Herrenhausen Palace Floorplan

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This meeting took place in 2018



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Pushing the Limits of Healthspan and Longevity (D3)


Organizer(s) Rochelle Buffenstein, Holly Brown-Borg and Colin Selman
April 15—19, 2018
Herrenhausen Palace • Hannover, Germany
Discounted Abstract Deadline: Dec 12, 2017
Abstract Deadline: Jan 10, 2018
Scholarship Deadline: Dec 12, 2017
Discounted Registration Deadline: Feb 13, 2018

Local Co-Organizer: Martin S. Denzel, Max Planck Institute for Biology of Aging.
Organized in collaboration with Volkswagen Foundation

Summary of Meeting:
This conference addresses factors that may contribute to healthier lifestyles and outcomes, thereby delaying the onset of age-associated diseases and extending longevity. The focus is to highlight cutting-edge advances in aging research, novel technologies and potential therapeutic interventions. Included are talks on mechanisms of aging in a wide range of established and non-traditional animal models with the key objective to enhance understanding of the basic biology behind experimental and lifestyle manipulations thought to have direct translational application to human aging. The conference will focus on topics not covered at previous Keystone Symposia meetings on aging biology and will specifically examine both the fundamental mechanisms involved in the aging process as well as interventions and potential therapeutics that may delay aging and the onset of age-associated diseases to forge a deeper understanding of the complex, multifactorial aging process. The discussions of novel interventions and/or therapeutics that appear to slow aging processes will, in turn, guide the field toward facilitating extended periods of good health and prolonging lifespan in humans.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, April 15 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, April 19 with a closing plenary session from 16:00 to 18:00, followed by dinner and entertainment. We recommend return travel on Friday, April 20 in order to fully experience the meeting.

SUNDAY, APRIL 15

16:00—20:00
Arrival and Registration

Grand Mussmann Hotel, Tivoli Room
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Central-Hotel Kaiserhof

MONDAY, APRIL 16

08:30—09:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Auditorium
* Rochelle Buffenstein, Calico Life Sciences LLC, USA

C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA
Controlling Metabolism during Aging, Role of Insulin and Adipose Depots

09:30—12:00
Communicating to Save Thyself: Is a Single Signaling Path the Answer?
Meeting has ended...abstracts no longer viewable online.

Auditorium
* Rochelle Buffenstein, Calico Life Sciences LLC, USA

Holly M. Brown-Borg, University of North Dakota School of Medicine, USA
Growth Hormone Signaling and Longevity

Coffee Break

Dana L. Miller, University of Washington, USA
Fasting Protects against Hypoxia-Induced Protein Aggregation by Inducing Non-Canonical Insulin Signaling

Reinhold G. Erben, University of Veterinary Medicine Vienna, Austria
Role of the Klotho/FGF23 Signaling Axis in Aging

Paul L. Fox, Lerner Research Institute, USA
Short Talk: Glutamyl-Prolyl tRNA Synthetase Is a Critical mTORC1-S6K1 Target Determining Adiposity and Lifespan in Mice

Christopher G. Proud, South Australian Health & Medical Research Institute, Australia
Short Talk: Regulation of the Elongation Phase of Protein Synthesis Enhances Translation Accuracy and Lifespan

12:00—13:00
Lunch

Ballroom
12:30—13:00
Poster Setup

Ballroom
13:00—19:30
Poster Viewing

Ballroom
13:00—15:30
Poster Session 1

Ballroom
15:30—16:00
Coffee Available

Foyer
16:00—18:15
Good Fat, Bad Fat, Brown Fat, White Fat….
Meeting has ended...abstracts no longer viewable online.

Auditorium
* Colin Selman, University of Glasgow, UK

Elisabetta Mueller, New York University, USA
Transcriptional Control of Adipocyte Function in Aging

Barbara Cannon, Stockholm University, Sweden
Environmental Temperature and Longevity

John Speakman, Institute of Genetics and Developmental Biology, CAS, China
Does Dietary Protein Content Leverage Total Food Intake and Hence Drive Obesity?

