic Genome
Shunhua Han,
University of Georgia, USA
Genomic Insights into the Pattern of Transposable Element Proliferation in Drosophila S2 Cells
Genomic Insights into the Pattern of Transposable Element Proliferation in Drosophila S2 Cells
Arnab Ghosh,
Texas Tech University, USA
Impact of Small RNA on Transposable Elements in the Salt Water Crocodile: Crocodylus porosus
Impact of Small RNA on Transposable Elements in the Salt Water Crocodile: Crocodylus porosus
Jasmine N. Baker,
Louisiana State University, USA
Evolution of Alu Subfamily Structure in the Saimiri Lineage of New World Monkeys
Evolution of Alu Subfamily Structure in the Saimiri Lineage of New World Monkeys
Sung-Yeon Hwang,
Seoul National University, South Korea
MOV10 Controls LINE-1 Retrotransposition through Interplay with RNASEH2
MOV10 Controls LINE-1 Retrotransposition through Interplay with RNASEH2
17:00—19:15
Dynamics of Plasticity
Meeting has ended...abstracts no longer viewable online.
Marlene Belfort,
University of Albany, SUNY, USA
Mobile Self-Splicing Introns and Inteins as Stress Sensor
Mobile Self-Splicing Introns and Inteins as Stress Sensor
Lingling Chen,
Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China
Biogenesis of Circular RNAs
Biogenesis of Circular RNAs
Orsolya Barabas,
European Molecular Biology Laboratory, Germany
Short Talk: Conjugative Transposition of Antibiotic Resistance: Structural Basis of Broad Target Specificity and Auto-Regulation
Short Talk: Conjugative Transposition of Antibiotic Resistance: Structural Basis of Broad Target Specificity and Auto-Regulation
David M. Walker,
University of Texas at Austin, USA
Short Talk: A Dynamic E. coli Genome Mapped by Following Mu Transposition
Short Talk: A Dynamic E. coli Genome Mapped by Following Mu Transposition
*
John M. Abrams,
University of Texas Southwestern Medical Center, USA
p53 and the Game of Transposons
p53 and the Game of Transposons
08:00—11:15
Silencing Mobile DNA Activity: Self and Non-Self Recognition
Meeting has ended...abstracts no longer viewable online.
R. Keith Slotkin,
Ohio State University, USA
Initiation of TE Silencing: How the Cell Recognizes and Triggers Transposable Elements for Trans-Generational Epigenetic Silencing
Initiation of TE Silencing: How the Cell Recognizes and Triggers Transposable Elements for Trans-Generational Epigenetic Silencing
Mikiko C. Siomi,
University of Tokyo, Japan
piRNA Biogenesis in Drosophila
piRNA Biogenesis in Drosophila
Coffee Break
Shiv I. S. Grewal,
NCI, National Institutes of Health, USA
Epigenetic Genome Control by Noncoding RNAs and RNA Processing Factors
Epigenetic Genome Control by Noncoding RNAs and RNA Processing Factors
Cameron Howard Lee,
Stanford University, USA
Short Talk: Selective Silencing of Euchromatic L1s Revealed by Genome-Wide Screens for L1 Regulators
Short Talk: Selective Silencing of Euchromatic L1s Revealed by Genome-Wide Screens for L1 Regulators
Todd S. Macfarlan,
NICHD, National Institutes of Health, USA
Short Talk: Why Do Zinc Finger Proteins Evolve to Bind TEs in Mammals?
Short Talk: Why Do Zinc Finger Proteins Evolve to Bind TEs in Mammals?
*
Brenda L. Bass,
University of Utah, USA
Self versus Non-Self: Is That My Double-Stranded RNA or Yours?
Self versus Non-Self: Is That My Double-Stranded RNA or Yours?
17:00—19:15
The Action of Mobile DNA in the Brain and in Cancer
Meeting has ended...abstracts no longer viewable online.
