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This meeting took place in 2017



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Neurogenesis during Development and in the Adult Brain (J2)


Organizer(s) Alysson R. Muotri, Kinichi Nakashima and Xinyu Zhao
January 8—12, 2017
Resort at Squaw Creek • Olympic Valley, California USA
Discounted Abstract Deadline: Sep 20, 2016
Abstract Deadline: Oct 10, 2016
Scholarship Deadline: Sep 20, 2016
Discounted Registration Deadline: Nov 9, 2016

Sponsored by California Institute for Regenerative Medicine (CIRM)


Summary of Meeting:
The complexity of the brain, with thousands of neuronal types, permits the development of sophisticated cognitive and behavioral repertoires. Neurogenesis, the fundamental phenomenon that creates the brain, starts early during development and continues in adult life, shaping our networks in close association with the environment. This unique meeting will explore neurogenesis from different perspectives, bringing new insights about the fundamental mechanisms that control normal brain development and that contribute to disease situations when this process is altered. It brings together scientists working on different aspects of neurogenesis to exchange ideas and facilitate novel collaborative projects. The pairing of the meeting with a stem cell meeting will enhance the opportunity for interactions among researchers from different fields pursuing similar questions.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, January 8 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, January 12 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, January 13 in order to fully experience the meeting.

SUNDAY, JANUARY 8

16:00—20:00
Arrival and Registration

Lobby Alcove
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Cascades

MONDAY, JANUARY 9

07:00—08:00
Breakfast

Cascades
08:00—09:00
Welcome and Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom
* Xinyu Zhao, University of Wisconsin-Madison, USA

* Konrad Hochedlinger, Massachusetts General Hospital, USA

Fred (Rusty) H. Gage, The Salk Institute for Biological Studies, USA
Regulation and Function of Neurogenesis in the Adult Hippocampus

09:00—12:15
Neural Stem Cells (Joint)
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom
* Xinyu Zhao, University of Wisconsin-Madison, USA

Arnold R. Kriegstein, University of California, San Francisco, USA
Genomic Insights into Human Cortical Development, Lissencephaly, and Zika Microcephaly

Coffee Break

Hongjun Song, University of Pennsylvania, USA
Tracking Neural Stem Cell Fate in vivo, One Cell at a Time

Jonas Frisén, Karolinska Institutet, Sweden
Adult Neurogenesis in Humans

Shradha Mukherjee, University of Texas Southwestern Medical Center, USA
Short Talk: Control of Adult Neural Stem Cell Quiescence by the REST/RPL4 Axis

Carol Schuurmans, Sunnybrook Research Institute, Canada
Short Talk: Proneural Genes Maintain a Neural Stem Cell Pool Through Multilineage Priming

12:15—17:00
On Own for Lunch

12:15—13:00
Poster Setup

Alpine Ballroom
13:00—22:00
Poster Viewing

Alpine Ballroom
14:30—16:30
Workshop 1: Disease “In-a-Dish” Modeling

Grand Sierra Ballroom A-B
* Hilde Van Esch, KU Leuven, Belgium

Cleber A. Trujillo, University of California, San Diego, USA
Cortical Neurotransmission Dysregulation as a Target for Rett Syndrome Treatment

Alex Shcheglovitov, University of Utah, USA
Generation of Organized Cortical Organoids with Synaptically Interconnected Neurons from Human iPSC-Derived Neural Rosettes

Meiyan Wang, University of California, San Diego, USA
Study Genetic Variations in the Development of Schizophrenia using Human Induced Pluripotent Stem Cells

Giorgia Quadrato, Harvard University, USA
Large-Scale Single Cell RNA-Seq Resolves Cellular Diversity in Long-Term Cultures of Human Brain Organoids

Anita Bhattacharyya, University of Wisconsin-Madison, USA
Establishment of an iPSC Reporter Line for Detecting Fragile X Mental Retardation (FMR1) Gene Reactivation in Human Neural Cells

16:30—17:00
Coffee Available

Sierra Prefunction
17:00—19:00
Adult Neurogenesis I
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom A-B
* Jenny Hsieh, University of Texas Southwestern Medical Center, USA

David V. Schaffer, University of California, Berkeley, USA
Molecular Elucidation and Engineering of Stem Cell Fate Decisions

Sebastian Jessberger, University of Zürich, Switzerland
Plasticity of Neural Stem Cells in the Adult Brain

D. Chichung Lie, University of Erlangen, Germany
Autophagy-Dependent Control of Neurogenesis

Anastasia Lobanova, The Scripps Research Institute, USA
Short Talk: Different Requirement for Functional Telomeres in Neural Progenitor Cells and Differentiated Postmitotic Neurons

