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This meeting took place in 2010
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HIV Biology and Pathogenesis (A6)
Organizer(s) Thomas J. Hope, Katherine A. Jones and Daniel C. Douek
January 12—17, 2010
Santa Fe Community Convention Center • Santa Fe, New Mexico USA
Abstract Deadline: Sep 16, 2009
Late Abstract Deadline: Oct 15, 2009
Scholarship Deadline: Sep 16, 2009
Early Registration Deadline: Nov 12, 2009
Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation. Sponsored by Gilead Sciences, Inc. and Sangamo BioSciences, Inc.
Summary of Meeting:
The Keystone Symposia Meeting on HIV Biology and Pathogenesis emphasizes key aspects of the basic virological, cell and molecular biological, and disease aspects of HIV. The focus will be to highlight recent advances in our understanding of HIV/AIDS ranging from the earliest events of transmission, to treatments for infected individuals, to interventions to prevent viral transmission. The goal of the meeting is to emphasize the basic mechanisms of viral replication and the interplay of the virus with the immune system leading to the development of AIDS.
View Scholarships/Awards
The Keystone Symposia Meeting on HIV Biology and Pathogenesis emphasizes key aspects of the basic virological, cell and molecular biological, and disease aspects of HIV. The focus will be to highlight recent advances in our understanding of HIV/AIDS ranging from the earliest events of transmission, to treatments for infected individuals, to interventions to prevent viral transmission. The goal of the meeting is to emphasize the basic mechanisms of viral replication and the interplay of the virus with the immune system leading to the development of AIDS.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
TUESDAY, JANUARY 12
WEDNESDAY, JANUARY 13
THURSDAY, JANUARY 14
FRIDAY, JANUARY 15
SATURDAY, JANUARY 16
SUNDAY, JANUARY 17
Conference Program Print | View meeting in 12 hr (am/pm) time
TUESDAY, JANUARY 12
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.
Stephen P. Goff,
Columbia University, USA
HIV-1 Interactions with Host Proteins
HIV-1 Interactions with Host Proteins
20:30—20:45
Orientation for New Attendees and New Investigators
Meeting Organizer, Dr. Thomas Hope, to lead discussion in a "What to Expect during your Attendance" for interested delegates.
08:00—11:00
HIV Transmission and Early Pathogenesis
Meeting has ended...abstracts no longer viewable online.
*
John P. Moore,
Weill Medical College of Cornell University, USA
Thomas J. Hope,
Northwestern University, USA
Defining the Mechanisms of HIV Entry and Interactions with the Female Genital Tract
Defining the Mechanisms of HIV Entry and Interactions with the Female Genital Tract
Beatrice H. Hahn,
University of Pennsylvania, USA
Natural History of SIVcpz in Wild Chimpanzees
Natural History of SIVcpz in Wild Chimpanzees
Daniel C. Douek,
NIAID, National Institutes of Health, USA
Immune Aspects of HIV Disease Pathogenesis
Immune Aspects of HIV Disease Pathogenesis
Guido Silvestri,
Emory University School of Medicine, USA
SIV Infection of Sooty Mangabeys
SIV Infection of Sooty Mangabeys
Jan Münch,
University Clinic of Ulm, Germany
Short Talk: Testing the Effect of Semen on HIV Infection
Short Talk: Testing the Effect of Semen on HIV Infection
14:30—16:30
Workshop 1: Interplay of Viral and Cellular Proteins
*
David McDonald,
National Institute of Allergy and Infectious Disease, USA
Hillel Haim,
University of Iowa, USA
An Inherent ‘Ligand-Reactivity’ Property of the HIV-1 Envelope Glycoproteins Determines both Fusion Capacity and General Inhibitor Sensitivity
An Inherent ‘Ligand-Reactivity’ Property of the HIV-1 Envelope Glycoproteins Determines both Fusion Capacity and General Inhibitor Sensitivity
Brian P. Doehle,
University of Washington, USA
HIV-1 Mediates Global Disruption of Innate Antiviral Signaling and Immune Defenses within Infected Cells
HIV-1 Mediates Global Disruption of Innate Antiviral Signaling and Immune Defenses within Infected Cells
Edward M. Campbell,
Loyola University, Stritch School of Medicine, USA
p62/Sequestosome1 Associates with and Stabilizes the Expression of TRIM5alpha Proteins
p62/Sequestosome1 Associates with and Stabilizes the Expression of TRIM5alpha Proteins
Jonathan Richard,
Centre de Recherche du CHUM, Canada
HIV-1 Vpr Promotes NK Cell-Mediated Killing by Upregulating Expression of Ligands for the Activating NKG2D Receptor
HIV-1 Vpr Promotes NK Cell-Mediated Killing by Upregulating Expression of Ligands for the Activating NKG2D Receptor
Amy J. Andrew,
NIAID, National Institutes of Health, USA
Functional Analysis of Bst-2/Tetherin Imposed Inhibition of HIV-1 Virus Release
Functional Analysis of Bst-2/Tetherin Imposed Inhibition of HIV-1 Virus Release
Elena Chertova,
NCI, National Institutes of Health, USA
Denying the Denialists: Purification of SIV Particles from Highly Viremic Monkey Plasma
Denying the Denialists: Purification of SIV Particles from Highly Viremic Monkey Plasma
Vincent Dussupt,
Walter Reed Army Institute of Research, USA
Mutations of Basic Residues in the Nucleocapsid Region of HIV-1 Gag cause Budding Arrests
Mutations of Basic Residues in the Nucleocapsid Region of HIV-1 Gag cause Budding Arrests
17:00—19:15
HIV Entry
Meeting has ended...abstracts no longer viewable online.
