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This meeting took place in 2018



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Phosphoinositide Biology: New Therapeutic Targets Beyond Class I PI3K (B5)


Organizer(s) Emilio Hirsch, Tamas Balla and Cristina Donini
February 11—15, 2018
Sagebrush Inn & Suites • Taos, New Mexico USA
Discounted Abstract Deadline: Oct 10, 2017
Abstract Deadline: Nov 8, 2017
Scholarship Deadline: Oct 10, 2017
Discounted Registration Deadline: Dec 12, 2017

Supported by the Directors' Fund

Summary of Meeting:
Phosphoinositides have been recognized since the 1980s as important regulatory lipids supporting signal transduction from G protein-coupled receptors and receptor tyrosine kinases. The discovery of PI 3-kinases and their roles in carcinogenesis and immune regulation has created a fertile ground for translational expansion of the phosphoinositide field with a focus on cancer and inflammation. Most of these advances focused on Class I PI3Ks and PIP3-mediated signaling. However, research on other PI kinases and phosphoinositides has expanded substantially over the years. Class II and -III PI 3-kinases and less characterized 3-phosphorylated phosphoinositides are now rapidly emerging as key controllers of development, trafficking, nutrition-sensing and autophagy. Furthermore, phosphoinositides different from the 3-phosphorylated species are gaining momentum in many aspects of cell physiology and pathology. Exciting new developments include PI 4-kinases controlling vesicular trafficking and non-vesicular lipid transfer between membrane contacts, and new details are emerging on the role of inositol lipid phosphatases in trafficking, endocytosis and ciliary function. The recently recognized roles of PI 4-kinases as obligate host factors for certain RNA viruses, and their importance in parasitic organisms such as Plasmodium falciparum or Legionella pneumophila, have raised significant interest from pharmaceutical companies that now focus on inositol lipids other than the products of PI 3-kinases. By expanding our knowledge of phosphoinositides beyond class I PI3K products, this Keystone Symposia meeting represents a unique opportunity to bolster the rising interest in these under-explored avenues with a strong potential for translational impact.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, February 11 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 15 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, February 16 in order to fully experience the meeting.

SUNDAY, FEBRUARY 11

16:00—20:00
Arrival and Registration

Sagebrush Lobby & Cantina
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Sagebrush Lobby & Cantina

MONDAY, FEBRUARY 12

07:00—08:00
Breakfast

Sagebrush Lobby & Cantina
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Emilio Hirsch, Fondazione per la Ricerca Biomedica – ONLUS, Italy

* Tamas Balla, NICHD, National Institutes of Health, USA

Pietro V. De Camilli, Yale University School of Medicine, USA
Phosphoinositide Signaling in the Control of Membrane Dynamics and Interactions

09:00—11:30
Phosphoinositide Gradients and Lipid Transport at Membrane Contact Sites
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Gerry Hammond, University of Pittsburgh, USA

Bruno Antonny, Institut de Pharmacologie Moleculaire et Cellulaire, France
PI4P as an Energy Source for Cholesterol Transfer by OSBP through the Activity of two PI4-Kinases with Contrasting Membrane-Binding Properties

Coffee Break

Tamas Balla, NICHD, National Institutes of Health, USA
The Role of PI4KA in Controlling Membrane Lipid Dynamics

Jen Liou, University of Texas Southwestern Medical Center, USA
The Role of ER-PM Junctions in Phosphoinositide Homeostasis and Ca2+ Signaling

Raghu Padinjat, National Centre for Biological Sciences, India
Short Talk: Tuning of Lipid Transfer Reactions at Membrane Contact Sites in Drosophila Photoreceptors

Jana Humpolickova, Institute of Organic Chemistry and Biochemistry, Czech Republic
Short Talk: Biophysical Determinants of Liposome-Reconstituted Lipid Transport by ORP5/ORP8

11:30—17:00
On Own for Lunch

11:30—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
PI 4-Kinases as Possible Drug Targets
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Antonella De Matteis, Telethon Institute of Genetics and Medicine, Italy

Nihal Altan-Bonnet, NHLBI, National Institutes of Health, USA
Lipid Blueprints for Viral Replication and Transmission

