Whistler Conference Centre Floorplan

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This meeting took place in 2018


Here are the related meetings in 2020:
Gene Regulation: From Mechanisms to Disease (J3)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Gene Control in Development and Disease (X6)


Organizer(s) Richard A. Young, Joanna Wysocka and Phillip A. Sharp
March 23—27, 2018
Whistler Conference Centre • Whistler, British Columbia Canada
Discounted Abstract Deadline: Nov 28, 2017
Abstract Deadline: Dec 20, 2017
Scholarship Deadline: Nov 28, 2017
Discounted Registration Deadline: Jan 17, 2018

Sponsored by Novartis Institutes for BioMedical Research


Summary of Meeting:
Proper control of gene expression is important for all fundamental cellular and organismal processes. With advancements in technology and genetics, researchers are now able to use a combination of genetic, biochemical and computational methods to investigate gene control in healthy cells, as well as to discern what happens when these controls go awry in disease. Learning how gene expression programs are regulated is essential to understanding the control of cell state and its impact on disease development. Multiple levels of gene regulation including basic transcriptional controls, enhancers, epigenetics and the role of phase separation in transcriptional control will be addressed. The goal of this conference is to share new insights into gene control in health and disease and to discuss advances that are being made in disease therapy based on gene control therapeutics.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Friday, March 23 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Tuesday, March 27 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Wednesday, March 28 in order to fully experience the meeting.

FRIDAY, MARCH 23

16:00—20:00
Arrival and Registration

Grand Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Grand Foyer

SATURDAY, MARCH 24

07:00—08:00
Breakfast

Sea to Sky A
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B
* Richard A. Young, Whitehead Institute for Biomedical Research, USA

* Joanna Wysocka, Stanford University, USA

* Phillip A. Sharp, Massachusetts Institute of Technology, USA

Jennifer A. Doudna, HHMI/University of California, Berkeley, USA
Unexpected Activities of RNA-Guided CRISPR Enzymes

08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
* Edith Heard, Institut Curie, France

* Peter Fraser, Florida State University, USA

Job Dekker, University of Massachusetts Medical School, USA
Folding, Unfolding and Refolding of Genomes

09:00—11:30
Basics
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B
* Jennifer A. Doudna, HHMI/University of California, Berkeley, USA

Patrick Cramer, Max Planck Institute for Biophysical Chemistry, Germany
Integrated Structural Biology of Gene Transcription

Coffee Break

Karen Adelman, Harvard Medical School, USA
Pause Control in Development and Disease

Ronald M. Evans, HHMI/The Salk Institute, USA
Vitamin D and Dysregulated Transcription

Xiong Ji, Peking University, China
Short Talk: RNAPII Elimination Reveals Transcriptional-Dependent Three-Dimensional Chromatin Landscape

Diego Villar Lozano, University of Cambridge, UK
Short Talk: The Gene Expression Consequences of Mammalian Regulatory Evolution

09:00—11:30
Chromosome Architecture
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
* Wendy A. Bickmore, University of Edinburgh, UK

* William Stafford Noble, University of Washington, USA

Carlo Vermeulen, Hubrecht Institute, Netherlands
Locus-Specific Enhancer Hubs and Architectural Loop Collisions Uncovered from Single Allele DNA Topologies

Coffee Break

Peter Fraser, Florida State University, USA
Chromosome Architecture Dynamics Using Single Cell HiC

Suzana Hadjur, University College London, UK
Role of Cohesin Complex Diversity in Genome Organization and Cell Fate Determination

Maciej Piotr Zaczek, Institute of Molecular Pathology, Austria
Short Talk: CTCF Constrains Cohesin Translocation along DNA

Elphège P. Nora, Gladstone Institute, USA
Short Talk: Dissecting the Molecular Connection between CTCF and Cohesin

11:30—17:00
On Own for Lunch

11:30—13:00
Poster Setup

Sea to Sky A
13:00—22:00
Poster Viewing

Sea to Sky A
14:30—16:30
Workshop 1: Transcription and Development

Sea to Sky B
* Karen Adelman, Harvard Medical School, USA

* Patrick Cramer, Max Planck Institute for Biophysical Chemistry, Germany

Richard G. Jenner, University College London, UK
RNA Antagonizes the Interaction of PRC2 and Other Epigenetic Modifiers with Chromatin

Natalia B. Ivanova, Yale University School of Medicine, USA
Chromatin-Associated Factors Dppa2 and Dppa4 Guide Epigenetic Remodeling during Cellular Reprogramming

