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This meeting took place in 2010
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Cell Biology of Virus Entry, Replication and Pathogenesis (B5)
Organizer(s) Margaret Kielian, Peter Sarnow, Terence S. Dermody and Paul D. Bieniasz
February 16—21, 2010
Sagebrush Inn & Suites • Taos, NM USA
Abstract Deadline: Oct 19, 2009
Late Abstract Deadline: Nov 16, 2009
Scholarship Deadline: Oct 19, 2009
Early Registration Deadline: Dec 16, 2009
Sponsored by Santaris Pharma A/S
Summary of Meeting:
The Keystone Symposia meeting on the Cell Biology of Virus Entry, Replication and Pathogenesis emphasizes key aspects of virus infection pathways and cellular responses. A central goal is the identification of critical virus-cell crosstalk during these processes. Rather than dividing viruses into separate “categories” such as positive-sense RNA viruses and DNA viruses, the meeting highlights common aspects of virus lifecycles among different virus groups. The multi-disciplinary nature of the proposed meeting is important in bringing together investigators using structural, molecular, cell biological, immunological and epidemiological methods. This emphasis on shared themes and multiple experimental approaches will continue to be critical to future advances in virology. While there has been spectacular recent progress in our understanding of virus lifecycles, we are still very far from being able to design antiviral strategies, and unexpected novel aspects of virus cell biology are constantly being discovered. Plenary sessions will cover the most important aspects of virus interactions with cells. Day 1 will include cutting-edge structural virology studies and imaging methods to follow single virus particles during entry. Day 2 will focus on the entry mechanisms of enveloped and non-enveloped viruses and the roles of cellular proteins in virus infection. Day 3 will cover viral and cellular aspects of virus replication and cellular antiviral responses. The last day will focus on the important areas of virus assembly and pathogenesis. Late-breaking exciting developments in this fast-moving field will be incorporated by short presentations and afternoon workshop sessions drawn from the submitted abstracts.
View Scholarships/Awards
The Keystone Symposia meeting on the Cell Biology of Virus Entry, Replication and Pathogenesis emphasizes key aspects of virus infection pathways and cellular responses. A central goal is the identification of critical virus-cell crosstalk during these processes. Rather than dividing viruses into separate “categories” such as positive-sense RNA viruses and DNA viruses, the meeting highlights common aspects of virus lifecycles among different virus groups. The multi-disciplinary nature of the proposed meeting is important in bringing together investigators using structural, molecular, cell biological, immunological and epidemiological methods. This emphasis on shared themes and multiple experimental approaches will continue to be critical to future advances in virology. While there has been spectacular recent progress in our understanding of virus lifecycles, we are still very far from being able to design antiviral strategies, and unexpected novel aspects of virus cell biology are constantly being discovered. Plenary sessions will cover the most important aspects of virus interactions with cells. Day 1 will include cutting-edge structural virology studies and imaging methods to follow single virus particles during entry. Day 2 will focus on the entry mechanisms of enveloped and non-enveloped viruses and the roles of cellular proteins in virus infection. Day 3 will cover viral and cellular aspects of virus replication and cellular antiviral responses. The last day will focus on the important areas of virus assembly and pathogenesis. Late-breaking exciting developments in this fast-moving field will be incorporated by short presentations and afternoon workshop sessions drawn from the submitted abstracts.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
TUESDAY, FEBRUARY 16
WEDNESDAY, FEBRUARY 17
THURSDAY, FEBRUARY 18
FRIDAY, FEBRUARY 19
SATURDAY, FEBRUARY 20
SUNDAY, FEBRUARY 21
Conference Program Print | View meeting in 12 hr (am/pm) time
TUESDAY, FEBRUARY 16
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.
Francis V. Chisari,
The Scripps Research Institute, USA
Induction and Evasion of the Innate Host Response to HCV
Induction and Evasion of the Innate Host Response to HCV
20:30—20:45
Orientation for New Attendees and New Investigators
Keystone Symposia's Chief Scientific Officer, Dr. Andy Robertson, to lead discussion in a "What to Expect during your Attendance" for interested delegates.
08:00—11:15
Advances in Understanding Virus Structure and Function
Meeting has ended...abstracts no longer viewable online.
