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This meeting took place in 2010
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Lymphocyte Activation and Gene Expression (B8)
Organizer(s) Leslie J. Berg, Lawrence E. Samelson and Facundo D. Batista
February 27—March 4, 2010
Beaver Run Resort • Breckenridge, Colorado USA
Abstract Deadline: Oct 27, 2009
Late Abstract Deadline: Nov 30, 2009
Scholarship Deadline: Oct 27, 2009
Early Registration Deadline: Dec 28, 2009
Sponsored by Amgen Inc., Genzyme Corporation and Novo Nordisk A/S
Summary of Meeting:
Lymphocytes mediate the adaptive immune responses to antigens derived from infectious agents, transformed cells, transplanted organs and, in the setting of autoimmunity, ones own cells. The study of lymphocyte activation and gene expression is central to understanding the complex biology of these cells and offers hope for regulating these cells in different clinical settings. Much has been learned in the past several decades in this field. Receptors, enzymes and adapter molecules have been identified, signaling cascades and networks have been defined, and the complex regulation of gene expression has been explored. Nonetheless many basic questions remain to be elucidated. Among several contentious areas of research that will be presented by experts at this meeting are the actual means by which antigen receptors initiate the activation process, how activation induces changes in signaling pathways, intracellular organelles and the cytoskeleton, and how changes in chromatin and transcriptional factors determine gene expression.
View Scholarships/Awards
Lymphocytes mediate the adaptive immune responses to antigens derived from infectious agents, transformed cells, transplanted organs and, in the setting of autoimmunity, ones own cells. The study of lymphocyte activation and gene expression is central to understanding the complex biology of these cells and offers hope for regulating these cells in different clinical settings. Much has been learned in the past several decades in this field. Receptors, enzymes and adapter molecules have been identified, signaling cascades and networks have been defined, and the complex regulation of gene expression has been explored. Nonetheless many basic questions remain to be elucidated. Among several contentious areas of research that will be presented by experts at this meeting are the actual means by which antigen receptors initiate the activation process, how activation induces changes in signaling pathways, intracellular organelles and the cytoskeleton, and how changes in chromatin and transcriptional factors determine gene expression.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SATURDAY, FEBRUARY 27
SUNDAY, FEBRUARY 28
MONDAY, MARCH 1
TUESDAY, MARCH 2
WEDNESDAY, MARCH 3
THURSDAY, MARCH 4
Conference Program Print | View meeting in 12 hr (am/pm) time
SATURDAY, FEBRUARY 27
19:30—20:30
Keynote Address: The TCR
Meeting has ended...abstracts no longer viewable online.
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Lawrence E. Samelson,
National Institutes of Health, USA
08:00—11:15
Initiation of Antigen Receptor Signaling
Meeting has ended...abstracts no longer viewable online.
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Susan K. Pierce,
NIAID, National Institutes of Health, USA
The Molecular Mechanisms Underlying the Initiation of BCR Signaling
The Molecular Mechanisms Underlying the Initiation of BCR Signaling
Balbino Alarcón,
CSIC-Universidad Autonoma de Madrid, Spain
Intramolecular Mechanism for Transmission of the Conformational Change in the TCR
Intramolecular Mechanism for Transmission of the Conformational Change in the TCR
Arup K. Chakraborty,
Massachusetts Institute of Technology, USA
How T Cells “See” Antigen
How T Cells “See” Antigen
Nina G. Caculitan,
Genentech, Inc., USA
Short Talk: The Regulation of Protein Spatial Sorting and its Effect on T Cell Signaling in the Immunological Synapse
Short Talk: The Regulation of Protein Spatial Sorting and its Effect on T Cell Signaling in the Immunological Synapse
Mira Barda-Saad,
Bar Ilan University, Israel
Short Talk: THE NEGATIVE REGULATION MECHANISM OF THE WISKOTT-ALDRICH SYNDROME PROTEIN
Short Talk: THE NEGATIVE REGULATION MECHANISM OF THE WISKOTT-ALDRICH SYNDROME PROTEIN
17:00—19:00
Cell Biology of Lymphocyte Activation
Meeting has ended...abstracts no longer viewable online.
Facundo D. Batista,
Ragon Institute of MGH, MIT and Harvard, USA
Interplay between the BCR and Cytoskeleton: A Mechanism to Regulate Lymphocyte Activation and Tonic Signaling?
Interplay between the BCR and Cytoskeleton: A Mechanism to Regulate Lymphocyte Activation and Tonic Signaling?
