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This meeting took place in 2018
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Gene Control in Development and Disease (X6)
Organizer(s) Richard A. Young, Joanna Wysocka and Phillip A. Sharp
March 23—27, 2018
Whistler Conference Centre • Whistler, British Columbia Canada
Discounted Abstract Deadline: Nov 28, 2017
Abstract Deadline: Dec 20, 2017
Scholarship Deadline: Nov 28, 2017
Discounted Registration Deadline: Jan 17, 2018
Sponsored by Novartis Institutes for BioMedical Research
Joint Meeting:
Chromatin Architecture and Chromosome Organization (X5)
Summary of Meeting:
Proper control of gene expression is important for all fundamental cellular and organismal processes. With advancements in technology and genetics, researchers are now able to use a combination of genetic, biochemical and computational methods to investigate gene control in healthy cells, as well as to discern what happens when these controls go awry in disease. Learning how gene expression programs are regulated is essential to understanding the control of cell state and its impact on disease development. Multiple levels of gene regulation including basic transcriptional controls, enhancers, epigenetics and the role of phase separation in transcriptional control will be addressed. The goal of this conference is to share new insights into gene control in health and disease and to discuss advances that are being made in disease therapy based on gene control therapeutics.
View Scholarships/Awards
Proper control of gene expression is important for all fundamental cellular and organismal processes. With advancements in technology and genetics, researchers are now able to use a combination of genetic, biochemical and computational methods to investigate gene control in healthy cells, as well as to discern what happens when these controls go awry in disease. Learning how gene expression programs are regulated is essential to understanding the control of cell state and its impact on disease development. Multiple levels of gene regulation including basic transcriptional controls, enhancers, epigenetics and the role of phase separation in transcriptional control will be addressed. The goal of this conference is to share new insights into gene control in health and disease and to discuss advances that are being made in disease therapy based on gene control therapeutics.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Friday, March 23 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Tuesday, March 27 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Wednesday, March 28 in order to fully experience the meeting.
FRIDAY, MARCH 23
SATURDAY, MARCH 24
SUNDAY, MARCH 25
MONDAY, MARCH 26
TUESDAY, MARCH 27
WEDNESDAY, MARCH 28
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Friday, March 23 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Tuesday, March 27 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Wednesday, March 28 in order to fully experience the meeting.
FRIDAY, MARCH 23
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.
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Richard A. Young,
Whitehead Institute for Biomedical Research, USA
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Joanna Wysocka,
Stanford University School of Medicine, USA
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Phillip A. Sharp,
Massachusetts Institute of Technology, USA
Jennifer A. Doudna,
HHMI/University of California, Berkeley, USA
Unexpected Activities of RNA-Guided CRISPR Enzymes
Unexpected Activities of RNA-Guided CRISPR Enzymes
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.
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Edith Heard,
Institut Curie, France
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Peter Fraser,
Florida State University, USA
Job Dekker,
University of Massachusetts Medical School, USA
Folding, Unfolding and Refolding of Genomes
Folding, Unfolding and Refolding of Genomes
09:00—11:30
Basics
Meeting has ended...abstracts no longer viewable online.
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Jennifer A. Doudna,
HHMI/University of California, Berkeley, USA
Patrick Cramer,
Max Planck Institute for Biophysical Chemistry, Germany
Integrated Structural Biology of Gene Transcription
Integrated Structural Biology of Gene Transcription
Coffee Break
Karen Adelman,
Harvard Medical School, USA
Pause Control in Development and Disease
Pause Control in Development and Disease
Xiong Ji,
Peking University, China
Short Talk: RNAPII Elimination Reveals Transcriptional-Dependent Three-Dimensional Chromatin Landscape
Short Talk: RNAPII Elimination Reveals Transcriptional-Dependent Three-Dimensional Chromatin Landscape
Diego Villar Lozano,
University of Cambridge, UK
Short Talk: The Gene Expression Consequences of Mammalian Regulatory Evolution
Short Talk: The Gene Expression Consequences of Mammalian Regulatory Evolution
09:00—11:30
Chromosome Architecture
Meeting has ended...abstracts no longer viewable online.
