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This meeting took place in 2019


Here are the related meetings in 2020:
Tissue Immunity (A6)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Innate Immune Receptors: Roles in Immunology and Beyond (M1)


Organizer(s) Jenny P.Y. Ting, Shie-Liang Edmond Hsieh, Fu-Tong Liu, Michael Gale, Jr. and Siamon Gordon
March 10—14, 2019
Humanities/Social Sciences Building of Academia Sinica • Taipei, Taiwan
Discounted Abstract Deadline: Nov 27, 2018
Abstract Deadline: Dec 11, 2018
Scholarship Deadline: Nov 27, 2018
Discounted Registration Deadline: Jan 17, 2019

Developed in collaboration with Academia Sinica

Sponsored by BioLegend, Inc. and Genentech, Inc.

Summary of Meeting:
Innate immune receptors include a plethora of membrane-associated proteins as well as intracellular receptors that directly bind or sense the presence of pathogen-associated molecular patterns (PAMPs). The importance of innate immune receptors was first appreciated in infectious diseases and autoinflammatory disorders, but it is now clear that their roles extend beyond innate immunology. The crucial roles of these receptors in many clinically relevant fields, and their newly documented role in non-immune cells, underscore their importance in biologic processes and diseases. This conference will address the ligands and signaling mechanisms of a diverse set of innate immune receptors as well as the profound impacts of innate immune receptors on the microbiome, which in turn has impacts on multiple organ systems. The program includes discussion of the intrinsic functions of innate immune receptors within adaptive immune cells, non-immune cells such as epithelial and endothelial cells, and their roles in cancer and stem cells. The pleitrophic effects of this important receptor class have far-reaching consequences for critical biological processes such as cancer cell death and signaling, DNA damage, stress response, stem cell proliferation/differentiation, vaccine adjuvanticity, age-related dementia, metabolic disorders and microbiome balance. By the nature of the topic, this conference brings together an interdisciplinary group of investigators to catalyze cross-fertilization of ideas and stimulate important medical advances.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, March 10 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 14 with a closing plenary session from 16:00 to 18:30, followed by a social hour and entertainment. We recommend return travel on Friday, March 15 in order to fully experience the meeting.

SUNDAY, MARCH 10

16:00—20:00
Arrival and Registration

Courtyard Marriott
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

The Lounge, Courtyard Marriott

MONDAY, MARCH 11

09:00—09:50
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

International Conference Hall
* Siamon Gordon, Chang Gung University / University of Oxford, UK

Vishva M. Dixit, Genentech, Inc., USA
Interplay Between Regulators of Apoptosis and Necroptosis

09:50—12:30
Innate Immune Receptors and Nucleic Acid Sensing
Meeting has ended...abstracts no longer viewable online.

International Conference Hall
* Michael S. Diamond, Washington University School of Medicine, USA

Michael Gale, Jr., University of Washington, USA
Programming Immunity against Virus Infection

Coffee Break

Zhijian "James" Chen, University of Texas Southwestern Medical Center, USA
DNA Sensing by cGAS: Chemistry, Biology and Application

Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA
Nucleic Acid Sensing and Immune Regulation

Sun Hur, Harvard Medical School, USA
RNA Sensing: Structure and Disease Relevance

Layal Liverpool, University of Oxford, UK
Short Talk: Z-Nucleic Acids in Virus-Host Interactions

10:30—12:30
Poster Setup

South Wing
12:30—13:30
Lunch

Back Corridor
12:45—15:00
Poster Session 1

South Wing
15:00—17:00
Workshop 1: Innate Immune Receptors: Regulation and Infection

International Conference Hall
* Ming-Daw Tsai, Academia Sinica, Taiwan

* Amal Amer, Ohio State University, USA

Baptiste Guey, École Polytechnique Fédérale de Lausanne, Switzerland
Chromatin Mechanics Regulate cGAS Activity against Self-DNA

Cynthia Korin Bullen, Johns Hopkins School of Medicine, USA
Mycobacterium tuberculosis Engages the MDA5 RNA Sensing Pathway to Subvert Innate Immune Responses and Facilitate its Survival within Macrophages

Szu-Ting Chen, National Yang Ming University, Taiwan
NLRP12 Regulates TRIM25 Activation and Ubiquitination of RIG-I

Yi-Shan Chien, National Taiwan University, Taiwan
A Novel DEAD Box RNA Helicase Negatively Regulates NLRP3 Inflammasome Activation

