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This meeting took place in 2018



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Mobile Genetic Elements and Genome Plasticity (B7)


Organizer(s) Marlene Belfort, Evan E. Eichler, Henry L. Levin and Lynne E. Maquat
February 11—15, 2018
Eldorado Hotel & Spa • Santa Fe, New Mexico USA
Discounted Abstract Deadline: Oct 12, 2017
Abstract Deadline: Nov 14, 2017
Scholarship Deadline: Oct 12, 2017
Discounted Registration Deadline: Dec 14, 2017

Supported by the Directors' Fund

Summary of Meeting:
Transposable elements are potent sources of genetic variation that also regulate the expression of large gene networks. They constitute the majority of genomic DNA in many eukaryotes, and they dramatically shape genetic content by causing insertions, deletions, rearrangements and sequence duplications. Of increasing significance is the link of these mobile elements to diseases such as cancer and neurodegeneration. Sequencing of human populations demonstrates that active transposable elements are substantially more prevalent than previously appreciated. The aims of this conference are to: 1) Apply recent innovations in high-throughput sequencing and genome analysis to the study of transposon biology and genome dynamics; 2) Discuss the discovery of cellular systems that inhibit transposon activity as examples of the evolutionary arms race between mobile DNA and their hosts; 3) Describe active transposition during neurogenesis and in tumor cells and raise questions about the role of mobile DNA in brain development and cancer; and 4) Discern mechanistic aspects of element mobility from bacteria to humans. This symposium is designed to foster ties between leaders in the field of transposon function and biology with the pioneers of genome analysis, a link that is still tenuous and nascent. Discussions of transposon activity and genome dynamics will focus on mechanistic models. Methods applied to these problems will include molecular structures, biochemistry, expression studies and bioinformatic analyses. The transposons and hosts represented in this conference include diverse examples from eubacteria, archaea, protists, plants and mammals.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, February 11 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 15 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, February 16 in order to fully experience the meeting.

SUNDAY, FEBRUARY 11

16:00—20:00
Arrival and Registration

Eldorado Lounge
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Eldorado Lounge

MONDAY, FEBRUARY 12

07:00—08:00
Breakfast

Anasazi Ballroom
07:30—08:00
Poster Setup

Anasazi Ballroom
08:00—17:00
Poster Viewing

Anasazi Ballroom
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Eldorado Grand Ballroom
* Henry L. Levin, National Institutes of Health, USA

* Marlene Belfort, University of Albany, SUNY, USA

Feng Zhang, Broad Institute of MIT and Harvard University, USA
Mining Microbial Diversity for Genome Editing

09:00—11:30
Mechanisms and Results of Genome Editing
Meeting has ended...abstracts no longer viewable online.

Eldorado Grand Ballroom
Mitchell R. O'Connell, University of Rochester Medical Center, USA
Targeting RNA using CRISPR-Cas Enzymes

John A. Schiel, Horizon Discovery, USA
Short Talk: Comparison of Different Repair Templates’ HDR Efficiency using CRISPR-Cas9 and Synthetic Guide RNAs

Coffee Break

Zoltan Ivics, Paul Ehrlich Institute, Germany
Short Talk: Transposase and Host Factor Determinants of Target Site Selection by DNA Transposons

Josh T. Dubnau, Stony Brook University, USA
Retrotransposon Activation Contributes to Non-Cell Autonomous Neurodegeneration in a Drosophila TDP-43 Model of ALS

* Laura Landweber, Columbia University, USA
RNA-Programmed Genome Rearrangements in the Ciliate Oxytricha

11:30—12:30
Lunch

Anasazi Ballroom
12:00—14:30
Poster Session 1

Anasazi Ballroom
14:30—16:30
Workshop 1: Evolutionary Mechanisms of Transposition

Eldorado Grand Ballroom
Hyo Won Ahn, University of Georgia, USA
Ribosome Biogenesis Modulates Ty1 Copy Number Control in Saccharomyces Cerevisiae

Agnes H. Michel, ETH, Switzerland
Functional Mapping of Yeast Genomes by Saturated Transposition

* Irina Arkhipova, Marine Biological Laboratory, USA
Non-Canonical Base Modifications of Bacterial Origin in a Eukaryotic Genome

Shunhua Han, University of Georgia, USA
Genomic Insights into the Pattern of Transposable Element Proliferation in Drosophila S2 Cells

Arnab Ghosh, Texas Tech University, USA
Impact of Small RNA on Transposable Elements in the Salt Water Crocodile: Crocodylus porosus

Jasmine N. Baker, Louisiana State University, USA
Evolution of Alu Subfamily Structure in the Saimiri Lineage of New World Monkeys

Sung-Yeon Hwang, Seoul National University, South Korea
MOV10 Controls LINE-1 Retrotransposition through Interplay with RNASEH2

16:30—17:00
Coffee Available

Concourse
17:00—19:15
Dynamics of Plasticity
Meeting has ended...abstracts no longer viewable online.