Susanne Klaus, German Institute of Human Nutrition, Germany
Mitochondrial Uncoupling, Diet, and Aging in Mice

18:15—19:30
Dinner
No registration fees are used to fund alcohol served at this function.

Ballroom

TUESDAY, APRIL 17

08:30—11:45
Trash Removal: Is Enhanced Proteostasis the Way Forward in Aging
Meeting has ended...abstracts no longer viewable online.

Auditorium
* David Gems, University College London, UK

Rochelle Buffenstein, Calico Life Sciences LLC, USA
Extreme Longevity in Naked Mole-Rats Is Associated with Upregulated Proteostasis

Martin S. Denzel, Max Planck Institute for Biology of Aging, Germany
Forward Genetic Approaches Reveal Multi-Layered Regulation of the Hexosamine Pathway that Modulates Protein Quality Control

Coffee Break

Karyn L. Hamilton, Colorado State University, USA
Contribution of Changes in Cell Proliferation to Proteostasis in Long-Lived Models

Louis R. Lapierre, Brown University, USA
A Novel and Druggable Modulator of HLH-30/TFEB, Autophagy and Lifespan

Fabian Finger, University of Cologne, Germany
Short Talk: Food Perception through a Pair of Olfactory Neurons Triggers Rewiring of Organismal Proteostasis

Mario Ost, German Institute of Human Nutrition, Germany
Short Talk: Elevated FGF21 during Aging Is Required to Preserve Hepatic Proteostasis and Metabolic Health

11:45—13:00
Lunch

Ballroom
12:30—13:00
Poster Setup

Ballroom
13:00—19:30
Poster Viewing

Ballroom
13:00—15:30
Poster Session 2

Ballroom
15:30—16:00
Coffee Available

Foyer
16:00—18:00
Powerhouse of the Cell: Manipulating Energy in Aging
Meeting has ended...abstracts no longer viewable online.

Auditorium
* Barbara Cannon, Stockholm University, Sweden

William B. Mair, Harvard School of Public Health, USA
Mitochondrial Dynamics and Healthy Aging

Hazel H. Szeto, Weill Cornell Medical College, USA
Novel Peptides Target Cellular Powerhouses to Delay Aging and Mitigate Age-Related Chronic Conditions

Fernanda Marques da Cunha, Federal University of São Paulo, Brazil
Short Talk: Mitochondrial Effects of Lifespan-Extending Interventions in Caenorhabditis elegans

Jan Nedergaard, Stockholm University, Sweden
Short Talk: Enhanced ROS Production in Mitochondria from Prematurely Aging mtDNA Mutator Mice

18:00—19:30
Dinner
No registration fees are used to fund alcohol served at this function.

Ballroom

WEDNESDAY, APRIL 18

08:30—11:30
Changing What and How We Eat and its Impact upon Healthspan
Meeting has ended...abstracts no longer viewable online.

Auditorium
* Holly M. Brown-Borg, University of North Dakota School of Medicine, USA

Colin Selman, University of Glasgow, UK
The Influence of Genetic Background on the Metabolic Responsiveness to Dietary Restriction in Mice

Matthew Piper, Monash University, Australia
The Role of Amino Acid Balance in Lifespan and Health in Drosophila

Coffee Break

Samantha Marie Biet, University of Sydney, Australia
Extending Healthspan and Lifespan: Insights From Nutritional Geometry

Olga Spadaro, Yale University, USA
Short Talk: Caloric Restriction in Humans Inhibits Inflammation: Insights from CALERIE-II

YongTian Liang, Free University of Berlin & Charité, Germany
Short Talk: Spermidine and Dietary Restriction Converging on Mitochondrial Metabolism in a Model of Cognitive Aging

11:30—13:00
Lunch

Ballroom
12:30—13:00
Poster Setup

Ballroom
13:00—19:30
Poster Viewing

Ballroom
13:00—15:30
Poster Session 3

Ballroom
15:30—16:00
Coffee Available

Foyer
16:00—18:00
Swords, Targets and Cell Death: Combatting Senescence
Meeting has ended...abstracts no longer viewable online.

