Granlibakken Tahoe Floorplan

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This meeting took place in 2019


Here are the related meetings in 2020:
New Discoveries in the Immunobiology of Asthma: Implications for Therapy (D1)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Origins of Allergic Disease: Microbial, Epithelial and Immune Interactions (M3)


Organizer(s) Marsha Wills-Karp, Donald Y.M. Leung and Kari Nadeau
March 24—27, 2019
Granlibakken Tahoe • Tahoe City, California USA
Discounted Abstract Deadline: Dec 4, 2018
Abstract Deadline: Dec 13, 2018
Scholarship Deadline: Dec 4, 2018
Discounted Registration Deadline: Jan 23, 2019

Supported by the Directors' Fund

Summary of Meeting:
Allergic diseases have been on the rise globally in recent decades. Although it has long been known that IgE-mediated immune responses are associated with the manifestations of a wide spectrum of allergic disorders (asthma, atopic dermatitis, atopic rhinitis, food allergy, eosinophilic esophagitis), the exact factors leading to these aberrant immune responses are not well understood. Recent insights into disease origins support a broader realm of factors that may predispose, initiate or exacerbate altered immunity in allergic diseases such as inherent epithelial barrier dysfunction, loss of immune tolerance at central and specific sites, disturbances in gut and organ specific microbiomes, diet and age. However, these studies are in their infancy and have only been considered in a reductionist, disease or tissue-specific manner to date. Few studies have addressed the cross-talk between various organs leading to the concept of allergy as a system disease. A better understanding of the distinct or shared complex web of factors underlying the spectrum of allergic disorders and the successes/failures of the current armature of therapies may lead to the development of safer, disease-modifying interventions in the future. Thus the major goal of this meeting is to explore the potential microbial-epithelial-immune interactions underlying the etiology of allergic disorders in order to promote the development of novel disease prevention or intervention strategies.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, March 24 with registration from 16:00 to 20:00 and a welcome mixer and light meal from 18:00 to 20:00. Conference events conclude on Wednesday, March 27 with a closing plenary session from 17:00 to 19:00, followed by dinner and entertainment. We recommend return travel on Thursday, March 28 in order to fully experience the meeting.

SUNDAY, MARCH 24

16:00—20:00
Arrival and Registration

Pre Function
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Granhall
18:00—20:00
Light Meal - Provided by Granlibakken

Granhall

MONDAY, MARCH 25

07:00—08:00
Breakfast

Granhall
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Marsha Wills-Karp, Johns Hopkins Bloomberg School of Public Health, USA

Cezmi A. Akdis, Swiss Institute of Allergy and Asthma Research, Switzerland
Origins of Allergic Disease: Microbial, Epithelial and Immune Interactions

09:00—11:30
Allergic Disease Phenotypes
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Donald Y.M. Leung, National Jewish Health, USA

Kari Nadeau, Stanford University, USA
Is There a Scientific Basis for Allergy as a “Systems Disease”?

Coffee Break

Sally Wenzel-Morganroth, University of Pittsburgh, USA
A Wounded Epithelium in the Cross Hairs of Asthma Pathogenesis

Hugh A. Sampson, Icahn School of Medicine at Mount Sinai, USA
Phenotypes and Endotypes of Food Allergy

Henry T. Bahnson, Benaroya Research Institute, USA
Short Talk: Longitudinal Trajectories of Eczema Severity, Duration, and Affected Body-Region Predict Risk of Food Allergy: An Integrated Analysis of Multiple Cohorts of Infants with Varying Risk Factors for Food Allergy

Jehan Alladina, Massachusetts General Hospital, USA
Short Talk: Airway Dendritic Cells Distinguish Allergic Asthmatics from Allergic Controls

11:30—17:00
On Own for Lunch

11:30—13:00
Poster Setup

Bay
13:00—22:00
Poster Viewing

Bay
14:30—16:30
Workshop 1: Novel Approaches to Defining Epithelial-Microbial Interactions in Allergy

Mountain/Lake
* Marc E. Rothenberg, Cincinnati Children's Hospital Medical Center, USA

* Gideon Lack, King's College London, UK

Derek Croote, Stanford University, USA
Allergen-Specific Human Monoclonal IgE and IgG4 Antibodies Discovered through Single-Cell RNA Sequencing