17:00—19:00
Chromatin Regulation during Development and Cell Fate Decisions
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom C-D
* Konrad Hochedlinger, Massachusetts General Hospital, USA

Richard A. Young, Whitehead Institute for Biomedical Research, USA
Development and Disease: The View From Chromosome Neighborhoods

Andrew Xiao, Yale University, USA
The Recent Expansion of Epigenetic Regulatory Repertoire in Mammals

Cheng-Yu Lee, University of Michigan, USA
Short Talk: A Novel Hdac1/Rpd3-Poised Circuit Balances Continual Self-Renewal and Rapid Restriction of Developmental Potential during Asymmetric Stem Cell Division

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Cascades/Alpine Ballroom
19:30—22:00
Poster Session 1

Alpine Ballroom

TUESDAY, JANUARY 10

07:00—08:00
Breakfast

Cascades
08:00—11:15
Neurodevelopmental Disorders
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom A-B
* Kinichi Nakashima, Kyushu University, Japan

Sergiu Pasca, Stanford University, USA
Developing Tridimensional Models of the Human Cerebral Cortex to Study Disease

Hilde Van Esch, KU Leuven, Belgium
From the Patient to the Dish and Back

Coffee Break

Xinyu Zhao, University of Wisconsin-Madison, USA
Targeting Stem Cells for Neurodevelopmental Disorders

Patricia C. B. Beltrão-Braga, University of São Paulo, Brazil
The Use of Brain Organoids to Measure the Impact of Zika Virus on Microcephaly

Wenying Liu, Weill Cornell Medical College/Memorial Sloan Kettering Cancer Center, USA
Short Talk: Distinct Temporal Regulation of Cortical Progenitor Division Pattern and Output by PARD3

Simoni Avansini, University of Campinas, Brazil
Short Talk: Dysregulation of NEUROG2 by miR-34a in Focal Cortical Dysplasia, Key Players in Neuroglial Differentiation

08:00—11:15
Chromatin Regulation in Pluripotent Stem Cells
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom C-D
* Kathrin Plath, University of California, Los Angeles, USA

Michael Elowitz, California Institute of Technology, USA
Dynamics of Gene Regulatory Network in Embryonic Stem Cells

Joanna Wysocka, Stanford University School of Medicine, USA
Epigenetic Control of Naïve and Primed Pluripotency

Coffee Break

Richard I. Gregory, Harvard Medical School, USA
RNA Regulation in Stem Cells and Disease

Alexander Meissner, Max Planck Institute for Molecular Genetics, Germany
Epigenetic Changes during Lineage Specification

Srinjan Basu, University of Cambridge, UK
Short Talk: Using 3D Super-Resolution Imaging to Understand the Assembly of the Nucleosome Remodeling and Deacetylase (NuRD) Complex on Chromatin

Simon Braun, Stanford University, USA
Short Talk: Broadly Applicable Inducible Epigenome Editing by CRISPR/Cas9

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Alpine Ballroom
13:00—22:00
Poster Viewing

Alpine Ballroom
14:30—16:30
Workshop and Panel 2: Bridging an Understanding of Basic Science to Enable/Predict Clinical Outcome. Organized in collaboration with the California Institute for Regenerative Medicine (CIRM).

* J. Kent Fitzgerald, California Institute for Regenerative Medicine, USA

Mark H. Tuszynski, University of California, San Diego, USA
Neural Stem Cell Therapy for Spinal Cord Injury

Clive N. Svendsen, Cedars-Sinai Regenerative Medicine Institute, USA
A New FDA Approved Stem Cell and Gene Therapy Trial for ALS

Gary K. Steinberg, Stanford University, USA
Stem Cell Therapy for Stroke

16:30—17:00
Coffee Available

Sierra Prefunction
17:00—19:00
Therapeutics
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom A-B
* Xinyu Zhao, University of Wisconsin-Madison, USA

Nobuko Uchida, StemCells, Inc., USA
Use of Neural Stem Cells as a Therapeutic Opportunity

Su-Chun Zhang, University of Wisconsin-Madison, USA
Functional Reconstruction of Neural Circuits by Human Stem Cells

Chay T. Kuo, Duke University School of Medicine, USA
Chemical Screen for Neurogenic Modulators in Disease

17:00—19:00
Capture of Stem Cells from the Preimplantation Embryo
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom C-D
* Marius Wernig, Stanford University, USA

Kat Hadjantonakis, Sloan Kettering Institute, USA
Emergence of Pluripotency in the Mouse Blastocyst: Coordination of Transcriptional Control and Signaling