Rei-Lin Kuo, Chang Gung University, Taiwan
Regulation of RIG-I-Initiated IFN-beta Transcription by the N Terminus-Truncated NS1 Protein of Influenza A Virus

MH Tsai, National Taiwan University, Taiwan
STAT3 Cooperates with Phospholipid Scramblase 2 to Suppress Type I Interferon-Induced Antiviral and Inflammatory Response

Bin Wu, Nanyang Technological University, Singapore
Structural Basis of RIP2 Activation and Signaling

Na Dong, China Agricultural University, China
The N-end Rule E3 Ligase UBR2 Mediates NLRP1B Inflammasome Activation by Anthrax Lethal Toxin

17:00—17:30
Coffee Available

Foyer
17:30—19:30
Innate Immune Receptors in Cell Death
Meeting has ended...abstracts no longer viewable online.

International Conference Hall
* Michael Gale, Jr., University of Washington, USA

Feng Shao, National Institute of Biological Sciences, China
Innate Sensing of Cytosolic LPS: Pyroptosis and Beyond

Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA
Molecular Targets for the Treatment of Inflammatory and Infectious Diseases

Edward A. Miao, University of North Carolina at Chapel Hill, USA
Infectious Models Reveal a Unique Role for Caspase-7 after Cytotoxic Lymphocyte Attack

Jye-Lin Hsu, China Medical University, Taiwan
Short Talk: Glutathione Peroxidase 8 Negatively Regulates Caspase-4/11 to Protect against Colitis by Restraining NLRP3-Inflammasome Activation

Jia Yao, Emory University, USA
Short Talk: p38MAPK Senses the Integrity of Endosomal Compartments through Regulating Necrotic Death

19:30
On Own for Dinner


TUESDAY, MARCH 12

09:00—12:00
Innate Immune Receptors and Diseases
Meeting has ended...abstracts no longer viewable online.

International Conference Hall
* Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA

Shizuo Akira, Osaka University, Japan
The Control of Inflammatory and Immune Responses by the Endoribonuclease Regnase-1

Amal Amer, Ohio State University, USA
The Role of Caspase-11 in Sickness and in Health

Coffee Break

Fu-Tong Liu, Academia Sinica, Taiwan
Galectins and Innate Immunity

Carla V. Rothlin, Yale University, USA
TAM Receptors and the Regulation of Macrophage Polarization

Shu-Hsia Chen, Methodist Research Institute, USA
Short Talk: Blocking Immunoinhibitory Receptor Reprograms Tumor-Associated Myeloid Cells and Promotes Antitumor Immunity

Pei-Yu Wu, Academica Sinica, Taiwan
Short Talk: TIFA-NF-κB Axis Skews Inflammatory Microenvironment to Confer Sorafenib-Resistant Niche for Recurrence of Hepatocellular Carcinoma

Victor R. DeFilippis, Oregon Health & Science University, USA
Short Talk: A Novel Small Molecule Inducer of cGAS Activity Exhibits Multiple Therapeutically Useful Effects

10:30—12:30
Poster Setup

South Wing
12:00—13:00
Lunch

Back Corridor
12:45—15:00
Poster Session 2

South Wing
15:00—17:00
Workshop 2: Innate Immune Receptors: Inflammation, Vaccines and Therapeutics

International Conference Hall
* Wan Wan Lin, National Taiwan University, Taiwan

* Shu-Hsia Chen, Methodist Research Institute, USA

Fu Hsin, National Taiwan University, Taiwan
Hepatic Suppression of STING-Mediated Type I Interferon Induction by Hepsin

Eunju Lee, Yonsei University, South Korea
Role of Microglial NLRP3 Inflammasome in the Dopaminergic Neurodegeneration of Parkinson's Disease

Subhash Mehto, Institute of Life Sciences, India
IRGM Limits NLRP3 Inflammasome Activation by Impeding its Assembly and by Mediating its Selective Autophagy

Hsi-Hsien Lin, Chang Gung University, Taiwan
The Role of Macrophage Adhesion-GPCR EMR2/ADGRE2 in the Activation of NLRP3 Inflammasome

Jia Tong Loh, Bioprocessing Technology Institute, Singapore
Dok3 Recruits PP1 to Attenuate Card9 Signaling in Neutrophils during Host Innate Anti-Fungal Immunity

Kuan-Ting Liu, Chang Gung University, Taiwan
Role of Gender on Disease Severity of Enterovirus A 71 Infection

Suktika Chandra, Institute of Molecular Biology, Taiwan
Deciphering the Innate Immune Response that Differentially Restricts Vaccinia Virus Having Different Entry Pathways

Amy Elizabeth Mawdesley, Newcastle University, UK
Preventing Cobalt-Chromium Wear Particle Mediated TLR4 Activation and Subsequent Inflammatory Response

17:00—17:30
Coffee Available

Foyer
17:30—19:30
Innate Immunity and Therapeutics
Meeting has ended...abstracts no longer viewable online.