Margaret Kielian,
Albert Einstein College of Medicine, USA
Virus-Membrane Fusion: Mechanisms of the Alphavirus and Flavivirus Fusion Proteins
Virus-Membrane Fusion: Mechanisms of the Alphavirus and Flavivirus Fusion Proteins
*
Kay Grünewald,
University of Oxford, UK
Probing Membrane Interactions of Herpesvirus Glycoproteins by Cryo Electron Tomography
Probing Membrane Interactions of Herpesvirus Glycoproteins by Cryo Electron Tomography
*
Erica Ollmann Saphire,
The Scripps Research Institute, USA
Crystal Structures Reveal a Shared Immunological Solution for Neutralizing Ebolaviruses
Crystal Structures Reveal a Shared Immunological Solution for Neutralizing Ebolaviruses
Richard J. Kuhn,
Purdue University, USA
Dengue Virus Structure and Function during Assembly, Maturation and Entry
Dengue Virus Structure and Function during Assembly, Maturation and Entry
Manidipa Banerjee,
Indian Institute of Technology, Delhi, India
Short Talk: Entry of a Non-Enveloped Virus Depends on Metal-Mediated pH Control of the Delivery of a Lytic Peptide to the Endosomal Membrane
Short Talk: Entry of a Non-Enveloped Virus Depends on Metal-Mediated pH Control of the Delivery of a Lytic Peptide to the Endosomal Membrane
Gaya K. Amarasinghe,
Washington University in St. Louis, USA
Short Talk: Structural Basis for Innate Immune Evasion by Ebola VP35
Short Talk: Structural Basis for Innate Immune Evasion by Ebola VP35
14:30—16:30
Workshop 1: Virus Entry and Assembly
Christopher A. Davis,
University of Birmingham, UK
Claudin Association with CD81 Defines Hepatitis C Virus Entry
Claudin Association with CD81 Defines Hepatitis C Virus Entry
Julia Bitzegeio,
TWINCORE, Germany
Adaptation of Hepatitis C Virus to Mouse CD81 Permits Infection of Mouse Cells in the Absence of Human Factors
Adaptation of Hepatitis C Virus to Mouse CD81 Permits Infection of Mouse Cells in the Absence of Human Factors
Walther Mothes,
Yale University School of Medicine, USA
Mechanism of Cell-to-Cell Transmission of Retroviruses
Mechanism of Cell-to-Cell Transmission of Retroviruses
Jason Laliberte,
NIAID, National Institutes of Health, USA
The Membrane Fusion Step of Vaccinia Virus Entry is Cooperatively Mediated by Twelve Viral Membrane Proteins
The Membrane Fusion Step of Vaccinia Virus Entry is Cooperatively Mediated by Twelve Viral Membrane Proteins
Kai Xu,
National Institutes of Health, USA
Structural Studies on the Henipavirus G Attachment Glycoprotein and a Cross-Reactive Neutralizing Human Monoclonal Antibody
Structural Studies on the Henipavirus G Attachment Glycoprotein and a Cross-Reactive Neutralizing Human Monoclonal Antibody
Rebecca Dutch,
University of Kentucky, USA
Paramyxovirus Fusion Protein Transmembrane Domain Interactions: Potential Roles in Protein Folding, Membrane Fusion and Intracellular Trafficking
Paramyxovirus Fusion Protein Transmembrane Domain Interactions: Potential Roles in Protein Folding, Membrane Fusion and Intracellular Trafficking
Joshua Matthew Costin,
Florida Gulf Coast University, USA
Peptide-Induced Ejection of the Dengue Virus Genome
Peptide-Induced Ejection of the Dengue Virus Genome
Andrew M. Lee,
The Scripps Research Institute, USA
Probing Arenavirus Fusion Using Unique Small Molecules
Probing Arenavirus Fusion Using Unique Small Molecules
17:00—19:00
Approaches to Visualizing Virus Entry
Meeting has ended...abstracts no longer viewable online.
Xiaowei Zhuang,
Harvard University, USA
Zooming in on Virus-Cell Interactions – By Single Particle Tracking and Sub-Diffraction Limit Imaging
Zooming in on Virus-Cell Interactions – By Single Particle Tracking and Sub-Diffraction Limit Imaging
Thomas J. Hope,
Northwestern University, USA
Single Virus Tracking of HIV in vivo
Single Virus Tracking of HIV in vivo
Sean P. Whelan,
Harvard Medical School, USA
Approaches to Characterizing the Entry of Vesicular Stomatitis Virus into Host Cells
Approaches to Characterizing the Entry of Vesicular Stomatitis Virus into Host Cells
Carolyn B. Coyne,
University of Pittsburgh, USA
Short Talk: Coxsackievirus B3 Internalization into Polarized Endothelial Cells Requires DAF-Mediated Release of ER-Derived Calcium Stores
Short Talk: Coxsackievirus B3 Internalization into Polarized Endothelial Cells Requires DAF-Mediated Release of ER-Derived Calcium Stores
08:00—11:15
Virus Entry Pathways
Meeting has ended...abstracts no longer viewable online.
