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This meeting took place in 2019



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Unraveling the Secrets of Kidney Disease (X4)


Organizer(s) Katalin Susztak, Caroline Fox and Masaomi Nangaku
March 3—7, 2019
Whistler Conference Centre • Whistler, British Columbia Canada
Discounted Abstract Deadline: Nov 19, 2018
Abstract Deadline: Dec 19, 2018
Scholarship Deadline: Nov 19, 2018
Discounted Registration Deadline: Jan 11, 2019

Sponsored by Akebia Therapeutics, Bayer AG and Vertex Pharmaceuticals Incorporated


Summary of Meeting:
Approximately one in 11 people in the world suffers from kidney disease. The incidence of kidney disease is increasing, especially in the developing world. This issue was recently reviewed and emphasized in a Lancet article (Global Health Atlas). Acute and chronic kidney disease is associated with a highly significant increase in cardiovascular death. Chronic kidney disease (CKD) represents a leading cause of death in the United States. There is no cure for this disease, with current treatment strategies relying on blood pressure control through blockade of the renin-angiotensin system. Such approaches only delay the development of end-stage kidney disease and can be associated with serious side effects. Recent identification of several novel mechanisms contributing to CKD development - including vascular changes, loss of podocytes and renal epithelial cells, matrix deposition, inflammation and metabolic dysregulation - has revealed new potential therapeutic approaches for CKD. This conference will review clinical and observational studies in the kidney disease area, highlight recent advances in basic biology of kidney and kidney disease, assess emerging strategies and agents for CKD treatment, and discuss major obstacles in drug development. The conference will also encourage collaborations among clinicians and researchers from academic institutes and pharmaceutical laboratories to accelerate innovation in this field. There has not been a conference in the area in kidney disease that brings together clinicians, basic scientists and industry to foster collaboration. Small focused conferences have been organized by the International Society of Nephrology, but these conferences are limited to a single special topic. Furthermore, more than half of kidney disease is caused by diabetes; pairing the conference with a conference focused on diabetes affords the opportunity to understand the role of diabetes in the development of kidney complications.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, March 3 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 7 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, March 8 in order to fully experience the meeting.

SUNDAY, MARCH 3

16:00—20:00
Arrival and Registration

Grand Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Grand Foyer

MONDAY, MARCH 4

07:00—08:00
Breakfast

Grand Foyer
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
* Masaomi Nangaku, University of Tokyo School of Medicine, Japan

* Katalin Susztak, University of Pennsylvania, USA

Caroline S. Fox, Merck Research Labs, USA
Using Genetics to Drive Drug Discovery: The Industry Perspective

09:00—12:00
Why Podocytes Are So Important in Kidney Disease?
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
* Hermann Haller, Hannover Medical School, Germany

* Reiko Inagi, University of Tokyo School of Medicine, Japan

Friedhelm Hildebrandt, Boston Children’s Hospital, Harvard Medical School, USA
Monogenic Causes of Podocyte Loss Reveal Targets for Personalized Treatment

Coffee Break

John Cijiang He, Icahn School of Medicine at Mount Sinai, USA
Potential New Therapies by Targeting on Podocyte Injury

Stuart J. Shankland, University of Washington, USA
Understanding Podocyte Regeneration

Kyung Lee, Icahn School of Medicine at Mount Sinai, USA
Short Talk: BAMBI Protects against Podocyte and Endothelial Cell Injury in Diabetic Kidneys through Two Distinct TGF-β Signaling Pathways

Markus M. Rinschen, The Scripps Research Institute, USA
Short Talk: Phenotype-Guided Ultrasensitive Proteomics for Discovery of Conserved Injury Mechanisms in Podocytes and Nephrocytes

Shizheng Huang, University of Pennsylvania, USA
Short Talk: Allele-Specific Expression Studies Identify Tubule Epithelial DACH1 as a Kidney Disease Gene

Fernanda V Duraes, Novartis Institute for Biomecial Research, Switzerland
Short Talk: The Role of Tissue-Resident Immune Cells in Kidney Injury and Fibrosis Development

08:00—10:30
State of the Union for Diabetes Care anno 2019: What Should We Expect from a Stellar Novel Diabetes Drug?
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B
* Philip J. Larsen, Grünenthal Group, Germany