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Wendy A. Bickmore,
University of Edinburgh, UK
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William Stafford Noble,
University of Washington, USA
Carlo Vermeulen,
Hubrecht Institute, Netherlands
Locus-Specific Enhancer Hubs and Architectural Loop Collisions Uncovered from Single Allele DNA Topologies
Locus-Specific Enhancer Hubs and Architectural Loop Collisions Uncovered from Single Allele DNA Topologies
Coffee Break
Suzana Hadjur,
University College London, UK
Role of Cohesin Complex Diversity in Genome Organization and Cell Fate Determination
Role of Cohesin Complex Diversity in Genome Organization and Cell Fate Determination
Maciej Piotr Zaczek,
Institute of Molecular Pathology, Austria
Short Talk: CTCF Constrains Cohesin Translocation along DNA
Short Talk: CTCF Constrains Cohesin Translocation along DNA
Elphège P. Nora,
Gladstone Institute, USA
Short Talk: Dissecting the Molecular Connection between CTCF and Cohesin
Short Talk: Dissecting the Molecular Connection between CTCF and Cohesin
14:30—16:30
Workshop 1: Transcription and Development
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Karen Adelman,
Harvard Medical School, USA
*
Patrick Cramer,
Max Planck Institute for Biophysical Chemistry, Germany
Richard G. Jenner,
University College London, UK
RNA Antagonizes the Interaction of PRC2 and Other Epigenetic Modifiers with Chromatin
RNA Antagonizes the Interaction of PRC2 and Other Epigenetic Modifiers with Chromatin
Natalia B. Ivanova,
Yale University School of Medicine, USA
Chromatin-Associated Factors Dppa2 and Dppa4 Guide Epigenetic Remodeling during Cellular Reprogramming
Chromatin-Associated Factors Dppa2 and Dppa4 Guide Epigenetic Remodeling during Cellular Reprogramming
Ido Sagi,
Hebrew University of Jerusalem, Israel
Studying Haploidy and Parental Imprinting in Human Pluripotent Stem Cells
Studying Haploidy and Parental Imprinting in Human Pluripotent Stem Cells
Aydan Bulut-Karslioglu,
University of California, San Francisco, USA
Chd1-Mediated Repair of Physiological DNA Breaks Sustains Hypertranscription and Proliferation of ES Cells
Chd1-Mediated Repair of Physiological DNA Breaks Sustains Hypertranscription and Proliferation of ES Cells
Ruben Esse,
Boston University, USA
DOT1L in Enhancer Regulation
DOT1L in Enhancer Regulation
Sudhir Thakurela,
Harvard University, USA
Genetic Determinants and Epigenetic Effects of Pioneer Factor Occupancy during Development
Genetic Determinants and Epigenetic Effects of Pioneer Factor Occupancy during Development
Elodie Emilie Thierion,
University of Cambridge, UK
Gene Regulation Dynamics and Evolution in Somites
Gene Regulation Dynamics and Evolution in Somites
14:30—16:30
Workshop 1: 4DN
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Job Dekker,
University of Massachusetts Medical School, USA
*
Thoru Pederson,
University of Massachusetts Medical School, USA
CRISPR Barcoding Reveals Changes in Interphase Chromosome Conformation and Dynamics in Human Cells
CRISPR Barcoding Reveals Changes in Interphase Chromosome Conformation and Dynamics in Human Cells
Josef Redolfi,