Ido Sagi, Hebrew University of Jerusalem, Israel
Studying Haploidy and Parental Imprinting in Human Pluripotent Stem Cells

Aydan Bulut-Karslioglu, University of California, San Francisco, USA
Chd1-Mediated Repair of Physiological DNA Breaks Sustains Hypertranscription and Proliferation of ES Cells

Ruben Esse, Boston University, USA
DOT1L in Enhancer Regulation

Sudhir Thakurela, Harvard University, USA
Genetic Determinants and Epigenetic Effects of Pioneer Factor Occupancy during Development

Elodie Emilie Thierion, University of Cambridge, UK
Gene Regulation Dynamics and Evolution in Somites

14:30—16:30
Workshop 1: 4DN

Sea to Sky C
* Job Dekker, University of Massachusetts Medical School, USA

* Thoru Pederson, University of Massachusetts Medical School, USA
CRISPR Barcoding Reveals Changes in Interphase Chromosome Conformation and Dynamics in Human Cells

Josef Redolfi, Friedrich Miescher Institute for Biomedical Research, Switzerland
Crosslinking- and Ligation-Free Detection of Chromosomal Interactions using DamID and Physical Modeling

Kerstin Bystricky, University of Toulouse, France
Chromatin Dynamics in Real Time and at Nanoscale Resolution Reveal Transcription-Dependent Long-Range Correlation

Saumya Agrawal, RIKEN, Yokohama Campus, Japan
Association between Three-Dimensional Localization and Function of Long Noncoding RNAs

Sofia Quinodoz, California Institute of Technology, USA
Higher-Order Inter-Chromosomal Hubs Shape 3-Dimensional Genome Organization in the Nucleus

Valerio Orlando, King Abdullah University of Science and Technology, Saudi Arabia
Ago1 in Association with NEAT1 lncRNA Contributes to Nuclear and 3D Chromatin Architecture in Human Cells

Alice Sherrard, University of Bristol, UK
Imaging Chromatin Dynamics Reveals a Novel Mechanism for Nuclear Organization after Cell Division

Marlies E. Oomen, University of Massachusetts Medical School, USA
Cell Cycle Dynamics of CTCF Binding and its Relation to Chromosome Organization

16:30—17:00
Coffee Available

Grand Foyer
17:00—19:00
Control Elements (Joint)
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B/C
* Bing Ren, Ludwig Institute for Cancer Research, USA

* Mikhail Spivakov, Babraham Institute, UK

Eileen E.M. Furlong, European Molecular Biology Laboratory, Germany
Functional Insights into Genome Topology and Enhancer Function during Embryonic Development

Joanna Wysocka, Stanford University, USA
Enhancers in Development

Rajat Gupta, Massachusetts General Hospital, USA
Short Talk: A Genetic Variant Associated with Five Vascular Diseases Distally Regulates Gene Expression via Long-Range Enhancer Interactions

Jeff Alexander, University of California, San Francisco, USA
Short Talk: Live-Cell Imaging Reveals Enhancer-Dependent Sox2 Transcription Is Not Associated with Enhancer Proximity

19:00—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sea to Sky A
19:30—22:00
Poster Session 1

Sea to Sky A

SUNDAY, MARCH 25

07:00—08:00
Breakfast

Sea to Sky A
08:00—11:00
Genome Structure (Joint)
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B/C
* Suzana Hadjur, University College London, UK

* Stavros Lomvardas, Columbia University, USA

Juanma Vaquerizas, Max Planck Institute for Molecular Biomedicine, Germany
Chromatin Architecture during Early Development

Bing Ren, Ludwig Institute for Cancer Research, USA
Regulation of Lineage-Specific Chromatin Organization at Enhancers

Coffee Break

Wendy A. Bickmore, University of Edinburgh, UK
The Remote Control of Gene Expression

Edda G. Schulz, Max Planck Institute for Molecular Genetics, Germany
Two Coupled Feedback Loops Explain Random Mono-Allelic Xist Upregulation at the Onset of X-Chromosome Inactivation

Julie Ahringer, University of Cambridge, UK
Short Talk: ARC-C for Genome-Wide Analysis of Regulatory Element Interactions at High Resolution

11:00—12:00
Meet the Editors Panel (Joint)

