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This meeting took place in 2013
Here are the related meetings in 2018:
Regulation and Dysregulation of Innate Immunity in Disease (B9)
For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.
The Innate Immune Response in the Pathogenesis of Infectious Disease (E1)
Organizer(s) Ricardo T. Gazzineli, Gustavo P. Amarante-Mendes, Anne O'Garra and Alan Sher
May 10—15, 2013
Centro de Artes e Convenções (UFOP) • Ouro Preto, MG Brazil
Abstract Deadline: Jan 7, 2013
Late Abstract Deadline: Feb 4, 2013
Scholarship Deadline: Jan 7, 2013
Early Registration Deadline: Mar 5, 2013
Organized as an international collaboration and with generous support from CNPq — the National Council for Scientific and Technological Development, Brazil, and FAPEMIG — Minas Gerais State Agency for Research Development. Part of the Keystone Symposia Global Health Series, travel awards supported by the Bill & Melinda Gates Foundation.
Summary of Meeting:
The rational development of immunological interventions that are effective for treating or preventing infectious diseases is still on its infancy. For decades, the majority of the studies on immunopathogenesis have dealt with physical damage and inflammation, primarily mediated by lymphocytes. The main focus of this Keystone Symposia meeting will be on the interface of the innate immune system and microbial pathogens and the role that it plays in protective versus deleterious immune responses and, thereby, of disease outcome. The program will promote discussions on fundamental concepts as well as new advances in the role of innate immunity in host resistance and pathogenesis of infectious diseases, with special emphasis on infections of the tropics. Investigators from different areas, such as biochemistry, cell biology, immunology, microbiology, parasitology, infectious diseases, tropical medicine and biotechnology will be included to encourage the discussion of interdisciplinary concepts and new directions for the field. This is the first of a series of Keystone Symposia meetings to be held in Brazil, and should also foster the participation of Latin American students and scientists. The close interaction of these participants with leading international experts in the field should lead to a stimulating atmosphere that we hope will promote the development of new South-North collaborations and research networks.
View Scholarships/Awards
The rational development of immunological interventions that are effective for treating or preventing infectious diseases is still on its infancy. For decades, the majority of the studies on immunopathogenesis have dealt with physical damage and inflammation, primarily mediated by lymphocytes. The main focus of this Keystone Symposia meeting will be on the interface of the innate immune system and microbial pathogens and the role that it plays in protective versus deleterious immune responses and, thereby, of disease outcome. The program will promote discussions on fundamental concepts as well as new advances in the role of innate immunity in host resistance and pathogenesis of infectious diseases, with special emphasis on infections of the tropics. Investigators from different areas, such as biochemistry, cell biology, immunology, microbiology, parasitology, infectious diseases, tropical medicine and biotechnology will be included to encourage the discussion of interdisciplinary concepts and new directions for the field. This is the first of a series of Keystone Symposia meetings to be held in Brazil, and should also foster the participation of Latin American students and scientists. The close interaction of these participants with leading international experts in the field should lead to a stimulating atmosphere that we hope will promote the development of new South-North collaborations and research networks.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
FRIDAY, MAY 10
SATURDAY, MAY 11
SUNDAY, MAY 12
MONDAY, MAY 13
TUESDAY, MAY 14
WEDNESDAY, MAY 15
Conference Program Print | View meeting in 12 hr (am/pm) time
FRIDAY, MAY 10
15:00—19:30
Arrival and Registration
Foyer/Diamantina
18:15—19:15
Refreshments
Foyer/Diamantina
19:15—21:30
Welcome and Keynote Session
Meeting has ended...abstracts no longer viewable online.
Teatro Ouro Preto
*
Rodrigo Corrêa-Oliveira,
FIOCRUZ, Brazil
Keystone Symposia Brazil and the Challenges of Global Tropical Diseases
Keystone Symposia Brazil and the Challenges of Global Tropical Diseases
Jean-Laurent Casanova,
Rockefeller University, USA
Toward a Genetic Theory of Infectious Diseases
Toward a Genetic Theory of Infectious Diseases
07:30—08:30
Breakfast
Your Lodging
08:00—10:00
Poster Setup
Diamantina
08:30—11:30
Innate Immune Recognition
Meeting has ended...abstracts no longer viewable online.