Friedrich Miescher Institute for Biomedical Research, Switzerland
Crosslinking- and Ligation-Free Detection of Chromosomal Interactions using DamID and Physical Modeling
Crosslinking- and Ligation-Free Detection of Chromosomal Interactions using DamID and Physical Modeling
Kerstin Bystricky,
University of Toulouse, France
Chromatin Dynamics in Real Time and at Nanoscale Resolution Reveal Transcription-Dependent Long-Range Correlation
Chromatin Dynamics in Real Time and at Nanoscale Resolution Reveal Transcription-Dependent Long-Range Correlation
Saumya Agrawal,
RIKEN, Yokohama Campus, Japan
Association between Three-Dimensional Localization and Function of Long Noncoding RNAs
Association between Three-Dimensional Localization and Function of Long Noncoding RNAs
Sofia Quinodoz,
California Institute of Technology, USA
Higher-Order Inter-Chromosomal Hubs Shape 3-Dimensional Genome Organization in the Nucleus
Higher-Order Inter-Chromosomal Hubs Shape 3-Dimensional Genome Organization in the Nucleus
Valerio Orlando,
King Abdullah University of Science and Technology, Saudi Arabia
Ago1 in Association with NEAT1 lncRNA Contributes to Nuclear and 3D Chromatin Architecture in Human Cells
Ago1 in Association with NEAT1 lncRNA Contributes to Nuclear and 3D Chromatin Architecture in Human Cells
Alice Sherrard,
University of Bristol, UK
Imaging Chromatin Dynamics Reveals a Novel Mechanism for Nuclear Organization after Cell Division
Imaging Chromatin Dynamics Reveals a Novel Mechanism for Nuclear Organization after Cell Division
Marlies E. Oomen,
University of Massachusetts Medical School, USA
Cell Cycle Dynamics of CTCF Binding and its Relation to Chromosome Organization
Cell Cycle Dynamics of CTCF Binding and its Relation to Chromosome Organization
17:00—19:00
Control Elements (Joint)
Meeting has ended...abstracts no longer viewable online.
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Bing Ren,
Ludwig Institute for Cancer Research, USA
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Mikhail Spivakov,
Babraham Institute, UK
Eileen E.M. Furlong,
European Molecular Biology Laboratory, Germany
Functional Insights into Genome Topology and Enhancer Function during Embryonic Development
Functional Insights into Genome Topology and Enhancer Function during Embryonic Development
Joanna Wysocka,
Stanford University School of Medicine, USA
Enhancers in Development
Enhancers in Development
Rajat Gupta,
Massachusetts General Hospital, USA
Short Talk: A Genetic Variant Associated with Five Vascular Diseases Distally Regulates Gene Expression via Long-Range Enhancer Interactions
Short Talk: A Genetic Variant Associated with Five Vascular Diseases Distally Regulates Gene Expression via Long-Range Enhancer Interactions
Jeff Alexander,
University of California, San Francisco, USA
Short Talk: Live-Cell Imaging Reveals Enhancer-Dependent Sox2 Transcription Is Not Associated with Enhancer Proximity
Short Talk: Live-Cell Imaging Reveals Enhancer-Dependent Sox2 Transcription Is Not Associated with Enhancer Proximity
19:00—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Genome Structure (Joint)
Meeting has ended...abstracts no longer viewable online.
