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Fairmont The Queen Elizabeth Floorplan

Fairmont The Queen Elizabeth Floorplan

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This meeting took place in 2015


Here are the related meetings in 2016:
Myeloid Cells (D3)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Dendritic Cells and Macrophages Reunited (C4)


Organizer(s) Jacques F. Banchereau and Siamon Gordon
March 8—13, 2015
Fairmont The Queen Elizabeth • Montreal, QC Canada
Discounted Abstract Deadline: Nov 10, 2014
Abstract Deadline: Dec 10, 2014
Scholarship Deadline: Nov 10, 2014
Discounted Registration Deadline: Jan 9, 2015

Sponsored by Biogen Idec, BioLegend, Inc., Novo Nordisk A/S and Roche

Summary of Meeting:
The fields of macrophage and dendritic cell biology diverged decades ago and have evolved in a relatively independent fashion. In particular, dendritic cell meetings are devoting considerable attention to adaptive immune responses while macrophage meetings focus on innate immunity. Yet, it is clear that both cell types share many common properties and eventually contribute to a protective immunity. This meeting therefore aims to reunite the two communities of scientists. The meeting is equally divided into basic biology and sessions dedicated to the importance of these cells in pathology including allergy, autoimmunity, cancer and infectious disease. Emphasis is on human diseases in order to educate and engage physician-scientists, both trained and in training.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MARCH 8

16:00—20:00
Arrival and Registration

18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.


MONDAY, MARCH 9

07:30—08:30
Breakfast

08:30—09:00
Welcoming Remarks
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA
40 years of Dendritic Cell Research by Ralph Steinman and Many Other Investigators

Siamon Gordon, University of Oxford, UK
Macrophages and Zanvil Cohn

09:00—11:15
Subsets of Macrophages and DCs
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Siamon Gordon, University of Oxford, UK

Sebastian Amigorena, Institut Curie, France
Antigen Cross-Presentation in Dendritic Cells

Julie Magarian Blander, Mount Sinai School of Medicine, USA
A Rogue Pathway of Cross-Presentation in Dendritic Cells

William R. Heath, University of Melbourne, Australia
Targeting APC Subsets for Immunity to Malaria

Alexandra-Chloé Villani, Broad Institute of MIT and Harvard, USA
Short Talk: Discovery of Dendritic Cell Sub-Populations in Human Blood by Single Cell RNA-Sequencing

11:15—12:30
Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA

Ronald N. Germain, NIAID, National Institutes of Health, USA
Dendritic Cells and Macrophages: Lessons Learned from Visualization and Quantitative Measurement of Myeloid Cell Dynamics, Localization and Function

10:20—10:50
Coffee Break

12:30—13:00
Poster Setup

13:00—22:00
Poster Viewing

12:30—14:30
On Own for Lunch

14:30—16:30
Workshop 1: Basics of Macrophages and DCs

Marten A. Hoeksema, Academic Medical Center, AMC, Netherlands
IFNy Priming Represses a Part of the Macrophage Inflammatory Program and Attenuates Neutrophil Recruitment

* Joachim L. Schultze, LIMES Institute, University of Bonn, Germany
A "Switch Panel" Model of Epigenomic Regulation of Transcriptional Regulators in Human Macrophage Activation

Luke Barron, Biogen Idec, USA
Macrophages Maintain IL-13-Dependent Lung Inflammation and Fibrosis

Marianne L. Boes, University Medical Centre Utrecht, Wilhelmina Children's Hospital, Netherlands
Cognate CD4 T-Cell Licensing of Dendritic Cells Heralds Anti-CMV CD8 T-Cell Immunity after Human Umbilical Cord Blood Transplantation

Diana Matheoud, Université de Montréal, Canada
MHC Class I Presentation of Mitochondrial Antigens Proceeds through the Rab9 and Sorting Nexin 9-Dependent Generation of Mitochondria-Derived Vesicles