Sea to Sky A
* Edith Heard, Institut Curie, France

* Richard A. Young, Whitehead Institute for Biomedical Research, USA

Sharon Ahmad, Journal of Cell Science, UK

Marie Bao, Cell Press, USA

Katherine Brown, Company of Biologists, UK

Melina Casadio, Rockefeller University Press, USA

Alex Eccleston, Nature, UK, UK

Markus Elsner, Nature Biotechnology, Germany

Tiago Faial, Nature Genetics, USA

Sarah Geisler, Cell, USA

Di Jiang, PLOS Biology, USA

Steve Mao, Science, AAAS, USA

Carolina Perdigoto, Nature Communications, UK

Nicole Rusk, Nature Methods, USA

Rupa Sarkar, Lancet Digital Health, UK

Esther Schnapp, European Molecular Biology Organization, Germany

Julie Sollier, Cell Press, USA

Anke Sparmann, Nature Structural and Molecular Biology, UK

Ruth Zearfoss, Cell Press, USA

Eytan Zlotorynski, Nature Reviews Molecular Cell Biology, UK

11:00—17:00
On Own for Lunch

11:00—13:00
Poster Setup

Sea to Sky A
13:00—22:00
Poster Viewing

Sea to Sky A
16:30—17:00
Coffee Available

Grand Foyer
17:00—19:00
Epigenetics
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B
* Geeta J. Narlikar, University of California, San Francisco, USA

* Joseph R. Ecker, The Salk Institute for Biological Studies, USA

Leonard I. Zon, HHMI/Boston Children's Hospital, USA
Epigenetic Pathways Regulating Cell Fate

Oliver J. Rando, University of Massachusetts Medical School, USA
Small RNA Trafficking during Sperm Epididymal Maturation Is Essential for Early Development in Mammals

Edith Heard, Institut Curie, France
Developmental Dynamics of X-Chromosome Structure

Zachary Hugh Harvey, Stanford University, USA
Short Talk: A Prion That Mediates Meiotic Inheritances of Activated Chromatin States

17:00—19:00
Spatio-Temporal Dynamics of Chromatin
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
* Eileen E.M. Furlong, European Molecular Biology Laboratory, Germany

* Juanma Vaquerizas, Max Planck Institute for Molecular Biomedicine, Germany

Stavros Lomvardas, Columbia University, USA
Interchromosomal Interactions Regulate Singular Olfactory Receptor Choice

Victor G. Corces, Emory University, USA
Mechanisms of Transgenerational Inheritance

Amos Tanay, Weizmann Institute, Israel
Single Cell Approaches in Epigenomics and 3D Chromosome Organization

Yong Hoon Kim, University of Pennsylvania School of Medicine, USA
Short Talk: Rev-erb alpha Dynamically Modulates Chromatin Looping to Control Circadian Gene Transcription

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sea to Sky A
19:30—22:00
Poster Session 2

Sea to Sky A

MONDAY, MARCH 26

07:00—08:00
Breakfast

Sea to Sky A
08:00—11:30
New Models
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B
* Magdalena D. Zernicka-Goetz, University of Cambridge, UK

* Yonatan Stelzer, Weizmann Institute of Science, Israel

Phillip A. Sharp, Massachusetts Institute of Technology, USA
Phase Separation in Transcription Control

Ibrahim Cissé, Massachusetts Institute of Technology, USA
Super-Resolution Imaging of Transcription in Live Mammalian Cells

Coffee Break

Geeta J. Narlikar, University of California, San Francisco, USA
Phase-Separation in Heterochromatin Formation

Ankur Jain, University of California, San Francisco, USA
RNA Phase Separation and Neurodegenerative Disease

Sheila Teves, University of California, Berkeley, USA
Short Talk: A Stable Mode of Bookmarking by TBP Recruits RNA Polymerase II to Mitotic Chromosomes

Mounia Lagha, Centre National de la Recherche Scientifique, France
Short Talk: Zelda and Transcriptional Memory in Drosophila Embryos

Yuelin Song, Massachusetts Institute of Technology, USA
Short Talk: Dynamic DNA Methylation Heterogeneity at Super-Enhancers in Single-Cells

08:00—11:15
Chromatin Architecture, Development and Disease
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
* Karen L. Reddy, Johns Hopkins University, USA

* Leonid Mirny, Massachusetts Institute of Technology, USA

Jane A. Skok, New York University School of Medicine, USA
The Mechanisms Underlying the Impact of MMSET Overexpression on Gene Regulation in Multiple Myeloma

Ana Pombo, Max-Delbrück-Centrum für Molekulare Medizin, Germany
Genome Architecture Mapping: Exploring Mechanisms of 3D Chromatin Folding in Rare Cell Types

Coffee Break

Mikhail Spivakov, Babraham Institute, UK
Mapping Genomic Regulatory Architecture and Interpreting Non-coding Variation with Promoter Capture Hi-C

