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This meeting took place in 2015



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Immunity to Veterinary Pathogens: Informing Vaccine Development (A3)


Organizer(s) William T. Golde, Wendy C. Brown and Ivan Morrison
January 20—25, 2015
Keystone Resort • Keystone, Colorado USA
Discounted Abstract Deadline: Sep 29, 2014
Abstract Deadline: Oct 21, 2014
Scholarship Deadline: Sep 29, 2014
Discounted Registration Deadline: Nov 19, 2014

Supported by the Directors' Fund

Summary of Meeting:
The need for more effective vaccines to protect food animals against infectious diseases has never been greater. Pressures on food sources are predicted to reach a critical state in a few decades, resulting in food shortages, especially in the developing world. While there is a long history of using vaccination to control animal diseases, the most notable success being the eradication of rinderpest, there are many important diseases for which no effective vaccines are available. Advances in genomic technologies, coupled with improved knowledge of the cellular and molecular events involved in the immune response, provide exciting new opportunities for vaccine development. However, effective exploitation of these advances needs to be based on an understanding of the immune responses that mediate effective immunity against the target pathogens. While laboratory animal models have proved invaluable in elucidating fundamental immunological principles, the results of vaccination studies have often failed to translate to larger animal species and humans. Hence, there is a need to study the target diseases in their natural hosts. Animals also provide valuable experimental models for studies of zoonotic pathogens that cause disease in both animals and humans (e.g., TB and influenza), as well as closely related pathogens that cause similar diseases in animals and humans. This meeting seeks to highlight the value of studying immune responses to infectious disease in animals not only to develop control measures for animal diseases but also to advance knowledge that may be more widely applicable for vaccine development. Understanding the immune response in veterinary species holds the promise of accelerating vaccine development for food animals, companion pets and clearly humans, directly addressing the One World, One Health concept emerging in vaccine research.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, JANUARY 20

16:00—20:00
Arrival and Registration

18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.


WEDNESDAY, JANUARY 21

07:00—08:00
Breakfast

08:00—09:00
Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Overview of the field of veterinary immunology and the relation of animal health to human health, especially as it relates to infectious diseases.

Linda J. Saif, Ohio State University, USA
Gut Reactions to Rotavirus Vaccines: Novel Strategies to Improve Efficacy in Piglets and Infants

09:00—11:15
The Role of gamma/delta T Cells in Innate and Acquired Immunity
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
This session will highlight the unique and informative data being generated on gamma delta T cells in cattle and swine where this cell subset is 30% of PBMC in young animals, compared to 5-10% in humans and are not present in mouse circulating lymphocytes.

* Wendy C. Brown, Washington State University, USA

* Douglas F. Antczak, Cornell University, USA

Mark Jutila, Montana State University, USA
Enhancing the Innate Lymphocyte Response with Plant and Microbial Products

Randy E. Sacco, National Animal Disease Center, US Department of Agriculture, USA
Influence of gammadelta T Cells on the Immunopathology of Bovine Respiratory Syncytial Virus

Janice C. Telfer, University of Massachusetts, USA
WC1 Is a Hybrid gammadelta TCR Coreceptor and Pattern Recognition Receptor for Pathogenic Bacteria

Efrain Guzman, Pirbright Institute, UK
Short Talk: Bovine gamma delta T Cells Are a Major Regulatory T Cell Subset

09:40—10:00
Coffee Break

11:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:15—14:30
On Own for Lunch

14:30—16:30
Workshop 1: Immune Function and Regulation

* Dirk Werling, Royal Veterinary College, UK

* Paul M. Coussens, Michigan State University, USA

Ellis J. Powell, Iowa State University, USA
Increased Percentages of Functional NK Cells in Pigs with Severe Combined Immune Deficiency (SCID) Caused by Natural Mutations in the Artemis Gene

Bianca Libanori Artiaga, University of Florida, USA
Targeting NKT Cells to Enhance Immunity: A Novel Swine Model

Tomohiro Okagawa, Hokkaido University, Japan
A Novel Strategy for Immunotherapy of Paratuberculosis in Cattle: Regulation of T-Cell Response to Mycobacterium avium subspecies paratuberculosis by the Blockade of Immunoinhibitory Receptors

Satoru Konnai, Hokkaido University, Japan
Increases of Cells Expressing PD-1 and PD-L1 in Bovine Leukemia Virus Infection and Enhancement of Anti-Viral Immune Responses in vitro via its Blockade

Michael C. Rahe, University of Minnesota, USA
Cytokine-Mediated Proliferation and Differentiation of Porcine B Cells into Ig Secreting Plasma Cells

Mark S. Fife, Pirbright Institute, UK
Chicken Interferon-Inducible Transmembrane (IFITM) Proteins Are Functional and Actively Restrict Avian Viruses

16:30—17:00
Coffee Available

17:00—19:00
Innate Responses to Infection
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
The early and often effective immune response to infection as well as to adjuvants in vaccine formulations is mediated by the cells of the innate immune system including dendritic cells, natural killer (NK) cells and gamma/delta T cells. This session will focus on DCs and NK as another session focuses on the gamma delta T cells.