Kenji Kabashima, Kyoto University, Japan
Perivascular Leukocyte Clusters Are Essential for Efficient Activation of Effector T Cells in the Skin: Identification of Inducible Skin Associated Lymphoid Tissue (iSALT)

Amra Saric, Ryerson University, Canada
mTOR Is Required for Lysosome Tubulation and MHCII Trafficking in Macrophages and Dendritic Cells

Javed Mohammed, University of Minnesota, USA
Regulated Activation of Latent TGF-beta by Keratinocytes Controls Homeostatic and UV-Induced Langerhans Cell Migration

16:30—17:00
Coffee Available

17:00—19:15
Molecular and Cellular Biology of Macrophages and DCs
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* A. Karolina Palucka, The Jackson Laboratory for Genomic Medicine, USA

Lionel B. Ivashkiv, Hospital for Special Surgery, New York, USA
Epigenetic Regulation of Macrophage Activation and Function

Steffen Jung, Weizmann Institute of Science, Israel
Origins and Epigenetic Tissue Specialization of Macrophages

Averil I. Ma, University of California, San Francisco, USA
A20 Restricts IL1b Ubiquitination and NLRP3 Inflammasome Activity

David Gosselin, University of California, San Diego, USA
Short Talk: Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities

Yonit Lavin, Mount Sinai School of Medicine, USA
Short Talk: Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

19:30—22:00
Poster Session 1


TUESDAY, MARCH 10

07:30—08:30
Breakfast

08:00—08:30
Poster Setup

08:30—11:45
Mucosal APC
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Julie Magarian Blander, Mount Sinai School of Medicine, USA

Dan R. Littman, HHMI/New York University School of Medicine, USA
Mucosal APC, Th17 and Microbiome

Shigekazu Nagata, IFReC, Osaka University, Japan
Exposure of Phosphatidylserine during Apoptosis

Anne Hosmalin, Institut Cochin, INSERM 1016, Université Paris Descartes, France
Antigen Presentation by Plasmacytoid DC from Live Cells

David G. Russell, Cornell University, USA
The Macrophage Plays a Pivotal Role in Mycobacterium tuberculosis Infections in the Absence and Presence of HIV

Milena Bogunovic, Pennsylvania State University College of Medicine, USA
Short Talk: Macrophage-Neuronal Crosstalk in Regulating Intestinal Physiology

09:50—10:10
Coffee Break

13:00—22:00
Poster Viewing

11:45—12:30
Lunch

12:00—14:30
Poster Session 2

14:30—16:30
Workshop 2: Infectious Diseases

* Anne Hosmalin, Institut Cochin, INSERM 1016, Université Paris Descartes, France

Shruti B. Athale, Baylor Institute of Immunology, USA
Molecular and Cellular Signature of Human Dendritic Cells in Response to Influenza Vaccines

Weiping Cao, Centers for Disease Control and Prevention, USA
A Newly Emerged Swine Origin A(H3N2)v Influenza Virus Containing M Gene from A(H1N1)pdm09 Virus Dampens Host Antiviral Immunity but Induces Potent Inflammasome Activation

Alexandre Deshiere, Laval University, Canada
Global Mapping of HIV-1 and Host-Macrophages Molecular Interactions

Yukio Fujiwara, Kumamoto University, Japan
CD163, a Scavenger Receptor for the Hemoglobin-Haptoglobin Complex, Impairs the Excessive Inflammatory Responses in Murine Model of Endotoxin Shock

Dawn M. E. Bowdish, McMaster University, Canada
Metchnikoff’s Theory of Aging: Intestinal Permeability Drives Age-Associated Inflammation and Macrophage Dysfunction

Jia Xue, University of Bonn, Germany
Reconstruction of a Consensus Gene Regulatory Network Reflects Human Macrophage Activation