Teatro Ouro Preto
Kate A. Fitzgerald,
University of Massachusetts Medical School, USA
Regulation of Inflammatory Gene Expression by Long Noncoding RNAs
Regulation of Inflammatory Gene Expression by Long Noncoding RNAs
Julie Magarian Blander,
Weill Cornell Medicine, Cornell University, USA
Detecting and Responding to Microbial Viability
Detecting and Responding to Microbial Viability
Egil Lien,
University of Massachusetts Medical School, USA
Short Talk: Innate Immunity to Plague
Short Talk: Innate Immunity to Plague
Sun Hur,
Harvard Medical School, USA
Short Talk: Molecular Mechanism for Viral dsRNA Detection by MDA5 Filaments
Short Talk: Molecular Mechanism for Viral dsRNA Detection by MDA5 Filaments
Jamie Lemon,
University of Pennsylvania, USA
Short Talk: Cytosolic Access and Sensing of Components of Extracellular Bacteria by Macrophages
Short Talk: Cytosolic Access and Sensing of Components of Extracellular Bacteria by Macrophages
09:50—10:10
Coffee Break
Diamantina
11:30—12:30
Lunch
Diamantina
12:00—14:30
Poster Session 1
Diamantina
14:30—16:30
Workshop 1: Innate Recognition and Signaling
Teatro Ouro Preto
*
Marcelo T. Bozza,
Universidade Federal do Rio de Janeiro, Brazil
*
Koichi S. Kobayashi,
Texas A&M Health Science Center, USA
Jiaxi Wu,
University of Texas Southwestern Medical Center, USA
Identification of Cyclic-GMP-AMP (cGAMP) and Cyclic-GMP-AMP Synthase (cGAS) as Important Cytosolic DNA Sensing Mediators
Identification of Cyclic-GMP-AMP (cGAMP) and Cyclic-GMP-AMP Synthase (cGAS) as Important Cytosolic DNA Sensing Mediators
Andrea Puhar,
Umeå University, Sweden
Shigella Effector IpgD Dampens Inflammation by Securing Hemichannel Closing through Production of PdtIns5P, Thereby Inhibiting Extracellular ATP-Mediated Endogenous Danger Signaling
Shigella Effector IpgD Dampens Inflammation by Securing Hemichannel Closing through Production of PdtIns5P, Thereby Inhibiting Extracellular ATP-Mediated Endogenous Danger Signaling
Rune Hartmann,
Aarhus University, Denmark
The Oligoadenylate Synthetase Like Protein (OASL) Enhances Viral Recognition and Interferon Production by Infected Cells
The Oligoadenylate Synthetase Like Protein (OASL) Enhances Viral Recognition and Interferon Production by Infected Cells
Warrison A. Andrade,
Faculdade de Medicina de Ribeirão Preto - FMRP-USP, Brazil
Combined Action of Nucleic Acid-Sensing Toll-Like Receptors (TLRs) and TLR11/TLR12 Heterodimers Imparts Host Resistance to Toxoplasma gondii
Combined Action of Nucleic Acid-Sensing Toll-Like Receptors (TLRs) and TLR11/TLR12 Heterodimers Imparts Host Resistance to Toxoplasma gondii
Jane Rasaiyaah,
University College London, UK
Inhibition of HIV-1-Cofactor Interactions Triggers Innate Sensors and Interferon Secretion
Inhibition of HIV-1-Cofactor Interactions Triggers Innate Sensors and Interferon Secretion
Anamelia Lorenzetti Bocca,
Universidade de Brasília, Brazil
Beta-Glucan Reverts the Macrophage Inability to Kill Cryptococcus neoformans in vitro
Beta-Glucan Reverts the Macrophage Inability to Kill Cryptococcus neoformans in vitro
Sterling C. Eckard,
University of Washington, USA
Intracellular Nucleic Acid Metabolism Limits the RIG-I-Mediated Antiviral Response
Intracellular Nucleic Acid Metabolism Limits the RIG-I-Mediated Antiviral Response
Felix Meissner,
Max Planck Institute of Biochemistry, Germany
Secretomics Defines How Proximal Adaptors of TLRs Regulate Inflammation
Secretomics Defines How Proximal Adaptors of TLRs Regulate Inflammation
16:30—17:00
Coffee Available
Diamantina
17:00—19:00
Innate Immunity in Vectors
Meeting has ended...abstracts no longer viewable online.