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Suzana Hadjur,
University College London, UK
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Stavros Lomvardas,
Columbia University, USA
Juanma Vaquerizas,
Max Planck Institute for Molecular Biomedicine, Germany
Chromatin Architecture during Early Development
Chromatin Architecture during Early Development
Bing Ren,
Ludwig Institute for Cancer Research, USA
Regulation of Lineage-Specific Chromatin Organization at Enhancers
Regulation of Lineage-Specific Chromatin Organization at Enhancers
Coffee Break
Wendy A. Bickmore,
University of Edinburgh, UK
The Remote Control of Gene Expression
The Remote Control of Gene Expression
Edda G. Schulz,
Max Planck Institute for Molecular Genetics, Germany
Two Coupled Feedback Loops Explain Random Mono-Allelic Xist Upregulation at the Onset of X-Chromosome Inactivation
Two Coupled Feedback Loops Explain Random Mono-Allelic Xist Upregulation at the Onset of X-Chromosome Inactivation
Julie Ahringer,
University of Cambridge, UK
Short Talk: ARC-C for Genome-Wide Analysis of Regulatory Element Interactions at High Resolution
Short Talk: ARC-C for Genome-Wide Analysis of Regulatory Element Interactions at High Resolution
11:00—12:00
Meet the Editors Panel (Joint)
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Edith Heard,
Institut Curie, France
*
Richard A. Young,
Whitehead Institute for Biomedical Research, USA
Sharon Ahmad,
Journal of Cell Science, UK
Marie Bao,
Cell Press, USA
Katherine Brown,
Company of Biologists, UK
Melina Casadio,
Rockefeller University Press, USA
Alex Eccleston,
Nature, UK, UK
Markus Elsner,
Nature Biotechnology, Germany
Sarah Geisler,
Cell, USA
Di Jiang,
PLOS Biology, USA
Carolina Perdigoto,
Nature Communications, UK
Nicole Rusk,
Nature Methods, USA
Rupa Sarkar,
Nature Protocols, UK
Esther Schnapp,
EMBO, Germany
Julie Sollier,
Cell Press, USA
Anke Sparmann,
Nature Structural and Molecular Biology, UK
Ruth Zearfoss,
Cell Press, USA
Eytan Zlotorynski,
Nature Reviews Molecular Cell Biology, UK
17:00—19:00
Epigenetics
Meeting has ended...abstracts no longer viewable online.
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Geeta J. Narlikar,
University of California, San Francisco, USA
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Joseph R. Ecker,
The Salk Institute for Biological Studies, USA
Leonard I. Zon,
HHMI/Boston Children's Hospital, USA
Epigenetic Pathways Regulating Cell Fate
Epigenetic Pathways Regulating Cell Fate
Oliver J. Rando,
University of Massachusetts Medical School, USA
Small RNA Trafficking during Sperm Epididymal Maturation Is Essential for Early Development in Mammals
Small RNA Trafficking during Sperm Epididymal Maturation Is Essential for Early Development in Mammals
Edith Heard,
Institut Curie, France
Developmental Dynamics of X-Chromosome Structure
Developmental Dynamics of X-Chromosome Structure
Zachary Hugh Harvey,
Stanford University, USA
Short Talk: A Prion That Mediates Meiotic Inheritances of Activated Chromatin States
Short Talk: A Prion That Mediates Meiotic Inheritances of Activated Chromatin States
17:00—19:00
Spatio-Temporal Dynamics of Chromatin
Meeting has ended...abstracts no longer viewable online.
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Eileen E.M. Furlong,
European Molecular Biology Laboratory, Germany
*
Juanma Vaquerizas,
Max Planck Institute for Molecular Biomedicine, Germany
Stavros Lomvardas,
Columbia University, USA
Interchromosomal Interactions Regulate Singular Olfactory Receptor Choice
Interchromosomal Interactions Regulate Singular Olfactory Receptor Choice
Amos Tanay,
Weizmann Institute, Israel
Single Cell Approaches in Epigenomics and 3D Chromosome Organization
Single Cell Approaches in Epigenomics and 3D Chromosome Organization
Yong Hoon Kim,
University of Pennsylvania School of Medicine, USA
Short Talk: Rev-erb alpha Dynamically Modulates Chromatin Looping to Control Circadian Gene Transcription
Short Talk: Rev-erb alpha Dynamically Modulates Chromatin Looping to Control Circadian Gene Transcription
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:30
New Models
Meeting has ended...abstracts no longer viewable online.