Amy Tsz Yan Yeung, Wellcome Trust Sanger Institute, UK
Conditional-Ready Mouse Embryonic Stem Cell Derived Macrophages Enable the Study of Essential Genes in Macrophage Function

16:30—17:00
Coffee Available

17:00—19:00
Macrophages and DCs in Infectious Diseases
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* David G. Russell, Cornell University, USA

Gwendalyn J. Randolph, Washington University, USA
A Role for Dendritic Cells in Maintenance of Tissue Homeostasis – a Job Not Only for Macrophages

Alan Sher, NIAID, National Institutes of Health, USA
The Monocyte/Dendritic Cell Response to Toxoplasma: A Tale of Mice and Men

Daniel A. Portnoy, University of California, Berkeley, USA
Glutathione Activates Listeria Monocytogenes Virulence Gene Expression

Susanne V. Schmidt, University of Bonn, Germany
Short Talk: IL4 Signal Integration Guides the Bifurcation of Human Dendritic Cell and Macrophage Differentiation

19:00—
On Own for Dinner


WEDNESDAY, MARCH 11

07:30—08:30
Breakfast

08:30—11:45
Macrophages and DCs in Tolerance, Autoimmunity and Allergy
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Dan R. Littman, HHMI/New York University School of Medicine, USA

Shimon Sakaguchi, Osaka University, Japan
APC and T Regs

Greg E. Lemke, The Salk Institute for Biological Studies, USA
TAM Signaling in Macrophages and DCs

Virginia Pascual, Baylor Institute for Immunology Research, USA
Neutrophils, pDCs and Autoimmunity

Zhijian James Chen, HHMI/University of Texas Southwestern Medical Center, USA
Innate Sensing of Cytosolic DNA through the cGAS-cGAMP-STING Pathway

Katrina J. Binger, Max-Delbrueck Center for Molecular Medicine, Germany
Short Talk: High Salt Reduces the Activation of IL-4+IL-13 Stimulated Macrophages

Dimitris Skokos, Regeneron Pharmaceuticals, Inc., USA
Short Talk: Dll4-Notch Signaling at the Cross-Roads of Immuno-Metabolism

11:45—12:30
Grantsmanship Updates

* Cheryl Lapham, NIAID, DHHS, National Institutes of Health, USA

09:50—10:10
Coffee Break

11:45—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:30—14:30
On Own for Lunch

14:30—16:30
Workshop 3: Allergy and Autoimmunity

* Kristin V. Tarbell, NIDDK, National Institutes of Health, USA

Estefania Claudio, NIAID, National Institutes of Health, USA
Dendritic Cells Are Novel and Functionally Relevant Targets of IL-25 in Allergic Lung Inflammation

Natacha Ipseiz, University of Erlangen, Germany
NR4A1 as Mediator of the Anti-Inflammatory Effects of Apoptotic Cells in Tissue Resident Macrophages

Richard E. Zigmond, Case Western Reserve University, USA
A New View of Macrophage Action in Nerve Degeneration and Regeneration

Jaehak Oh, University of California, San Francisco, USA
Ubiquitinated MHCII Supports Regulatory T Cell Development by Mediating Maturation of Dendritic Cells in the Thymus

Jennifer L. Scott, Medical University of South Carolina, USA
Estrogen Receptor Alpha Impacts Activation of Plasmacytoid Dendritic Cells in Pre-Disease Lupus Prone Mice

Deborah R. Winter, Weizmann Institute, Israel
Nature vs. Nurture: Chromatin Dynamics in Microglia Development

16:30—17:00
Coffee Available

17:00—19:15
Tissue Responses
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Lisa M. Coussens, Oregon Health & Science University, USA

Richard M. Ransohoff, Biogen Idec, USA
Fractalkinomics: One Key to the Place of Microglia in the CNS Firmament

Pamela S. Ohashi, Ontario Cancer Institute, Canada
Programming Activating and Inhibitory DCs