Haig H. Kazazian,
Johns Hopkins University School of Medicine, USA
Somatic L1 Retrotransposition in Cancers and their Normal Tissues
Somatic L1 Retrotransposition in Cancers and their Normal Tissues
Kathleen H. Burns,
Johns Hopkins University School of Medicine, USA
Roles for Mobile Elements in Human Disease
Roles for Mobile Elements in Human Disease
Patricia Goerner-Potvin,
McGill University, Canada
Short Talk: Detecting Germline and Novel L1 Insertions using Long-Read Technologies
Short Talk: Detecting Germline and Novel L1 Insertions using Long-Read Technologies
E. Alice Lee,
Boston Children's Hospital & Harvard Medical School, USA
Short Talk: Immune Signatures Correlate with L1 Retrotransposition in Gastrointestinal Cancers
Short Talk: Immune Signatures Correlate with L1 Retrotransposition in Gastrointestinal Cancers
*
Geoffrey J. Faulkner,
Queensland Brain Institute, Australia
Hot Donor L1s in Mammalian Somatic Cells
Hot Donor L1s in Mammalian Somatic Cells
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Evolution and Regulation of Mobile Elements
Meeting has ended...abstracts no longer viewable online.
Cedric Feschotte,
Cornell University, USA
Transposable Elements as Catalysts of Convergent Evolution
Transposable Elements as Catalysts of Convergent Evolution
Henry L. Levin,
National Institutes of Health, USA
Transposable Element Integration Rewires Regulatory Networks to Protect Cells Against Stress
Transposable Element Integration Rewires Regulatory Networks to Protect Cells Against Stress
Coffee Break
Manvendra Singh,
Max-Delbrueck Centre for Molecular Medicine, Germany
Short Talk: Reactivation of Endogenous Retroviruses Aid the Development of Human-Specific Embryogenesis
Short Talk: Reactivation of Endogenous Retroviruses Aid the Development of Human-Specific Embryogenesis
Tugce Aktas,
Max Planck Institute of Immunobiology and Epigenetics, Germany
Short Talk: RNA Binding Proteins at the Crossroads of Transposable Element Suppression and Post-Transcriptional Regulation of Gene Expression
Short Talk: RNA Binding Proteins at the Crossroads of Transposable Element Suppression and Post-Transcriptional Regulation of Gene Expression
*
Ruth Lehmann,
NYU School of Medicine, USA
Regulation of Transposon Splicing by piRNA-Mediated Repressive Chromatin
Regulation of Transposon Splicing by piRNA-Mediated Repressive Chromatin
17:00—19:15
Genome Structural Variation and Neuroplasticity in Primates
Meeting has ended...abstracts no longer viewable online.
Evan E. Eichler,
HHMI/University of Washington, USA
Dynamic Duplications and Primate Genome Evolution
Dynamic Duplications and Primate Genome Evolution
Christopher A. Walsh,
Children's Hospital Boston, USA
L1 Retrotransposition and Somatic Mutation in the Human Brain
L1 Retrotransposition and Somatic Mutation in the Human Brain
Molly C. Hammell,
Cold Spring Harbor Laboratory, USA
Short Talk: Awakening Old Foes: Transposon De-Silencing in ALS Patient Tissues
Short Talk: Awakening Old Foes: Transposon De-Silencing in ALS Patient Tissues
Angela Macia,
University of California, San Diego, USA
Short Talk: Blocking LINE-1 Reverse Transcriptase Activity in TREX1-Deficient Cells Rescues Neurotoxicity in Aicardi-Goutières Syndrome
Short Talk: Blocking LINE-1 Reverse Transcriptase Activity in TREX1-Deficient Cells Rescues Neurotoxicity in Aicardi-Goutières Syndrome
*
Fred (Rusty) H. Gage,
The Salk Institute for Biological Studies, USA
Retroelements in Brain, Behavior and Evolution
Retroelements in Brain, Behavior and Evolution
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Transposition and Gene Regulation
Meeting has ended...abstracts no longer viewable online.