International Conference Hall
* Fu-Tong Liu, Academia Sinica, Taiwan

Robert L. Coffman, Dynavax Technologies, USA
Harnessing Innate Immunity for Cancer Immunotherapy

Mihai G. Netea, Radboud University, Netherlands
Metabolic and Epigenetic Reprogramming in Trained Immunity

Glen N. Barber, University of Miami, USA
STING Signaling in Infectious Disease, Inflammation and Cancer

Wan Wan Lin, National Taiwan University, Taiwan
Short Talk: Purinergic P2X7 in Inflammation: Regulation of Mitochondrial Dynamics and Lysosomal Biogenesis in Macrophages

Marcin T. Kortylewski, Beckman Research Institute, City of Hope, USA
Short Talk: Targeted Delivery of CpG-miR-146a Mimic Oligonucleotides to Reduce NF-κB-driven Pathogenic Inflammation and Myeloid Leukemia Progression

19:30
On Own for Dinner
No registration fees are used to fund alcohol served at this function.


WEDNESDAY, MARCH 13

09:00—12:00
Innate Immune Receptors in Viral Infection
Meeting has ended...abstracts no longer viewable online.

International Conference Hall
* Glen N. Barber, University of Miami, USA

Michael S. Diamond, Washington University School of Medicine, USA
The Protective Role of Interferon-λ in the Placenta and Female Reproductive Tract during Zika Virus Infection

Hao Wu, Harvard Medical School, Boston Children's Hospital, USA
Structures and Functions of GSDM Pores

Coffee Break

Shie-Liang Hsieh, Academia Sinica, Taiwan
Lectins are Potential Therapeutic Targets in Acute and Chronic Viral Infections

Gabriel Nuñez, University of Michigan, USA
Linking NOD2, the Microbiota and Inflammatory Intestinal Disease

Chih-Peng Chang, National Cheng Kung University, Taiwan
Short Talk: Integrin-Linked Kinase Supports Dengue Viral Infection by Antagonizing Interferon Signaling

Melissa Stunnenberg, Amsterdam University Medical Centers, Netherlands
Short Talk: RNA Sensor DDX3 Is a Potent Inducer of Antiviral Type I Interferon and Adaptive Immunity

Donghai Wang, Duke University Medical Center, USA
Short Talk: Control of Antiviral Innate Immune Response by Protein Geranylgeranylation

10:30—13:00
Poster Setup

South Wing
12:00—12:30
Box Lunches

Foyer
12:30—13:30
Meet the Editors

1st Conference Room
Gaia Trincucci, Journal of Experimental Medicine, USA

Zoltan Fehervari, Nature Publishing Group, UK

Bruce D. Koppelman, Cell Press, USA

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Innate Immunity in Bacterial and Fungal Infection
Meeting has ended...abstracts no longer viewable online.

International Conference Hall
* Shie-Liang Hsieh, Academia Sinica, Taiwan

Betty A. Wu-Hsieh, National Taiwan University, Taiwan
Innate Immune Receptors in Antifungal Responses

Alan Sher, NIAID, National Institutes of Health, USA
A Role for Ferroptosis in Pathogen Induced Cell Death and Tissue Necrosis

Robert L. Modlin, University of California, Los Angeles, USA
Antimicrobial T Cells Combat Mycobacterial Infection

Ernest Y. Lee, University of California, Los Angeles, USA
Short Talk: Host Defense Peptides Amplify TLR9-Mediated Inflammation in Autoimmune Diseases by Scaffolding dsDNA into Spatially-Periodic Nanocrystals

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

South Wing
19:45—22:00
Poster Session 3

South Wing

THURSDAY, MARCH 14

09:00—12:00
Innate Immunity and Diseases
Meeting has ended...abstracts no longer viewable online.