Kevin G. Monahan, Columbia University, USA
Short Talk: Ldb1 Is Required for the Formation of a Multi-Chromosomal Enhancer Hub that Governs Singular Olfactory Receptor Transcription

Alistair Boettiger, Stanford University, USA
Short Talk: Nanoscale Visualization of cis-Regulation in Development using ORCA

Jean J. Gautier, Columbia University, College of Physicians and Surgeons, USA
Short Talk: Nuclear Actin Polymerization Drives DNA Double-Strand Break Mobility and Clustering for Homology-Directed Repair

Rani E. George, Dana-Farber Cancer Institute, USA
Short Talk: The CTCF Paralog BORIS Promotes Novel Chromatin Regulatory Interactions in Cancer Cells

11:30—17:00
On Own for Lunch

11:30—13:00
Poster Setup

Sea to Sky A
13:00—22:00
Poster Viewing

Sea to Sky A
16:30—17:00
Coffee Available

Grand Foyer
17:00—19:00
Development
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B
* Natalia B. Ivanova, Yale University School of Medicine, USA

* Peter C. Scacheri, Case Western Reserve University, USA

Eliezer Calo, Massachusetts Institute of Technology, USA
Tissue-Selective Effects of Nucleolar Stress and rDNA Damage in Developmental Disorders

Magdalena D. Zernicka-Goetz, University of Cambridge, UK
Building the Mammalian Embryo in vivo and in vitro

Joseph R. Ecker, The Salk Institute for Biological Studies, USA
Single Cell Methylomes Reveal Neuronal Populations and Regulatory Elements in the Mammalian Brain

Yonatan Stelzer, Weizmann Institute of Science, Israel
Short Talk: Parent- and Sex-Specific DNA Methylation Dynamics during Mouse Development

17:00—19:00
Integrating Chromatin States and Genome Architecture to Understand Genome Function
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
* Susan M. Gasser, Friedrich Miescher Institute for Biomedical Research, Switzerland

* Giacomo Cavalli, Institute of Human Genetics, France

John A. Stamatoyannopoulos, Altius Institute for Biomedical Sciences, USA
Transcriptional Circuitry and Regulatory Landscapes

Richard A. Young, Whitehead Institute for Biomedical Research, USA
Phase Separation and Genome Architecture

William J. Greenleaf, Stanford University, USA
Understanding the Physical Genome

Jiao Sima, Florida State University, USA
Short Talk: CRISPR Dissection of a Replication Domain Reveals Discrete Internal cis Elements Regulating Replication Timing and Chromatin Compartment

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sea to Sky A
19:30—22:00
Poster Session 3

Sea to Sky A

TUESDAY, MARCH 27

07:00—08:00
Breakfast

Sea to Sky A
07:30—08:00
Poster Setup

Sea to Sky A
08:00—17:00
Poster Viewing

Sea to Sky A
08:00—11:00
Disease
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B
* Richard A. Young, Whitehead Institute for Biomedical Research, USA

* Cheryl Arrowsmith, University of Toronto, Canada

Peter C. Scacheri, Case Western Reserve University, USA
Mechanisms of Aberrant Enhancer Activation in Cancer

Manolis Kellis, Massachusetts Institute of Technology, Broad Institute, USA
Functional Dissection of Disease-Associated Variation

Coffee Break

Matthias Merkenschlager, Imperial College London, UK
Cohesin Links Inflammation and Cancer

Chao Lu, Columbia University, USA
Short Talk: Reprogramming of Chromatin Organization by Cancer-Associated Histone H3 Mutations

Michele Gabriele, University of Milan, European Institute of Oncology, Italy
Short Talk: YY1 Haploinsufficiency Disrupts Histone Acetylation in Gabriele-De Vries Neurodevelopmental Syndrome

Jesse M. Engreitz, Harvard University and Broad Institute, USA
Short Talk: Principles of Enhancer Function from Thousands of CRISPR Perturbations

08:00—11:15
Chromatin Architecture and the Nuclear Positioning
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
* Ana Pombo, Max-Delbrück-Centrum für Molekulare Medizin, Germany

* Jane A. Skok, New York University School of Medicine, USA

Karen L. Reddy, Johns Hopkins University, USA
The Nuclear Lamina and the Shifting Shape of Epigenomes

Bas van Steensel, Netherlands Cancer Institute, Netherlands
Mechanisms of Gene Regulation in Lamina-Associated Domains.