David McDonald,
National Institute of Allergy and Infectious Disease, USA
Cell Biology of HIV Trans-Infection
Cell Biology of HIV Trans-Infection
Benjamin Dale,
Mount Sinai School of Medicine, USA
Short Talk: The Virological Synapse Promotes HIV Entry into Fusion-Permissive Compartments
Short Talk: The Virological Synapse Promotes HIV Entry into Fusion-Permissive Compartments
Andrea Polacchini-Oliveira Jordan,
University of Pennsylvania School of Medicine, USA
Short Talk: Pathological Correlates of Attenuation for SIVmac239 Containing a Mutation in a Tyr-Dependent Trafficking Motif in the Envelope Transmembrane Cytoplasmic Tail
Short Talk: Pathological Correlates of Attenuation for SIVmac239 Containing a Mutation in a Tyr-Dependent Trafficking Motif in the Envelope Transmembrane Cytoplasmic Tail
08:00—11:00
Innate Restriction of HIV Infection
Meeting has ended...abstracts no longer viewable online.
Michael H. Malim,
King's College London, UK
APOBEC3G and HIV-1 Vif
APOBEC3G and HIV-1 Vif
Jeremy Luban,
University of Massachusetts Medical School, USA
TRIM5 is a Receptor for Retroviral Capsid that Contributes to the Antiviral State
TRIM5 is a Receptor for Retroviral Capsid that Contributes to the Antiviral State
Paula M. Cannon,
University of Southern California, Keck School of Medicine, USA
Tetherin Restriction and its Ablation by Diverse Viral Proteins
Tetherin Restriction and its Ablation by Diverse Viral Proteins
Mark Yeager,
University of Virginia School of Medicine, USA
Structural Studies of HIV Capsid and TRIM5 alpha
Structural Studies of HIV Capsid and TRIM5 alpha
Robert A. Barnitz,
NIAID, National Institutes of Health, USA
Short Talk: Protein Kinase A Phosphorylation Activates Vpr-induced Cell Cycle Arrest during HIV-1 Infection
Short Talk: Protein Kinase A Phosphorylation Activates Vpr-induced Cell Cycle Arrest during HIV-1 Infection
14:30—16:30
Workshop 2: Towards Understanding How HIV Causes AIDS
*
Richard A. Koup,
NIAID, National Institutes of Health, USA
*
Galit Alter,
Ragon Institute of MGH, MIT, and Harvard, USA
Boris Dominik Julg,
Ragon Institute, Massachusetts General Hospital, USA
Strong Antiviral CD8 T Cell Function in-vitro Correlates with Better Disease Outcome in HIV Elite Controllers Lacking Protective HLA Class I Alleles
Strong Antiviral CD8 T Cell Function in-vitro Correlates with Better Disease Outcome in HIV Elite Controllers Lacking Protective HLA Class I Alleles
Benjamin C. Chaon,
University of Iowa, USA
Simultaneous ex vivo Expression of the PD-1/PD-L1 Axis, a Potential Mediator of T-T Cell Interactions, Characterizes HIV-Specific CD4+ T Cells
Simultaneous ex vivo Expression of the PD-1/PD-L1 Axis, a Potential Mediator of T-T Cell Interactions, Characterizes HIV-Specific CD4+ T Cells
Donald L. Sodora,
Center for Infectious Disease Research, USA
Double Negative T Cells (CD3+/CD4-/CD8-) with Potential CD4 T Cell Function during Natural SIV Infection of Sooty Mangabeys
Double Negative T Cells (CD3+/CD4-/CD8-) with Potential CD4 T Cell Function during Natural SIV Infection of Sooty Mangabeys
Lena Al-Harthi,
Rush University, USA
CD4dimCD8bright T-Cells have Potent Anti-HIV-Specific Responses and their Phenotype is Induced in a beta-Catenin-Dependent Manner
CD4dimCD8bright T-Cells have Potent Anti-HIV-Specific Responses and their Phenotype is Induced in a beta-Catenin-Dependent Manner
Kelly M. Fahrbach,
Northwestern University, USA
Enhanced Cellular Responses and Environmental Sampling in Inner Foreskin Explants: Evidence for the Foreskin's Role in HIV Transmission