Auditorium
* Martin S. Denzel, Max Planck Institute for Biology of Aging, Germany

Judith Campisi, Buck Institute for Research on Aging, USA
Cellular Senescence: A Double-Edged Sword

Manlio Vinciguerra, International Clinical Research Center, Czech Republic
Epigenetic Links between Senescence and Cancer Stemness

Nathan K. LeBrasseur, Mayo Clinic, USA
Senolytic Mechanism to Extend Healthspan

Anil Bhushan, University of California, San Francisco, USA
Short Talk: Eliminating Senescent Beta Cells Prevents Type 1 Diabetes

18:00—19:30
Dinner
No registration fees are used to fund alcohol served at this function.

Ballroom

THURSDAY, APRIL 19

08:30—11:45
A View from Above: Aging at the Top of the Food Chain
Meeting has ended...abstracts no longer viewable online.

Auditorium
* Susanne Klaus, German Institute of Human Nutrition, Germany

Riikka Hamalainen, University of Eastern Finland, Finland
Mitochondrial DNA Mutagenesis and Aging

P. Eline Slagboom, Leiden University, Netherlands
Three Generations of Human Top Survivors: What Have We Learned

Coffee Break

Maiken Nedergaard, University of Rochester, USA
The Gymphatic System

Alexander Bürkle, University of Konstanz, Germany
Biomarkers of Human Aging – The EU FP7 MARK-AGE Project and Beyond

Pénélope Andreux, Amazentis, Switzerland
Short Talk: Orally Administered Urolithin A Is Safe and Modulates Muscle and Mitochondrial Biomarkers in Elderly

Ian R. Lanza, Mayo Clinic College of Medicine, USA
Short Talk: Therapeutic Potential of Dietary Omega-3 Fatty Acids in Aging Skeletal Muscle

11:45—13:30
Lunch

Ballroom
13:30—15:30
Workshop

Auditorium
* Karyn L. Hamilton, Colorado State University, USA

David A. Ferenbach, University of Edinburgh, UK
The Impact of a Young Circulation on Renal Injury and Fibrosis in Aged Mice

Zoe E. Gillespie, University of Saskatchewan, Canada
Metformin Treatment and Amino Acid Restriction Induce Progerin Degradation in Hutchinson-Gilford Progeria Syndrome Fibroblasts

Samir Morsli, University of Sheffield, UK
Establishing a Model of Stress-Induced Senescence in Zebrafish Larvae

Teresa G. Valencak, University of Veterinary Medicine, Vienna, Austria
Becoming Obese and Hyperthermic en Miniature in Ames Dwarf Mice (Prop1 df/df)

Reza Esmaillie, University of Cologne, Germany
Dissecting the Role of Hypoxia-Signaling in Extracellular Matrix Formation of the Nematode

Johannes Grillari, BOKU - University of Natural Resources and Applied Life Sciences Vienna, Austria
Extracellular Vesicles and their miRNA Cargo in Aging and Age-Associated Diseases

Irina G. Shabalina, Stockholm University, Sweden
Upregulated Cytochrome b5 May Rescue Normal Androgen Production in Mitochondrial Respiratory Chain Deficient Leydig Cells from Prematurely Aging Mice

Asael Roichman, Bar Ilan University, Israel
SIRT6 Controls Energy Metabolism to Regulate Lifespan and Healthspan

15:30—16:00
Coffee Available

Foyer
16:00—17:45
Drugging Aging - Interventions to Extend Human Health and Lifespan
Meeting has ended...abstracts no longer viewable online.

Auditorium
* Nathan K. LeBrasseur, Mayo Clinic, USA

Andrew Phillips, C4 Therapeutics, USA
Targeted Protein Degradation

David Gems, University College London, UK
What Is an Anti-Aging Drug?

Pedro Beltran, UNITY Biotechnology, USA
Senolytic Drugs: From Mutant Mice to Human Clinical Trials

17:45—18:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Ballroom
18:00—19:30
Dinner
No registration fees are used to fund alcohol served at this function.

Ballroom
19:00—22:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Ballroom

FRIDAY, APRIL 20

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks the Volkswagen Foundation for hosting this meeting:

in Cooperation with Volkswagen Foundation
 

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

Zymo Research Corporation Aging Cell

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676