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This meeting took place in 2011
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Genetics, Immunology and Repair in Multiple Sclerosis (B8)
Organizer(s) Wendy B. Macklin, Gavin Giovannoni and Stephen L. Hauser
February 15—20, 2011
Sagebrush Inn & Suites • Taos, New Mexico USA
Abstract Deadline: Oct 18, 2010
Late Abstract Deadline: Nov 19, 2010
Scholarship Deadline: Oct 18, 2010
Early Registration Deadline: Dec 15, 2010
Sponsored by National Multiple Sclerosis Society and Teva Pharmaceuticals
Summary of Meeting:
Although the specific etiology of Multiple Sclerosis (MS) remains unknown, important insights into the genetics and environmental triggers underlying the disease have been made. This conference will discuss advances in MS genetics, epigenetics and the interaction of genetics with the environment, particularly with vitamin D metabolism and Epstein Barr Virus. There will be a focus on the immunopathogenesis of MS, including pre-active MS lesions, mechanisms of lymphocyte activation, the B cell and trafficking of cells across the blood brain barrier. The application of new imaging methods and therapeutic strategies that target the immune system and promote remyelination will be discussed. The challenge of integrating emerging insights in the basic mechanisms of myelination, autoimmune demyelination, and neurodegeneration with translational science will he discussed. The goal of this meeting is to provide a broad spectrum of MS researchers with a forum to discuss recent advances, and to foster cross-disciplinary interactions and collaborations.
View Scholarships/Awards
Although the specific etiology of Multiple Sclerosis (MS) remains unknown, important insights into the genetics and environmental triggers underlying the disease have been made. This conference will discuss advances in MS genetics, epigenetics and the interaction of genetics with the environment, particularly with vitamin D metabolism and Epstein Barr Virus. There will be a focus on the immunopathogenesis of MS, including pre-active MS lesions, mechanisms of lymphocyte activation, the B cell and trafficking of cells across the blood brain barrier. The application of new imaging methods and therapeutic strategies that target the immune system and promote remyelination will be discussed. The challenge of integrating emerging insights in the basic mechanisms of myelination, autoimmune demyelination, and neurodegeneration with translational science will he discussed. The goal of this meeting is to provide a broad spectrum of MS researchers with a forum to discuss recent advances, and to foster cross-disciplinary interactions and collaborations.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
TUESDAY, FEBRUARY 15
WEDNESDAY, FEBRUARY 16
THURSDAY, FEBRUARY 17
FRIDAY, FEBRUARY 18
SATURDAY, FEBRUARY 19
SUNDAY, FEBRUARY 20
Conference Program Print | View meeting in 12 hr (am/pm) time
TUESDAY, FEBRUARY 15
19:15—20:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.
Stephen Sawcer,
University of Cambridge, UK
Whole Genome Studies in MS: Past, Present and Future
Whole Genome Studies in MS: Past, Present and Future
08:00—11:00
Genetic Susceptibility in MS
Meeting has ended...abstracts no longer viewable online.
*
Stephen L. Hauser,
University of California, San Francisco, USA
Trevor J. Kilpatrick,
University of Melbourne, Australia
Approaches to Identifying and Studying Genes Relevant to Multiple Sclerosis
Approaches to Identifying and Studying Genes Relevant to Multiple Sclerosis
Lars Fugger,
University of Oxford, UK
Humanized Animal Models for Mutiple Sclerosis
Humanized Animal Models for Mutiple Sclerosis
Linda Ottoboni,
Harvard University, USA
Short Talk: Pathways Convergence of Transcriptomic Signatures from Multiple Sclerosis Susceptibility Alleles
Short Talk: Pathways Convergence of Transcriptomic Signatures from Multiple Sclerosis Susceptibility Alleles
Justin Spanier,
University of Minnesota, USA
Short Talk: 1,25-Dihydroxyvitamin D3 Suppresses Fatal Progressive Experimental Autoimmune Encephalomyelitis in Interferon-gamma-Null Mice
Short Talk: 1,25-Dihydroxyvitamin D3 Suppresses Fatal Progressive Experimental Autoimmune Encephalomyelitis in Interferon-gamma-Null Mice
Pierre-Antoine Gourraud,
University of California, San Francisco, USA
Aggregation of Genetic Risk Variants in Multiple Sclerosis
Aggregation of Genetic Risk Variants in Multiple Sclerosis
17:00—19:00
Epidemiology of MS
Meeting has ended...abstracts no longer viewable online.