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Magdalena D. Zernicka-Goetz,
University of Cambridge, UK
*
Yonatan Stelzer,
Weizmann Institute of Science, Israel
Phillip A. Sharp,
Massachusetts Institute of Technology, USA
Phase Separation in Transcription Control
Phase Separation in Transcription Control
Ibrahim Cissé,
Massachusetts Institute of Technology, USA
Super-Resolution Imaging of Transcription in Live Mammalian Cells
Super-Resolution Imaging of Transcription in Live Mammalian Cells
Coffee Break
Geeta J. Narlikar,
University of California, San Francisco, USA
Phase-Separation in Heterochromatin Formation
Phase-Separation in Heterochromatin Formation
Ankur Jain,
University of California, San Francisco, USA
RNA Phase Separation and Neurodegenerative Disease
RNA Phase Separation and Neurodegenerative Disease
Sheila Teves,
University of California, Berkeley, USA
Short Talk: A Stable Mode of Bookmarking by TBP Recruits RNA Polymerase II to Mitotic Chromosomes
Short Talk: A Stable Mode of Bookmarking by TBP Recruits RNA Polymerase II to Mitotic Chromosomes
Mounia Lagha,
Centre National de la Recherche Scientifique, France
Short Talk: Zelda and Transcriptional Memory in Drosophila Embryos
Short Talk: Zelda and Transcriptional Memory in Drosophila Embryos
Yuelin Song,
Massachusetts Institute of Technology, USA
Short Talk: Dynamic DNA Methylation Heterogeneity at Super-Enhancers in Single-Cells
Short Talk: Dynamic DNA Methylation Heterogeneity at Super-Enhancers in Single-Cells
08:00—11:15
Chromatin Architecture, Development and Disease
Meeting has ended...abstracts no longer viewable online.
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Karen L. Reddy,
Johns Hopkins University, USA
*
Leonid Mirny,
Massachusetts Institute of Technology, USA
Jane A. Skok,
New York University School of Medicine, USA
The Mechanisms Underlying the Impact of MMSET Overexpression on Gene Regulation in Multiple Myeloma
The Mechanisms Underlying the Impact of MMSET Overexpression on Gene Regulation in Multiple Myeloma
Ana Pombo,
Max-Delbrück-Centrum für Molekulare Medizin, Germany
Genome Architecture Mapping: Exploring Mechanisms of 3D Chromatin Folding in Rare Cell Types
Genome Architecture Mapping: Exploring Mechanisms of 3D Chromatin Folding in Rare Cell Types
Coffee Break
Mikhail Spivakov,
Babraham Institute, UK
Mapping Genomic Regulatory Architecture and Interpreting Non-coding Variation with Promoter Capture Hi-C
Mapping Genomic Regulatory Architecture and Interpreting Non-coding Variation with Promoter Capture Hi-C
Kevin G. Monahan,
Columbia University, USA
Short Talk: Ldb1 Is Required for the Formation of a Multi-Chromosomal Enhancer Hub that Governs Singular Olfactory Receptor Transcription
Short Talk: Ldb1 Is Required for the Formation of a Multi-Chromosomal Enhancer Hub that Governs Singular Olfactory Receptor Transcription
Alistair Boettiger,
Stanford University, USA
Short Talk: Nanoscale Visualization of cis-Regulation in Development using ORCA
Short Talk: Nanoscale Visualization of cis-Regulation in Development using ORCA
Jean J. Gautier,
Columbia University, College of Physicians and Surgeons, USA
Short Talk: Nuclear Actin Polymerization Drives DNA Double-Strand Break Mobility and Clustering for Homology-Directed Repair
Short Talk: Nuclear Actin Polymerization Drives DNA Double-Strand Break Mobility and Clustering for Homology-Directed Repair
Rani E. George,
Dana-Farber Cancer Institute, USA
Short Talk: The CTCF Paralog BORIS Promotes Novel Chromatin Regulatory Interactions in Cancer Cells
Short Talk: The CTCF Paralog BORIS Promotes Novel Chromatin Regulatory Interactions in Cancer Cells
17:00—19:00
Development
Meeting has ended...abstracts no longer viewable online.