International Conference Hall
Douglas Golenbock, University of Massachusetts Medical School, USA
Innate Immune Memory in Falciparum Malaria

Cheng-Lun Ku, Chang Gung University, Taiwan
Dissect the Molecular Property of Anti-Interferon-γ Autoantibodies in Patients with Mycobacterial Infection

Coffee Break

Gregory M. Barton, University of California, Berkeley, USA
TLR

* Raphaela Theresia Goldbach-Mansky, NIAID, National Institutes of Health, USA
Genetic Basis of Autoinflammatory Diseases

Theresa Li-Yun Chang, Rutgers, New Jersey Medical School, USA
Short Talk: Human IFNε and IFNa Modulate Immune and Anti-HIV Functions through the Differential Involvement of IFNa Receptors

Guangxun Meng, Institut Pasteur, China
Short Talk: Gasdermin D Drives the Non-Exosomal Secretion of Insulin Signal Antagonist Galectin-3

Kim S. Robinson, ASTAR, Singapore
Short Talk: ASC Exists in a “Hyper-Alert” State in Psoriatic Lesional Skin which Drives and Amplifies IL-1 Psoriatic Inflammation

12:00—13:30
Lunch

Back Corridor
13:30—15:30
Workshop 3: Innate Immune Receptors: Role in Diseases and the Microbiome

International Conference Hall
* Betty A. Wu-Hsieh, National Taiwan University, Taiwan

* Carla V. Rothlin, Yale University, USA

Brendan J. Jenkins, Hudson Institute of Medical Research, Australia
Uncovering the Pro-Tumourigenic Role of Innate Immune DNA Sensors in Cancer

Miyu Moriyama, University of Tokyo, Japan
Recognition of Influenza A Virus by DNA Sensors

Meihong Deng, University of Pittsburgh, USA
TLR9 Signaling in Fibroblastic Reticular Cells Controls Peritoneal Immunity in Sepsis

Amanda Gavin, The Scripps Research Institute, USA
PLD3 and PLD4 Are ssDNA Exonucleases that Are Required to Prevent Lethal Primary HLH-Like Disease in Mice

Miao-Hsi Hsieh, National Cheng Kung University, Taiwan
Surfactant Protein D Alleviate Ozone and Cigarette-Induced Lung Inflammation and Emphysema in Murine Model of COPD

Bo Liu, University of California, Berkeley, USA
Unc93b1 Recruits Syntenin-1 to Dampen TLR7 Signaling and Prevent Autoimmunity

Hiroyuki Oshiumi, Kumamoto University, Japan
Circulating miR-451 within Exosomes Regulates Toll-Like Receptor-Mediated Innate Immune Responses

Hai Huang, Ohio State University, USA
Caspase-11 Dependent-Pyroptosis Exacerbates Sterile Liver Inflammation

15:30—16:00
Coffee Available

Foyer
16:00—18:00
Innate Immune Receptors and the Microbiome
Meeting has ended...abstracts no longer viewable online.

International Conference Hall
* Alan Sher, NIAID, National Institutes of Health, USA

Cathryn R. Nagler, University of Chicago, USA
Microbiome and Food Allergy

Yang-Xin Fu, University of Texas Southwestern Medical Center, USA
Tumor Targeting Antibodies to Improve Innate and Adaptive Immunity

Seth L. Masters, Walter and Eliza Hall Institute, Australia
Innate Immune Activation in ALS

Ya-Jen Chang, Academia Sinica, Taiwan
Short Talk: The Microbial Metabolite Butyrate Regulates Type 2 Innate Lymphoid Cell-Dependent Airway Hyperreactivity

Jr-Wen Shui, Academia Sinica, Taiwan
Short Talk: Dual Function of ATF3 in Intestinal Epithelial and Th17 Cells in Maintaining Mucosal Immunity

18:00—18:30
Meeting Wrap-Up: Outcomes and Future Directions
Meeting has ended...abstracts no longer viewable online.

International Conference Hall
* Siamon Gordon, Chang Gung University / University of Oxford, UK

18:30—19:30
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Back Corridor
19:30—22:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Back Corridor

FRIDAY, MARCH 15

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Academia Sinica BioLegend, Inc.
Genentech, Inc.
 

We gratefully acknowledge additional support from these exhibitors at this conference:

BD Biosciences Fluidigm
InvivoGen
 
Please stop by to meet these exhibitors during the conference.


We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI142987-01

Funding for this conference was made possible (in part) by 1R13AI142987-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

AdipoGen Life Sciences China Medical University
Chinese Society of Immunology eLife
Ministry of Science and Technology National Cheng Kung University College of Medicine
National Health Research Institutes National Taiwan University College of Medicine
National Yang-Ming University Taiwan Rheumatology Association
Tekon Scientific Corporation The Bureau of Foreign Trade, MOEA

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Dynavax Technologies Corporation


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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If you are interested in becoming an advertising/marketing in-kind partner, please contact:
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Phone:+1 970-262-1179