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This meeting took place in 2017
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Hematopoiesis (B1)
Organizer(s) Catriona H.M. Jamieson, Andreas Trumpp and Paul S. Frenette
January 31—February 4, 2017
Fairmont Banff Springs • Banff, Alberta Canada
Discounted Abstract Deadline: Oct 4, 2016
Abstract Deadline: Nov 1, 2016
Scholarship Deadline: Oct 4, 2016
Discounted Registration Deadline: Dec 1, 2016
Sponsored by Bayer HealthCare Pharmaceuticals
Summary of Meeting:
Since the discovery that hematopoiesis could be established by a single cell over five decades ago, advances in model systems, sequencing, reprogramming and genome editing technologies have enabled precise molecular characterization of regulators of hematopoiesis. These discoveries have informed and accelerated implementation of clinical trials for a broad array of benign and malignant hematologic disorders, including bone marrow failure syndromes and leukemia, as well as guided the development of molecular prognostication strategies. This Keystone Symposia meeting will bring together basic, translational and clinical researchers to discuss key regulators of hematopoietic stem and progenitor cell ontogeny, cell fate specification and self-renewal during homeostasis, stress and malignant transformation. The relative importance of cell-autonomous genetic, epigenetic, transcriptional and post-transcriptional hematopoietic regulatory mechanisms as well as local niche or systemic factors will be presented by international leaders in the field of hematopoiesis and stem cell biology. The culmination of innovative genome editing, reprogramming, single-cell sequencing and imaging in different model systems to unravel essential regulators of hematopoiesis will be highlighted. This meeting should provide a vital opportunity for forging collaborations between researchers from disparate disciplines and result in novel insights from a plethora of model systems that will enable investigators to address basic, translational and clinical hematopoiesis research challenges.
View Scholarships/Awards
Since the discovery that hematopoiesis could be established by a single cell over five decades ago, advances in model systems, sequencing, reprogramming and genome editing technologies have enabled precise molecular characterization of regulators of hematopoiesis. These discoveries have informed and accelerated implementation of clinical trials for a broad array of benign and malignant hematologic disorders, including bone marrow failure syndromes and leukemia, as well as guided the development of molecular prognostication strategies. This Keystone Symposia meeting will bring together basic, translational and clinical researchers to discuss key regulators of hematopoietic stem and progenitor cell ontogeny, cell fate specification and self-renewal during homeostasis, stress and malignant transformation. The relative importance of cell-autonomous genetic, epigenetic, transcriptional and post-transcriptional hematopoietic regulatory mechanisms as well as local niche or systemic factors will be presented by international leaders in the field of hematopoiesis and stem cell biology. The culmination of innovative genome editing, reprogramming, single-cell sequencing and imaging in different model systems to unravel essential regulators of hematopoiesis will be highlighted. This meeting should provide a vital opportunity for forging collaborations between researchers from disparate disciplines and result in novel insights from a plethora of model systems that will enable investigators to address basic, translational and clinical hematopoiesis research challenges.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Tuesday, January 31 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Saturday, February 4 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Sunday, February 5 in order to fully experience the meeting.
TUESDAY, JANUARY 31
WEDNESDAY, FEBRUARY 1
THURSDAY, FEBRUARY 2
FRIDAY, FEBRUARY 3
SATURDAY, FEBRUARY 4
SUNDAY, FEBRUARY 5
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Tuesday, January 31 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Saturday, February 4 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Sunday, February 5 in order to fully experience the meeting.
TUESDAY, JANUARY 31
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.
*
Catriona H.M. Jamieson,
University of California, San Diego, USA
Leonard I. Zon,
HHMI/Boston Children's Hospital, USA
Pathways Regulating Stem Cell Induction, Self-Renewal and Engraftment
Pathways Regulating Stem Cell Induction, Self-Renewal and Engraftment
09:00—11:30
Development
Meeting has ended...abstracts no longer viewable online.