Kasturi Haldar, University of Notre Dame, USA
A Mechanism of Artemisinin Resistance in Plasmodium falciparum Malaria

Cristina Donini, Medicines for Malaria Venture, Switzerland
MMV048, a Plasmodium PI4K Inhibitor as Potential Malarial Treatment

Radim Nencka, IOCB Prague, Czech Republic
Short Talk: Phosphatidylinositol 4-Kinase IIIβ Inhibitors as Potential Therapeutics

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Chamisa Ballroom 2
19:30—22:00
Poster Session 1

Chamisa Ballroom 2

TUESDAY, FEBRUARY 13

07:00—08:00
Breakfast

Sagebrush Lobby & Cantina
08:00—11:15
Inositide Phosphatases in Cancer and Development
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Amy Kiger, University of California, San Diego, USA

Gerry Hammond, University of Pittsburgh, USA
SAC1 Degrades its Lipid Substrate PtdIns4P in the Endoplasmic Reticulum to Maintain a Steep Chemical Gradient with Donor Membranes

Jeremy F. Reiter, University of California, San Francisco, USA
Cilia Have a Distinct Composition of Phosphoinositides and Other Lipids Critical for Signaling

Coffee Break

Christina Anne Mitchell, Monash University, Australia
Identification of Novel Roles for Inositol Polyphosphate 5-Phosphatases

Antonella De Matteis, Telethon Institute of Genetics and Medicine, Italy
The Phosphoinositides and the Golgi Complex

John D. York, Vanderbilt University, USA
Short Talk: Coordinated and Independent Biological Functions of Inositide Phosphatase Activities in Synaptojanins

Leonardo Salmena, University of Toronto, Canada
Short Talk: INPP4B-Associated Leukemic Stem Cell Self-Renewal as a New Target in AML Therapy

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
14:30—16:30
Workshop: New and Emerging Paradigms and Possible Drug Targets

Chamisa Ballroom 1
* Cristina Donini, Medicines for Malaria Venture, Switzerland

Evzen Boura, Institute of Organic Chemistry and Biochemistry, Czech Republic
Hijacking of PI4KB by Picornaviruses – Structural Insights and the Role of ACBD3

Brooke M. Emerling, Sanford Burnham Prebys Medical Discovery Institute, USA
Phosphatidylinositol-5-Phosphate 4-Kinases in the Control of Cellular Lipid Metabolism and Autophagy

Michael P. Sheetz, Mechanobiology Institute, National University of Singapore, Singapore
DNA Damage Causes Rapid Accumulation of Phosphoinositides for ATR Signaling

Carmen Sivakumaren, Harvard University, USA
Targeting the PIP4K2 Lipid Kinase Family in Cancer using Novel Covalent Inhibitors

Yoko Yoshikawa, Kobe University Graduate School of Medicine, Japan
Development of Anti-Cancer and Anti-Inflammatory Drugs Targeting Phospholipase Cε

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:15
Structural Insights into Pharmacological Targeting of Lipid Kinases
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Evzen Boura, Institute of Organic Chemistry and Biochemistry, Czech Republic

John E. Burke, University of Victoria, Canada
Structural Basis of Regulation and Inhibition of Phosphatidylinositol 4-Kinase III Beta (PI4KIIIB)

Ujjini H. Manjunatha, Novartis Institute for Tropical Diseases, USA
Cryptosporidium Lipid Kinase Is a Promising Molecular Target to Treat Cryptosporidiosis

Roger L. Williams, Medical Research Council, UK
Structural Mechanisms of Regulation of the PI3K Superfamily

Chunmei Chang, University of California, Berkeley, USA
Short Talk: Rubicon Inhibits the PI3KC3 Complex II by Blocking a Membrane Docking Site

Raymond Blind, Vanderbilt University School of Medicine, USA
Short Talk: Intrinsic Kinase Auto-Regulation Mediated by Disordered Domains: Crystallographic and Enzyme Kinetic Analyses of the Human Inositol Polyphosphate Multikinase (IPMK)

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Chamisa Ballroom 2
19:30—22:00
Poster Session 2

