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This meeting took place in 2012
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Cancer and Metabolism (Q3)
Organizer(s) Reuben J. Shaw and David M. Sabatini
February 12—17, 2012
Fairmont Banff Springs • Banff, Alberta Canada
Abstract Deadline: Oct 13, 2011
Late Abstract Deadline: Nov 14, 2011
Scholarship Deadline: Oct 13, 2011
Early Registration Deadline: Dec 12, 2011
Sponsored by Astellas Pharma Inc., Celgene Corporation, Pfizer Inc. and Takeda Pharmaceutical Company Limited
Joint Meeting:
Advances in Hypoxic Signaling: From Bench to Bedside (Q4)
Summary of Meeting:
Although altered glucose metabolism was first noted as a characteristic of tumor cells by Otto Warburg in the 1920s, the molecular underpinning for this observation did not begin to be appreciated fully until the past decade. This area has exploded over the last five years with the identification of extensive interactions of genuine tumor suppressor genes and oncogenes with metabolic control. The increased biosynthetic needs of tumor cells demand a reprogramming of cellular metabolism, which also creates increased energy demands and makes tumor cells more vulnerable to interventions targeting their metabolism. The goal of the Keystone Symposia meeting on Cancer and Metabolism is to bring together leaders in the fields of cancer and metabolic control with those studying the signaling pathways linking and governing each. The latest discoveries will be discussed as well as how this knowledge can be exploited to design future cancer therapeutics. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Advances in Hypoxic Signaling: From Bench to Bedside, which will share a keynote address and a plenary session with this meeting.
View Scholarships/Awards
Although altered glucose metabolism was first noted as a characteristic of tumor cells by Otto Warburg in the 1920s, the molecular underpinning for this observation did not begin to be appreciated fully until the past decade. This area has exploded over the last five years with the identification of extensive interactions of genuine tumor suppressor genes and oncogenes with metabolic control. The increased biosynthetic needs of tumor cells demand a reprogramming of cellular metabolism, which also creates increased energy demands and makes tumor cells more vulnerable to interventions targeting their metabolism. The goal of the Keystone Symposia meeting on Cancer and Metabolism is to bring together leaders in the fields of cancer and metabolic control with those studying the signaling pathways linking and governing each. The latest discoveries will be discussed as well as how this knowledge can be exploited to design future cancer therapeutics. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Advances in Hypoxic Signaling: From Bench to Bedside, which will share a keynote address and a plenary session with this meeting.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SUNDAY, FEBRUARY 12
MONDAY, FEBRUARY 13
TUESDAY, FEBRUARY 14
WEDNESDAY, FEBRUARY 15
THURSDAY, FEBRUARY 16
FRIDAY, FEBRUARY 17
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, FEBRUARY 12
19:15—21:30
Welcome and Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.
Craig B. Thompson,
Memorial Sloan Kettering Cancer Center, USA
Metabolism and Cancer Are Intertwined
Metabolism and Cancer Are Intertwined
08:00—11:15
Oncogene Control of Metabolism
Meeting has ended...abstracts no longer viewable online.