Rudolf Jaenisch, Whitehead Institute for Biomedical Research, USA
Human iPS Cells, Pluripotency and Developmental Potential

Austin Smith, University of Cambridge, UK
Phases of Pluripotency

Aydan Bulut-Karslioglu, University of California, San Francisco, USA
Short Talk: Inhibition of mTor Induces a Paused Pluripotent State

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Cascades/Alpine Ballroom
19:30—22:00
Poster Session 2

Alpine Ballroom

WEDNESDAY, JANUARY 11

07:00—08:00
Breakfast

Cascades
08:00—11:00
Disease and Regeneration
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom A-B
* Hongjun Song, University of Pennsylvania, USA

Kinichi Nakashima, Kyushu University, Japan
Insights into Rett Syndrome using Neural Stem Cells

Guo-li Ming, University of Pennsylvania, USA
Understanding ZIKV Pathogenesis during Neural Development

Coffee Break

Yechiel Elkabetz, Max Planck Institute for Molecular Genetics, Germany
Reliable Modeling of Cortical Development and Microcephaly in Rosettes and Organoids by Combined Pathway Inhibition

Chun-Li Zhang, University of Texas Southwestern Medical Center, USA
Neural Regeneration and Reprogramming

Justyna Nitarska, University College London, UK
Short Talk: A Functional Switch of ATPase Subunit of NuRD Chromatin Remodeling Complex Regulates Mouse Cortical Development

08:00—11:45
Mechanisms of Reprogramming
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom C-D
* Kat Hadjantonakis, Sloan Kettering Institute, USA

Kathrin Plath, University of California, Los Angeles, USA
Mechanisms of Transcription Factor-Induced Pluripotency

Konrad Hochedlinger, Massachusetts General Hospital, USA
Programming and Reprogramming Cell Fate

Coffee Break

Kristin Baldwin, The Scripps Research Institute, USA
Reprogramming-Based Insights into Neuronal Diversity

Peter Hendrickson, University of Utah, USA
Short Talk: Double Homeobox (DUX) Retrogenes Activate Early Embryonic Gene and Retroviral Transcription

Effie Apostolou, Weill Cornell Medicine, USA
Short Talk: Self-Renewal Genes Remain Bookmarked by Selected Transcription Factors and Epigenetic Marks during Mitosis

Jian Feng, University at Buffalo, State University of New York, USA
Short Talk: p53 and Cell Cycle in Reprogramming Fibroblasts to Neurons

Sophie M. Morgani, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Developing a Pluripotent Stem Cell Culture System to Model Gastrulation in vitro

Magdalena Götz, University of Munich, Germany
New Players in Neurogenesis

11:00—17:00
On Own for Lunch

11:00—13:00
Poster Setup

Alpine Ballroom
13:00—22:00
Poster Viewing

Alpine Ballroom
14:30—16:30
Workshop

Grand Sierra Ballroom C-D
* Richard A. Young, Whitehead Institute for Biomedical Research, USA

Matthias Merkenschlager, Imperial College London, UK
A High-Resolution Map of Transcriptional Repression

Ryan J. Cedeno, University of Pennsylvania, USA
The Histone Variant MacroH2A Reinforces Intestinal Stem Cell Epigenetic Identity and Function

Amy F. Chen, University of California, San Francisco, USA
Expression-Neutral Enhancer Switching Suppresses Premature EMT during ESC Differentiation

Jeremy Naftali Rich, Cleveland Clinic, USA
Targeting Glioma Stem Cells through Combined BMI1 and EZH2 Inhibition

Wen Gu, UT Southwestern Medical Center, USA
N-MYC Transcriptional Activity is Important for Increased Glycolytic Metabolism in Naive Human Pluripotent Stem Cells

Jacob H. Hanna, Weizmann Institute of Science, Israel
Enhanced Human Naïve Pluripotency Growth Conditions that Endow Tolerance for Loss of Epigenetic Repressors

16:30—17:00
Coffee Available

Sierra Prefunction
17:00—19:00
Neurogenesis and Environment
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom A-B
* Sebastian Jessberger, University of Zürich, Switzerland

Amar Sahay, Harvard Medical School, USA
Rejuvenating and Re-Engineering Aging Memory Circuits

Jenny Hsieh, University of Texas Southwestern Medical Center, USA
Pathological Roles of Aberrant Adult-Generated Neurons

Yanhong Shi, Beckman Research Institute of City of Hope, USA
Modeling Neurodevelopment and Disease