Chamisa Ballroom 2

WEDNESDAY, FEBRUARY 14

07:00—08:00
Breakfast

Sagebrush Lobby & Cantina
08:00—11:15
Phosphoinositides Directing Trafficking for Degradation
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Volker Haucke, Leibniz Institut für Molekulare Pharmakologie, Germany

Lois S. Weisman, University of Michigan, USA
Multiple Mechanisms Dynamically Regulate the Signaling Lipid PI(3,5)P2

Haoxing Xu, University of Michigan, USA
Lipid Regulation of Lysosomal Ion Channels

Coffee Break

Mariella Vicinanza, Cambridge Institute for Medical Research, UK
PI(5)P Regulates Autophagy

Ankita Jaykumar, University of Texas Southwestern Medical Center, USA
Identifying Novel Functions of WNK1 Pathway in Autophagy

Benoit Bilanges, University College London, UK
Short Talk: Vps34 PI 3-Kinase Inactivation Enhances Insulin Sensitivity through Reprogramming of Mitochondrial Metabolism

Golam Saffi, Ryerson University, Canada
Short Talk: Lysosome Enlargement during PIKfyve Inhibition Occurs through Lysosome Coalescence Instead of Increased Biosynthesis

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:15
Monoinositide Phosphatases
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Lois S. Weisman, University of Michigan, USA

Lewis C. Cantley, Weill Cornell Medicine, USA
Type 2 Phosphatidylinositol-5-Phosphate 4-Kinases in Cancer

Jocelyn Laporte, Institute of Genetics and Molecular and Cellular Biology, France
Myotubularin Phosphoinositides Phosphatases Implication and Targeting in Neuromuscular Diseases

Amy Kiger, University of California, San Diego, USA
Coordination of Class II PI3-Kinase and Mtm PI3-Phosphatase Functions

Elizabeth A. Allen, University of Massachusetts Medical School, USA
Short Talk: Discovery of a Myotubularin-Related Phosphatase in Autophagy

Andrew T. Hale, Vanderbilt University School of Medicine, USA
Short Talk: Coordinated Inositide Lipid-Phosphatase Activities of Synaptojanin Modulate Actin Cytoskeleton Organization

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Chamisa Ballroom 2
19:30—22:00
Poster Session 3

Chamisa Ballroom 2

THURSDAY, FEBRUARY 15

07:00—08:00
Breakfast

Sagebrush Lobby & Cantina
08:00—08:45
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Emilio Hirsch, Fondazione per la Ricerca Biomedica – ONLUS, Italy

Pier Paolo Pandolfi, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Novel Modes of PI3K Signaling Regulation and Deregulation in Disease Pathogenesis

08:45—11:30
Beyond Class I PI 3-Kinases
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Tamas Balla, NICHD, National Institutes of Health, USA

Emilio Hirsch, Fondazione per la Ricerca Biomedica – ONLUS, Italy
Class II PI3K Signaling in Cancer

Coffee Break

James Dowling, Hospital for Sick Children, Canada
3-Phosphoinositide Metabolism in Muscle Development, Muscle Disease and as a Therapeutic Target

Jonathan M. Backer, Albert Einstein College of Medicine, USA
PIK3CB Signaling in Breast Cancer

York Posor, University College London, UK
Short Talk: PI3K-C2α in dsRNA Sensing and Inflammation

Antonija Jurak Begonja, Department of Biotechnology, Croatia
Short Talk: PI3P Modulates Megakaryocyte Maturation and Platelet Production through Late Endosomes/Lysosomes

11:30—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—18:45
PIP Kinases as Emerging Drug Targets
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Pier Paolo Pandolfi, Beth Israel Deaconess Medical Center, Harvard Medical School, USA

Volker Haucke, Leibniz Institut für Molekulare Pharmakologie, Germany
Phosphoinositide Conversion Directs Vesicular Trafficking

Richard A. Anderson, University of Wisconsin Medical School, USA
Agonist-Stimulated PI3,4,5P3 Generation by Scaffolded Phosphoinositide Kinases

Atsuo T. Sasaki, University of Cincinnati, USA
PI5P4Kbeta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Tamas Balla, NICHD, National Institutes of Health, USA

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Chamisa Ballroom 2
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Chamisa Ballroom 2

FRIDAY, FEBRUARY 16

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:






Novartis Institute for Tropical Diseases


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676