Lewis C. Cantley,
Weill Cornell Medicine, USA
PI3K and Mitogenic Signals Control Metabolism
PI3K and Mitogenic Signals Control Metabolism
Michael Pollak,
Jewish General Hospital, Canada
Actions of Insulin and myc on Cancer Metabolism are Influenced by Metformin
Actions of Insulin and myc on Cancer Metabolism are Influenced by Metformin
Eileen P. White,
Rutgers University, USA
Role of Autophagy and Metabolic Control in Tumorigenesis
Role of Autophagy and Metabolic Control in Tumorigenesis
Almut Schulze,
University of Würzburg/Theodor-Boveri Institute, Germany
EMBO Young Investigator Lecture: Regulation of Lipogenesis by the Akt/mTORC1 Pathway and Its Role in Cell Growth and Cancer
EMBO Young Investigator Lecture: Regulation of Lipogenesis by the Akt/mTORC1 Pathway and Its Role in Cell Growth and Cancer
E. Alejandro Sweet-Cordero,
Stanford University, USA
Short Talk: Oncogenic Kras Inhibits Mitochondrial Metabolism by Regulating the Pyruvate Dehydrogenase Complex under Conditions of Nutrient Stress
Short Talk: Oncogenic Kras Inhibits Mitochondrial Metabolism by Regulating the Pyruvate Dehydrogenase Complex under Conditions of Nutrient Stress
Taru Muranen,
Harvard Medical School, USA
Short Talk: Inhibition of PI3K/mTOR Leads to Adaptive Resistance in Matrix-Attached Cancer Cells
Short Talk: Inhibition of PI3K/mTOR Leads to Adaptive Resistance in Matrix-Attached Cancer Cells
08:00—11:15
Transcriptional and Non-Transcriptional Regulation of Hypoxia Responses
Meeting has ended...abstracts no longer viewable online.
*
Agnes Görlach,
German Heart Center Munich, TU Munich, Germany
Johanna Myllyharju,
University of Oulu, Finland
Enzymatic Responses to Hypoxia
Enzymatic Responses to Hypoxia
Murray L. Whitelaw,
Adelaide University, Australia
Signaling through bHLH/PAS Domain Proteins
Signaling through bHLH/PAS Domain Proteins
Peter F. Carmeliet,
University of Leuven, VIB, Belgium
Endothelial Metabolism: A Target in Angiogenesis?
Endothelial Metabolism: A Target in Angiogenesis?
Peppi Koivunen,
University of Oulu, Finland
Short Talk: Transformation by the R Enantiomer of 2-Hydroxyglutarate Linked to EglN Activation
Short Talk: Transformation by the R Enantiomer of 2-Hydroxyglutarate Linked to EglN Activation
Florian Riess,
German Heart Center Munich, Germany
Short Talk: HIF-3alpha Inhibits HIF-2 in Vascular Endothelial Cells by Dimerization with ARNT
Short Talk: HIF-3alpha Inhibits HIF-2 in Vascular Endothelial Cells by Dimerization with ARNT
14:30—16:30
Workshop: Health Disparities (Joint). Supported by Novartis Institutes for BioMedical Research
*
Timothy R. Rebbeck,
University of Pennsylvania School of Medicine, USA
Introduction and Overview
Introduction and Overview
Josef Prchal,
University of Utah, USA
Congenital Disorders of Hypoxic Sensing and Tibetan Hypoxic Adaptation
Congenital Disorders of Hypoxic Sensing and Tibetan Hypoxic Adaptation
Suzanne D. Conzen,
University of Chicago, USA
Effects of Social Stressors on Cancer Progression: Potential Metabolic Mechanisms
Effects of Social Stressors on Cancer Progression: Potential Metabolic Mechanisms
17:00—19:00
HIF Signaling in Cancer (Joint)
Meeting has ended...abstracts no longer viewable online.
William G. Kaelin, Jr.,
Dana-Farber Cancer Institute, USA
Cancer Metabolism and 2-Oxoglutarate-dependent Dioxygenases
Cancer Metabolism and 2-Oxoglutarate-dependent Dioxygenases
M. Celeste Simon,
University of Pennsylvania, USA
Genetic Dissection of HIF Function in Cancer and Stem Cells
Genetic Dissection of HIF Function in Cancer and Stem Cells
Gregg L. Semenza,
Johns Hopkins University School of Medicine, USA
Multiple Roles of Hypoxia-Inducible Factors in Breast Cancer Metastasis
Multiple Roles of Hypoxia-Inducible Factors in Breast Cancer Metastasis
Till Acker,
University of Giessen, Germany
Short Talk: Control of Tumor Growth by Prolyl-Hydroxylases
Short Talk: Control of Tumor Growth by Prolyl-Hydroxylases
08:00—11:15
mTOR Signaling in Growth and Metabolic Control
Meeting has ended...abstracts no longer viewable online.
