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This meeting took place in 2012



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Mitochondrial Dynamics and Function (X3)


Organizer(s) Luca Scorrano and Jodi Nunnari
March 19—24, 2012
Fairmont Banff Springs • Banff, Alberta Canada
Abstract Deadline: Nov 17, 2011
Late Abstract Deadline: Dec 21, 2011
Scholarship Deadline: Nov 17, 2011
Early Registration Deadline: Jan 19, 2012

Sponsored by Takeda Pharmaceutical Company Limited


Summary of Meeting:
Mitochondria are no longer considered “only” as the cellular thermodynamic converter: mounting evidence implicates them as key organelles in cell signaling, proliferation, aging, disease and death. Indeed, our view of this organelle was profoundly altered with the discovery that mitochondria function within a connected network that is continuously remodeled by fusion and division events. This reality has sparked and accelerated new scientific discoveries through the intersection of different fields about the functional roles and molecular features of mitochondrial behaviors. The interaction between the cell death and mitochondrial dynamics fields is the best example of such interplay and has led to the discovery that modulators governing cell death and mitochondrial dynamics, respectively, are in fact interacting with one another. This Keystone Symposia meeting uniquely builds on this rich interdisciplinary interaction, which continues to provide novel insights into the mechanisms underlying mitochondrial behavior and mitochondrial-associated diseases. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Cell Death Pathways: Beyond Apoptosis, which will share a keynote address and two plenary sessions with this meeting.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


MONDAY, MARCH 19

15:00—19:30
Registration

Van Horne Foyer
18:15—19:15
Refreshments

Van Horne Foyer
19:15—21:30
Welcome and Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne A-B
* Luca Scorrano, University of Padova, Italy

Heidi M. McBride, McGill University, Canada
Mitochondrial Dynamics and Quality Control

Junying Yuan, Harvard Medical School, USA
Programmed Cell Death: From Apoptosis to Necroptosis

* Serge Przedborski, Columbia University, USA


TUESDAY, MARCH 20

07:00—08:00
Breakfast

Mezzanine 2
08:00—11:15
Mitochondrial Dynamics in Cell Death (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne A-B
* Richard J. Youle, NINDS, National Institutes of Health, USA

Kim McCall, Boston University, USA
Mitochondrial Dynamics and Cell Death in Drosophila Oogenesis

Luca Scorrano, University of Padova, Italy
Integrating Mitochondrial Morphology and Ultrastructure in the Control of Apoptosis: Lessons from Cellular and Mouse Models

Seamus J. Martin, Trinity College Dublin, Ireland
Mitochondrial Quality Control and the Bcl-2 Family

Joseph T. Opferman, St. Jude Children's Research Hospital, USA
Anti-Apoptotic MCL-1 Localizes to the Mitochondrial Matrix and Regulates Mitochondrial Function

Michelangelo Campanella, RVC and UCL Consortium for Mitochondrial Research, UK
Short Talk: The F1FO-ATPsynthase Inhibitor IF1 Controls Apoptosis by Regulating Mitochondrial Dynamics

Nuno Raimundo, University Medical Center Goettingen, Germany
Short Talk: Mitochondrial Stress Triggers E2F1 Apoptotic Signaling to Cause Deafness – Insights into Tissue-Specific Mechanisms

09:20—09:40
Coffee Break

Van Horne Foyer
11:15—13:00
Poster Setup

Mezzanine 2
11:15
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Mezzanine 2
14:30—16:30
Workshop 1: Non-Apoptotic Death Pathways: Mechanisms and Consequences

Van Horne C
* Carol M. Troy, Columbia University Medical Center, USA

Patrick A. Lewis, University of Reading, UK
The ROC Domain of DAPK1 as a Controller of DAPK1 Function and Cell Death

Meera Nanjundan, University of South Florida, USA
Role of SnoN/SkiL in Modulating Cell Death Pathways in the Pathogenesis of Ovarian Cancer

Sho Morioka, North Carolina State University, USA
TAK1 Regulates Mitochondrial Integrity, Which Is Important for Preventing TNF-Induced Endothelial Cell Death and Vascular Development

Yuxing Zhao, St. Vincent's Institute, Australia
Apoptotic and Non-Apoptotic Pathways Lead to Pancreatic beta Cell Destruction in Type 1 Diabetes

Susan E. Brockerhoff, University of Washington, USA
Mechanisms of Photoreceptor Degeneration

Jason Karch, Cincinnati Children's Hospital Medical Center, USA
Bax and Bak Are Required For Mitochondrial Permeability Transition Pore-Dependent Programmed Cellular Necrosis

16:30—17:00
Coffee Available

Van Horne Foyer
17:00—19:00
Building the Organelle: The Import of Protein and Lipids
Meeting has ended...abstracts no longer viewable online.