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Natalia B. Ivanova,
Yale University School of Medicine, USA
*
Peter C. Scacheri,
Case Western Reserve University, USA
Eliezer Calo,
Massachusetts Institute of Technology, USA
Tissue-Selective Effects of Nucleolar Stress and rDNA Damage in Developmental Disorders
Tissue-Selective Effects of Nucleolar Stress and rDNA Damage in Developmental Disorders
Magdalena D. Zernicka-Goetz,
University of Cambridge, UK
Building the Mammalian Embryo in vivo and in vitro
Building the Mammalian Embryo in vivo and in vitro
Joseph R. Ecker,
The Salk Institute for Biological Studies, USA
Single Cell Methylomes Reveal Neuronal Populations and Regulatory Elements in the Mammalian Brain
Single Cell Methylomes Reveal Neuronal Populations and Regulatory Elements in the Mammalian Brain
Yonatan Stelzer,
Weizmann Institute of Science, Israel
Short Talk: Parent- and Sex-Specific DNA Methylation Dynamics during Mouse Development
Short Talk: Parent- and Sex-Specific DNA Methylation Dynamics during Mouse Development
17:00—19:00
Integrating Chromatin States and Genome Architecture to Understand Genome Function
Meeting has ended...abstracts no longer viewable online.
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Susan M. Gasser,
Friedrich Miescher Institute for Biomedical Research, Switzerland
*
Giacomo Cavalli,
Institute of Human Genetics, France
John A. Stamatoyannopoulos,
Altius Institute for Biomedical Sciences, USA
Transcriptional Circuitry and Regulatory Landscapes
Transcriptional Circuitry and Regulatory Landscapes
Richard A. Young,
Whitehead Institute for Biomedical Research, USA
Phase Separation and Genome Architecture
Phase Separation and Genome Architecture
William J. Greenleaf,
Stanford University, USA
Understanding the Physical Genome
Understanding the Physical Genome
Jiao Sima,
Florida State University, USA
Short Talk: CRISPR Dissection of a Replication Domain Reveals Discrete Internal cis Elements Regulating Replication Timing and Chromatin Compartment
Short Talk: CRISPR Dissection of a Replication Domain Reveals Discrete Internal cis Elements Regulating Replication Timing and Chromatin Compartment
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Disease
Meeting has ended...abstracts no longer viewable online.
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Richard A. Young,
Whitehead Institute for Biomedical Research, USA
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Cheryl Arrowsmith,
University of Toronto, Canada
Peter C. Scacheri,
Case Western Reserve University, USA
Mechanisms of Aberrant Enhancer Activation in Cancer
Mechanisms of Aberrant Enhancer Activation in Cancer
Manolis Kellis,
Massachusetts Institute of Technology, Broad Institute, USA
Functional Dissection of Disease-Associated Variation
Functional Dissection of Disease-Associated Variation
Coffee Break
Matthias Merkenschlager,
Imperial College London, UK
Cohesin Links Inflammation and Cancer
Cohesin Links Inflammation and Cancer
Chao Lu,
Columbia University, USA
Short Talk: Reprogramming of Chromatin Organization by Cancer-Associated Histone H3 Mutations
Short Talk: Reprogramming of Chromatin Organization by Cancer-Associated Histone H3 Mutations
Michele Gabriele,
University of Milan, European Institute of Oncology, Italy
Short Talk: YY1 Haploinsufficiency Disrupts Histone Acetylation in Gabriele-De Vries Neurodevelopmental Syndrome
Short Talk: YY1 Haploinsufficiency Disrupts Histone Acetylation in Gabriele-De Vries Neurodevelopmental Syndrome
Jesse M. Engreitz,
Broad Institute of Harvard and MIT, USA
Short Talk: Principles of Enhancer Function from Thousands of CRISPR Perturbations
Short Talk: Principles of Enhancer Function from Thousands of CRISPR Perturbations
08:00—11:15
Chromatin Architecture and the Nuclear Positioning
Meeting has ended...abstracts no longer viewable online.