*
Gavin Giovannoni,
Barts and The London School of Medicine and Dentistry, UK
Francesca Aloisi,
Instituto Superior de Sanita, Italy
Epstein Barr Virus Infection in MS Pathogenesis
Epstein Barr Virus Infection in MS Pathogenesis
Ute C. Meier,
ICMS London, UK
Short Talk: Innate Immune Responses is Innate Immune Activation as a Hallmark of the Active Multiple Sclerosis Lesion
Short Talk: Innate Immune Responses is Innate Immune Activation as a Hallmark of the Active Multiple Sclerosis Lesion
Anne-Louise Ponsonby,
Murdoch Children's Research Institute, Australia
The Hygiene Hypothesis and the Development of Multiple Sclerosis
The Hygiene Hypothesis and the Development of Multiple Sclerosis
Bruce Hollis,
Medical University of South Carolina, USA
Achieving Adequate Vitamin D Status and its Role in Multiple Sclerosis
Achieving Adequate Vitamin D Status and its Role in Multiple Sclerosis
08:00—11:15
Updates on Current Therapeutics
Meeting has ended...abstracts no longer viewable online.
*
Bibi Bielekova,
NIAID, National Institutes of Health, USA
Gavin Giovannoni,
Barts and The London School of Medicine and Dentistry, UK
Emerging Therapies for Multiple Sclerosis
Emerging Therapies for Multiple Sclerosis
Alasdair Coles,
University of Cambridge, UK
Autoimmunity - Good and Bad - After Alemtuzumab Treatment of Muliple Sclerosis
Autoimmunity - Good and Bad - After Alemtuzumab Treatment of Muliple Sclerosis
Kenneth L. Tyler,
University of Colorado School of Medicine, USA
Association of PML with Immunomodulatory MS Therapeutics
Association of PML with Immunomodulatory MS Therapeutics
Susan Goelz,
, USA
JC Virus Pathobiology and PML in Multiple Sclerosis Patients
JC Virus Pathobiology and PML in Multiple Sclerosis Patients
Sybil Rose Stacpoole,
University of Cambridge, UK
Short Talk: Human Oligodendrocytes from Embyronic Stem Cells – A Valuable Tool and Potential Therapy for Multiple Sclerosis
Short Talk: Human Oligodendrocytes from Embyronic Stem Cells – A Valuable Tool and Potential Therapy for Multiple Sclerosis
17:00—19:30
Role of B Cells in MS
Meeting has ended...abstracts no longer viewable online.
*
Colleen E. Hayes,
University of Wisconsin-Madison, USA
Stephen L. Hauser,
University of California, San Francisco, USA
Multiple Sclerosis: Current B Cell Therapies in MS
Multiple Sclerosis: Current B Cell Therapies in MS
Peter K. Gregersen,
Feinstein Institute for Medical Research, USA
Linking Genotype to Phenotype: Examples from Human Autoimmunity
Linking Genotype to Phenotype: Examples from Human Autoimmunity
Jeffrey Bennett,
University of Colorado Denver, USA
The Targets of Cerebrospinal Fluid Oligoclonal Bands in Multiple Sclerosis
The Targets of Cerebrospinal Fluid Oligoclonal Bands in Multiple Sclerosis
Emily Pierson,
University of Washington, USA
Short Talk: B Cells are Important for the Expansion of T Cells in the CNS during the Induction of EAE
Short Talk: B Cells are Important for the Expansion of T Cells in the CNS during the Induction of EAE
08:00—11:15
Events at the Blood-Brain Barrier
Meeting has ended...abstracts no longer viewable online.
*
Raymond A. Sobel,
Stanford University School of Medicine, USA
Richard Daneman,
University of California, San Diego, USA
Cellular and Molecular Regulation of Blood-Brain Barrier Regulation during Health and Disease
Cellular and Molecular Regulation of Blood-Brain Barrier Regulation during Health and Disease
Britta Engelhardt,
Theodor Kocher Institute/Universitat Bern, Switzerland
T Cell Migration into the CNS during Health and Disease: Different Molecular Keys Allow Access to Different CNS Compartments
T Cell Migration into the CNS during Health and Disease: Different Molecular Keys Allow Access to Different CNS Compartments
Piet Stinissen,
Hasselt University, Belgium
Short Talk: CX3CR1 Drives CD4+CD28null Cytotoxic T Cells into the Central Nervous System of Patients with MS
Short Talk: CX3CR1 Drives CD4+CD28null Cytotoxic T Cells into the Central Nervous System of Patients with MS
Ann M. Ranger,
Biogen Idec, USA
Short Talk: The Level of CXCL13 Correlates with a B Cell and Plasma Cell Transcriptionl Signature in the Cerebrospinal Fluid of Secondary Progressive Multiple Sclerosis Patients
Short Talk: The Level of CXCL13 Correlates with a B Cell and Plasma Cell Transcriptionl Signature in the Cerebrospinal Fluid of Secondary Progressive Multiple Sclerosis Patients
Stephen McQuaid,
Queen's University Belfast, UK
Tight Junction Abnormalities at Blood Brain Barrier in Multiple Sclerosis
Tight Junction Abnormalities at Blood Brain Barrier in Multiple Sclerosis
Paula Dore-Duffy,
Wayne State University, USA
Microvascular Pericytes: A Source of Adult Stem Cells
Microvascular Pericytes: A Source of Adult Stem Cells
14:30—16:30
Workshop: MS Research: Prospects for Funding and Training
Stephen L. Hauser,
University of California, San Francisco, USA
Richard A. Rudick,
Cleveland Clinic Foundation, USA
Henry McFarland,
NINDS, National Institutes of Health, USA
17:00—19:00
Imaging in MS Diagnosis and Therapeutics
Meeting has ended...abstracts no longer viewable online.