Teatro Ouro Preto
*
Elena A. Levashina,
Max Planck Institute for Infection Biology, Germany
Mechanisms of Innate Resistance to Malaria Parasites in the Mosquito
Mechanisms of Innate Resistance to Malaria Parasites in the Mosquito
George Dimopoulos,
Johns Hopkins University, USA
Innate and Microbiota-Mediated Control of Dengue Virus in Mosquitoes
Innate and Microbiota-Mediated Control of Dengue Virus in Mosquitoes
Simona Paro,
IBMC-CNRS/Université de Strasbourg, France
Short Talk: Sensing Viral Nucleic Acids by the Innate Immune System: Lessons from Drosophila
Short Talk: Sensing Viral Nucleic Acids by the Innate Immune System: Lessons from Drosophila
David L. Sacks,
NIAID, National Institutes of Health, USA
Influence of Vector Transmission on the Innate Immune Response to Leishmania major
Influence of Vector Transmission on the Innate Immune Response to Leishmania major
19:00
On Own for Dinner
07:30—08:30
Breakfast
Your Lodging
08:30—11:45
Innate Lymphoid Cells (ILC) and Mucosal Immunity
Meeting has ended...abstracts no longer viewable online.
Teatro Ouro Preto
*
Fiona M. Powrie,
University of Oxford, UK
IL-23-Driven Cellular and Molecular Pathways that Promote Intestinal Inflammation and Colon Cancer
IL-23-Driven Cellular and Molecular Pathways that Promote Intestinal Inflammation and Colon Cancer
Dan R. Littman,
HHMI/New York University School of Medicine, USA
Microbiota-Host Interactions in T Cell Homeostasis and Autoimmune Disease
Microbiota-Host Interactions in T Cell Homeostasis and Autoimmune Disease
Marco Colonna,
Washington University School of Medicine, USA
Innate Lymphoid Cells in Mucosal Immunity
Innate Lymphoid Cells in Mucosal Immunity
Lucille Rankin,
Walter and Eliza Hall Institute of Medical Research, Australia
Short Talk: T-bet Is Required for the Development of NKp46+ Innate Lymphoid Cells via a Notch Dependent Pathway
Short Talk: T-bet Is Required for the Development of NKp46+ Innate Lymphoid Cells via a Notch Dependent Pathway
Kevin J. Maloy,
University of Oxford, UK
Nlrp3 Inflammasome Activation in the Intestinal Epithelium Protects Against a Mucosal Pathogen
Nlrp3 Inflammasome Activation in the Intestinal Epithelium Protects Against a Mucosal Pathogen
09:50—10:10
Coffee Break
Diamantina
11:45—13:00
Poster Setup
Diamantina
11:45
On Own for Lunch and Recreation
16:30—17:00
Coffee Available
Diamantina
17:00—19:15
Effector Mechanisms
Meeting has ended...abstracts no longer viewable online.
Teatro Ouro Preto
*
Arturo Zychlinsky,
Max Planck Institute for Infection Biology, Germany
NETs – From Infection to Autoimmunity
NETs – From Infection to Autoimmunity
Jonathan Howard,
Instituto Gulbenkian de Ciência, Portugal
Genetic Basis of Innate Immune Control of a Parasitic Disease
Genetic Basis of Innate Immune Control of a Parasitic Disease
Dario S. Zamboni,
University of São Paulo, Brazil
Short Talk: Inflammasome-Mediated Innate Immune Responses to Leishmania
Short Talk: Inflammasome-Mediated Innate Immune Responses to Leishmania
Lynda M. Stuart,
Bill & Melinda Gates Foundation, USA
Short Talk: Activation of Caspase-1 by the NLRP3 Inflammasome Regulates NOX2 to Control Phagosome Function
Short Talk: Activation of Caspase-1 by the NLRP3 Inflammasome Regulates NOX2 to Control Phagosome Function
19:15—20:15
Social Hour with Lite Bites
Diamantina
19:30—22:00
Poster Session 2
Diamantina
07:30—08:30
Breakfast
Your Lodging
08:30—11:45
Innate Cytokines Influencing Adaptive Immunity and Inflammation
Meeting has ended...abstracts no longer viewable online.