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Gillian Griffiths,
Cambridge Institute for Medical Research, UK
The Immunological Synapse: A Focal Point for Exocytosis and Endocytosis
The Immunological Synapse: A Focal Point for Exocytosis and Endocytosis
Matthew F. Krummel,
University of California, San Francisco, USA
The Interplay of T Motility and Signaling
The Interplay of T Motility and Signaling
Sarah Russell,
Swinburne University of Technology, Australia
Short Talk: Orchestratation of Lymphocyte Fate by the Polarity Network
Short Talk: Orchestratation of Lymphocyte Fate by the Polarity Network
08:00—11:15
Transcriptional Regulation and Chromatin Remodeling during Lymphocyte Activation
Meeting has ended...abstracts no longer viewable online.
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Anjana Rao,
La Jolla Institute for Allergy and Immunology, USA
Ca Signaling and Transcription Regulation in Lymphocytes
Ca Signaling and Transcription Regulation in Lymphocytes
Steven L. Reiner,
Columbia University, USA
Specifying the T Cell Fates Required for Immunity
Specifying the T Cell Fates Required for Immunity
Joonsoo Kang,
University of Massachusetts Medical School, USA
Transcriptional Regulation of alpha-beta vs. gamma-delta T Cell Lineage Commitment
Transcriptional Regulation of alpha-beta vs. gamma-delta T Cell Lineage Commitment
Casey T. Weaver,
University of Alabama at Birmingham, USA
Gene Expression and the TH17 Response
Gene Expression and the TH17 Response
Michael J. Pazin,
National Human Genome Research Institute, National Institutes of Health, USA
Short Talk: The Chromatin Remodeling Landscape of T Helper Cell Differentiation
Short Talk: The Chromatin Remodeling Landscape of T Helper Cell Differentiation
Robert J. Johnston,
Bristol-Myers Squibb, USA
Short Talk: Bcl6 and Blimp-1 are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation
Short Talk: Bcl6 and Blimp-1 are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation
14:30—16:30
Workshop 1: Early Events in Lymphocyte Activation
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Arthur Weiss,
University of California, San Francisco, USA
Melania Capasso,
Barts Cancer Institute, UK
Control of B Cell Activation and Metabolism by the Voltage-Gated Proton Channel HVCN1
Control of B Cell Activation and Metabolism by the Voltage-Gated Proton Channel HVCN1
Olga Anna Ksionda,
University of California, San Francisco, USA
The Role of the Localization of Vav1 during T Cell Activation
The Role of the Localization of Vav1 during T Cell Activation
Aaron J. Marshall,
University of Manitoba, Canada
The Phosphoinositide 3-Kinase Effector Molecule Bam32/DAPP1 Promotes B Cell Adhesion and Formation of Polarized Conjugates with T Cells
The Phosphoinositide 3-Kinase Effector Molecule Bam32/DAPP1 Promotes B Cell Adhesion and Formation of Polarized Conjugates with T Cells
David Oh,
Stanford University, USA
Ca2+ Signaling and the Regulation of Thymocyte Mobility during Negative Selection in Thymic Slices
Ca2+ Signaling and the Regulation of Thymocyte Mobility during Negative Selection in Thymic Slices
Hanne L. Ostergaard,
University of Alberta, Canada
Regulation of the Tyrosine Kinase Pyk2 By Calcium in Cytotoxic T Lymphocytes
Regulation of the Tyrosine Kinase Pyk2 By Calcium in Cytotoxic T Lymphocytes
Bruno Silva-Santos,
University of Lisbon, Portugal
Differential Requirements on TCR/ CD27 versus TLR Signaling for Activation of Discrete Pro-Inflammatory gamma-delta T Cell Subsets
Differential Requirements on TCR/ CD27 versus TLR Signaling for Activation of Discrete Pro-Inflammatory gamma-delta T Cell Subsets
Neetu Gupta,
Cleveland Clinic, USA
Regulation of Antigen-Dependent B Cell Activation by Tyrosine and Threonine Phosphorylation of the ERM Family Protein Ezrin
Regulation of Antigen-Dependent B Cell Activation by Tyrosine and Threonine Phosphorylation of the ERM Family Protein Ezrin
Steve R. Roffler,
Academia Sinica, Taiwan
Mechanical Forces Acting on the T Cell Receptor Complex Can Trigger TCR Signaling
Mechanical Forces Acting on the T Cell Receptor Complex Can Trigger TCR Signaling
17:00—19:00
Downstream Pathways of Antigen Receptor Signaling I
Meeting has ended...abstracts no longer viewable online.