*
Henry McFarland,
NINDS, National Institutes of Health, USA
Sergio E. Baranzini,
University of California, San Francisco, USA
Linking Voxel-Based Morphometry with Genetic Variation in MS
Linking Voxel-Based Morphometry with Genetic Variation in MS
Elizabeth Fisher,
Cleveland Clinic, USA
Short Talk: A Four-Year Longitudinal Study of Cortical Thickness in Multiple Sclerosis
Short Talk: A Four-Year Longitudinal Study of Cortical Thickness in Multiple Sclerosis
Douglas Arnold,
Montreal Neurological Hospital and Institute, Canada
Magnetization Transfer Ratio as a Marker of Demyelination and Remyelination in MS
Magnetization Transfer Ratio as a Marker of Demyelination and Remyelination in MS
Laura J. Balcer,
University of Pennsylvania, USA
Optical Coherence Tomography as a Measure of Axonal and Neuronal Loss in MS
Optical Coherence Tomography as a Measure of Axonal and Neuronal Loss in MS
08:00—11:15
Mechanisms of MS Progression
Meeting has ended...abstracts no longer viewable online.
*
Richard A. Rudick,
Cleveland Clinic Foundation, USA
Amit Bar-Or,
University of Pennsylvania, USA
Pediatric-Onset MS: A Window into the MS Spectrum
Pediatric-Onset MS: A Window into the MS Spectrum
Selva Baltan,
University of Washington, USA
Excitotoxicity and Mitochondrial Dysfunction Lead to Axonal Degeneration
Excitotoxicity and Mitochondrial Dysfunction Lead to Axonal Degeneration
Bruce D. Trapp,
Cleveland Clinic Foundation, Lerner Research Institute, USA
Cortical Remyelination in Multiple Sclerosis: Environment, Not Age, Modulates Cell Replacement in Human Brain
Cortical Remyelination in Multiple Sclerosis: Environment, Not Age, Modulates Cell Replacement in Human Brain
David Baker,
Blizard Institute, Queen Mary University of London, UK
Control of Spasticity using Central Nervous System-Excluded Cannabinoid Receptor Agonists
Control of Spasticity using Central Nervous System-Excluded Cannabinoid Receptor Agonists
Nicole Schaeren-Wiemers,
University Hospital Basel, Switzerland
Short Talk: Remyelinated Lesions Express a Distinct Pattern of Genes Involved in Oligodendrocyte Proliferation and Differentiation
Short Talk: Remyelinated Lesions Express a Distinct Pattern of Genes Involved in Oligodendrocyte Proliferation and Differentiation
Ranjan Dutta,
Lerner Research Institute, Cleveland Clinic, USA
Short Talk: Loss of Myelin Leads to Alteration of a Neuronal MicroRNA in Multiple Sclerosis Hippocampus
Short Talk: Loss of Myelin Leads to Alteration of a Neuronal MicroRNA in Multiple Sclerosis Hippocampus
17:00—19:00
Regulation of Remyelination
Meeting has ended...abstracts no longer viewable online.
*
Robyn S. Klein,
Washington University School of Medicine, USA
Wendy B. Macklin,
University of Colorado Denver, USA
Signaling Mechanisms Regulating CNS Myelination
Signaling Mechanisms Regulating CNS Myelination
V. Wee Yong,
University of Calgary, Canada
Promoting Remyelination by Reducing an Inhibitory Microenvironment
Promoting Remyelination by Reducing an Inhibitory Microenvironment
Steve Fancy,
University of California, San Francisco, USA
A Therapeutic Target for Repair in Human Newborn Brain Injury and Multiple Sclerosis
A Therapeutic Target for Repair in Human Newborn Brain Injury and Multiple Sclerosis
Danette Nicolay,
University of Colorado Denver, USA
Short Talk: Promoting Remyelination of MS Lesions: Where do Fish Fit in?
Short Talk: Promoting Remyelination of MS Lesions: Where do Fish Fit in?
*Session Chair †Invited, not yet responded.
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