Coffee Break

Susan M. Gasser, Friedrich Miescher Institute for Biomedical Research, Switzerland
Histone H3K9me Mediates Heterochromatin Sequestration and Stabilizes Repeat Elements with BRCA1

Giacomo Cavalli, Institute of Human Genetics, France
Polycomb Proteins and 3D Genome Folding in the Epigenetic Regulation of Development

Robert Johnston, Johns Hopkins University, USA
Short Talk: Pairing TADs (PairiTs) Drive Homologous Chromosomes Together to Promote Interchromosomal Gene Regulation

Wei Xie, Tsinghua University, China
Short Talk: Conservation and Divergence of Chromatin Reprogramming in Early Mammalian Development

11:00—12:00
Lunch

Sea to Sky A
12:00—14:30
Poster Session 4

Sea to Sky A
14:30—16:30
Workshop 2: Disease Connections

Sea to Sky B
* Ross L. Levine, Memorial Sloan Kettering Cancer Center, USA

* Manolis Kellis, Massachusetts Institute of Technology, Broad Institute, USA

Zuzana Tothova, Dana-Farber Cancer Institute, USA
STAG2 Mutations Alter Cohesin Ring Structure and Function and Provide Therapeutic Vulnerabilities in Acute Myeloid Leukemia

Damien Downes, University of Oxford, UK
Systematic Dissection of GWAS loci using Chromatin Conformation and NG Sequencing Approaches

Elliott C. Ferris, University of Utah, USA
Convergent Patterns of Accelerated Evolution in Hibernating Mammals May Elucidate New Regulatory Mechanisms Shaping Human Metabolic Disease

Nicholas C. Gomez, Rockefeller University, USA
Stem Cell Reprogramming during Oncogenesis and Development

Kai Ge, NIDDK, National Institutes of Health, USA
Enhancer Epigenomic Regulation in Differentiation, Development and Cancer

Debora R. Sobreira, University of Chicago, USA
Obesity-Associated Variants within FTO Are Functionally Connected to the Coordinated Expression of IRX3 and IRX5 in Brain and Adipose Tissue

Rajesh C. Rao, University of Michigan, USA
Wdr5 Acts as a Temporal Rheostat to Control Retinal Neuroectoderm Versus Mesoderm Fate Choice

14:30—16:30
Workshop 2: Modeling and Simulations

Sea to Sky C
* Geoffrey Fudenberg, University of California, San Francisco, USA

* Marc A. Marti-Renom, CNAG-CRG, Spain

Kristin Abramo, University of Massachusetts Medical School, USA
Building an Interphase Nucleus

Annaelle Brunet, University of Oslo, Norway
Lamina-Associated Domains as Tuning Actors Configuring the Mechanical Constraints of the Chromatin Domain at Nuclear Periphery

Nick Gilbert, University of Edinburgh, UK
Chromatin-Associated RNA Recycling by XRN2 Regulates Transcription and Chromosome Structure

Kohta Ikegami, University of Chicago, USA
Phospho-Lamin A Binding at Enhancers Coordinates Nuclear Envelope Breakdown with Mitotic Transcriptional Quiescence

Michele Di Pierro, Rice University, USA
De Novo Prediction of Human Chromosome Structures: Epigenetic Marking Patterns Encode Genome Architecture

Jie Liang, University of Illinois at Chicago, USA
Deep Sampling to Reconstruct Large 3D Ensembles of Chromatin Chains from 2D Heatmaps of Captured Conformations

16:30—17:00
Coffee Available

Grand Foyer
17:00—18:45
Therapeutics
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B
* Leonard I. Zon, HHMI/Boston Children's Hospital, USA

* Zuzana Tothova, Dana-Farber Cancer Institute, USA

James E. Bradner, Novartis Institutes for BioMedical Research, USA
Transcription and Drug Discovery

Cheryl Arrowsmith, University of Toronto, Canada
Probing the Epigenome using Chemical Biology

Ross L. Levine, Memorial Sloan Kettering Cancer Center, USA
Mutations in Epigenetic Regulators in the Biology and Therapy of Myeloid Malignancies

17:00—18:45
Physical Modeling of Chromatin and Chromosomes
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
* William J. Greenleaf, Stanford University, USA

William Stafford Noble, University of Washington, USA
Modeling the 3D Architecture of the Genome

Leonid Mirny, Massachusetts Institute of Technology, USA
Biophysical Models of Chromatin (re)Organization

Marc A. Marti-Renom, CNAG-CRG, Spain
Structure Determination of Genomes and Genomic Domains by Satisfaction of Spatial Restraints

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B
18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sea to Sky A
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Sea to Sky A

WEDNESDAY, MARCH 28

 
Departure


*Session Chair †Invited, not yet responded.


We gratefully acknowledge support for this conference from:


Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Novartis Institutes for BioMedical Research

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