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Eldorado Hotel & Spa Floorplan

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This meeting took place in 2014



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Growth and Wasting in Heart and Skeletal Muscle (A8)


Organizer(s) Elizabeth M. McNally, Nadia A. Rosenthal and Leslie A. Leinwand
January 26—31, 2014
Eldorado Hotel & Spa • Santa Fe, New Mexico USA
Discounted Abstract Deadline: Oct 10, 2013
Abstract Deadline: Nov 4, 2013
Scholarship Deadline: Oct 10, 2013
Discounted Registration Deadline: Nov 26, 2013

Sponsored by Bayer HealthCare Pharmaceuticals

Summary of Meeting:
Maintenance of cardiac and skeletal muscle mass and function is central to well-being in aging and illness. Striated muscles, including cardiac and skeletal muscles, increase in size and mass in response to exercise, nutritional status, pregnancy and other concomitant energy demand states. The mass of cardiac and skeletal muscle declines in response to sepsis, cancer, aging and immobility. A confluence of metabolic and genetic factors regulates muscle mass, and both cardiac and skeletal muscle each have significant paracrine actions for growth beyond heart and muscle. This unique meeting highlights mechanisms and targets for both cardiac and skeletal muscle growth, emphasizing novel pathways and new applications.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JANUARY 26

16:00—20:00
Arrival and Registration


MONDAY, JANUARY 27

07:00—08:00
Breakfast

08:00—09:00
Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Leslie A. Leinwand, University of Colorado, Boulder, USA
Opening Remarks

Eric N. Olson, University of Texas Southwestern Medical Center, USA
New Myogenic Regulatory Molecules and Mechanisms

09:00—11:15
Atrophy Signaling Pathways
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Issei Komuro, Tokyo University Graduate School, Japan

Marco Sandri, University of Padova, Italy
FoxO, Autophagy and Ubiquitin Proteasome: The Crossroad of Muscle Mass Regulation

Sue Bodine, , USA
MuRF1 and the Regulation of Skeletal Muscle Mass

Kenneth Walsh, Boston University School of Medicine, USA
Parallel Mechanisms of Cardiac and Skeletal Muscle Growth: Lessons from Akt Signaling

Jose M. Garcia, Baylor College of Medicine, USA
Short Talk: Ghrelin Prevents Cancer-Related Muscle Wasting through GHSR-Independent Regulation of Myostatin and p38

09:40—10:00
Coffee Break

11:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:15—17:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Growth Factors for Heart and Muscle
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Denis C. Guttridge, Ohio State University, USA

Deepak Srivastava, Gladstone Institute of Cardiovascular Disease and University of California, San Francisco, USA
Reprogramming Approaches for Cardiovascular Disease

H.Q. Han, Amgen Inc., USA
Activation of Activin-Smad Signaling Leads to Atrophy and Dysfunction of the Heart

Nadia A. Rosenthal, Monash University, Australia
Immune Regulation of Muscle Regeneration

Federica Accornero, Cincinnati Children's Medical Center, USA
Short Talk: TGF-beta Inhibits Skeletal Muscle Regeneration by Antagonizing Metallothioneins Induction

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 1


TUESDAY, JANUARY 28

07:00—08:00
Breakfast

07:30—08:00
Poster Setup

08:00—19:00
Poster Viewing

08:00—11:00
Paracrine Mechanisms
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Timothy A. McKinsey, University of Colorado Denver, USA

Zoltan P. Arany, Beth Israel Deaconess Medical Center, USA
Peripartum Mechanisms of Heart Growth and Disease

Leslie A. Leinwand, University of Colorado, Boulder, USA
Postprandial Heart Growth in Pythons

Lynn A. Megeney, Ottawa Hospital Research Institute, Canada
Intrinsic-Mediated Caspase Activation Is Essential for Cardiomyocyte Hypertrophy

Lily C. Chao, Children's Hospital Los Angeles, USA
Short Talk: NR4A1 – A Novel Regulator of Muscle Mass

Samuel Cadena, Novartis Institutes for Biomedical Research, USA
Short Talk: GPRC5b: A Potent Regulator of Skeletal Muscle Growth with Potential Role in Muscle Regeneration

Anna Foryst-Ludwig, CCR, Charite-Berlin, Germany
Short Talk: Specific Set of Plasma FFAs Mediates Cardiac Hypertrophic Response to Exercise

09:20—09:40
Coffee Break

11:15—12:00
Lunch

12:00—14:30
Poster Session 2

14:30—15:00
Coffee Available

15:00—17:00
Genetic and Epigenetic Regulation
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Lynn A. Megeney, Ottawa Hospital Research Institute, Canada