Van Horne A-B
* Mike Ryan, Monash University, Australia

Jodi Nunnari, University of California, Davis, USA
The Behavior of Mitochondria

Hiromi Sesaki, Johns Hopkins University School of Medicine, USA
Mitochondrial Division Prevents Neurodegeneration

Thomas Langer, CECAD Research Center, Germany
Proteolytic Control of Mitochondrial Membrane Dynamics

Nils-Goran Larsson, Max Planck Institute for the Biology of Aging, Germany
Short Talk: Posttranscriptional Regulation of mtDNA Expression in Animals

17:00—19:15
Atypical Caspase-Dependent Cell Death Mechanisms
Meeting has ended...abstracts no longer viewable online.

Van Horne C
* Junying Yuan, Harvard Medical School, USA

Andreas Villunger, Medical University Innsbruck, Austria
The PIDDosome in Cell Death and Cell Cycle Regulation

David Wallach, Weizmann Institute of Science, Israel
The ‘Apoptotic’ Caspases as Regulators of Inflammation: New Lessons about Caspase-8 Function

Douglas R. Green, St. Jude Children's Research Hospital, USA
Cutting Both Ways: Why FADD, FLIP, and Caspase-8 are Required for Embryonic Development

Kenta Moriwaki, University of Massachusetts Medical School, USA
Short Talk: Molecular Mechanism and Pathophysiological Roles of RIP3-Dependent Necrosis

Liming Sun, Institute of Biochemistry and Cell Biology, SIBS, CAS, China
Short Talk: MLKL Mediates Necrosis Signaling Downstream of RIP3

19:00—20:00
Social Hour with Lite Bites

Mezzanine 2
19:30—22:00
Poster Session 1

Mezzanine 2

WEDNESDAY, MARCH 21

07:00—08:00
Breakfast

Mezzanine 2
08:00—11:15
Making the Organelle to Work: From Genetics to (Dys)function
Meeting has ended...abstracts no longer viewable online.

Van Horne A-B
* Nils-Goran Larsson, Max Planck Institute for the Biology of Aging, Germany

Paolo Bernardi, University of Padova Medical School, Italy
Pathophysiology of the Mitochondrial Permeability Transition

Rosario Rizzuto, University of Padua, Italy
Identification of the Mitochondrial Calcium Uniporter

David C. Chan, California Institute of Technology, USA
Analysis of Mitochondrial Dynamics in Mouse Tissues

Anu Suomalainen Wartiovaara, University of Helsinki, Finland
Global and Tissue-Specific Consequences of Mitochondrial Dysfunction

Pénélope Andreux, Amazentis, Switzerland
Short Talk: A Multi-Level Screen in Mammals and the Worm C. elegans for the Identification of Compounds Improving Mitochondrial Function

Vanessa A. Morais, Katholieke Universiteit Leuven & VIB, Belgium
Short Talk: Parkinson’s Disease: PINK1 Regulates Complex I Activity

08:00—11:15
Bioinformatics at the Service of the Death-omes
Meeting has ended...abstracts no longer viewable online.

Van Horne C
* Maya Saleh, McGill University, Canada

Andrea Califano, Columbia University, USA
Interrogating Gene Regulatory Networks to Discover Oncogene and Non-Oncogene Addictions in Cancer

Al L. Burlingame, University of California, San Francisco, USA
Cell Death Pathways: Beyond Apoptosis

Paul J. Muchowski, University of California, San Francisco, USA
Using Yeast to Identify Pathways that Modify Neurodegeneration

Cole M. Haynes, University of Massachusetts Medical School, USA
Retrograde Signaling a Mitochondrial Unfolded Protein Response

Burcin Ikiz, Trustees of Columbia University in the City of New York, USA
Short Talk: Unraveling the Molecular Mechanism Underlying ALS-Linked Astrocyte Toxicity to Motor Neurons

Lars Brichta, Rockefeller University, USA
Short Talk: Comparative Translational Profiling of Dopaminergic Neurons in Mouse Models for Parkinson’s Disease

09:20—09:40
Coffee Break

Van Horne Foyer
11:15—13:00
Poster Setup

Mezzanine 2
11:15
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Mezzanine 2
14:30—16:30
Workshop 1: Extending Mitochondrial Fusion and Fission: Mechanisms and Consequences

