This meeting took place in 2015



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Neuroinflammation in Diseases of the Central Nervous System (A5)


Organizer(s) Richard M. Ransohoff, Christopher K. Glass and V. Hugh Perry
January 25—30, 2015
Sagebrush Inn & Suites • Taos, New Mexico USA
Discounted Abstract Deadline: Sep 30, 2014
Abstract Deadline: Oct 23, 2014
Scholarship Deadline: Sep 30, 2014
Discounted Registration Deadline: Nov 24, 2014

Sponsored by Abide Therapeutics Inc., Biogen Idec, FORUM Pharmaceuticals Inc., Shire Human Genetic Therapies and Takeda Pharmaceutical Company Limited. Supported by an educational donation provided by Amgen.

Summary of Meeting:
Neuroinflammation, the response of the central nervous system (CNS) to disturbed homeostasis, typifies all neurological diseases, including primary-inflammatory, developmental, traumatic, ischemic, neoplastic and neurodegenerative. Disease-associated neuroinflammatory responses may be helpful, harmful or neutral. This Keystone Symposia meeting will: (i) address the developmental roles of neuroinflammatory cells including microglia and blood-brain barrier (BBB) neurovascular elements; (ii) clarify how neuroinflammatory reactions mediate host defense against neuroinvasive microbial pathogens, and also how the response to systemic inflammation affects the neuroinflammatory elements; (iii) specify critically-important neuroinflammatory cells (microglia; astrocytes; NG2+ glia; BBB), receptors (toll-like receptors; inflammasomes; cytokine receptors), signaling pathways and effector mechanisms; and (iv) identify the most salient targets of neuroinflammation (neurons; neural progenitor and stem cells; oligodendroglia) and mechanisms of injury. This meeting will be the first Keystone Symposia meeting on neuroinflammation and will be the first to bring together the many communities of disease-focused neuroscientists and immunologists with an interest in the CNS.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JANUARY 25

16:00—20:00
Arrival and Registration

18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.


MONDAY, JANUARY 26

07:00—08:00
Breakfast

08:00—09:00
Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Richard M. Ransohoff, Biogen Idec, USA

David M. Holtzman, Washington University, USA
Effects of ApoE on Abeta and tau Pathology: Where Might a Role for ApoE in Neuroinflammation Fit In?

09:00—11:15
Neuroinflammation during Neurodevelopment
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* V. Hugh Perry, University of Southampton, UK

Marc R. Freeman, University of Massachusetts Medical School, USA
TRAF4 Couples Draper to JNK and STAT Signaling to Activate Glia after Axonal Injury

Carla J. Shatz, James H. Clark Center, USA
Developmental Critical Periods and Alzheimer's Disease – Can Knowledge of One Help Cure the Other?

Beth Stevens, Children's Hospital Boston, USA
Immune Mechanisms of Synapse Loss in Health and Disease

E. Richard Stanley, Albert Einstein College of Medicine, USA
Short Talk: A Csf1r Haploinsufficient Mouse Model of Adult-Onset Leukodystrophy with Axonal Spheroids and Pigmented glia (ALSP)

09:40—10:00
Coffee Break

11:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:15—17:00
On Own for Lunch

14:30—16:30
Workshop

* Christopher K. Glass, University of California, San Diego, USA

Mark W. Albers, Massachusetts General Hospital, USA
Innate Immune Pattern Recognition Receptors Link Genomic Instability and Neurodegeneration

Lien Beckers, Catholic University of Leuven, Belgium
A Novel Chronic and Non-Phagocytic Activation State of Microglia Comprising mTOR Induction in Peroxisomal beta-Oxidation Deficiency

Eva Czirr, Stanford University, USA
Microglial Complement Receptor 3 Is a Modulator of Abeta Degradation

Lawrence Fourgeaud, The Salk Institute for Biological Studies, USA
TAM Receptor Regulation of Microglial Physiology

Lily Keane, Bart's Cancer Institute, UK
Pathways Mediating the Increased Inflammatory Phenotype of Microglia from the Aging Brain

Claire L. Davies, Roslin Institute, University of Edinburgh, Scotland
A Murine Model of Self-Limiting Neuroinflammation Reveals a CCR2-Independent Mechanism of Inflammation Resolution

Christine L. Hsieh, San Francisco VA Medical Center, University of California, San Francisco, USA
Single Cell RNA Sequencing Reveals Monocyte-Derived Macrophage Heterogeneity in TBI

Taylor R. Jay, Case Western Reserve University, USA
Trem2 Deficiency Alters Monocyte Infiltration and Pathology in Mouse Models of Alzheimer’s Disease

16:30—17:00
Coffee Available

17:00—19:00
Neuroinflammatory Pathways of Host Defense
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* E. Richard Stanley, Albert Einstein College of Medicine, USA

Donald H. Gilden, University of Colorado Denver School of Medicine, USA
Varicella Zoster Virus Causes Giant Cell Arteritis

Glenn F. Rall, Fox Chase Cancer Center, USA
Neuropathogenesis as a Consequence of Peripheral Viral Infection

Robyn S. Klein, Washington University School of Medicine, USA
CNS Host Defense: Action at the BBB

Bevan Main, University of Melbourne, Australia
Short Talk: Targeting Interferon-alpha Receptor 1 (IFNAR1) Attenuates Nigral Degeneration in the MPTP Mouse Model of Parkinson’s Disease