David M. Sabatini,
Whitehead Institute for Biomedical Research, USA
Regulation of Growth by the mTOR Pathway
Regulation of Growth by the mTOR Pathway
Brendan D. Manning,
Harvard School of Public Health, USA
mTOR Links Oncogenic Signaling to Tumor Cell Metabolism
mTOR Links Oncogenic Signaling to Tumor Cell Metabolism
Kun-Liang Guan,
University of California, San Diego, USA
Nutrient and mTOR Signals
Nutrient and mTOR Signals
Camilla Norrmén,
ETH Zurich, Switzerland
Short Talk: mTOR Signaling in Myelination of Peripheral Nerves
Short Talk: mTOR Signaling in Myelination of Peripheral Nerves
David A. Guertin,
University of Massachusetts Medical School, USA
Short Talk: Tissue Growth Control by PI3K-mTOR Signaling
Short Talk: Tissue Growth Control by PI3K-mTOR Signaling
08:00—11:15
Metabolic Adaptation to Hypoxia
Meeting has ended...abstracts no longer viewable online.
*
Dörthe M. Katschinski,
Georg August University, Germany
Lorenz Poellinger,
Karolinska Institutet, Sweden
Epigenetic Control of Hypoxia Gene Expression and Metabolic Stress
Epigenetic Control of Hypoxia Gene Expression and Metabolic Stress
Jenny E. Gunton,
University of Sydney, Australia
HIF-1alpha in the Development of Type 2 Diabetes and Metabolic Syndrome
HIF-1alpha in the Development of Type 2 Diabetes and Metabolic Syndrome
Calvin Kuo,
Stanford University, USA
Short Talk: Hypoxic Regulation of Hepatic Glucose Metabolism
Short Talk: Hypoxic Regulation of Hepatic Glucose Metabolism
Martina U. Muckenthaler,
Children's Hospital, University of Heidelberg, Germany
Oxygen-Dependent Regulation of Iron Metabolism
Oxygen-Dependent Regulation of Iron Metabolism
Julián Aragonés Lopez,
Research Institute Princesa, Spain
Short Talk: Essential Role of the HIF1alpha Osygen-Sensing Pathway in Controlling Body Weight
Short Talk: Essential Role of the HIF1alpha Osygen-Sensing Pathway in Controlling Body Weight
14:30—16:30
Workshop 1: Hot Topics in Cancer Metabolism I
*
Lewis C. Cantley,
Weill Cornell Medicine, USA
Jessica J. Howell,
Harvard School of Public Health, USA
Mechanisms and Consequences of mTORC1 Inhibition by Pharmacological Doses of Metformin
Mechanisms and Consequences of mTORC1 Inhibition by Pharmacological Doses of Metformin
Peter Rahl,
Massachusetts Institute of Technology, USA
c-Myc Overexpression Drives Binding to Distinct Enhancers in Different Cancers
c-Myc Overexpression Drives Binding to Distinct Enhancers in Different Cancers
Kevin J. Williams,
University of California, Los Angeles, USA
A Critical Role for SREBP1 in the Warburg Effect and Tumor Growth
A Critical Role for SREBP1 in the Warburg Effect and Tumor Growth
Kivanc Birsoy,
Rockefeller University, USA
Use of Functional Genomic Screens and Nutrostats to Identify Metabolic Liabilities of Cancer Cells under Limiting Glucose and Oxygen Conditions
Use of Functional Genomic Screens and Nutrostats to Identify Metabolic Liabilities of Cancer Cells under Limiting Glucose and Oxygen Conditions
Katharine V. Brown,
University of California, Berkeley, USA
SIRT3 Regulates Hematopoeitic Stem Cell Aging
SIRT3 Regulates Hematopoeitic Stem Cell Aging
Lluis Fajas,
Université de Lausanne, Switzerland
Cdk4-E2F1 Mediate a Metabolic Switch in Normal and in Cancer Cells and Facilitate Whole Body Metabolic Adaptation to Cancer