Tina Vilsbøll, Steno Diabetes Center Copenhagen, Denmark
How to Demonstrate Medical Value for Diabetes Drugs Fast and Convincingly

Brian Finan, Novo Nordisk, USA
Mechanisms of GIP Induced Augmentation of GLP-1 Pharmacology

Coffee Break

Niels Porksen, Sanofi, France
Insulin Therapy: A Corner Stone of Diabetes Therapy, But is There Still Room for Innovation

George L. King, Joslin Diabetes Center, USA
Identification of Protective Factors against Nephropathy and Retinopathy in People with Diabetes of Extreme Duration

10:30—11:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B
Mark I. McCarthy, University of Oxford, UK
Now We Have 400+ Signals for Type 2 Diabetes Risk, What on Earth Are We Going to Do with Them?

12:00—17:00
On Own for Lunch

12:00—13:00
Poster Setup

Sea to Sky A
13:00—22:00
Poster Viewing

Sea to Sky A
14:30—15:30
Workshop

Sea to Sky B
* Philip J. Larsen, Grünenthal Group, Germany

Rami Al Batran, University of Alberta, Canada
Skeletal Muscle Ketone Body Oxidation as a Novel Target for Improving Obesity-Induced Dysglycemia in Mice

Simone C. da Silva Rosa, University of Manitoba, Canada
Therapeutic Targeting of Skeletal Muscle Nix in Early-Onset Insulin Resistance

Keshav Gopal, University of Alberta, Canada
The Antianginal Ranolazine Mitigates Obesity-Induced Non-Alcoholic Fatty Liver Disease and Increases Hepatic Pyruvate Dehydrogenase Activity

Johnna D. Wesley, Novo Nordisk Research Center Seattle, Inc., USA
Multicistronic Plasmid Immunotherapy for the Prevention of T1D

15:30—16:30
Panel Discussion

Sea to Sky B
* Philip J. Larsen, Grünenthal Group, Germany

Niels Porksen, Sanofi, France

Craig Hammond, Eli Lilly and Company, USA

Brian Finan, Novo Nordisk, USA

16:30—17:00
Coffee Available

Grand Foyer
17:00—19:15
Harnessing the Immune System for Kidney Protection
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
* Stuart A. Cook, Duke-NUS Graduate Medical School Singapore, Enleofen, Singapore

* Laura Denby, University of Edinburgh, UK

Ali Gharavi, Columbia University Medical Center, USA
Genetic and Immunological Studies of IgA Nephropathy

Martin Pollak, Beth Israel Deaconess Medical Center, USA
Mechanisms of APOL1-Associated Kidney Disease

David J. Salant, Boston University School of Medicine, USA
Membranous Nephropathy and PLA2R

Mark Douglas Okusa, University of Virginia, USA
Neural Control of Inflammation in AKI

Archana Raman, University of Pennsylvania, USA
Short Talk: APOL1 Risk Variant-Induced Kidney Injury in Mice Podocytes Is Caused by Inflammasome-Mediated Pyroptotic Cell Death

17:00—19:00
Diabetes and Its Many Phenotypes
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B
* Leif C. Groop, Lund University, Sweden

Tai E. Shyong, National University of Singapore, Singapore
Ethnically Determined Diabetes Variants (Asian Diabetes)

Keld Fosgerau, Gubra, Denmark
Short Talk: Stereological Quantification and Whole-Kidney 3D Imaging for Assessment of Key Pathological Features in a Uni-Nephrectomised db/db Mouse Model of Diabetic Nephropathy

Simon N. Dankel, University of Bergen, Norway
Short Talk: Integrative Genomics Links Homeobox Transcription Factors to Risk of Visceral Adiposity

Joji Kusuyama, Joslin Diabetes Center, USA
Short Talk: Identification of a Novel Placenta-Derived Protein that Mediates the Beneficial Effects of Maternal Exercise on Offspring Liver

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sea to Sky A
19:30—22:00
Poster Session 1