Enhanced Cellular Responses and Environmental Sampling in Inner Foreskin Explants: Evidence for the Foreskin's Role in HIV Transmission
Victor H. Ferreira,
McMaster University, Canada
The Effect of Co-Infection on HIV-1 Replication in the Female Genital Tract
The Effect of Co-Infection on HIV-1 Replication in the Female Genital Tract
Tara Edmonds,
University of Alabama, Birmingham, USA
Infectious Molecular Clones of Transmitted/Founder HIV-1 Infect Monocyte-Derived Macrophages Less Efficiently Than Highly Macrophage Tropic Viruses
Infectious Molecular Clones of Transmitted/Founder HIV-1 Infect Monocyte-Derived Macrophages Less Efficiently Than Highly Macrophage Tropic Viruses
Steven E. Bosinger,
Emory University, USA
Global Genomic Analysis Reveals Rapid Control of a Robust Innate Response in SIV-Infected Sooty Mangabeys
Global Genomic Analysis Reveals Rapid Control of a Robust Innate Response in SIV-Infected Sooty Mangabeys
17:00—19:15
Immune Responses to HIV Infection
Meeting has ended...abstracts no longer viewable online.
Galit Alter,
Ragon Institute of MGH, MIT, and Harvard, USA
NK Cells in HIV Infection
NK Cells in HIV Infection
Richard A. Koup,
NIAID, National Institutes of Health, USA
Interplay of HIV and the Immune Response
Interplay of HIV and the Immune Response
Timothy W. Schacker,
University of Minnesota, USA
Mechanisms of Lymphoid Tissue Fibrosis and he Subsequrnt Impact on in HIV Infection
Mechanisms of Lymphoid Tissue Fibrosis and he Subsequrnt Impact on in HIV Infection
Judith Angeline Briant,
NIAID, National Institutes of Health, USA
Short Talk: Are Infant African Green Monkeys Resistant to SIVagm Infection?
Short Talk: Are Infant African Green Monkeys Resistant to SIVagm Infection?
Leonid Margolis,
NICHD, National Institutes of Health, USA
Short Talk: HIV Interactions with Other Viruses: And How to Exploit Them
Short Talk: HIV Interactions with Other Viruses: And How to Exploit Them
08:00—11:00
Regulation of HIV Integration and Gene Expression
Meeting has ended...abstracts no longer viewable online.
Frederic D. Bushman,
University of Pennsylvania, USA
HIV DNA Integration: Mechanism and Consequences
HIV DNA Integration: Mechanism and Consequences
Peter P. Cherepanov,
Imperial College London, UK
Structural Basis for Retroviral PIC Assembly and Strand Transfer Inhibitor Action
Structural Basis for Retroviral PIC Assembly and Strand Transfer Inhibitor Action
Katherine A. Jones,
The Salk Institute, USA
Tat and Cellular Stress Induce the HIV-1 Core Promoter via Distinct Mechanisms
Tat and Cellular Stress Induce the HIV-1 Core Promoter via Distinct Mechanisms
Qiang Zhou,
University of California, Berkeley, USA
Novel Cellular Cofactors and Mechanism for Tat-Activation of HIV-1 Transcription
Novel Cellular Cofactors and Mechanism for Tat-Activation of HIV-1 Transcription
Ivan D'Orso,
University of Texas Southwestern Medical Center, USA
Short Talk: Proteomic Study of HIV-host Transcription Complexes
Short Talk: Proteomic Study of HIV-host Transcription Complexes
13:30—16:30
NIAID Workshop: The Next Challenge: Elimination of HIV Reservoirs
Janet Siliciano,
Johns Hopkins University School of Medicine, USA
Issues in HIV-1 Persistence and Latency
Issues in HIV-1 Persistence and Latency
Carl H. June,
University of Pennsylvania, USA
Exploring the Potential of Gene Modified CD4 T Cells to Target the HIV-1 Reservoir
Exploring the Potential of Gene Modified CD4 T Cells to Target the HIV-1 Reservoir
Olaf Kutsch,
University of Alabama at Birmingham, USA
HIV-1 Latency – Does Site of Integration Matter?
HIV-1 Latency – Does Site of Integration Matter?