* William T. Golde, Plum Island Animal Disease Center, USA

* Cynthia L. Baldwin, University of Massachusetts, USA

Artur Summerfield, Institute of Virology and Immunoprophylaxis, Switzerland
Plasmacytoid Dendritic Cells in the Early Response to Infection

John A. Hammond, Pirbright Institute, UK
Genetics of Natural Killer Cell Receptors in Cattle

David A. Hume, University of Edinburgh, UK
The Role of Macrophages in Innate Immunity following Infection

Dirk Werling, Royal Veterinary College, UK
Short Talk: Differences in Inflammasome Activation between Cow Breeds Impact on Bacterial Killing

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

19:30—22:00
Poster Session 1


THURSDAY, JANUARY 22

07:00—08:00
Breakfast

08:00—11:00
Mucosal Immune Responses to Infection
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
This session will explore the unique aspects of mucosal immune responses to infections with enteric and respiratory pathogens.

* Randy E. Sacco, National Animal Disease Center, US Department of Agriculture, USA

* Gregers Jungersen, Technical University of Denmark, Denmark

David W. Pascual, University of Florida, USA
Mucosal Vaccines for Brucellosis

Crystal L. Loving, US Department of Agriculture, ARS, National Animal Disease Center, USA
Provocation versus Protection – Immune Responses and Differential Outcomes following Influenza Virus Vaccination and Challenge in Pigs

Massimo Amadori, Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia-Romagna, Italy
Immunoprophylaxis in Intensive Farming Systems: The Way Forward

Armin Saalmüller, Inst Immunology, University Veterinary Medicine, Veinna, Austria
Immune Response of Porcine CD4+ T Cells following Infection with Influenza- or PRRS Virus

Heidi Mikkelsen, National Veterinary Institute, Technical University of Denmark, Denmark
Short Talk: Vaccination with Peptides of Mycobacterium avium subspecies paratuberculosis (MAP) Reduces MAP Burden of Infected Goats

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

17:00—19:15
Immune Responses to Swine and Avian Influenza
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Understanding the immunopathology and epidemiology of influenza infections in reservoir species is central to the design and deployment of new vaccines to control this zoonotic disease.

* Armin Saalmüller, Inst Immunology, University Veterinary Medicine, Veinna, Austria

* David W. Pascual, University of Florida, USA

Kristien Van Reeth, Universiteit Ghent, Belgium
Cross-Protection Studies with Diverse Swine Influenza Viruses: A Case for Revising Cross-Protective Immunity between Influenza A Viruses

María Montoya, Centre de Recerca en Sanitat Animal and The Pirbright Institute, UK
Immune Response to Influenza Infection of Swine, Friend or Foe?

Jesús Hernández, Centro de Investigación en Alimentación y Desarrollo, Mexico
Influenza Transmission in Swine and Birds

Ignacio Mena, Icahn School of Medicine at Mount Sinai, USA
Short Talk: Recombinant Newcastle Disease Viruses Expressing swine and Avian Influenza Hemagglutinins Induce Protective Antibody Responses in Pigs and Chickens

Elma Z. Tchilian, Pirbright Institute, UK
Short Talk: Immune Responses to a Candidate Universal Influenza Vaccine in Pigs

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

19:30—22:00
Poster Session 2


FRIDAY, JANUARY 23

07:00—08:00
Breakfast

08:00—11:00
Analysis of Immune Responses to Vector-Borne Pathogens
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Arthropod borne diseases have a unique landscape of immunopathology and immune responses that will be highlighted in this session. For the livestock diseases, there are major adverse impacts on populations in tropical, developing countries and loss of livestock results in severe effects on food sources in these regions.

* Samuel James Black, University of Massachusetts, USA

* Vish Nene, International Livestock Research Institute, Kenya

Ivan Morrison, University of Edinburgh, UK
CD8 T Cells Mediate Immunity in Cattle that Survive Infections with Theileria parva

Jayne Raper, Hunter College, USA
Introducing Genetic Resistance for Trypanasomiasis into Sheep and Cattle

Robert H. Mealey, Washington State University, USA
Challenges Facing Chemotherapeutic and Immune Control of Theileria equi

Wendy C. Brown, Washington State University, USA
Dysfunctional CD4 T-Cell Responses during Anaplasma marginale Infection

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:00—14:30
On Own for Lunch

14:30—16:30
Workshop 2: Antigen Identification and Vaccine Formulation

* W. Ray Waters, National Animal Disease Center, USA

* Tim Connelley, University of Edinburgh, UK

Elizabeth Rieder, Agricultural Research Service, US Department of Agriculture, USA
Marker Foot-and-Mouth Disease Vaccine Platform: A Safe and Potentially Low-Cost Option for Global Production of Inactivated FMDV Vaccines

Douglas F. Antczak, Cornell University, USA
Identification of Peptide Motifs for Equine Major Histocompatibility Complex Class I Molecules