Saptarsi M. Haldar, Case Western Reserve University School of Medicine, USA
Targeting Chromatin-Dependent Signaling in Pathologic Cardiac Hypertrophy and Heart Failure

Timothy A. McKinsey, University of Colorado Denver, USA
HDACs in Cardiomyocyte Growth and Dysfunction

Eva van Rooij, Hubrecht Institute, Netherlands
MicroRNAs as Regulators of Growth

Kathryn N. Ivey, Gladstone Institute of Cardiovascular Disease, USA
Short Talk: Differential Regulation of Bicistronic Muscle miRNAs by the RNA Binding Protein, TDP-43

17:00—
On Own for Dinner


WEDNESDAY, JANUARY 29

07:00—08:00
Breakfast

08:00—11:00
Common Pathways in Cardiac and Skeletal Muscle Growth
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Eva van Rooij, Hubrecht Institute, Netherlands

David A. Kass, Johns Hopkins Hospital, USA
Cardiac Mechano-Sensing Gone Bad: Elucidating the Mechanisms

David J. Glass, Novartis Institutes for Biomedical Research, USA
TGF-beta Signaling in Skeletal Muscle Hypertrophy

Denis C. Guttridge, Ohio State University, USA
Cancer Cachexia and the Muscle Microenvironment

Elizabeth M. McNally, University of Chicago, USA
Modifiers of Heart and Muscle Function

Matthew M. Goddeeris, University of Iowa, USA
Short Talk: LARGE Glycans on Dystroglycan Function as a Tunable Matrix Scaffold to Prevent Dystrophy

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:00—17:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Metabolic Regulation of Skeletal Muscle Mass and Function
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Gustavo A. Nader, Karolinska Institute, Sweden

Ronald Cohn, Hospital for Sick Children, Canada
Serum/Glucocorticoid-Regulated Kinase 1 (SGK1) Mediates Muscle Homeostasis in Health and Disease

E. Dale Abel, University of Iowa, Carver College of Medicine, USA
Insulin Signaling in the Regulation of Physiological versus Pathological Cardiac Hypertrophy

Daniel P. Kelly, Sanford-Burnham Medical Research Institute, USA
Delineating the Transcriptional Regulatory Circuitry Controlling Muscle Fiber Type

Brian Timothy O'Neill, Joslin Diabetes Center, USA
Short Talk: Loss of Insulin and IGF-1 Receptor Signaling in Muscle Markedly Impairs Muscle Growth via Enhanced Autophagy

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 3


THURSDAY, JANUARY 30

07:00—08:00
Breakfast

08:00—11:00
Metabolic Regulators of Cardiac Regeneration and Hypertrophy
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Paul H. Goldspink, Medical College of Wisconsin, USA

Heinrich Taegtmeyer, University of Texas Medical School at Houston, USA
Metabolic Regulation of Myocardial Protein Turnover

James F. Martin, Baylor College of Medicine, USA
Hippo Signaling in Heart Regeneration

Karyn A. Esser, University of Kentucky Medical Center, USA
Circadian Rhythms, Molecular Clock and Muscle Homeostasis

Joseph A. Hill, University of Texas Southwestern Medical Center, USA
Diabetic Cardiomyopathy and Metabolic Remodeling in the Heart

Dawn A. Delfín, Ohio State University, USA
Short Talk: Dissecting the Role of Claudin-5 Reductions in Human and Mouse Cardiomyopathy

09:20—09:40
Coffee Break

11:00—17:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Stem Cells and Cardioskeletal Growth
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Elizabeth M. McNally, University of Chicago, USA

Gordon M. Keller, University Health Network, MaRS Centre, Canada
Generation of Cardiomyocytes and Epicardial-Like Cells from Human Pluripotent Stem Cells

Kenneth D. Poss, Duke University Medical Center, USA
Epicardial Cells and Heart Regeneration

Megan Chase, Mount Desert Biological Laboratory, USA
Short Talk: miR-101 Controls Cardiomyocyte Proliferation and Scar Tissue Resolution during Zebrafish Heart Regeneration

Bernhard Kühn, Children's Hospital, Boston, USA
Short Talk: A Strategy for Regenerating Myocardium in Infants with Heart Disease

19:00—20:00
Social Hour w/ Lite Bites

20:00—23:00
Entertainment


FRIDAY, JANUARY 31

 
Departure


*Session Chair †Speaker invited, not yet responded.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Bayer HealthCare Pharmaceuticals

We gratefully acknowledge additional support for this conference from:

Cellular Dynamics International Cytokinetics, Inc.

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AR065744-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

S. Karger AG - Cardiology

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Amanda Deem, Assistant Director of Development, Email: AmandaD@keystonesymposia.org,
Phone:+1 970-262-2668

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676