Teatro Ouro Preto
*
Alan Sher,
NIAID, National Institutes of Health, USA
TLR12: A New Player in Innate Recognition and Host Resistance to Protozoan Infection
TLR12: A New Player in Innate Recognition and Host Resistance to Protozoan Infection
Robert L. Coffman,
Dynavax Technologies, USA
Clinical Applications of Innate Immune Signals
Clinical Applications of Innate Immune Signals
Kingston H.G. Mills,
Trinity College Dublin, Ireland
Innate Determinates of Th1/Th17 versus Treg Cells
Innate Determinates of Th1/Th17 versus Treg Cells
Edgar M. Carvalho,
Universidade Federal da Bahia, Brazil
Innate Determinants in the Control and Pathology of Human Tegumentary Leishmaniasis
Innate Determinants in the Control and Pathology of Human Tegumentary Leishmaniasis
Katrijn Neyt,
VIB, Ghent University, Belgium
Short Talk: The Innate Cytokine IL-1alpha Is Necessary and Sufficient for Formation of Tertiary Lymphoid Tissues following Influenza A Virus Infection
Short Talk: The Innate Cytokine IL-1alpha Is Necessary and Sufficient for Formation of Tertiary Lymphoid Tissues following Influenza A Virus Infection
Andreas Wack,
Francis Crick Institute, UK
Short Talk: Pathogenic Potential of Type I IFN in Influenza Infection
Short Talk: Pathogenic Potential of Type I IFN in Influenza Infection
09:50—10:10
Coffee Break
Diamantina
09:50—10:10
Poster Setup
Diamantina
11:30—12:30
Lunch
Diamantina
12:00—14:30
Poster Session 3
Diamantina
14:30—16:30
Workshop 2: Cytokines, Inflammation and Pathogenesis
Teatro Ouro Preto
*
Sergio Costa Oliveira,
Universidade Federal de Minas Gerais, Brazil
*
Kevin J. Maloy,
University of Oxford, UK
David Sancho,
CNIC-Fundación Centro Nacional de Investigaciones Cardiovasculares, Spain
Recognition of Leishmania Parasites by the Macrophage-Inducible C-Type Lectin Mincle Subverts Adaptive Immunity and Promotes Susceptibility to Infection
Recognition of Leishmania Parasites by the Macrophage-Inducible C-Type Lectin Mincle Subverts Adaptive Immunity and Promotes Susceptibility to Infection
Jennifer Palomo,
CNRS - INEM - UMR7355, France
Type I Interferons Contribute to Orchestrate IFNgamma Dependent Development of Experimental Cerebral Malaria
Type I Interferons Contribute to Orchestrate IFNgamma Dependent Development of Experimental Cerebral Malaria
Maria Bellio,
Universidade Federal do Rio de Janeiro, Brazil
Intrinsic IL-18R1 Signaling Pathway Plays a Crucial Role in Th1 Cell Expansion in Mice Infected with Trypanosoma cruzi
Intrinsic IL-18R1 Signaling Pathway Plays a Crucial Role in Th1 Cell Expansion in Mice Infected with Trypanosoma cruzi
Catalina D. Alba Soto,
Universidad de Buenos Aires, Argentina
Impairment of Natural Killer (NK) Cells Editing of Immature Dendritic Cells (DC) by Infection with a Virulent Trypanosoma cruzi Population
Impairment of Natural Killer (NK) Cells Editing of Immature Dendritic Cells (DC) by Infection with a Virulent Trypanosoma cruzi Population
Gregory F. Sonnenberg,
University of Pennsylvania, USA
Innate Lymphoid Cells Are Critical Regulators of Host Immune Responses to Bacteria and Intestinal Homeostasis
Innate Lymphoid Cells Are Critical Regulators of Host Immune Responses to Bacteria and Intestinal Homeostasis
Shie-Liang Hsieh,
Academia Sinica, Taiwan
C-Type Lectin 5A (CLEC5A) Is Critical for the Pathogenesis of Flaviviral Infections
C-Type Lectin 5A (CLEC5A) Is Critical for the Pathogenesis of Flaviviral Infections
Catherine L. Kennedy,
University of Melbourne, Australia
Fas Signaling in Immune Defense Against the Intestinal Pathogen, Citrobacter rodentium
Fas Signaling in Immune Defense Against the Intestinal Pathogen, Citrobacter rodentium
Monica Macal,
Five Prime Therapeutics, Inc, USA
TLR7 Is Required for Both Plasmacytoid Dendritic Cell IFN-I Production and Subsequent Exhaustion during Chronic Viral Infection
TLR7 Is Required for Both Plasmacytoid Dendritic Cell IFN-I Production and Subsequent Exhaustion during Chronic Viral Infection
16:30—17:00
Coffee Available
Diamantina
17:00—19:15
Innate Signals in Disease Pathogenesis
Meeting has ended...abstracts no longer viewable online.