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Doreen A. Cantrell,
University of Dundee, UK
The Function of Protein Kinase B/Akt in Peripheral T Cells
The Function of Protein Kinase B/Akt in Peripheral T Cells
Pamela L. Schwartzberg,
NIAID, NHGRI, USA
Altered T Cell Function in Mice Deficient in SAP, a Model for X-Linked Lymphoproliferative Disease
Altered T Cell Function in Mice Deficient in SAP, a Model for X-Linked Lymphoproliferative Disease
Bernard Malissen,
Centre d'Immunologie de Marseille-Luminy, France
Th2 Lymphoproliferative Disorders Resulting from Defective LAT Signalosomes
Th2 Lymphoproliferative Disorders Resulting from Defective LAT Signalosomes
Debbie A. Yablonski,
Technion - Israel Institute of Technology, Israel
Short Talk: Regulatory Interactions within the SLP-76-Nucleated Complex
Short Talk: Regulatory Interactions within the SLP-76-Nucleated Complex
Morgan Huse,
Memorial Sloan Kettering Cancer Center, USA
Short Talk: Probing Inhibitory Signaling Dynamics in NK Cells by Photostimulation
Short Talk: Probing Inhibitory Signaling Dynamics in NK Cells by Photostimulation
08:00—11:15
Downstream Pathways of Antigen Receptor Signaling II
Meeting has ended...abstracts no longer viewable online.
Arthur Weiss,
University of California, San Francisco, USA
Turning T Cells Off and On with Small Molecule Inhibitors of Tyrosine Kinases
Turning T Cells Off and On with Small Molecule Inhibitors of Tyrosine Kinases
Jürgen Wienands,
Georg August University of Goettingen, Germany
Short Talk: Composition and Dynamic Assembly of B Cell Signalosomes as Revealed by Functional Proteomics
Short Talk: Composition and Dynamic Assembly of B Cell Signalosomes as Revealed by Functional Proteomics
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Gary A. Koretzky,
University of Pennsylvania School of Medicine, USA
Role of SLP-76 in Immune Cell Development and Function
Role of SLP-76 in Immune Cell Development and Function
Bridget S. Wilson,
University of New Mexico Health Science Center, USA
High Resolution Imaging of Fc[epislon]RI Organization and Receptor Dynamics: Immobilization is not a Requirement for Signal Initiation
High Resolution Imaging of Fc[epislon]RI Organization and Receptor Dynamics: Immobilization is not a Requirement for Signal Initiation
Stephen C. Bunnell,
Tufts University School of Medicine, USA
Short Talk: VLA-4 Inhibits the Centralization of SLP-76 Microclusters by Resisting the Contraction of Myosin IIA Filaments
Short Talk: VLA-4 Inhibits the Centralization of SLP-76 Microclusters by Resisting the Contraction of Myosin IIA Filaments
17:00—19:00
Downstream Pathways of Antigen Receptor Signaling III
Meeting has ended...abstracts no longer viewable online.
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Leslie J. Berg,
University of Massachusetts Medical Center, USA
Tec Kinases in T Cell Differentiation
Tec Kinases in T Cell Differentiation
Lawrence E. Samelson,
National Institutes of Health, USA
Signaling at the TCR
Signaling at the TCR
Richard S. Lewis,
Stanford University School of Medicine, USA
Molecular Mechanisms for Activation and Inactivation of Calcium Channels in T Cells
Molecular Mechanisms for Activation and Inactivation of Calcium Channels in T Cells
Patrick G. Hogan,
La Jolla Institute of Allergy and Immunology, USA
Short Talk: Minimal Requirement for Store-Operated Calcium Entry: STIM1 Gates ORAI1 Channels in vitro
Short Talk: Minimal Requirement for Store-Operated Calcium Entry: STIM1 Gates ORAI1 Channels in vitro
08:00—11:15
Visualization of Lymphocyte Activation
Meeting has ended...abstracts no longer viewable online.