Cdk4-E2F1 Mediate a Metabolic Switch in Normal and in Cancer Cells and Facilitate Whole Body Metabolic Adaptation to Cancer
Shi Chi Leow,
ASTAR Singapore Institute for Clinical Sciences, Singapore
NF-kappaB Controls Energy Homeostasis and Metabolic Adaptation by Upregulating Mitochondrial Respiration
NF-kappaB Controls Energy Homeostasis and Metabolic Adaptation by Upregulating Mitochondrial Respiration
14:30—16:30
Workshop 1: Student/Postdoc Workshop
*
Pablo Wappner,
Fundacion Instituto Leloir, Argentina
Brooke M. Emerling,
Sanford Burnham Prebys Medical Discovery Institute, USA
Identification of CDCP1 as a HIF-2alpha Target Gene Involved in the Regulation of Cancer Cell Migration and Metastasis
Identification of CDCP1 as a HIF-2alpha Target Gene Involved in the Regulation of Cancer Cell Migration and Metastasis
Sofie Deschoemaeker,
University of Leuven, Belgium
Gene-Targeting of PHD2 Oxygen Sensor Improved Tumor Response to Chemotherapy and Prevents Side-Toxicity in Mice
Gene-Targeting of PHD2 Oxygen Sensor Improved Tumor Response to Chemotherapy and Prevents Side-Toxicity in Mice
Jung-Whan Kim,
University of Texas, Dallas, USA
Deletion of Hypoxia Inducible Factor-1alpha (HIF-1alpha) In Stromal Fibroblasts Accelerates Mammary Tumor Progression through Vascular Normalization
Deletion of Hypoxia Inducible Factor-1alpha (HIF-1alpha) In Stromal Fibroblasts Accelerates Mammary Tumor Progression through Vascular Normalization
Muriel R. Kaufmann,
University of Zürich, Switzerland
Presenilin Membrane Proteases as Novel Regulators of HIF via the APP/AICD Cleavage Cascade
Presenilin Membrane Proteases as Novel Regulators of HIF via the APP/AICD Cleavage Cascade
Pardeep Heir,
University of Toronto, Canada
HIFalpha Binding to VHL Cues DCNL1 Recruitment to Trigger CUL2 Neddylation
HIFalpha Binding to VHL Cues DCNL1 Recruitment to Trigger CUL2 Neddylation
Kirsten Schneider,
University Clinic Essen, Germany
Factor Inhibiting HIF-1 Modulates Protein Interactions of ASPP2
Factor Inhibiting HIF-1 Modulates Protein Interactions of ASPP2
Yukimi Sakoda,
Yamaguchi University, Japan
Regulation of HIF-1alpha Erythropoiesis by HVEM
Regulation of HIF-1alpha Erythropoiesis by HVEM
Johannes Schödel,
Universitätsklinikum Erlangen, Germany
Common Genetic Variants at the 11q13.3 Renal Cancer Susceptibility Locus Influence Binding of HIF to an Enhancer of Cyclin D1 Expression
Common Genetic Variants at the 11q13.3 Renal Cancer Susceptibility Locus Influence Binding of HIF to an Enhancer of Cyclin D1 Expression
17:00—19:00
Metabolic Stress Control
Meeting has ended...abstracts no longer viewable online.
D. Grahame Hardie,
University of Dundee, UK
AMPK – A Metabolic Master Switch Activated by Many Anti-Cancer Drugs
AMPK – A Metabolic Master Switch Activated by Many Anti-Cancer Drugs
Reuben J. Shaw,
The Salk Institute for Biological Studies, USA
LKB1 and AMPK Signaling in Cancer and Metabolism
LKB1 and AMPK Signaling in Cancer and Metabolism
Kevin Struhl,
Harvard Medical School, USA
Anti-Cancer Effects of Metformin
Anti-Cancer Effects of Metformin
Linda Z. Penn,
Princess Margaret Cancer Centre, Canada
Short Talk: Targeting the Mevalonate Pathway in Cancer
Short Talk: Targeting the Mevalonate Pathway in Cancer
17:00—19:00
Systemic Responses to Hypoxia and High Altitude
Meeting has ended...abstracts no longer viewable online.