*
Catriona H.M. Jamieson,
University of California, San Diego, USA
Coffee Break
Robert A.J. Signer,
University of California, San Diego, USA
Translational Control of Hematopoietic Stem Cells
Translational Control of Hematopoietic Stem Cells
Nina Cabezas-Wallscheid,
German Cancer Research Center, Germany
Short Talk: Vitamin A/Retinoic Acid Signaling Regulates the Dormancy State of Hematopoietic Stem Cells
Short Talk: Vitamin A/Retinoic Acid Signaling Regulates the Dormancy State of Hematopoietic Stem Cells
Leslie Crews,
University of California, San Diego, USA
Short Talk: Decoding the RNA Editome of Normal versus Malignant Hematopoietic Progenitor Cell Aging
Short Talk: Decoding the RNA Editome of Normal versus Malignant Hematopoietic Progenitor Cell Aging
Linda T. Vo,
University of California, San Francisco, USA
Short Talk: Unlocking Definitive Hematopoietic Potential via Epigenetic Modulation
Short Talk: Unlocking Definitive Hematopoietic Potential via Epigenetic Modulation
Lucas Greder,
University of Oxford, UK
Short Talk: Chromatin Accessibility and Expression Profiling of the Endothelial-to-Hematopoietic Transition
Short Talk: Chromatin Accessibility and Expression Profiling of the Endothelial-to-Hematopoietic Transition
17:00—19:00
HSC Versus Progenitor Contribution to Hematopoiesis
Meeting has ended...abstracts no longer viewable online.
*
Andreas Trumpp,
German Cancer Research Center, Germany
John E. Dick,
Princess Margaret Cancer Centre, Canada
Mechanistic Insight Into Human Hematopoietic Lineage Determination
Mechanistic Insight Into Human Hematopoietic Lineage Determination
Adolfo Ferrando,
Columbia University, USA
Mechanisms of Clonal Evolution and Relapse in Acute Lymphoblastic Leukemia
Mechanisms of Clonal Evolution and Relapse in Acute Lymphoblastic Leukemia
Alejo Ezequiel Rodriguez Fraticelli,
Boston Children's Hospital, USA
Clonal Analysis of Hematopoietic Development
Clonal Analysis of Hematopoietic Development
Bilyana Stoilova,
Weatherall Institute of Molecular Medicine, University of Oxford, UK
Short Talk: Functional and Transcriptional Heterogeneity of Human Hemopoietic Lympho-Myeloid Progenitors at the Single Cell Level
Short Talk: Functional and Transcriptional Heterogeneity of Human Hemopoietic Lympho-Myeloid Progenitors at the Single Cell Level
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Microenvironment
Meeting has ended...abstracts no longer viewable online.
*
Paul S. Frenette,
Albert Einstein College of Medicine, USA
HSC Niche and its Regulation by Long-Range Signals
HSC Niche and its Regulation by Long-Range Signals
David T. Scadden,
Massachusetts General Hospital and Harvard University, USA
Hematopoietic Cell Fate is Clone Specific and Epigenetically Constrained: Implications for Concepts of the Bone Marrow Niche
Hematopoietic Cell Fate is Clone Specific and Epigenetically Constrained: Implications for Concepts of the Bone Marrow Niche
Coffee Break
Irving L. Weissman,
Stanford University, USA
Targeting Don’t Eat Me Signals in Malignant Hematopoiesis
Targeting Don’t Eat Me Signals in Malignant Hematopoiesis
Laura M. Calvi,
University of Rochester Medical Center, USA
Short Talk: Age-and Region-Dependent Architectural Remodeling of Niche Constituents in the Hematopoietic Microenvironment Contributes to Hematopoietic Stem Cell Aging
Short Talk: Age-and Region-Dependent Architectural Remodeling of Niche Constituents in the Hematopoietic Microenvironment Contributes to Hematopoietic Stem Cell Aging
Michael Poulos,
Weill Cornell Medical College, USA
Short Talk: Rejuvenation of the Aged Vascular Niche to Enhance Hematopoietic Function
Short Talk: Rejuvenation of the Aged Vascular Niche to Enhance Hematopoietic Function
17:00—19:15
Epigenetics and Transcription
Meeting has ended...abstracts no longer viewable online.
Andreas Trumpp,
German Cancer Research Center, Germany
Human Haematopoietic Stem Cell Differentiation is a Continuous Process without Discrete Progenitor Populations
Human Haematopoietic Stem Cell Differentiation is a Continuous Process without Discrete Progenitor Populations
*
Maria E. Figueroa,
University of Miami Miller School of Medicine, USA
Epigenetic Deregulation in the Aging Hematopoietic Stem Cell
Epigenetic Deregulation in the Aging Hematopoietic Stem Cell
Scott A. Armstrong,
Dana-Farber Cancer Institute, USA
Histone Modifications and Gene Expression in Leukemia
Histone Modifications and Gene Expression in Leukemia
Iannis Aifantis,
New York University School of Medicine, USA
The Missing Lncs: Regulation of Blood Cell Transformation by LncRNAs
The Missing Lncs: Regulation of Blood Cell Transformation by LncRNAs
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Directed Differentiation and Expansion
Meeting has ended...abstracts no longer viewable online.