Van Horne A-B
* David C. Chan, California Institute of Technology, USA

Maria Bohnert, Weizmann Institute of Science, Israel
MINOS, a Novel Mitochondrial Inner Membrane Organizing System

Uma Sankar, University of Louisville, USA
Regulation of the Mitochondrial Fission GTPase Drp1 by the Sulfhydryl Oxidase GFER

Axel Niemann, ETH Zürich, Switzerland
GDAP1-Induced Fission Allows Protection during ROS Stress Conditions

Julio C. B. Ferreira, Institute of Biomedical Sciences, Brazil
Disruption of Mitochondria Fusion Contributes to Heart Failure; A Role for betaIIPKC

Adam L. Hughes, University of Utah, USA
A Yeast PINK1/Parkin-Like Mitophagy Pathway

Jonathon L. Burman, University of Washington, USA
Selective Vulnerability of Mitochondria in Parkin Mutant Dopaminergic Neurons

Lindsay DeVorkin, Deeley Research Centre, Canada
A Drosophila Effector Caspase Mediates Mitochondrial Dynamics and Autophagy

John J. Lemasters, Medical University of South Carolina, USA
Different Initiators of Mitochondrial Autophagy in Types 1 and 2 Mitophagy

16:30—17:00
Coffee Available

Van Horne Foyer
17:00—19:00
The Interface between Mitochondria and the Endoplasmic Reticulum
Meeting has ended...abstracts no longer viewable online.

Van Horne A-B
* Jodi Nunnari, University of California, Davis, USA

Gia K. Voeltz, University of Colorado Boulder, USA
ER Tubules Mark Sites of Mitochondrial Division

György Hajnóczky, Thomas Jefferson University, USA
Mechanisms of ER-Mitochondrial Local Communication

Francesco Cecconi, University of Rome Tor Vergata, Italy
ER-Mitochondria Cross-Talk and the Clash between Autophagy and Cell Cycle Progression

Brendan J. Battersby, University of Helsinki, Finland
Short Talk: Gimap3 Modifying mtDNA Segregation through Autophagy

17:00—19:15
Bcl-2 Protein Family
Meeting has ended...abstracts no longer viewable online.

Van Horne C
* Rajiv R. Ratan, Burke-Cornell Medical Research Institute, USA

Atan J. Gross, Weizmann Institute of Science, Israel
A Novel Mitochondrial Pathway that Regulates Cell Fate and Function

Ruth M. Kluck, Walter and Eliza Hall Institute of Medical Research, Australia
How Bak and Bax Permeabilize Mitochondria during Cell Death

Maya Saleh, McGill University, Canada
The Pro-Apoptotic Protein BID is Required for NOD-Mediated Inflammation and Innate Immunity

Tomomi Kuwana, La Jolla Institute for Allergy and Immunology, USA
Short Talk: Bax Forms Two Types of Pores in the Mitochondrial Outer Membrane: Slow- and Fast-Release

Levi J. Beverly, University of Louisville, USA
Short Talk: Combining Mouse Models, Biochemistry and Drug Screens to Understand the Role BCL2-Proteins in Human Cancer Initiation and Therapeutic Interventions

19:00—20:00
Social Hour with Lite Bites

Mezzanine 2
19:30—22:00
Poster Session 2

Mezzanine 2

THURSDAY, MARCH 22

07:00—08:00
Breakfast

Mezzanine 2
08:00—11:30
Mitochondrial Fusion and Fission: Mechanisms and Regulation
Meeting has ended...abstracts no longer viewable online.

Van Horne A-B
* Thomas Langer, CECAD Research Center, Germany

Janet M. Shaw, University of Utah, USA
Identification of the Minimal Mitochondrial Fission Machinery in Yeast and Humans

Mike Ryan, Monash University, Australia
Novel Mediators of Mitochondrial Morphology

Robert A. Screaton, Sunnybrook Research Institute, Canada
Short Talk: Genome-Wide RNAi Screening Identifies Novel Regulators of Mitochondrial Morphology

Antonio Zorzano, Institute for Research in Biomedicine, Spain
Mfn2 Links Mitochondrial and ER Function with Insulin Signaling

Jennifer A. Lippincott-Schwartz, Howard Hughes Medical Institute - Janelia Farm, USA
Cell-Cycle Regulation of Mitochondrial Fusion and Fission

Xiaodong Wang, BeiGene, China
Mitochondrial Phosphatase PGAM5 Participates in Necrosis Execution

08:00—11:00
Non-Cell Autonomous Mechanisms of Death
Meeting has ended...abstracts no longer viewable online.