*
Josef Prchal,
University of Utah, USA
José López-Barneo,
Hospital Universitario Virgen del Rocío, Spain
Contrasting Effects of Chronic Hypoxia on Central and Peripheral Neurogenic Centers
Contrasting Effects of Chronic Hypoxia on Central and Peripheral Neurogenic Centers
Donald A. McClain,
University of Utah School of Medicine, USA
Short Talk: Metabolic Consequences of Genetic Adaptation to High Altitude in Tibetans
Short Talk: Metabolic Consequences of Genetic Adaptation to High Altitude in Tibetans
08:00—11:15
Connecting Metabolic Pathways to Growth Control
Meeting has ended...abstracts no longer viewable online.
*
Jeffrey C. Rathmell,
Vanderbilt University, USA
Jared Rutter,
University of Utah, USA
Good and Bad Growth: The Virtues and Vices of Mitochondria and Metabolism
Good and Bad Growth: The Virtues and Vices of Mitochondria and Metabolism
Matthew G. Vander Heiden,
Massachusetts Institute of Technology, USA
Regulation of Metabolic Pathways to Support Anabolic Metabolism
Regulation of Metabolic Pathways to Support Anabolic Metabolism
Richard L. Possemato,
New York University School of Medicine, USA
Short Talk: Identification of Metabolic Liabilities in Breast Cancer
Short Talk: Identification of Metabolic Liabilities in Breast Cancer
Heather Christofk,
University of California, Los Angeles, USA
Short Talk: Role of MCT1 in Cancer Metabolism
Short Talk: Role of MCT1 in Cancer Metabolism
Andrew Mullen,
University of Texas Southwestern Medical Center, USA
Short Talk: A Novel Pathway of Glutamine Metabolism Fuels Growth in Cancer Cells with Defective Mitochondria
Short Talk: A Novel Pathway of Glutamine Metabolism Fuels Growth in Cancer Cells with Defective Mitochondria
Christian Metallo,
University of California, San Diego, USA
Short Talk: Reductive Tricarboxylic Acid Metabolism of Glutamine Mediates Lipogenesis under Hypoxia
Short Talk: Reductive Tricarboxylic Acid Metabolism of Glutamine Mediates Lipogenesis under Hypoxia
08:00—11:15
Oxygen Signaling in Tissue Injury, Repair and Inflammation
Meeting has ended...abstracts no longer viewable online.
*
Larrisa A. Shimoda,
Johns Hopkins School of Medicine, USA
Bernhard Brüne,
Goethe University Frankfurt, Germany
Oxygen-Dependent Regulation of Macrophage Function
Oxygen-Dependent Regulation of Macrophage Function
Benoit Sebastien Marteyn,
Institut Pasteur, France
Short Talk: Hypoxic Response during Pathogenic Enterobacterium Shigella Infection
Short Talk: Hypoxic Response during Pathogenic Enterobacterium Shigella Infection
Eric L. Campbell,
University of Colorado - Anschutz Medical Campus, USA
Short Talk: Transmigrating Neutrophils Induce “Transcriptional Imprinting” within the Epithelium and Reveals a Fundamental Role for Hypoxic Signaling Attributable to Localized Oxygen Depletion
Short Talk: Transmigrating Neutrophils Induce “Transcriptional Imprinting” within the Epithelium and Reveals a Fundamental Role for Hypoxic Signaling Attributable to Localized Oxygen Depletion
Holger K. Eltzschig,
University of Colorado Denver, USA
Hypoxia Responses in Acute Ischemia-Reperfusion Injury
Hypoxia Responses in Acute Ischemia-Reperfusion Injury
14:30—16:30
Workshop 2: Technological Advances in Hypoxia Research
*
Frank S. Lee,
University of Pennsylvania School of Medicine, USA
David T. Eddington,
University of Illinois, Chicago, USA
Microfluidic Oxygenated Substrates for Studying Ischemia Reperfusion and Intermittent Hypoxia