Marie-Claire Arrieta, University of Calgary, Canada
Early-Life Fungal Colonization Impacts the Gut Bacterial Microbiome and Elicits Host Immune Changes Related to Atopy

Veronika Kucharova Pettersen, University of Calgary, Canada
Unraveling the Functional Role of Gastrointestinal Mycobiota in Asthma Development by High-Throughput Proteomics

Katie Emma Block, University of Minnesota, USA
Normalizing Microbial Exposure Blunts Innate and Adaptive Responses to Airway Allergens

Darin L. Wiesner, University of Wisconsin-Madison, USA
A Calcium Signaling Circuit in Club Cells Initiates Allergic Response to Protease Allergen

Angela Haczku, University of California, Davis, USA
The Airway Epithelial Immune Modulator Surfactant Protein-D (SP-D) Regulates Innate Lymphoid Cell (ILC) Phenotype at Baseline and during Ozone-Induced Inflammation

Mark Rochman, Cincinnati Children's Hospital Medical Center, USA
Transcriptional and Epigenetic Signature of IL-13 Response in Esophageal Epithelial Cells

Renee W.Y. Chan, Chinese University of Hong Kong, Hong Kong
Differentiated Human Nasopharyngeal Organoids and Air-Liquid Interface Culture of Nasopharyngeal Epithelial Cells Are Susceptible Models to Study Human Rhinovirus C Infection

16:30—17:00
Coffee Available

Pre Function
17:00—19:00
Immunological Mechanisms of Allergic Disease and Tolerance
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Kari Nadeau, Stanford University, USA

* George D. Yancopoulos, Regeneron Pharmaceuticals, Inc., USA

Marsha Wills-Karp, Johns Hopkins Bloomberg School of Public Health, USA
Dysfunction in Epithelial-Cell Dectin-1/IL-33 Signaling and Susceptibility to Allergic Disorders

Steven F. Ziegler, Benaroya Research Institute, USA
TSLP Mediates Acute Allergic Airway Inflammation via Non-Classical CD11c+ Interstitial Macrophages

Willem van de Veen, Swiss Institute of Allergy and Asthma Research, Switzerland
The Role of B Cells in the Regulation of Allergic Immune Responses

Olivier Gasser, Malaghan Institute of Medical Research, New Zealand
Short Talk: Mucosal-Associated Invariant T Cells as a Novel Therapeutic Target Against Atopic Dermatitis

Tristan Kooistra, Massachusetts General Hospital, USA
Short Talk: Airway Basal Cell Notch Signaling Coordinates Immune Cell Localization and Activation in Asthma

19:00—20:00
Dinner

Granhall
19:30—22:00
Poster Session 1

Bay
20:00—21:00
Social Hour
No registration fees are used to fund alcohol served at this function.

Bay

TUESDAY, MARCH 26

07:00—08:00
Breakfast

Granhall
08:00—11:15
Early Life Origins of Allergic Disease
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Hugh A. Sampson, Icahn School of Medicine at Mount Sinai, USA

* Corinne Keet, Johns Hopkins School of Medicine, USA

Fernando D. Martinez, University of Arizona, USA
Molecular Basis of Asthma Protection

James E. Gern, University of Wisconsin, USA
Rhinoviruses, Allergy and Asthma

Coffee Break

Maria G. Dominguez-Bello, Rutgers University, USA
Delivery Mode, Gut-Microbiota Structure and Metabolic Function

Susan Prescott, University of Western Australia, Australia
An Exposome Perspective on Early-Life Events and Immune Development: The Need for Integrated Ecological Approaches to Dysbiotic Drift for Personal and Planetary Health

Thomas A.E. Platts-Mills, University of Virginia, USA
Short Talk: Dust Mite Allergen Components in Children from Ghana, Costa Rica and Ecuador: A Model for Understanding the Impact of Hygiene on Allergic Disease

Loreen Thürmann, Charité, Universitätsmedizin and Berlin Institute of Health, Germany
Short Talk: Are We What We Experienced before Birth? Prenatal Epigenetic Perturbations as Origin of Higher Allergy Susceptibility

Diego A. Lopez, University of California, Merced, USA
Short Talk: Defining Fetal Origins of Allergic Asthma Susceptibility

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Bay
13:00—22:00
Poster Viewing