Van Horne C
* Kim McCall, Boston University, USA

Serge Przedborski, Columbia University, USA
Astrocytes and Motor Neuron Degeneration

Gwenn A. Garden, University of Washington, USA
Microglia Mediated Neurotoxicity is Downstream of Reactive Oxygen Species, p53 and microRNAs

Christian Münch, Harvard Medical School, The Harper Lab, USA
Prion-Like Propagation of Mutant Superoxide Dismutase-1 Misfolding

Beata Jablonska, Children's National Medical Center, USA
FoxO-Dependent Regulation of p27Kip1 Controls Oligodendrocyte Differentiation after Perinatal Hypoxia

Takeshi Watanabe, University of Tokyo, Japan
Short Talk: Regulation of NR4A Nuclear Receptors by the ASK-p38 MAP Kinase Pathway-Dependent Phosphorylation

09:20—09:40
Coffee Break

Van Horne Foyer
11:30—13:00
Poster Setup

Mezzanine 2
11:30
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Mezzanine 2
14:30—15:30
Workshop 2: Mitochondria on the Move

Van Horne A-B
* György Hajnóczky, Thomas Jefferson University, USA

Konrad E. Zinsmaier, University of Arizona, USA
Miro Controls Mitochondrial Transport, Structure, and Health in Axons through its GTPase or EF-Hand Domains

Richard A. Kahn, Emory University School of Medicine, USA
Roles of the ARL2 GTPase at Mitochondria

Ghazaleh Ashrafi, Harvard University, USA
Damage to Neuronal Mitochondria Arrests their Motility Prior to Mitophagy

Romain Cartoni, Children's Hospital Boston, Harvard Medical School, USA
Co-Deletion of PTEN and SOCS3 Enhance Mitochondrial Transport after Axonal Injury

15:30—16:30
Workshop 3: Mitochondria and Endoplasmic Reticulum: Structural and Functional Interplay

Van Horne A-B
* Gia K. Voeltz, University of Colorado Boulder, USA

Laura L. Lackner, Northwestern University, USA
An ER-Associated Mitochondria-Cortex Tether Functions in the Distribution and Inheritance of Mitochondria

Valentina Debattisti, Thomas Jefferson University, USA
Marf, the Single Mitofusin of D. Melanogaster, is Selectively Complemented by Mitofusin 2

Heather M. Lamb, Johns Hopkins Bloomberg School of Public Health, USA
Coexpression of Bax and Bcl-xL in the Secretory Pathway Alters ER Structure

Clement A. Gautier, Institut du Cerveau et de la moelle Epiniere, France
Novel Role for Parkin in the Regulation of the Physical and Functional Interactions between Mitochondria and the Endoplasmic Reticulum

16:30—17:00
Coffee Available

Van Horne Foyer
17:00—19:00
The Interface between Mitochondria, Metabolism and Cell Death
Meeting has ended...abstracts no longer viewable online.

Van Horne A-B
* Paolo Bernardi, University of Padova Medical School, Italy

Vamsi K. Mootha, Massachusetts General Hospital, USA
Discovery of the Mitochondrial Calcium Uniporter via Genomics

Eileen P. White, Rutgers University, USA
Mitochondrial Control of Autophagy

Nika N. Danial, Dana-Farber Cancer Institute, USA
Programming the Mitochondrial Carbon Substrate Utilization: A Role for BAD

Christian Frezza, Hutchison/MRC Research Centre, UK
Short Talk: Haem Oxygenase is Synthetically Lethal with the Tumor Suppressor Fumarate Hydratase

17:00—19:15
Cell Death Therapeutics
Meeting has ended...abstracts no longer viewable online.

Van Horne C
* Douglas R. Green, St. Jude Children's Research Hospital, USA

Carol M. Troy, Columbia University Medical Center, USA
Intranasal Cell Permeant Caspase Inhibitors – Therapeutics for Cerebral Ischemia and other Neurologic Disorders

Loren D. Walensky, Dana-Farber Cancer Institute, USA
Mining the Repertoire of BH3 Interaction Sites for Next Generation Pro-Apoptotic Therapies

Rajiv R. Ratan, Burke-Cornell Medical Research Institute, USA
Epigenetic Modifiers Prevent Neurodegeneration: HDACs and Beyond

Liane Wagner, University Medical Center Ulm, Germany
Short Talk: Smac Mimetic Sensitizes Glioblastoma Cells to Temozolomide-Induced Apoptosis via Ripoptosome Formation

Johannes Noack, DKFZ - German Cancer Research Center, Germany
Short Talk: Combination of a Sphingosine Kinase Inhibitor and Temozolomide Results in a Strong Synergistic Cytotoxic Effect which Displays Features of Various Cell Death Pathways