Sea to Sky A

TUESDAY, MARCH 5

07:00—08:00
Breakfast

Grand Foyer
08:00—09:00
Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B/C
* Tina Vilsbøll, Steno Diabetes Center Copenhagen, Denmark

Leif C. Groop, Lund University, Sweden
A Novel Reclassification of Type 2 Diabetes – Steps Toward Precision Medicine

09:00—11:15
Genetics and Epigenetics of Diabetes and Complications (Joint)
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B/C
* Gregory Dressler, University of Michigan, USA

Jose C. Florez, Massachusetts General Hospital, USA
Genetics of Diabetic Kidney Disease

Coffee Break

Melina Claussnitzer, Beth Israel Deaconess Medical Center, USA
Type 2 Diabetes and its Comorbidities: The Journey from GWAS to Disease Mechanism

Katalin Susztak, University of Pennsylvania, USA
Post-GWAS Annotation of Kidney Disease Risk Loci using eQTL and Single Cell Analysis

Shreeram Akilesh, University of Washington, USA
Short Talk: Integrated Genomic Analysis Enables Functional Annotation of Kidney GWAS Loci

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Sea to Sky A
13:00—22:00
Poster Viewing

Sea to Sky A
16:30—17:00
Coffee Available

Grand Foyer
17:00—19:00
Understanding Tubule Injury and Function
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
* Alexander Staruschenko, Medical College of Wisconsin, USA

* Hyug Moo Kwon, Ulsan National Institute of Science and Technology, South Korea

Masaomi Nangaku, University of Tokyo School of Medicine, Japan
The Role of Hypoxia and HIF in Tubule Injury

Matthias Kretzler, University of Michigan, USA
Progression Pathways in CKD: Toward Molecular Targeting of Renal Disease

Eugene Park Rhee, Massachusetts General Hospital, USA
Revisiting Kidney Function through Unbiased Profiling

Verónica Miguel, Centro de Biologia Molecular Severo Ochoa, Spain
Short Talk: Cpt1a-Mediated Enhancement of Fatty Acid Oxidation in the Renal Tubule Mitigates Kidney Fibrosis

Gregory Dressler, University of Michigan, USA
Short Talk: Fine Tuning TGF-ß Superfamily Signaling with Genetics or Small Molecules to Attenuate Kidney and Liver Fibrosis

17:00—19:00
Deciphering Cellular Function of Target Tissues of Relevance for Diabetes
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B
* Maike Sander, University of California, San Diego, USA

Marcelo Nobrega, University of Chicago, USA
Experimental Dissection of the Cellular and Organismal Effects of T2D Genes

Kenichiro Furuyama, University of Geneva, Switzerland
Conversion of Human non-β-Cells into Insulin Producers

James C. Lo, Weill Cornell Medicine, USA
Short Talk: Adipsin Preserves Beta Cells in Diabetic Mice and Associates with Protection from Type 2 Diabetes in Humans

José Rivera-Feliciano, Harvard University, USA
Short Talk: A Novel Insulin-Independent Glucose Lowering Activity

Nasa Sinnott-Armstrong, Stanford University and The Broad Institute of MIT and Harvard, USA
Short Talk: A Regulatory Variant at 3q21.1 Confers Pleiotropic Risk for High Bone Mineral Density and Hyperglycaemia

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sea to Sky A
19:30—22:00
Poster Session 2

Sea to Sky A

WEDNESDAY, MARCH 6

07:00—08:00
Breakfast

Grand Foyer
08:00—12:00
Mechanism and Treatment of Complications of Diabetes (Joint)
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B/C
* George L. King, Joslin Diabetes Center, USA

* Julia Scialla, Duke University, USA

Susan Quaggin, Northwestern University, USA
The Role of Endothelial Cell Injury in Diabetic Kidney Disease

Farhad Danesh, University of Texas MD Anderson Cancer Center, USA
Podocyte and Mitochondrial Dysfunction in Diabetes

Coffee Break

Hiddo Lambers Heerspink, University Medical Center Groningen, Netherlands
SGLT-2 Inhibitors and the Kidney: Extending from Diabetic to Non-Diabetic Kidneys

Donald Kohan, University of Utah Health Center, USA
Endothelin Receptors Antagonists in DKD: SONAR and Beyond