Terence S. Dermody,
Vanderbilt University School of Medicine, USA
Reovirus Internalization and Proteolytic Disassembly
Reovirus Internalization and Proteolytic Disassembly
Matthew J. Evans,
Icahn School of Medicine at Mount Sinai, USA
Hepatitis C Virus Cell Entry Factors And Pathways
Hepatitis C Virus Cell Entry Factors And Pathways
Kartik Chandran,
Albert Einstein College of Medicine, USA
Proteolysis and the Membrane Fusion Mechanism of Ebolavirus
Proteolysis and the Membrane Fusion Mechanism of Ebolavirus
*
Billy Tsai,
University of Michigan Medical School, USA
Polyomavirus Entry Pathway
Polyomavirus Entry Pathway
Daniel C. DiMaio,
Yale University School of Medicine, USA
Short Talk: Cellular DNAJ Proteins are Required for Efficient SV40 Infection
Short Talk: Cellular DNAJ Proteins are Required for Efficient SV40 Infection
Megan Shaw,
Icahn School of Medicine at Mount Sinai, USA
Short Talk: Human Host Factors Required for Influenza Virus Replication
Short Talk: Human Host Factors Required for Influenza Virus Replication
17:00—19:00
Cellular Genes and Virus Infection
Meeting has ended...abstracts no longer viewable online.
Karla A. Kirkegaard,
Stanford University School of Medicine, USA
Autophagy and Virus Infection
Autophagy and Virus Infection
*
Sara R. Cherry,
University of Pennsylvania, USA
Identification of Factors Involved in Virus Replication using RNAi Screens
Identification of Factors Involved in Virus Replication using RNAi Screens
*
Susana Lopez,
Instituto de Biotecnologia, Mexico
Rotavirus Strategies to Control the Cell Protein Synthesis Apparatus
Rotavirus Strategies to Control the Cell Protein Synthesis Apparatus
Matthew D. Weitzman,
Children's Hospital of Philadelphia, USA
Short Talk: A Viral Ubiquitin Ligase Targets RNF8 and RNF168 to Modulate Histone Ubiquitination and the Cellular DNA Damage Response
Short Talk: A Viral Ubiquitin Ligase Targets RNF8 and RNF168 to Modulate Histone Ubiquitination and the Cellular DNA Damage Response
08:00—11:15
Virus Replication
Meeting has ended...abstracts no longer viewable online.
*
Robert F. Kalejta,
University of Wisconsin-Madison, USA
Peter Sarnow,
Stanford University School of Medicine, USA
Modulation of Hepatitis C Virus RNA Abundance by MicroRNA 122 and Residents of Processing Bodies
Modulation of Hepatitis C Virus RNA Abundance by MicroRNA 122 and Residents of Processing Bodies
Ian J. Mohr,
New York University School of Medicine, USA
Regulation of Translation during Virus Infection
Regulation of Translation during Virus Infection
Peter D. Nagy,
University of Kentucky, USA
A Systems Biology Approach to Dissect the Roles of Host Proteins in Tombusvirus RNA Replication
A Systems Biology Approach to Dissect the Roles of Host Proteins in Tombusvirus RNA Replication
Andrea Gamarnik,
Fundación Instituto Leloir, Argentina
Dengue Virus Capsid Protein Localization in Lipid Droplets and its Interplay with Viral RNA Synthesis
Dengue Virus Capsid Protein Localization in Lipid Droplets and its Interplay with Viral RNA Synthesis
Sunnie R. Thompson,
University of Alabama, Birmingham, USA
Short Talk: A Genetic Approach to Understanding how Viral Internal Ribosome Sites Recruit Host Ribosomes
Short Talk: A Genetic Approach to Understanding how Viral Internal Ribosome Sites Recruit Host Ribosomes
Oren Kobiler,
Tel Aviv University, Israel
Short Talk: A “Brainbow” Herpesvirus, Able to Switch Fluorophores, Suggests a Limited Number of Viral Genomes Express and Replicate in a Newly Infected Cell
Short Talk: A “Brainbow” Herpesvirus, Able to Switch Fluorophores, Suggests a Limited Number of Viral Genomes Express and Replicate in a Newly Infected Cell
14:30—16:30
Workshop 2: Viral Pathogenesis and Host Interactions
Daniel Popkin,
The Scripps Research Institute, USA
Mapping the Chronic Viral Infection Resistome
Mapping the Chronic Viral Infection Resistome
Jan E. Carette,
Stanford University, USA
Haploid Genetic Screens in Human Cells Identify Host Factors Used by Pathogens
Haploid Genetic Screens in Human Cells Identify Host Factors Used by Pathogens
Shane D. Trask,
NIAID, National Institutes of Health, USA