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Ellen A. Robey,
University of California, Berkeley, USA
Visualizing Thymic Selection in situ
Visualizing Thymic Selection in situ
Michael L. Dustin,
University of Oxford, UK
Immunological Synapse Formation in Normal and Pathological Immune Responses
Immunological Synapse Formation in Normal and Pathological Immune Responses
Ronald N. Germain,
NIAID, National Institutes of Health, USA
Cell Dynamics during the Initiation and Effector Phases of Adaptive Immune Responses
Cell Dynamics during the Initiation and Effector Phases of Adaptive Immune Responses
Takashi Saito,
RIKEN Center for Allergy and Immunology, Japan
Molecular Dynamics for T-Cell Activation and Co-stimulation
Molecular Dynamics for T-Cell Activation and Co-stimulation
Daniel M. Davis,
Imperial College London, UK
Short Talk: Membrane Nanotubes Support Sub-Micron Scale Immune Synapses and Aid Cytolysis of Distant Target Cells
Short Talk: Membrane Nanotubes Support Sub-Micron Scale Immune Synapses and Aid Cytolysis of Distant Target Cells
Philippe Bousso,
Institute Pasteur, France
Short Talk: Intravital Imaging Reveals Distinct Dynamics of NK Cells and CD8+ T Cells during Effector Function in Solid Tumors
Short Talk: Intravital Imaging Reveals Distinct Dynamics of NK Cells and CD8+ T Cells during Effector Function in Solid Tumors
14:30—16:30
Workshop 2: Late Events in Lymphocyte Activation
Mark R. Boothby,
Vanderbilt University Medical Center, USA
Stage-Specific Essential Roles of Rictor, a Mammalian Target of Rapamycin Complex 2 (mTORC2) Subunit, in T Cell Differentiation Define a Bifurcation in the Signal Relay
Stage-Specific Essential Roles of Rictor, a Mammalian Target of Rapamycin Complex 2 (mTORC2) Subunit, in T Cell Differentiation Define a Bifurcation in the Signal Relay
Jennifer L. Cannons,
National Institutes of Health, USA
A Multi-Stage T:B Lymphocyte Adhesion Process is Required for Germinal Centre Responses
A Multi-Stage T:B Lymphocyte Adhesion Process is Required for Germinal Centre Responses
Greg M. Delgoffe,
University of Pittsburgh, USA
The mTOR Signaling Complexes TORC1 and TORC2 Selectively Regulate CD4+ T Cell Differentiation
The mTOR Signaling Complexes TORC1 and TORC2 Selectively Regulate CD4+ T Cell Differentiation
Guo Fu,
Xiamen University, China
Themis Regulates Thymocyte Signaling
Themis Regulates Thymocyte Signaling
Katrina L. Randall,
Canberra Hospital, Australia
DOCK8 Mutations Cripple B Cell Immune Synapse Formation, Germinal Centers and Long-Lived Antibody Production
DOCK8 Mutations Cripple B Cell Immune Synapse Formation, Germinal Centers and Long-Lived Antibody Production
Yuri K. Sykulev,
Thomas Jefferson University, USA
Kinetics of Early TCR Signaling Influences the Path of Granule Delivery by CTL
Kinetics of Early TCR Signaling Influences the Path of Granule Delivery by CTL
Bazarragchaa Damdinsuren,
National Institute on Aging, National Institutes of Health, USA
Single-Round of Antigen Receptor Signaling Programs Naive B Cells to Receive T Cell Help
Single-Round of Antigen Receptor Signaling Programs Naive B Cells to Receive T Cell Help
Vanessa Marie Hubbard-Lucey,
New York University School of Medicine, USA
Macroautophagy Regulates CD4+ T Cell Function
Macroautophagy Regulates CD4+ T Cell Function
17:00—19:00
Regulation of the Immune Response by microRNA
Meeting has ended...abstracts no longer viewable online.
Session supported in part by the Juvenile Diabetes Research Foundation
*
Matthias Merkenschlager,
Imperial College London, UK
Cohesins and Gene Expression: From Proof-of-Principle Towards Cell Lineage- and Developmental Stage-Specific Regulation
Cohesins and Gene Expression: From Proof-of-Principle Towards Cell Lineage- and Developmental Stage-Specific Regulation
Carola G. Vinuesa,
Australian National University, Australia
Role of Bcl-6 in Specializing the Function of T Follicular Helper Cells
Role of Bcl-6 in Specializing the Function of T Follicular Helper Cells
Li-Fan Lu,
University of California, San Diego, USA
Short Talk: Function of miR-146a in Controlling Treg Cell-Mediated Regulation of TH1 Responses
Short Talk: Function of miR-146a in Controlling Treg Cell-Mediated Regulation of TH1 Responses
Anna Barbara Stittrich,
German Arthritis Research Center, Germany
Short Talk: MicroRNA-182 Promotes Clonal Expansion of Activated T Helper Cells
Short Talk: MicroRNA-182 Promotes Clonal Expansion of Activated T Helper Cells
*Session Chair †Invited, not yet responded.
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