Microfluidic Oxygenated Substrates for Studying Ischemia Reperfusion and Intermittent Hypoxia
Patrick R. Arsenault,
University of Pennsylvania, USA
Effects of Mutations in Mouse Phd2 on Hematological and Physiological Phenotypes
Effects of Mutations in Mouse Phd2 on Hematological and Physiological Phenotypes
Analía Nuñez O´Mara,
Center for Cooperative Research in Biosciences, Spain
The Role of SUMOylation in the Cellular Response to Hypoxia
The Role of SUMOylation in the Cellular Response to Hypoxia
Violaine Sée,
University of Liverpool, UK
Single Cell Imaging and Mathematical Modeling to Depict the Role of the Prolyl Hydroxylase-Negative Feedback Loop on HIF-1alpha Dynamics
Single Cell Imaging and Mathematical Modeling to Depict the Role of the Prolyl Hydroxylase-Negative Feedback Loop on HIF-1alpha Dynamics
Othon Iliopoulos,
Massachusetts General Hospital Cancer Center, USA
Regulation of Reductive TCA Cycle Metabolism by Hypoxia-HIF-VHL Signaling: New Opportunities for Therapy of Renal Cell Carcinoma
Regulation of Reductive TCA Cycle Metabolism by Hypoxia-HIF-VHL Signaling: New Opportunities for Therapy of Renal Cell Carcinoma
Antonio Martinez-Ruiz,
Fund Inv Biomed Hospital Univ La Princesa, Spain
Differential Redox Proteomics Identify Proteins Reversibly Oxidized in Cysteines in Endothelial Cells in Response to Acute Hypoxia
Differential Redox Proteomics Identify Proteins Reversibly Oxidized in Cysteines in Endothelial Cells in Response to Acute Hypoxia
Ali Tavassoli,
University of Southampton, UK
Inhibition of Hypoxia Signalling with Cyclic Peptide Inhibitors of HIF Heterodimerization
Inhibition of Hypoxia Signalling with Cyclic Peptide Inhibitors of HIF Heterodimerization
17:00—19:00
Lessons from Mouse Models
Meeting has ended...abstracts no longer viewable online.
John L. Cleveland,
The Scripps Research Institute, USA
Blocking Lactate Export by Inhibiting the Myc target Mct1 Disables Cancer Cell Metabolism and Impairs Tumorigenesis
Blocking Lactate Export by Inhibiting the Myc target Mct1 Disables Cancer Cell Metabolism and Impairs Tumorigenesis
Nada Y. Kalaany,
Boston Children's Hospital at Harvard Medical School, USA
Short Talk: Adjacent Tumors Cohabiting the Same Tissue Respond Differentially to Dietary Restriction
Short Talk: Adjacent Tumors Cohabiting the Same Tissue Respond Differentially to Dietary Restriction
17:00—19:00
Cellular Stress Responses to Hypoxia
Meeting has ended...abstracts no longer viewable online.
*
Joachim Fandrey,
University Duisburg-Essen, Germany
Paul T. Schumacker,
Northwestern University, USA
Mitochondrial ROS Signaling under Hypoxic Stress
Mitochondrial ROS Signaling under Hypoxic Stress
Ezra Burstein,
University of Texas Southwestern Medical Center, USA
COMMD Proteins and Hypoxic Stress
COMMD Proteins and Hypoxic Stress
Masayuki Yamamoto,
Tohoku University Graduate School of Medicine, Japan
Hypoxia-Inducible and Tissue-Specific Erythropoietin Gene Regulation
Hypoxia-Inducible and Tissue-Specific Erythropoietin Gene Regulation
Ho Jeong Kwon,
Yonsei University, South Korea
Short Talk: Terpestacin and UQCRB, a New Small Molecule and its Target Protein in Hypoxia Signaling
Short Talk: Terpestacin and UQCRB, a New Small Molecule and its Target Protein in Hypoxia Signaling
08:00—11:15
Novel Mechanisms in Metabolic Control
Meeting has ended...abstracts no longer viewable online.