Mital Pandya, University of Vermont, USA
Identification of Peptides from Foot-and-Mouth Disease Virus Structural Proteins Bound by Bovine Leukocyte Antigen (BoLA) Class I Molecules

Simon Welner, National Veterinary Institute, Technical University of Denmark, Denmark
Bioinformatics Prediction of Swine MHC Class I Epitopes from Porcine Reproductive and Respiratory Syndrome Virus

Jean-Pierre Y. Scheerlinck, University of Melbourne, Australia
Immune Memory Resilience, a New Way of Evaluating Adjuvants

Charlotte R. Bell, Roslin Institute, University of Edinburgh, UK
Haematopoietic Depletion in Vaccine-Induced Bovine Neonatal Pancytopenia (BNP) Depends on the Titre and Specificity of Alloantibody and Levels of MHC I Expression

Preben Boysen, Norwegian University of Life Sciences, Norway
Transient Recruitment of Inflammatory Monocytes and Early Activation of Lymphocytes in the Draining Lymph Node of Calves following Injection of a Saponin-Based Adjuvant

16:30—17:00
Coffee Available

17:00—19:00
Immunodeficiency Virus Infections in Veterinary Species
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Originally described in veterinary species, the study of immunodeficiency viruses has been greatly aided by studying these infections in cats, monkeys and horses.

* Christopher K. Tuggle, Iowa State University, USA

* Jayne Raper, Hunter College, USA

Simon M. Barratt-Boyes, University of Pittsburgh, USA
Immunopathology of Simian Immunodeficiency Virus Infection

Hannah J. Barbian, University of Pennsylvania, USA
Short Talk: Broad and Potent Neutralization of Simian Immunodeficiency Viruses from Chimpanzees and Gorillas by Host Receptor Antibodies and CD4 Immunoadhesins

Sue VandeWoude, Colorado State University, USA
Antibody Repertoire following Feline Immunodeficiency Virus Infection and Novel Vaccine Delivery

Mia Smith, Colorado State University, USA
Short Talk: A Novel Viral Immune Evasion Mechanism Suppresses the PI3-Kinase Signaling Pathway by Induction of Expression of PTEN in B Cells

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

19:30—22:00
Poster Session 3


SATURDAY, JANUARY 24

07:00—08:00
Breakfast

08:00—11:15
Immune Responses to Mycobacterium Infection
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Bovine tuberculosis is a cause of significant morbidity and mortality in cattle in developing countries and is also zoonotic for the farmer. Control of M. bovis and other mycobacterial infections is a high priority to elevating small holder farmers to more stable food and income sources. Speakers in this session will address recent work analyzing innate and adaptive immune responses to these infections.

* John Barlow, University of Vermont, USA

* Chris Chase, South Dakota State University, USA

H. Martin Vordermeier, Animal Health & Veterinary Laboratories Agency, UK
Antigen Mining Strategies to Identify Diagnostic and Sub-Unit Vaccine Antigens of Protective of Mycobacterium bovis: Successes and Challenges

Paul M. Coussens, Michigan State University, USA
Immune Dysregulation and Regulatory T Cell Responses of Cattle to Infection with Mycobacterium avium subspecies paratuberculosis

Gregers Jungersen, Technical University of Denmark, Denmark
Short Talk: A Recombinant Multi-Stage Vaccine against Paratuberculosis Significantly Reduces Bacterial Level in Tissues without Interference in Diagnostics

Kumudika I. de Silva, University of Sydney, Australia
Short Talk: CD4+ T Cells, gammadelta T Cells and B Cells Are Associated with Non-Responsiveness to Vaccination in Mycobacterium avium subspecies paratuberculosis Infection

Jayne C. Hope, University of Edinburgh, UK
Innate Immune Responses and Bovine Tuberculosis

W. Ray Waters, National Animal Disease Center, USA
Vaccine Approaches for Bovine Tuberculosis: Correlates of Protection and Relevance to Human Tuberculosis

09:20—09:40
Coffee Break

11:15—17:00
On Own for Lunch

16:30—17:00
Coffee Available

17:00—18:45
Veterinary Vaccines for the 21st Century
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
This session will highlight new, cutting-edge approaches to designing vaccines for livestock and new technologies to assess vaccine performance that will lead to the accelerated development of veterinary vaccines.

* Ivan Morrison, University of Edinburgh, UK

* Linda J. Saif, Ohio State University, USA

William T. Golde, Plum Island Animal Disease Center, USA
Analysis of the Adaptive Immune Response to Foot-and-Mouth Disease Virus (FMDV) following Infection or Vaccination of Cattle or Swine

Tim Connelley, University of Edinburgh, UK
Tracking T-Cell Responses at a Clonal Level following T. parva Infection

Vish Nene, International Livestock Research Institute, Kenya
Design of Recombinant Vaccines for East Coast Fever (ECF) via Reverse Immunology

18:45—19:15
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.


SUNDAY, JANUARY 25

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge additional support for this conference from:

Zoetis

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institute of Food and Agriculture (NIFA)
US Department of Agriculture (USDA)

Grant No. 2015-67015-22933

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the National Institute of Food and Agriculture, USDA; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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