Vicente Planelles,
University of Utah, USA
The Role of NFAT in HIV-1 Latency: New Insights from a Central Memory T-Cell Model
The Role of NFAT in HIV-1 Latency: New Insights from a Central Memory T-Cell Model
Javier Martinez-Picado,
ICREA and irsiCaixa Foundation, Spain
HIV-1 Replication and Immune Dynamics are Impacted by Raltegravir Intensification of HAART-Suppressed Patients
HIV-1 Replication and Immune Dynamics are Impacted by Raltegravir Intensification of HAART-Suppressed Patients
Sarah E. Palmer,
University of Sydney, Australia
Characterizing Persistent HIV Viremia
Characterizing Persistent HIV Viremia
Jeffrey C. Laurence,
Weill Cornell Medical College, USA
Proving the Concept: The First Well-Documented Functional, and Probably Complete, Case of HIV Eradication
Proving the Concept: The First Well-Documented Functional, and Probably Complete, Case of HIV Eradication
*
Diana Finzi,
NIAID, National Institutes of Health, USA
Wrap-Up and Discussion
Wrap-Up and Discussion
*
Janet Siliciano,
Johns Hopkins University School of Medicine, USA
Wrap Up and Discussion
Wrap Up and Discussion
17:00—19:00
Treatment and Prevention of HIV Infection
Meeting has ended...abstracts no longer viewable online.
*
Dana H. Gabuzda,
Dana Farber Cancer Institute, USA
Steven G. Deeks,
University of California, San Francisco, USA
HIV-Association Inflammation as a Cause of Accelerated Aging
HIV-Association Inflammation as a Cause of Accelerated Aging
John P. Moore,
Weill Medical College of Cornell University, USA
Studying Entry Inhibitor-based Vaginal Microbicides in the Rhesus Macaque
Studying Entry Inhibitor-based Vaginal Microbicides in the Rhesus Macaque
Jerome H. Kim,
International Vaccine Institute, South Korea
Understanding the Results of the Thai Vaccine Trial
Understanding the Results of the Thai Vaccine Trial
Christopher Aiken,
Vanderbilt University School of Medicine, USA
Short Talk: Inhibition of HIV-1 Infection by Small Molecule Destabilization of the Viral Capsid
Short Talk: Inhibition of HIV-1 Infection by Small Molecule Destabilization of the Viral Capsid
08:00—11:00
HIV Latency and Reservoirs
Meeting has ended...abstracts no longer viewable online.
Anna Aldovini,
Boston Children's Hospital and Harvard Medical School, USA
Tat-mediated Gene Modulation in HIV Target Cells
Tat-mediated Gene Modulation in HIV Target Cells
Dana H. Gabuzda,
Dana Farber Cancer Institute, USA
NeuroAIDS and HIV Reservoirs
NeuroAIDS and HIV Reservoirs
Bette Tina Marie Korber,
Los Alamos National Laboratory, USA
Transmission of HIV-1 and Dynamics of Early Escape from Cytotoxic T-Cells: with an Ultradeep View
Transmission of HIV-1 and Dynamics of Early Escape from Cytotoxic T-Cells: with an Ultradeep View
Wendy A. Burgers,
University of Cape Town, South Africa
Short Talk: Immune Activation during Early HIV Infection Associates with the Rate of Disease Progression
Short Talk: Immune Activation during Early HIV Infection Associates with the Rate of Disease Progression
17:00—19:15
HIV Interactions with the Cell and Host
Meeting has ended...abstracts no longer viewable online.
*
Michael H. Malim,
King's College London, UK
Frank Kirchhoff,
University of Ulm, Germany
Role of Nef and Vpu in Primate Lentiviral Pathogenesis and Transmission
Role of Nef and Vpu in Primate Lentiviral Pathogenesis and Transmission
Wesley I. Sundquist,
University of Utah School of Medicine, USA
Hexameric Assemblies of a Restricting TRIM5Ą Protein: Implications for Molecular Recognition of Viral Capsids
Hexameric Assemblies of a Restricting TRIM5Ą Protein: Implications for Molecular Recognition of Viral Capsids
Vineet N. KewalRamani,
NCI, National Institutes of Health, USA
Postentry Restriction of HIV-1 by a Capsid Interacting Factor
Postentry Restriction of HIV-1 by a Capsid Interacting Factor
Marc C. Johnson,
University of Missouri, Columbia, USA
Short Talk: The Minimal Requirements for Viral Pseudotyping
Short Talk: The Minimal Requirements for Viral Pseudotyping
Greg J. Towers,
University College London, UK
Short Talk: A Role for the Nuclear Pore Protein Nup358 (RANBP2) in Capsid Dependent Nuclear Entry of Lentiviruses
Short Talk: A Role for the Nuclear Pore Protein Nup358 (RANBP2) in Capsid Dependent Nuclear Entry of Lentiviruses
*Session Chair †Invited, not yet responded.
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