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Ana Pombo,
Max-Delbrück-Centrum für Molekulare Medizin, Germany
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Jane A. Skok,
New York University School of Medicine, USA
Karen L. Reddy,
Johns Hopkins University, USA
The Nuclear Lamina and the Shifting Shape of Epigenomes
The Nuclear Lamina and the Shifting Shape of Epigenomes
Bas van Steensel,
Netherlands Cancer Institute, Netherlands
Mechanisms of Gene Regulation in Lamina-Associated Domains.
Mechanisms of Gene Regulation in Lamina-Associated Domains.
Coffee Break
Susan M. Gasser,
Friedrich Miescher Institute for Biomedical Research, Switzerland
Histone H3K9me Mediates Heterochromatin Sequestration and Stabilizes Repeat Elements with BRCA1
Histone H3K9me Mediates Heterochromatin Sequestration and Stabilizes Repeat Elements with BRCA1
Giacomo Cavalli,
Institute of Human Genetics, France
Polycomb Proteins and 3D Genome Folding in the Epigenetic Regulation of Development
Polycomb Proteins and 3D Genome Folding in the Epigenetic Regulation of Development
Robert Johnston,
Johns Hopkins University, USA
Short Talk: Pairing TADs (PairiTs) Drive Homologous Chromosomes Together to Promote Interchromosomal Gene Regulation
Short Talk: Pairing TADs (PairiTs) Drive Homologous Chromosomes Together to Promote Interchromosomal Gene Regulation
Wei Xie,
Tsinghua University, China
Short Talk: Conservation and Divergence of Chromatin Reprogramming in Early Mammalian Development
Short Talk: Conservation and Divergence of Chromatin Reprogramming in Early Mammalian Development
14:30—16:30
Workshop 2: Disease Connections
*
Ross L. Levine,
Memorial Sloan Kettering Cancer Center, USA
*
Manolis Kellis,
Massachusetts Institute of Technology, Broad Institute, USA
Zuzana Tothova,
Dana-Farber Cancer Institute, USA
STAG2 Mutations Alter Cohesin Ring Structure and Function and Provide Therapeutic Vulnerabilities in Acute Myeloid Leukemia
STAG2 Mutations Alter Cohesin Ring Structure and Function and Provide Therapeutic Vulnerabilities in Acute Myeloid Leukemia
Damien Downes,
University of Oxford, UK
Systematic Dissection of GWAS loci using Chromatin Conformation and NG Sequencing Approaches
Systematic Dissection of GWAS loci using Chromatin Conformation and NG Sequencing Approaches
Elliott C. Ferris,
University of Utah, USA
Convergent Patterns of Accelerated Evolution in Hibernating Mammals May Elucidate New Regulatory Mechanisms Shaping Human Metabolic Disease
Convergent Patterns of Accelerated Evolution in Hibernating Mammals May Elucidate New Regulatory Mechanisms Shaping Human Metabolic Disease
Nicholas C. Gomez,
Rockefeller University, USA
Stem Cell Reprogramming during Oncogenesis and Development
Stem Cell Reprogramming during Oncogenesis and Development
Kai Ge,
NIDDK, National Institutes of Health, USA
Enhancer Epigenomic Regulation in Differentiation, Development and Cancer
Enhancer Epigenomic Regulation in Differentiation, Development and Cancer
Debora R. Sobreira,
University of Chicago, USA
Obesity-Associated Variants within FTO Are Functionally Connected to the Coordinated Expression of IRX3 and IRX5 in Brain and Adipose Tissue
Obesity-Associated Variants within FTO Are Functionally Connected to the Coordinated Expression of IRX3 and IRX5 in Brain and Adipose Tissue
Rajesh C. Rao,
University of Michigan, USA
Wdr5 Acts as a Temporal Rheostat to Control Retinal Neuroectoderm Versus Mesoderm Fate Choice
Wdr5 Acts as a Temporal Rheostat to Control Retinal Neuroectoderm Versus Mesoderm Fate Choice
14:30—16:30
Workshop 2: Modeling and Simulations
*
Geoffrey Fudenberg,