*
E. Camilla Forsberg,
University of California, Santa Cruz, USA
Bloody Commitments: Hematopoietic Stem Cell Fate Decisions
Bloody Commitments: Hematopoietic Stem Cell Fate Decisions
Derrick J. Rossi,
Harvard University, USA
Diminished Apoptotic Priming Underlies Increased Survival of Aged Hematopoietic Stem Cells in Response to DNA Damage
Diminished Apoptotic Priming Underlies Increased Survival of Aged Hematopoietic Stem Cells in Response to DNA Damage
Coffee Break
Dan S. Kaufman,
University of California, San Diego, USA
Pluripotent Stem Cells to Model Human Hemato-Lymphoid Development
Pluripotent Stem Cells to Model Human Hemato-Lymphoid Development
Melanie Mumau,
University of Pennsylvania, USA
Short Talk: NR4A1 Identifies a Population of Multipotent Progenitors in the Spleen that Restrict Erythropoiesis
Short Talk: NR4A1 Identifies a Population of Multipotent Progenitors in the Spleen that Restrict Erythropoiesis
Gabriela Pregernig,
Decibel Therapeutics, USA
Short Talk: GATA1 and The Cohesin Complex Cooperate to Regulate Erythroid Gene expression
Short Talk: GATA1 and The Cohesin Complex Cooperate to Regulate Erythroid Gene expression
Katie Matatall,
Baylor College of Medicine, USA
Short Talk: Batf2 is a Mediator of Stress-Induced Terminal Differentiation Driving Hematopoietic Stem Cell Depletion Following Chronic Infection
Short Talk: Batf2 is a Mediator of Stress-Induced Terminal Differentiation Driving Hematopoietic Stem Cell Depletion Following Chronic Infection
17:00—19:00
Genome and Transcriptome Editing in Normal and Malignant Progenitors
Meeting has ended...abstracts no longer viewable online.
*
Derrick J. Rossi,
Harvard University, USA
Catriona H.M. Jamieson,
University of California, San Diego, USA
RNA Editing and Malignant Reprogramming
RNA Editing and Malignant Reprogramming
Carlo M. Croce,
Ohio State University, USA
MicroRNA Dysregulation to Identify Therapeutic Targets
MicroRNA Dysregulation to Identify Therapeutic Targets
Daniel G. Tenen,
Cancer Science Institute, Singapore
Regulation of Myeloid Transcription Factors, DNA Methylation and Leukemia by Noncoding RNA
Regulation of Myeloid Transcription Factors, DNA Methylation and Leukemia by Noncoding RNA
Laura PMH de Rooij,
McMaster University, Canada
Short Talk: Unraveling the Importance of RNA Binding Proteins in Leukemic Stem Cells by CRISPR-Cas9 Screening
Short Talk: Unraveling the Importance of RNA Binding Proteins in Leukemic Stem Cells by CRISPR-Cas9 Screening
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Hematopoietic Malignancies
Meeting has ended...abstracts no longer viewable online.
*
Ross L. Levine,
Memorial Sloan Kettering Cancer Center, USA
Clonal Hematopoiesis during Aging
Clonal Hematopoiesis during Aging
Coffee Break
Tannishtha Reya,
University of California, San Diego, USA
In vivo Imaging of Regulators of Normal and Leukemia Stem Cell Symmetric and Asymmetric Division
In vivo Imaging of Regulators of Normal and Leukemia Stem Cell Symmetric and Asymmetric Division
Luigi M. Naldini,
San Raffaele Telethon Institute, Italy
Genetic Engineering of Hematopoiesis for Treating Human Diseases
Genetic Engineering of Hematopoiesis for Treating Human Diseases
Toshio Kitamura,
University of Tokyo, Institute of Medical Science, Japan
Short Talk: Disruption of EZH2 Induces Myelodysplastc Syndromes (MDS) in Mice via Derepression of ABC-G2
Short Talk: Disruption of EZH2 Induces Myelodysplastc Syndromes (MDS) in Mice via Derepression of ABC-G2
Virginia Turati,
UCL Cancer Institute, UK
Short Talk: Single-Cell Analysis of Clonal Dynamics of childhood ALL
Short Talk: Single-Cell Analysis of Clonal Dynamics of childhood ALL
17:00—18:45
DNA Damage, Repair and Aging
Meeting has ended...abstracts no longer viewable online.
*
Amy J. Wagers,
Harvard University, USA
Intrinsic and Extrinsic Signals Regulating Stem Cell Aging
Intrinsic and Extrinsic Signals Regulating Stem Cell Aging
Elaine R. Mardis,
Nationwide Children's Hospital, USA
AML Genomics: Clinical Translation from Large-Scale Discovery
AML Genomics: Clinical Translation from Large-Scale Discovery
18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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