Teatro Ouro Preto
Zhijian James Chen,
University of Texas Southwestern Medical Center, USA
Innate Immune Sensing and Signaling of Cytosolic DNA through a Cyclic Dinucleotide Pathway
Innate Immune Sensing and Signaling of Cytosolic DNA through a Cyclic Dinucleotide Pathway
Douglas Golenbock,
University of Massachusetts Medical School, USA
DNA Sensing Drives the Innate Immune Response in Malaria
DNA Sensing Drives the Innate Immune Response in Malaria
*
Anne O'Garra,
Francis Crick Institute, UK
The Immune Response in Tuberculosis: From Mouse Models to Human Disease
The Immune Response in Tuberculosis: From Mouse Models to Human Disease
Corey A. Balinsky,
NIAID, National Institutes of Health, USA
Short Talk: NF45 Interacts with Dengue Virus Capsid Protein and Modulates Induction of Interferon Beta
Short Talk: NF45 Interacts with Dengue Virus Capsid Protein and Modulates Induction of Interferon Beta
Sergio Costa Oliveira,
Universidade Federal de Minas Gerais, Brazil
Short Talk: Critical Role of ASC Inflammasomes and Bacterial Type IV Secretion System in Caspase-1 Activation and Host Innate Resistance to Brucella abortus Infection
Short Talk: Critical Role of ASC Inflammasomes and Bacterial Type IV Secretion System in Caspase-1 Activation and Host Innate Resistance to Brucella abortus Infection
19:15
On Own for Dinner
07:30—08:30
Breakfast
Your Lodging
08:30—12:00
Cell Death in Host Resistance and Pathogenesis of Infectious Diseases
Meeting has ended...abstracts no longer viewable online.
Teatro Ouro Preto
Douglas R. Green,
St. Jude Children's Research Hospital, USA
Dead on Arrival: How Caspases Promote and Prevent Cell Death
Dead on Arrival: How Caspases Promote and Prevent Cell Death
*
Ricardo T. Gazzinelli,
Fundação Oswaldo Cruz-CPqRR, Brazil
NLRP12/NLRP3-Dependent Caspase-1 Driven Inflammation in Malaria
NLRP12/NLRP3-Dependent Caspase-1 Driven Inflammation in Malaria
Maya Saleh,
McGill University, Canada
cIAP2 Protects Mice from Alveolar Epithelial Injury during Influenza A Virus Infection
cIAP2 Protects Mice from Alveolar Epithelial Injury during Influenza A Virus Infection
Thirumala-Devi Kanneganti,
St. Jude Children's Research Hospital, USA
Inflammasome-Dependent and -Independent Regulation of IL-1 Cytokines in Inflammatory Disease
Inflammasome-Dependent and -Independent Regulation of IL-1 Cytokines in Inflammatory Disease
Karina R. Bortoluci,
Federal University of São Paulo, Brazil
Short Talk: Inflammasome-Independent Cell Death Induced by Cytosolic flagellin
Short Talk: Inflammasome-Independent Cell Death Induced by Cytosolic flagellin
Edward A. Miao,
University of North Carolina at Chapel Hill, USA
Non-Canonical Inflammasome Activation of Caspase-11 Protects Against Cytosolic Bacteria
Non-Canonical Inflammasome Activation of Caspase-11 Protects Against Cytosolic Bacteria
Mohamed Lamkanfi,
Ghent University, Belgium
Short Talk: Regulation of Nlrp3 Inflammasome Activation by the Ubiquitin-Editing Enzyme A20
Short Talk: Regulation of Nlrp3 Inflammasome Activation by the Ubiquitin-Editing Enzyme A20
09:50—10:10
Coffee Break
Diamantina
11:30
On Own for Lunch and Recreation
14:30—16:30