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

19:30—22:00
Poster Session 1


TUESDAY, JANUARY 27

07:00—08:00
Breakfast

08:00—11:00
Mononuclear Phagocytes in Neuroinflammation
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA

Frederic Geissmann, King's College London, UK
Investigating the Functions of Yolk-Sac Derived Tissue-Resident Macrophages

Marco Prinz, University of Freiburg, Germany
The Myeloid Side of the Brain

Marco Colonna, Washington University School of Medicine, USA
Lipid Sensing by TREM2 Sustains the Microglia Response to Amyloid-beta Deposition in an Alzheimer’s Disease Model

Christopher K. Glass, University of California, San Diego, USA
Enhancer Landscapes Specifying Microglia and Macrophage Identity and Function

Bahareh Ajami, Stanford University School of Medicine, USA
Short Talk: Single-Cell Immune Signatures Reveal Functional Heterogeneity in Myeloid Populations in Neuroinflammation and Neurodegeneration

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

17:00—19:00
Neuroinflammation: BBB and Glial Cells
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Cheryl L. Wellington, University of British Columbia, Canada

Richard Daneman, University of California, San Diego, USA
The BBB: Cells and Signaling

Robert Bell, Pfizer Inc., USA
Targeting Blood-Brain Barrier Pathology for Treating CNS Disorders

Ryan J. Watts, Genentech, Inc., USA
BBB Disruption and Drug Delivery in Neurodegenerative Disease

Susanna Rosi, University of California, San Francisco, USA
Short Talk: The Impact of Aging on the Innate Immune Response to Traumatic Brain Injury

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

19:30—22:00
Poster Session 2


WEDNESDAY, JANUARY 28

07:00—08:00
Breakfast

08:00—11:00
Neuroinflammation in Neurodegeneration
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Malu G. Tansey, Emory University, USA

Chris Gaiteri, Rush University Medical Center, USA
Ripples in Networks: Recreating Alzheimer's Expression and Endophenotypes Based on Causal Molecular Network Models of Microglia and Other Systems

Cheryl L. Wellington, University of British Columbia, Canada
Inflammation after Traumatic Brain Injury: Challenges and Opportunities

Robin Franklin, University of Cambridge, UK
Inflammation and Remyelination

Soyon Hong, Boston Children's Hospital, USA
Short Talk: Classical Complement Cascade Mediates Early Synapse Loss in AD

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

11:00—17:00
On Own for Lunch

13:00—22:00
Poster Viewing

16:30—17:00
Coffee Available

17:00—19:00
Innate Neuroinflammation: The Basics
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Beth Stevens, Children's Hospital Boston, USA

Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA
NLRs and their Roles in Neuroinflammation

Eicke Latz, University of Bonn, Germany
Sensing the Environment – Role of Inflammasomes in Sterile Inflammatory Diseases

Iain L. Campbell, University of Sydney, Australia
The IL-6/gp130 Family of Cytokines and the Astroglial/Microglial Nexus

Pushpalatha Palle, Institute for Medical Microbiology, Immunology and Hygiene, Germany
Short Talk: Deciphering the Role of Combined Deficiencies of TLRs2,3,4,7,9 in the Mouse Model of Multiple Sclerosis

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

19:30—22:00
Poster Session 3


THURSDAY, JANUARY 29

07:00—08:00
Breakfast

08:00—11:00
Beyond Innate Neuroinflammation
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Tammy L. Kielian, University of Nebraska, USA

Josep Dalmau, IDIBAPS/University of Barcelona and University of Pennsylvania
Antibody-Mediated Diseases of the CNS

Oleg Butovsky, Harvard Institutes of Medicine, USA
Identification of a Unique Molecular and Functional Microglia Signature in Health and Disease

Makoto Inoue, Duke University Medical Center, USA
Intensive Stimulation of Innate Immunity Induces IFNbeta-Resistant EAE with Neural Retraction

Hartmut Wekerle, Max Planck Institute, Germany
Sign Posts: CNS Phagocytes Presenting Myelin Autoantigen Guide Autoimmune T Cells into the Target Tissue

Marion S. Buckwalter, Stanford Medical School, USA
Short Talk: B Lymphocyte-Mediated Delayed Cognitive Impairment following Stroke

09:20—09:40
Coffee Break

11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

17:00—19:00
Glial Cells in Neurodegeneration
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

V. Hugh Perry, University of Southampton, UK
Microglia Priming in Chronic Neurodegeneration: A Role for Systemic Inflammation

Richard M. Ransohoff, Biogen Idec, USA
Microglia Among the Myeloid Cells: Functions and their Regulation

Tammy L. Kielian, University of Nebraska, USA
Glial Dysfunction in Lysosomal Storage Disease

Kathryn P. MacPherson, Emory University, USA
Short Talk: Inhibition of Soluble TNF Signaling with Systemic XPro1595 Modulates CNS and Peripheral Immune Cell Populations in 5xFAD Mice

19:00—19:30
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

19:30—20:30
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.


FRIDAY, JANUARY 30

 
Departure


*Session Chair †Invited, not yet responded.

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Sagebrush Inn & Suites Floorplan




Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Abide Therapeutics Inc. Educational donation provided by Amgen
Biogen Idec FORUM Pharmaceuticals Inc.
Shire Human Genetic Therapies Takeda Pharmaceutical Company Limited

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13NS090833-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

NeuroscientistNews

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676