Eldorado Grand Ballroom
Marlene Belfort, University of Albany, SUNY, USA
Mobile Self-Splicing Introns and Inteins as Stress Sensor

Lingling Chen, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China
Biogenesis of Circular RNAs

Orsolya Barabas, European Molecular Biology Laboratory, Germany
Short Talk: Conjugative Transposition of Antibiotic Resistance: Structural Basis of Broad Target Specificity and Auto-Regulation

David M. Walker, University of Texas at Austin, USA
Short Talk: A Dynamic E. coli Genome Mapped by Following Mu Transposition

* John M. Abrams, University of Texas Southwestern Medical Center, USA
p53 and the Game of Transposons

19:15
On Own for Dinner
No registration fees are used to fund alcohol served at this function.


TUESDAY, FEBRUARY 13

07:00—08:00
Breakfast

Anasazi Ballroom
08:00—11:15
Silencing Mobile DNA Activity: Self and Non-Self Recognition
Meeting has ended...abstracts no longer viewable online.

Eldorado Grand Ballroom
R. Keith Slotkin, Ohio State University, USA
Initiation of TE Silencing: How the Cell Recognizes and Triggers Transposable Elements for Trans-Generational Epigenetic Silencing

Mikiko C. Siomi, University of Tokyo, Japan
piRNA Biogenesis in Drosophila

Coffee Break

Shiv I. S. Grewal, NCI, National Institutes of Health, USA
Epigenetic Genome Control by Noncoding RNAs and RNA Processing Factors

Cameron Howard Lee, Stanford University, USA
Short Talk: Selective Silencing of Euchromatic L1s Revealed by Genome-Wide Screens for L1 Regulators

Todd S. Macfarlan, NICHD, National Institutes of Health, USA
Short Talk: Why Do Zinc Finger Proteins Evolve to Bind TEs in Mammals?

* Brenda L. Bass, University of Utah, USA
Self versus Non-Self: Is That My Double-Stranded RNA or Yours?

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Anasazi Ballroom
13:00—22:00
Poster Viewing

Anasazi Ballroom
16:30—17:00
Coffee Available

Concourse
17:00—19:15
The Action of Mobile DNA in the Brain and in Cancer
Meeting has ended...abstracts no longer viewable online.

Eldorado Grand Ballroom
Haig H. Kazazian, Johns Hopkins University School of Medicine, USA
Somatic L1 Retrotransposition in Cancers and their Normal Tissues

Kathleen H. Burns, Johns Hopkins University School of Medicine, USA
Roles for Mobile Elements in Human Disease

Patricia Goerner-Potvin, McGill University, Canada
Short Talk: Detecting Germline and Novel L1 Insertions using Long-Read Technologies

E. Alice Lee, Boston Children's Hospital & Harvard Medical School, USA
Short Talk: Immune Signatures Correlate with L1 Retrotransposition in Gastrointestinal Cancers

* Geoffrey J. Faulkner, Queensland Brain Institute, Australia
Hot Donor L1s in Mammalian Somatic Cells

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Anasazi Ballroom
19:30—22:00
Poster Session 2

Anasazi Ballroom

WEDNESDAY, FEBRUARY 14

07:00—08:00
Breakfast

Anasazi Ballroom
08:00—11:00
Evolution and Regulation of Mobile Elements
Meeting has ended...abstracts no longer viewable online.

Eldorado Grand Ballroom
Cedric Feschotte, Cornell University, USA
Transposable Elements as Catalysts of Convergent Evolution

Henry L. Levin, National Institutes of Health, USA
Transposable Element Integration Rewires Regulatory Networks to Protect Cells Against Stress

Coffee Break

Manvendra Singh, Max-Delbrueck Centre for Molecular Medicine, Germany
Short Talk: Reactivation of Endogenous Retroviruses Aid the Development of Human-Specific Embryogenesis

Tugce Aktas, Max Planck Institute of Immunobiology and Epigenetics, Germany
Short Talk: RNA Binding Proteins at the Crossroads of Transposable Element Suppression and Post-Transcriptional Regulation of Gene Expression

* Ruth Lehmann, NYU School of Medicine, USA
Regulation of Transposon Splicing by piRNA-Mediated Repressive Chromatin

11:00—17:00
On Own for Lunch

11:00—13:00
Poster Setup

Anasazi Ballroom
13:00—22:00
Poster Viewing

Anasazi Ballroom
16:30—17:00
Coffee Available

Concourse
17:00—19:15
Genome Structural Variation and Neuroplasticity in Primates
Meeting has ended...abstracts no longer viewable online.