Hamida Hammad, Ghent University & VIB, Belgium
Lung Epithelial Cells as Regulators of Th2 Immunity to Inhaled Allergens

Charlotte L. Scott, University of Ghent & VIB, Belgium
Short Talk: Novel Kupffer Cell Tools Reveal that Niche Availability Determines the Cellular Origin of Tissue-Resident Macrophages

Annette E. Neele, Academic Medical Centre, University of Amsterdam, Netherlands
Short Talk: H3K27 Methylation in Macrophages and Atherosclerosis

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

19:30—22:00
Poster Session 3


THURSDAY, MARCH 12

07:30—08:30
Breakfast

08:30—11:45
Macrophages and DCs in Cancer
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Alan Sher, NIAID, National Institutes of Health, USA

Jeffrey W. Pollard, Queen's Medical Research Institute, UK
Tumor-Associated Macrophages: From Mechanism to Therapy

Lisa M. Coussens, Oregon Health & Science University, USA
Inflammation and Cancer: Reprogramming the Immune Microenvironment as an Anti-Cancer Therapeutic Strategy

Ira Mellman, Genentech, Inc., USA
DCs and Cancer

Kristin V. Tarbell, NIDDK, National Institutes of Health, USA
DCIR2+ cDC2 Dendritic Cells and zbtb32 Expression Restore CD4 T Cell Tolerance and Inhibit Diabetes

Miranda L. Broz, University of California, San Francisco, USA
Short Talk: Live-Imaging and Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Dendritic Cells, Critical for T Cell Immunity

Oscar R. Colegio, Yale University, USA
Short Talk: Tumor-Derived Lactic Acid Functionally Polarizes Tumor-Associated Macrophages

09:50—10:10
Coffee Break

11:45—14:30
On Own for Lunch

14:30—16:30
Workshop 4: Cancer

Dorothee Brech, Helmholtz Center Munich, Germany
Profiling a Unique Human Myeloid Cell Type in Renal Cell Carcinoma Reveals Promising Targets for Therapeutic Repolarization

Jordi C. Ochando, Mount Sinai School of Medicine, USA
DC-SIGN+ Macrophages Mediate the Induction of Tolerance

* Richard N. Hanna, La Jolla Institute for Allergy and Immunology, USA
Patrolling Monocytes Inhibit Tumor Metastasis to the Lung

Barbara Platzer, Boston Children's Hospital, USA
Dendritic Cells Use IgE for Antigen Cross-Presentation to Prime Cytotoxic T Cells and Enhance Anti-Tumor Immune Responses

Christa I. DeVette, Huntsman Cancer Institute, USA
Ron Signaling in LCMV and Cancer Vaccine Settings

Jiri Keirsse, Vrije Universiteit Brussel, Belgium
Tumors Are Infiltrated with Ontogenically and Functionally Distinct Tumor-Associated Dendritic Cell Subpopulations

Daniel C. Rabe, University of Chicago, USA
Metastasis Suppressors Regulate the Tumor Microenvironment by Blocking Recruitment of Pro-Metastatic TAMs

16:30—17:00
Coffee Available

17:00—18:45
DCs and Macrophages: Development, Wound Repair and Cancer
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Sebastian Amigorena, Institut Curie, France

Florent Ginhoux, Singapore Immunology Network, Singapore
Dendritic Cell and Macrophage Ontogeny

Paul Martin, University of Bristol, UK
Inflammation in Wound Repair and Cancer

A. Karolina Palucka, The Jackson Laboratory for Genomic Medicine, USA
Dendritic Cells and Macrophages in Cancer Therapy

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.


FRIDAY, MARCH 13

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Biogen Idec BioLegend, Inc.
Novo Nordisk A/S Roche

We gratefully acknowledge additional support for this conference from:

CEDARLANE eBioscience, an Affymetrix company

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI115919-01

Funding for this conference was made possible [in part] by 1 R13 AI 115919 - 01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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Phone:+1 970-262-2676