*
Matthew G. Vander Heiden,
Massachusetts Institute of Technology, USA
Eyal Gottlieb,
Technion Integrated Cancer Center, Israel
The use of Metabolomics to Discover Novel Metabolic Networks and New Targets for Cancer Treatment
The use of Metabolomics to Discover Novel Metabolic Networks and New Targets for Cancer Treatment
Jeffrey C. Rathmell,
Vanderbilt University, USA
Glucose Uptake and Metabolic Links to Cell Death
Glucose Uptake and Metabolic Links to Cell Death
Joan S. Brugge,
Harvard Medical School, USA
Extracellular Matrix, Growth Factor and Oncogene Control of Cellular Survival and Metabolism
Extracellular Matrix, Growth Factor and Oncogene Control of Cellular Survival and Metabolism
Kay F. Macleod,
University of Chicago, USA
Short Talk: BNip3 Limits HIF-1alpha Stabilization and Metastasis in a Mouse Model of Breast Cancer through Effects on Mitochondrial Integrity and ROS Generation
Short Talk: BNip3 Limits HIF-1alpha Stabilization and Metastasis in a Mouse Model of Breast Cancer through Effects on Mitochondrial Integrity and ROS Generation
Gerald Hoefler,
Medical University of Graz, Austria
Short Talk: Ablation of Triglyceride Lipases Protects from Cancer Associated Cachexia
Short Talk: Ablation of Triglyceride Lipases Protects from Cancer Associated Cachexia
08:00—11:15
Therapeutic Targeting of Hypoxia Response Pathways
Meeting has ended...abstracts no longer viewable online.
Michael H. Rabinowitz,
Akebia Therapeutics, Inc., USA
Drug Development: Targeting Prolyl Hydroxylases
Drug Development: Targeting Prolyl Hydroxylases
Kai-Uwe Eckardt,
University Clinic Erlangen, Germany
Clinical Application of Prolyl-Hydroxylase Inhibition
Clinical Application of Prolyl-Hydroxylase Inhibition
Karen A. Vincent,
Genzyme Corporation, USA
Cardiovascular Gene Therapy: Targeting Hypoxia
Cardiovascular Gene Therapy: Targeting Hypoxia
Christian Stockmann,
PARCC – Paris Cardiovascular Research Center, France
Short Talk: Tuning Tumor Oxygenation and Reshaping the Tumor Microenvironment by Compartmentalized VEGF Expression - Impact on Tumor Relapse
Short Talk: Tuning Tumor Oxygenation and Reshaping the Tumor Microenvironment by Compartmentalized VEGF Expression - Impact on Tumor Relapse
Mark W. Dewhirst,
Duke University Medical Center, USA
Aerobic Exercise Training Decreases Tumor Growth Rates in Murine Models of Breast Cancer
Aerobic Exercise Training Decreases Tumor Growth Rates in Murine Models of Breast Cancer
Alessio Ciulli,
University of Dundee, College of Life Sciences, UK
Short Talk: Targeting the von Hippel-Lindau (pVHL) E3 Ubiquitin Ligase Multisubunit Protein Complex using Small Molecules to Disrupt its Interaction with Hypoxia Inducible Factor 1 alpha (Hif-1a)
Short Talk: Targeting the von Hippel-Lindau (pVHL) E3 Ubiquitin Ligase Multisubunit Protein Complex using Small Molecules to Disrupt its Interaction with Hypoxia Inducible Factor 1 alpha (Hif-1a)
14:30—16:30
Workshop 2: Hot Topics in Cancer Metabolism II
Cristina Muñoz-Pinedo,
Institut d'Investigacio Biomedica de Bellvitge, Spain
Mechanisms of Tumor Cell Death Induced by Inhibition of Glucose Metabolism
Mechanisms of Tumor Cell Death Induced by Inhibition of Glucose Metabolism
Patrick J. Pollard,
University of Edinburgh, UK