Joshua Thurman, University of Colorado, USA
Therapeutic Targeting the Complement Cascade in Kidney Disease

James Varani, University of Michigan, USA
Short Talk: CCN3-Based Peptide Inhibits Liver Injury in a Diabetic Mouse Model

Tony Wang, Kunming Biomed International, China
Short Talk: Development and Characterization of High Fat Diet-induced Non-Human Primate Models of Diabetes and Metabolic Complications of Kidney, Cardiovascular, Liver and Eye Disease

Parker C. Wilson, Washington University in St. Louis, USA
Short Talk: The Single Cell Transcriptomic Landscape of Early Human Diabetic Nephropathy

Hongbo Liu, University of Pennsylvania, USA
Short Talk: Functional Methylome Analysis of Human Diabetic Kidney Disease

12:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Grand Foyer
17:00—19:00
Novel Pathways and Targets for Kidney Disease
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
Katalin Susztak, University of Pennsylvania, USA

Samir M. Parikh, Beth Israel Deaconess Medical Center, USA
Kidney Mitochondria, NAD and Saving Kidneys

Janos Peti-Peterdi, University of Southern California, USA
New Role of Macula Densa Cells in Glomerular Remodeling

Pinelopi P. Kapitsinou, University of Kansas, USA
Short Talk: Inhibition of Endothelial PHD2 Protects Against Ischemic Kidney Injury through HIF-1 Dependent Suppression of Post-Ischemic Inflammation

Mark E. Cooper, Monash University, Australia
Short Talk: Lipoxin A4 Protects against Diabetic Nephropathy in Part by Attenuating the NLRP3 Inflammasome

Hiroshi Maekawa, University of Tokyo, Japan
Short Talk: Mitochondrial DNA Leakage Causes Inflammation via the cGAS-STING Axis in Cisplatin-Mediated Tubular Damage

17:00—19:00
Omics Stuff and Profiling
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B
* Samantha Laber, Broad Institute of MIT and Harvard, USA

Christopher B. Newgard, Duke University Medical Center, USA
Multi-Omics Strategies for Defining Cardiometabolic Disease Mechanisms and Therapeutic Targets

Hindrik Mulder, Lund University, Sweden
Omics Analyses of Human Islets Demonstrate Mitochondrial Dysfunction in Type 2 Diabetes

Martin Heni, Eberhard Karls University Tübingen, Germany
Insulin Sensitivity: More than Glycemic Control

Stephan Sachs, Helmholtz Zentrum München, Germany
Short Talk: Single Cell RNA Sequencing Deciphers Mechanisms of β-Cell Failure and Regeneration after Drug Treatment

Ken Suzuki, University of Tokyo, Japan
Short Talk: Identification of 28 New Susceptibility loci for Type 2 Diabetes in the Japanese Population

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sea to Sky A

THURSDAY, MARCH 7

07:00—08:00
Breakfast

Grand Foyer
08:00—11:00
Organoids and Single Cell Approaches
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
* Gerd Walz, University Freiburg Medical Center, Germany

* Jurgen Heymann, National Institutes of Health, USA

Jonathan Himmelfarb, University of Washington, USA
A Kidney on a Chip for Drug Development

Benjamin D. Humphreys, Washington University, USA
Modeling Kidney Development and Repair with Organoids and scRNA-Seq

Coffee Break

Jochen Reiser, Rush University, USA
suPAR – Immunological Risk Factor for Kidney Diseases

Sho Hasegawa, University of Tokyo, Japan
Short Talk: Whole-Kidney Three-Dimensional Analysis (CUBIC-kidney) Reveals Abnormal Renal Sympathetic Nerves After Ischemia-Reperfusion Injury

Matthew Ishahak, University of Miami, USA
Short Talk: Engineering a Physiomimetic Glomerulus-on-Chip to Model Diabetic Kidney Disease

Ian M. Rogers, University of Toronto, Canada
Short Talk: Manufacturing a Kidney from Stem Cells and Decellularized Kidney Matrix

08:00—11:00
Epigenomics of T2D
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B
* Patrick Guye, InSphero AG, Switzerland

Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA
Epigenomic Regulation of Metabolism