Eldorado Grand Ballroom
Evan E. Eichler, HHMI/University of Washington, USA
Dynamic Duplications and Primate Genome Evolution

Christopher A. Walsh, Children's Hospital Boston, USA
L1 Retrotransposition and Somatic Mutation in the Human Brain

Molly C. Hammell, Cold Spring Harbor Laboratory, USA
Short Talk: Awakening Old Foes: Transposon De-Silencing in ALS Patient Tissues

Angela Macia, University of California, San Diego, USA
Short Talk: Blocking LINE-1 Reverse Transcriptase Activity in TREX1-Deficient Cells Rescues Neurotoxicity in Aicardi-Goutières Syndrome

* Fred (Rusty) H. Gage, The Salk Institute for Biological Studies, USA
Retroelements in Brain, Behavior and Evolution

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Anasazi Ballroom
19:30—22:00
Poster Session 3

Anasazi Ballroom

THURSDAY, FEBRUARY 15

07:00—08:00
Breakfast

Anasazi Ballroom
08:00—11:00
Transposition and Gene Regulation
Meeting has ended...abstracts no longer viewable online.

Eldorado Grand Ballroom
Joanna Wysocka, Stanford University School of Medicine, USA
Intrinsic Retroviral Reactivation in Human Preimplantation Embryos and Pluripotent Cells

Elizabeth H. Kellogg, University of California, Berkeley, USA
Short Talk: Cryo-EM Structural Studies of the P-Element Transposase

Robert A. Martienssen, Cold Spring Harbor Laboratory, USA
Epigenetically Activated Small RNAs Mediate Chromosome Segregation and Dosage

Coffee Break

Pascale Lesage, Institut Universitaire d'Hématologie, France
Molecular Mechanisms and Regulation of Ty1 Retrotransposon Integration Site Selection

* M. Joan Curcio, Wadsworth Center, USA
LTR-Retrotransposon Activity Perturbs Asymmetric Centrosome Inheritance

11:00—17:00
On Own for Lunch

14:30—16:30
Workshop 2: The Neurobiology of Mobile Elements

Eldorado Grand Ballroom
Jasmine Jacob-Hirsch, Sheba Medical Center, Israel
Enhanced Brain Retrotransposition in Neurodevelopmental Disorders

Julia Fuchs Sebe, Collège de France, France
LINE-1 Retrotransposon Repression Attenuates Neurodegeneration in Adult Dopaminergic Neurons

Frank MJ Jacobs, University of Amsterdam, Netherlands
The Evolutionary Impact of Transposable Element Invasions on Human Neuronal Gene Expression

Johan Jakobsson, Wallenberg Neuroscience Center, Lund University, Sweden
LINE-2 Elements Shape Post-Transcriptional Gene Regulation in the Human Brain

Michelle Percharde, University of California, San Francisco, USA
A LINE1-Nucleolin Partnership Regulates Embryonic Stem Cell Identity

Caterina Gasperini, Italian Institute of Technology, Italy
Identification and Functional Investigation of Mammalian piRNA-Pathway in Adult Hippocampal Neurogenesis

Zsuzsanna Izsvak, Max-Delbrück Center, Germany
PGBD1, a Domesticated PiggyBac-Derived Gene, Has a Neuroprotective Function

* John L. Goodier, Johns Hopkins School of Medicine, USA
Considering an Association of Retrotransposons and Neurodegenerative Disease

16:30—17:00
Coffee Available

Concourse
17:00—19:15
LINE-1 Dances and Transposon Architecture
Meeting has ended...abstracts no longer viewable online.

Eldorado Grand Ballroom
John V. Moran, University of Michigan Medical School, USA
Studies of a Human Retrotransposable Element

Prescott L. Deininger, Tulane University, USA
Short Talk: Transcription-Coupled Nucleotide Excision Repair Influences L1 Orientation in Genes

Gael Cristofari, IRCAN - INSERM/CNRS, France
Genomic Approaches to Study the Activity of Human LINE-1 Elements

Tao P. Wu, Yale University, USA
Short Talk: Novel DNA Methylation N6-Methyladenine-Regulated Retrotransposon LINE-1 in Mammals

* Jef D. Boeke, New York University Langone Medical Center, USA
Systems Analyses of L1 Elements and their Friends Suggest S Phase Is Critical

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Anasazi Ballroom
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Anasazi Ballroom

FRIDAY, FEBRUARY 16

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1U13CA224884-01

Funding for this conference was made possible (in part) by 1 U13 CA224884-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:


Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

March of Dimes Foundation, Grant No. 4-FY18-826
New England Biolabs, Inc. The RNA Society

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676