Candidate Roles for Protein Succination in Altered Cellular Metabolism and Oncogenesis
Candidate Roles for Protein Succination in Altered Cellular Metabolism and Oncogenesis
Charles Kung,
Agios Pharmaceuticals Inc., USA
Induced Dependency on Amino Acid Metabolism in Proliferating Cancer Cells Upon PKM2 Activation
Induced Dependency on Amino Acid Metabolism in Proliferating Cancer Cells Upon PKM2 Activation
William J. Israelsen,
Massachusetts Institute of Technology, USA
Role of PKM2 in Tumor Development
Role of PKM2 in Tumor Development
Patrick S. Ward,
Massachusetts General Hospital, USA
Hypoxia Promotes IDH2-Dependent Carboxylation of alpha-Ketoglutarate to Citrate to Support Cell Growth and Viability
Hypoxia Promotes IDH2-Dependent Carboxylation of alpha-Ketoglutarate to Citrate to Support Cell Growth and Viability
David B. Shackelford,
University of California, Los Angeles, USA
LKB1/STK11 Deficiency Sensitizes Genetically Engineered Mouse Models of Non Small Cell Lung Cancer to Phenformin Therapy
LKB1/STK11 Deficiency Sensitizes Genetically Engineered Mouse Models of Non Small Cell Lung Cancer to Phenformin Therapy
Brandon Faubert,
University of Texas Southwestern Medical Center, USA
The Energy Sensor AMP-activated Protein Kinase (AMPK) Mediates a Metabolic Switch to Warburg Metabolism in Cancer
The Energy Sensor AMP-activated Protein Kinase (AMPK) Mediates a Metabolic Switch to Warburg Metabolism in Cancer
Robert E. Lewis,
University of Nebraska Medical Center, USA
Coordinate Detection of New Targets and Small Molecules in Cancer Therapy
Coordinate Detection of New Targets and Small Molecules in Cancer Therapy
17:00—19:00
Metabolic Drugs as Cancer Therapeutics
Meeting has ended...abstracts no longer viewable online.
Paul S. Mischel,
University of California, San Diego, USA
Targeting Metabolic Pathways in EGFR-Activated Glioblastoma
Targeting Metabolic Pathways in EGFR-Activated Glioblastoma
Beat Nyfeler,
Novartis Institutes for BioMedical Research, Switzerland
Targeting mTOR in Cancer
Targeting mTOR in Cancer
Jonathan Mandelbaum,
Accelerator Life Science Partners, USA
Short Talk: Generation of Chemical and Genetic Tools for Inhibiting ATG7 Function
Short Talk: Generation of Chemical and Genetic Tools for Inhibiting ATG7 Function
17:00—19:00
Hypoxic Signaling in Tumor Development and Progression
Meeting has ended...abstracts no longer viewable online.
*
Thomas Kietzmann,
University of Oulu, Finland
Amato J. Giaccia,
Stanford University, USA
Hypoxia and Metastasis
Hypoxia and Metastasis
Elizabeth Koch,
Princess Margaret Hospital/Ontario Cancer Institute, Canada
Short Talk: Hypoxic Regulation of DICER1, microRNA, and their Influence on the Cancer Phenotype
Short Talk: Hypoxic Regulation of DICER1, microRNA, and their Influence on the Cancer Phenotype
Margaret Ashcroft,
University of Cambridge, UK
Mitochondrial Protein Regulators of Hypoxia Signaling and Tumour Progression
Mitochondrial Protein Regulators of Hypoxia Signaling and Tumour Progression
Michael Ohh,
University of Toronto, Canada
Non-Canonical Regulation of Gene Expression via HIF
Non-Canonical Regulation of Gene Expression via HIF
*Session Chair †Invited, not yet responded.
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