Maike Sander, University of California, San Diego, USA
Epigenetic Mechanisms of Beta Cell Functional Adaption

Coffee Break

Evan D. Rosen, Harvard University, USA
Novel Thermoregulatory Mechanisms Exposed by Single Cell Analysis of Adipose Tissue

Regine Aasen Jersin, University of Bergen, Norway
Short Talk: Inhibition of the Serine Transporter SLC7A10 Limits Antioxidant Capacity and Promotes Lipid Storage in Adipocytes

Debora R. Sobreira, University of Chicago, USA
Short Talk: Diabetes-Associated Variants in the FTO Locus: Dissecting the Complex Landscape of GWAS

11:00—17:00
On Own for Lunch

14:30—16:30
Workshop

Sea to Sky C
* Pinelopi P. Kapitsinou, University of Kansas, USA

* Catherine Godson, University College Dublin, Ireland

Daria Ilatovskaya, Medical University of South Carolina, USA
Detecting Mitochondria ROS in Podocytes of Freshly Isolated Glomeruli during Salt-Sensitive Hypertension

Krisztian Stadler, Pennington Biomedical, USA
Chronic Kidney Disease in a New Mouse Model of Mitochondrial Overload

Tsuyoshi Inoue, University of Tokyo, Japan
Non-Canonical Cholinergic Anti-Inflammatory Pathway-Mediated Activation of Peritoneal Macrophages Induces Hes1 and Blocks Ischemia/Reperfusion Injury in the Kidney

Hiroshi Nishi, University of Tokyo, Japan
Neutrophil Interferon-Induced, Double-Stranded RNA-Activated Protein Kinase (EIF2AK2) Promotes Vascular Adhesion and Transmigration in Non-Viral Inflammatory Disease

Jay C. Jha, Monash University, Australia
The Relative Roles of Pro-Oxidant Enzymes Nox4/Nox5 in Diabetic Kidney Disease

Francesca Oltrabella, Genentech, Inc., USA
Designing a Whole Genome CRISPR KO Pooled Screen to Identify Factors that Facilitate APOL1 Variant-Induced Cytotoxicity

Joseph M. Rutkowski, Texas A&M College of Medicine, USA
Increased Renal Lymphatic Density Improves Inflammation following AKI

16:30—17:00
Coffee Available

Grand Foyer
17:00—19:15
Novel Approaches for Drug Discovery
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
* Santiago Lamas, Centro de Biología Molecular, Spain

Alan R. Shuldiner, Regeneron Pharmaceuticals, Inc, USA
Drug Discovery 2.0, the Use of Human Knock-Outs and Other Genetic Experiments of Nature

Carine Boustany, Boehringer Ingelheim, USA
Novel Strategies to Treat Diabetic Kidney Disease

Alex Bell, Ionis Pharmaceuticals, USA
RNA Therapeutics for Kidney Disease

Stephanie Cherqui, University of California, San Diego, USA
Stem Cell and Gene Therapy for Cystinosis

Thomas Soare, Goldfinch Bio, USA
Short Talk: Comparative Transcriptomic Analysis of Cultured Podocytes and Human Kidney Organoids at Single Cell-Resolution

17:00—18:45
Metabolic Surgery
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B
* Brian Finan, Novo Nordisk, USA

Lee M. Kaplan, Massachusetts General Hospital, USA
Variability of Response and Prediction of Outcome

Filip K. Knop, Gentofte Hospital, University of Copenhagen, Denmark
A Gut Feeling About Glucagon

Philip J. Larsen, Grünenthal Group, Germany
Can We Translate Bariatric Surgery into Equi-Efficacious Pharmacotherapy

Berit Svendsen, Duke University, USA
Short Talk: GIP Receptor Blocking Improves Body Composition and Glucose Tolerance in Mice

19:00—19:15
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sea to Sky A
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Sea to Sky A

FRIDAY, MARCH 8

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Akebia Therapeutics Bayer AG
Vertex Pharmaceuticals Incorporated
 

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13DK120137-01

Funding for this conference was made possible (in part) by 1R13DK120137-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Boehringer Ingelheim Pharmaceuticals, Inc.


Regeneron Genetics Center, LLC


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676