University of California, San Francisco, USA
*
Marc A. Marti-Renom,
CNAG-CRG, Spain
Annaelle Brunet,
University of Oslo, Norway
Lamina-Associated Domains as Tuning Actors Configuring the Mechanical Constraints of the Chromatin Domain at Nuclear Periphery
Lamina-Associated Domains as Tuning Actors Configuring the Mechanical Constraints of the Chromatin Domain at Nuclear Periphery
Nick Gilbert,
University of Edinburgh, UK
Chromatin-Associated RNA Recycling by XRN2 Regulates Transcription and Chromosome Structure
Chromatin-Associated RNA Recycling by XRN2 Regulates Transcription and Chromosome Structure
Kohta Ikegami,
University of Chicago, USA
Phospho-Lamin A Binding at Enhancers Coordinates Nuclear Envelope Breakdown with Mitotic Transcriptional Quiescence
Phospho-Lamin A Binding at Enhancers Coordinates Nuclear Envelope Breakdown with Mitotic Transcriptional Quiescence
Michele Di Pierro,
Rice University, USA
De Novo Prediction of Human Chromosome Structures: Epigenetic Marking Patterns Encode Genome Architecture
De Novo Prediction of Human Chromosome Structures: Epigenetic Marking Patterns Encode Genome Architecture
Jie Liang,
University of Illinois at Chicago, USA
Deep Sampling to Reconstruct Large 3D Ensembles of Chromatin Chains from 2D Heatmaps of Captured Conformations
Deep Sampling to Reconstruct Large 3D Ensembles of Chromatin Chains from 2D Heatmaps of Captured Conformations
17:00—18:45
Therapeutics
Meeting has ended...abstracts no longer viewable online.
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Leonard I. Zon,
HHMI/Boston Children's Hospital, USA
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Zuzana Tothova,
Dana-Farber Cancer Institute, USA
James E. Bradner,
Novartis Institutes for BioMedical Research, USA
Transcription and Drug Discovery
Transcription and Drug Discovery
Cheryl Arrowsmith,
University of Toronto, Canada
Probing the Epigenome using Chemical Biology
Probing the Epigenome using Chemical Biology
Ross L. Levine,
Memorial Sloan Kettering Cancer Center, USA
Mutations in Epigenetic Regulators in the Biology and Therapy of Myeloid Malignancies
Mutations in Epigenetic Regulators in the Biology and Therapy of Myeloid Malignancies
17:00—18:45
Physical Modeling of Chromatin and Chromosomes
Meeting has ended...abstracts no longer viewable online.
*
William J. Greenleaf,
Stanford University, USA
Leonid Mirny,
Massachusetts Institute of Technology, USA
Biophysical Models of Chromatin (re)Organization
Biophysical Models of Chromatin (re)Organization
Marc A. Marti-Renom,
CNAG-CRG, Spain
Structure Determination of Genomes and Genomic Domains by Satisfaction of Spatial Restraints
Structure Determination of Genomes and Genomic Domains by Satisfaction of Spatial Restraints
18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.
18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
We gratefully acknowledge support for this conference from:
Keystone Symposia thanks our Sponsor for generously supporting this meeting:
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We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:
Click here to view more of these organizations
If your organization is interested in joining these entities in support of Keystone
Symposia, please contact: Sarah Lavicka,
Director of Development, Email: sarahl@keystonesymposia.org, Phone:+1 970-262-2690 Click here for more information on Industry Support and Recognition Opportunities. If you are interested in becoming an advertising/marketing in-kind partner, please contact: Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org, Phone:+1 970-262-2676 |