Joanna Wysocka,
Stanford University School of Medicine, USA
Intrinsic Retroviral Reactivation in Human Preimplantation Embryos and Pluripotent Cells
Intrinsic Retroviral Reactivation in Human Preimplantation Embryos and Pluripotent Cells
Elizabeth H. Kellogg,
University of California, Berkeley, USA
Short Talk: Cryo-EM Structural Studies of the P-Element Transposase
Short Talk: Cryo-EM Structural Studies of the P-Element Transposase
Robert A. Martienssen,
Cold Spring Harbor Laboratory, USA
Epigenetically Activated Small RNAs Mediate Chromosome Segregation and Dosage
Epigenetically Activated Small RNAs Mediate Chromosome Segregation and Dosage
Coffee Break
Pascale Lesage,
Institut Universitaire d'Hématologie, France
Molecular Mechanisms and Regulation of Ty1 Retrotransposon Integration Site Selection
Molecular Mechanisms and Regulation of Ty1 Retrotransposon Integration Site Selection
*
M. Joan Curcio,
Wadsworth Center, USA
LTR-Retrotransposon Activity Perturbs Asymmetric Centrosome Inheritance
LTR-Retrotransposon Activity Perturbs Asymmetric Centrosome Inheritance
14:30—16:30
Workshop 2: The Neurobiology of Mobile Elements
Jasmine Jacob-Hirsch,
Sheba Medical Center, Israel
Enhanced Brain Retrotransposition in Neurodevelopmental Disorders
Enhanced Brain Retrotransposition in Neurodevelopmental Disorders
Julia Fuchs Sebe,
Collège de France, France
LINE-1 Retrotransposon Repression Attenuates Neurodegeneration in Adult Dopaminergic Neurons
LINE-1 Retrotransposon Repression Attenuates Neurodegeneration in Adult Dopaminergic Neurons
Frank MJ Jacobs,
University of Amsterdam, Netherlands
The Evolutionary Impact of Transposable Element Invasions on Human Neuronal Gene Expression
The Evolutionary Impact of Transposable Element Invasions on Human Neuronal Gene Expression
Johan Jakobsson,
Wallenberg Neuroscience Center, Lund University, Sweden
LINE-2 Elements Shape Post-Transcriptional Gene Regulation in the Human Brain
LINE-2 Elements Shape Post-Transcriptional Gene Regulation in the Human Brain
Michelle Percharde,
University of California, San Francisco, USA
A LINE1-Nucleolin Partnership Regulates Embryonic Stem Cell Identity
A LINE1-Nucleolin Partnership Regulates Embryonic Stem Cell Identity
Caterina Gasperini,
Italian Institute of Technology, Italy
Identification and Functional Investigation of Mammalian piRNA-Pathway in Adult Hippocampal Neurogenesis
Identification and Functional Investigation of Mammalian piRNA-Pathway in Adult Hippocampal Neurogenesis
Zsuzsanna Izsvak,
Max-Delbrück Center, Germany
PGBD1, a Domesticated PiggyBac-Derived Gene, Has a Neuroprotective Function
PGBD1, a Domesticated PiggyBac-Derived Gene, Has a Neuroprotective Function
*
John L. Goodier,
Johns Hopkins School of Medicine, USA
Considering an Association of Retrotransposons and Neurodegenerative Disease
Considering an Association of Retrotransposons and Neurodegenerative Disease
17:00—19:15
LINE-1 Dances and Transposon Architecture
Meeting has ended...abstracts no longer viewable online.
John V. Moran,
University of Michigan Medical School, USA
Studies of a Human Retrotransposable Element
Studies of a Human Retrotransposable Element
Prescott L. Deininger,
Tulane University, USA
Short Talk: Transcription-Coupled Nucleotide Excision Repair Influences L1 Orientation in Genes
Short Talk: Transcription-Coupled Nucleotide Excision Repair Influences L1 Orientation in Genes
Gael Cristofari,
IRCAN - INSERM/CNRS, France
Genomic Approaches to Study the Activity of Human LINE-1 Elements
Genomic Approaches to Study the Activity of Human LINE-1 Elements
Tao P. Wu,
Yale University, USA
Short Talk: Novel DNA Methylation N6-Methyladenine-Regulated Retrotransposon LINE-1 in Mammals
Short Talk: Novel DNA Methylation N6-Methyladenine-Regulated Retrotransposon LINE-1 in Mammals
*
Jef D. Boeke,
New York University Langone Medical Center, USA
Systems Analyses of L1 Elements and their Friends Suggest S Phase Is Critical
Systems Analyses of L1 Elements and their Friends Suggest S Phase Is Critical
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
We gratefully acknowledge support for this conference from:
We gratefully acknowledge the generous grant for this conference provided by:
We gratefully acknowledge additional support for this conference from:
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