19:00—20:00
Social Hour with Lite Bites

Mezzanine 2
19:30—22:00
Poster Session 3

Mezzanine 2

FRIDAY, MARCH 23

07:00—08:00
Breakfast

Mezzanine 2
08:00—11:15
Mitophagy/Quality Control (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne A-B
* Heidi M. McBride, McGill University, Canada

Mondira Kundu, St. Jude Children's Hospital, USA
ULK1: Linking Mitophagy with the Cellular Response to Stress

Koji Okamoto, Osaka University, Japan
Molecular Mechanism of Mitochondria-specific Autophagy in Yeast

Paul A. Ney, New York Blood Center, USA
A Single Amino in NIX is Essential for Mitochondrial Clearance in Reticulocytes

Richard J. Youle, NINDS, National Institutes of Health, USA
Damage Control - How the Pink1/Parkin pathway can regulate removal of impaired mitochondria by autophagy

Rudolf J. Wiesner, University of Cologne, Germany
Short Talk: Not the Assembly, the Stability of Respiratory Chain Complexes is Impaired by Nonsense Mutations in mtDNA Encoded Respiratory Chain Subunits

Matthew J. LaVoie, Brigham and Women's Hospital and Harvard Medical School, USA
Short Talk: Parkin Ubiquitinates Bax to Regulate the Apoptotic Response of Mitochondria

09:00—09:20
Coffee Break

Van Horne Foyer
11:15
On Own for Lunch and Recreation

14:30—16:30
Workshop 2: Autophagy in Pathological Conditions

Van Horne C
* John J. Lemasters, Medical University of South Carolina, USA

Su-Jeong Kim, University of Southern California, USA
Nuclear Translocation of DJ-1 during Oxidative Stress-Induced Neuronal Cell Death

Devrim Gozuacik, Sabanci University, Turkey
MicroRNA Control of Autophagy

Charles A. O'Brien, University of Arkansas for Medical Sciences, USA
Osteocyte Autophagy Declines with Age in Mice and Suppression of Osteocyte Autophagy Decreases Bone Mass and Mimics Skeletal Aging

Jennifer Martinez, NIEHS, National Institutes of Health, USA
LC3-Associated Phagocytosis is Required for Efficient Clearance of Dead Cells

Babul Moni Ram, National Cancer Institute, USA
Calcineurin Inhibitor Cyclosporine A Induces Endoplasmic Reticulum Stress Mediated Non Apoptotic Cell Death Response

Melanie J. Scott, University of Pittsburgh, USA
Caspase-1-Dependent Mitophagy Regulates Liver Damage and Cell Death after Hemorrhagic Shock in Mice

Melissa Vos, University of Lübeck, Germany
Vitamin K2 is a Mitochondrial Electron Carrier that Rescues Pink1 Deficiency

16:30—17:00
Coffee Available

Van Horne Foyer
17:00—19:00
Mitochondrial Dynamics and Disease
Meeting has ended...abstracts no longer viewable online.

Van Horne A-B
* Anu Suomalainen Wartiovaara, University of Helsinki, Finland

Gerald W. Dorn, II, Washington University School of Medicine, USA
The Varied Roles of Mitofusins in the Heart

Vojo Deretic, University of New Mexico Health Sciences Center, USA
Autophagy: An Immunity Paradigm with Mitochondria as a Centerpiece

Michelle L. Boland, Medimmune, USA
Short Talk: Bnip3 is Required to Prevent Hepatic Steatosis and Deficiencies in Gluconeogensis through Effects at the Mitochondria

17:00—19:00
Use and Interpretation of Assays for Monitoring Mitophagy
Meeting has ended...abstracts no longer viewable online.

Van Horne C
* Paul A. Ney, New York Blood Center, USA

Orian S. Shirihai, University of California, Los Angeles, USA
Live Imaging of Mitophagy in Mammalian Cells

Hagai Abeliovich, Hebrew University of Jerusalem, Israel
Mitophagy as a Quality Control Mechanism in Saccharomyces cerevisiae

19:00—20:00
Social Hour with Lite Bites

Mezzanine 2
20:00—23:00
Entertainment

Mezzanine 2

SATURDAY, MARCH 24

 
Departure


*Session Chair †Invited, not yet responded.


We gratefully acknowledge support for this conference from:


Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Takeda Pharmaceutical Company Limited

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13GM100698-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

EMBO (European Molecular Biology Organization)

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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Phone:+1 970-262-1179