Workshop 3: Cell Death and Pathogenesis
Teatro Ouro Preto
*
Gustavo P. Amarante-Mendes,
Universidade de São Paulo, Brazil
*
Clare E. Bryant,
University of Cambridge, UK
A Critical Link between Innate Immunity and Cellular Mechanics to Control Bacterial Load in Macrophages
A Critical Link between Innate Immunity and Cellular Mechanics to Control Bacterial Load in Macrophages
Petr Broz,
Biozentrum, University of Basel, Switzerland
Caspase-11 Increases Susceptibility to Salmonella Infection in the Absence of Caspase-1
Caspase-11 Increases Susceptibility to Salmonella Infection in the Absence of Caspase-1
William J. Kaiser,
Emory University School of Medicine, USA
Virus Inhibition of Caspase 8 Restricts Pathogenesis via RIP3-Dependent Programmed Necrosis
Virus Inhibition of Caspase 8 Restricts Pathogenesis via RIP3-Dependent Programmed Necrosis
Marco A. Ataíde,
Universidade Federal de Minas Gerais, Brazil
CD14dimCD16+ Monocytes Are a Main Source of Active Caspase-1 and IL-1beta Release during Plasmodium vivax Malaria
CD14dimCD16+ Monocytes Are a Main Source of Active Caspase-1 and IL-1beta Release during Plasmodium vivax Malaria
Vijay Pancholi,
Ohio State University College of Medicine, USA
Group A Streptococcus Ser/Thr Phosphatase-Mediated Apoptosis of Human Respiratory Cells
Group A Streptococcus Ser/Thr Phosphatase-Mediated Apoptosis of Human Respiratory Cells
Mordechay Gerlic,
Sackler Faculty of Medicine, Tel Aviv University, Israel
EBV-miR-BART15 Regulates the Nlrp3 Inflammasome and IL-1beta Production
EBV-miR-BART15 Regulates the Nlrp3 Inflammasome and IL-1beta Production
Ivan Tattoli,
University of Toronto, Canada
mTOR Signaling and Metabolic Stress Response Pathways in the Host Response to Intracellular Bacteria
mTOR Signaling and Metabolic Stress Response Pathways in the Host Response to Intracellular Bacteria
Larissa Dias Cunha,
St. Jude Children's Research Hospital, USA
Coxiella burnetii Inhibits Inflammasome Activation through a Dot/Icm-Dependent Effector Protein
Coxiella burnetii Inhibits Inflammasome Activation through a Dot/Icm-Dependent Effector Protein
16:30—17:00
Coffee Available
Diamantina
17:00—18:15
Immunological Adjuvants and Vaccines
Meeting has ended...abstracts no longer viewable online.
Teatro Ouro Preto
*
Jorge Kalil,
Instituto Butantan, Brazil
Dengue Vaccine Candidates
Dengue Vaccine Candidates
Jacques F. Banchereau,
The Jackson Laboratory for Genomic Medicine, USA
Harnessing Human Dendritic Cell Subsets and Follicular Helper T Cell Subsets for Next Generation Vaccines
Harnessing Human Dendritic Cell Subsets and Follicular Helper T Cell Subsets for Next Generation Vaccines
18:15—19:00
Closing Keynote Address
Meeting has ended...abstracts no longer viewable online.
Teatro Ouro Preto
Michel C. Nussenzweig,
HHMI/Rockefeller University, USA
Targeting Dendritic Cells in Malaria Vaccine
Targeting Dendritic Cells in Malaria Vaccine
19:00—20:00
Social Hour with Lite Bites
Diamantina
20:00—23:00
Entertainment
Diamantina
Departure
*Session Chair †Invited, not yet responded.
Keystone Symposia thanks our Sponsors for generously supporting this meeting:
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