Mariagrazia Grilli, University of Piemonte Orientale, Italy
Short Talk: Cell Autonomous and Non Cell-Autonomous Role of NF-kB p50 in Astrocyte-Mediated Fate Specification of Adult Neural Progenitor Cells

17:00—19:00
Mechanisms of Direct Lineage Conversion
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom C-D
* Magdalena Götz, University of Munich, Germany

Marius Wernig, Stanford University, USA
Dissecting Mechanisms of Neural Transdifferentiation

Oliver Hobert, Columbia University, USA
Terminal Differentiation Restricts Cellular Plasticity

Deepak Srivastava, Gladstone Institute of Cardiovascular Disease and University of California, San Francisco, USA
Cellular Reprogramming Approaches for Cardiovascular Disease

Nicole Stone, University of California, San Francisco, USA
Short Talk: Chemical Enhancement of Direct Cardiac Reprogramming Mediated by Chromatin Accessibility

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Cascades/Alpine Ballroom
19:30—22:00
Poster Session 3

Alpine Ballroom

THURSDAY, JANUARY 12

07:00—08:00
Breakfast

Cascades
08:00—11:00
Adult Neurogenesis II
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom A-B
* D. Chichung Lie, University of Erlangen, Germany

Kazunobu Sawamoto, Nagoya City University Graduate School of Medical Sciences, Japan
Migration of New Neurons for Maintenance and Repair of Adult Mammalian Brain

Elena Cattaneo, University of Milano, Italy
Potential Application of Neural Stem Cells in Huntington's Disease Research

Coffee Break

Kunimasa Ohta, Kumamoto University, Japan
Short Talk: Disruption of Tsukushi Function Leads to the Hydrocephalus by Aberrant Neurogenesis in the Brain

Luiz O. Penalva, University of Texas Health Science Center, USA
Neurogenesis vs. Glioblastoma Development: Same Post-Transcriptional Paths, Different Outcomes

08:00—11:15
Stem Cells and Disease Modeling
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom C-D
* Rudolf Jaenisch, Whitehead Institute for Biomedical Research, USA

Jun Wu, The Salk Institute for Biological Studies, USA
Stem Cells, Interspecies Chimeras and Interspecies Chimera Complementation

Lorenz Studer, Memorial Sloan Kettering Cancer Center, USA
Exploiting Pluripotent Stem Cells for the Treatment of Neurological Diseases

Coffee Break

Jürgen A. Knoblich, IMBA, Institute of Molecular Biotechnology, Austria
Modeling Human Brain Development and Disease in Stem Cell-Derived 3D Organoid Culture

Ali H. Brivanlou, Rockefeller University, USA
Mechanisms of Self-Organization in Human Embryonic Stem Cells

Hiroko Nobuta, University of California, San Francisco, USA
Short Talk: Human Oligodendrocyte Death in Pelizaeus-Merzbacher Disease is Rescued by Iron Chelation

Yun Li, Hospital for Sick Children, Canada
Short Talk: Induction of Cortical Expansion and Folding in Human Cerebral Organoids

11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Sierra Prefunction
17:00—18:45
Embryonic Neurogenesis
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom A-B
* Guo-li Ming, University of Pennsylvania, USA

Ryoichiro Kageyama, Kyoto University, Japan
Oscillatory Control of Neural Stem Cells

Alysson R. Muotri, University of California, San Diego, USA
Modeling the Human Social Brain with Stem Cells

John L.R. Rubenstein, University of California, San Francisco, USA
Transcriptional Regulation of Telencephalic GABAergic Neurons

17:00—18:45
Path Towards Therapy Using Stem Cells
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom C-D
* Lorenz Studer, Memorial Sloan Kettering Cancer Center, USA

Hiromitsu Nakauchi, Stanford University, USA
Inter-Species Organogenesis: Generation of Mouse Islets in Rats for Long-Term, Immunosuppression-Free Glycemic Control in Diabetic Mice

Viviane Tabar, Memorial Sloan Kettering Cancer Center, USA
Modeling Histone Mutation-Bearing Gliomas in Human ES Cell Progeny

Irving L. Weissman, Stanford University, USA
Normal and Neoplastic Stem Cells

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom A-B
18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom C-D
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Cascades/Alpine Ballroom
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Cascades/Alpine Ballroom

FRIDAY, JANUARY 13

 
Departure


*Session Chair †Invited, not yet responded.


We gratefully acknowledge support for this conference from:


Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

Keystone Symposia thanks our Sponsor for generously supporting this meeting:

California Institute for Regenerative Medicine (CIRM)

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13NS100145-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We gratefully acknowledge additional support for this conference from:

CEDARLANE

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

NeuroscientistNews

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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Phone:+1 970-262-2676