Engineering Rotavirus Reassortants by Reverse Genetics
Engineering Rotavirus Reassortants by Reverse Genetics
Ivo Lorenz,
Tri-Institutional Therapeutics Discovery Institute, USA
Insertion of the HIV-1 gp41 Epitopes 2F5 and 4E10 into the Membrane-Proximal Region of the Vesicular Stomatitis Virus Glycoprotein
Insertion of the HIV-1 gp41 Epitopes 2F5 and 4E10 into the Membrane-Proximal Region of the Vesicular Stomatitis Virus Glycoprotein
Svetlana M. Atasheva,
University of Alabama at Birmingham, USA
Venezuelan Equine Encephalitis Virus Capsid Forms a Tetrameric Complex with CRM1 and Importin-alphabeta that Obstructs Nuclear Pore Complex Function
Venezuelan Equine Encephalitis Virus Capsid Forms a Tetrameric Complex with CRM1 and Importin-alphabeta that Obstructs Nuclear Pore Complex Function
Sarah Cohen,
University of British Columbia, Canada
Caspase-Mediated Nuclear Envelope Disruption is Important for the Parvovirus Replication Cycle
Caspase-Mediated Nuclear Envelope Disruption is Important for the Parvovirus Replication Cycle
Eric Chi-Wang Yu,
Sanford-Burnham Medical Research Institute, USA
A Bcl-2-like, Vaccinia Viral Protein, F1L is a Caspase-9 Inhibitor
A Bcl-2-like, Vaccinia Viral Protein, F1L is a Caspase-9 Inhibitor
Andrew Mehle,
University of Wisconsin, Madison, USA
Adaptive Strategies of the Influenza Virus Polymerase for Replication in Humans
Adaptive Strategies of the Influenza Virus Polymerase for Replication in Humans
17:00—19:00
Immune Responses and Viral Evasion
Meeting has ended...abstracts no longer viewable online.
Harmit S. Malik,
Fred Hutchinson Cancer Research Center, USA
Molecular Arms Races between Viruses and Primate Genomes
Molecular Arms Races between Viruses and Primate Genomes
Beth Levine,
University of Texas Southwestern Medical Center, USA
Autophagy in Mammalian Alphavirus Host Defense
Autophagy in Mammalian Alphavirus Host Defense
Julie K. Pfeiffer,
University of Texas Southwestern Medical Center, USA
Short Talk: The Gut Microbiota Influence Enteric Virus Shedding, Replication, and Pathogenesis
Short Talk: The Gut Microbiota Influence Enteric Virus Shedding, Replication, and Pathogenesis
08:00—11:15
Virus Assembly and Exit
Meeting has ended...abstracts no longer viewable online.
*
Heinrich Gottlinger,
University of Massachusetts Medical School, USA
Paul D. Bieniasz,
Rockefeller University, USA
Retrovirus Particle Assembly and Release
Retrovirus Particle Assembly and Release
Juan Martin-Serrano,
King's College London School of Medicine, UK
Parallels between Viral Budding and Cytokinesis
Parallels between Viral Budding and Cytokinesis
Thomas C. Mettenleiter,
Friedrich-Loeffler-Institut, Germany
Assembly and Exit Pathway of Herpesvirus
Assembly and Exit Pathway of Herpesvirus
Anette Schneemann,
The Scripps Research Institute, USA
Molecular and Cell Biological Requirements for Specific Packaging of a Multipartite Viral Genome
Molecular and Cell Biological Requirements for Specific Packaging of a Multipartite Viral Genome
Jeremy Rossman,
Northwestern University, USA
Short Talk: The Influenza Virus M2 Ion Channel Protein Mediates the ESCRT-Independent Budding of Filamentous Virions
Short Talk: The Influenza Virus M2 Ion Channel Protein Mediates the ESCRT-Independent Budding of Filamentous Virions
Brett D. Lindenbach,
Yale University School of Medicine, USA
Short Talk: Hepatitis C Virus NS2 Protein Mediates Distinct, Early Steps in Virus Particle Assembly
Short Talk: Hepatitis C Virus NS2 Protein Mediates Distinct, Early Steps in Virus Particle Assembly
17:00—19:00
Viral Pathogenesis
Meeting has ended...abstracts no longer viewable online.
*
Barbara Sherry,
North Carolina State University, USA
Nancy C. Reich,
Stony Brook University, USA
Activation of Cellular Transcription Factors in Innate Host Defense
Activation of Cellular Transcription Factors in Innate Host Defense
Raul Andino,
University of California, San Francisco, USA
Short Talk: The Structure of the Viral Quasispecies and its Evolvability
Short Talk: The Structure of the Viral Quasispecies and its Evolvability
*Session Chair †Invited, not yet responded.
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