Bay
16:30—17:00
Coffee Available

Pre Function
17:00—19:00
Microbes, and Metabolites Controlling Tolerance in Allergic Disease
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* James E. Gern, University of Wisconsin, USA

Eran Elinav, Weizmann Institute of Science, Israel
Host Microbiome Interactions in Health and Disease

Cathryn R. Nagler, University of Chicago, USA
The Microbiome, Timing and Barrier Function in the Context of Allergic Disease

Benjamin J. Marsland, Monash University, Australia
Influence of Diet, Microbes and Metabolites on Allergic Disease

Rozlyn C.T. Boutin, University of British Columbia, Canada
Short Talk: Bacterial-Derived Short-Chain Fatty Acids Inhibit the Growth of an Asthma-Exacerbating Yeast of the Infant Gut Microbiota

Sergejs Berdnikovs, Northwestern University, USA
Short Talk: Metabolic Underpinnings of Allergic Disease

19:00—20:00
Dinner

Granhall
19:30—22:00
Poster Session 2

Bay
20:00—21:00
Social Hour
No registration fees are used to fund alcohol served at this function.

Bay

WEDNESDAY, MARCH 27

07:00—08:00
Breakfast

Granhall
08:00—11:15
Barrier Dysfunction in Allergic Diseases
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Cezmi A. Akdis, Swiss Institute of Allergy and Asthma Research, Switzerland

Alan Irvine, Trinity College Dublin, Ireland
Role of Filaggrin and Epidermal Differentiation Complex in Atopic Dermatitis

Donald Y.M. Leung, National Jewish Health, USA
Role of Lipids in Skin Barrier Function

Coffee Break

Marc E. Rothenberg, Cincinnati Children's Hospital Medical Center, USA
Barrier Dysfunction in Eosinophiic Esophagitis

Gideon Lack, King's College London, UK
Targeting the Epithelial Barrier to Prevent Food Allergy

Erin Cathleen Steinbach, University of North Carolina at Chapel Hill, USA
Short Talk: Altered Gastrointestinal Immunoglobulins, Microbial Communities and Barrier Function Are Associated with Peanut Allergy in the Oral Allergy-Prone CC027/GeniUnc Mouse

Melanie A. Ruffner, Children's Hospital of Philadelphia, USA
Short Talk: IL-13 Dampens Barrier Protective Effects of Toll-Like Receptor 2 Stimulation on Esophageal Epithelium

Janelle Veazey, University of Rochester, USA
Short Talk: Protein Kinase D Isoforms Coordinate Airway Epithelial Barrier Integrity and Inflammation

11:15—17:00
On Own for Lunch

14:30—16:30
Workshop 2: Exploring the System Disease Concept of Allergic Disorders

Mountain/Lake
* Benjamin J. Marsland, Monash University, Australia

* Wendy F. Davidson, NIAID, National Institutes of Health, USA

Xingbin AI, Brigham & Women's Hospital, USA
Age-Related Dopaminergic Innervation Augments Th2 Inflammation in the Postnatal Lung

Toshinori Nakayama, Chiba University, Japan
Pathogenic Th2 (Tpath2) Cells in Airway Inflammation: Fibrosis Inducing Tpath2 Cells

Rod A. Rahimi, Massachusetts General Hospital, Harvard Medical School, USA
Lung-Resident and Circulating Memory Th2 Cells Perform Distinct Functions in Allergic Asthma

Rose Szabady, Vedanta Biosciences, USA
Development of a Microbiome-Based Drug to Target Food Allergy

Scott A. Smith, Vanderbilt University Medical Center, USA
Antigenic Determinants Underlying Peanut-Induced Anaphylaxis

Jennifer Jackson, Stanford School of Medicine, USA
Reprogramming of IL-3-Dependent Bone Marrow Cultured Mast Cells by Stem Cell Factor

Heenam Stanley Kim, Korea University, South Korea
Subspecies-Level Misbalance in Faecalibacterium Prausnitzii in the Gut Microbiota Underlying the Atopic Dermatitis

16:30—17:00
Coffee Available

Pre Function
17:00—18:45
Immunotherapeutic Opportunities in Allergic Disease
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Steven F. Ziegler, Benaroya Research Institute, USA

Corinne Keet, Johns Hopkins School of Medicine, USA
Successes and Failures of Immunotherapy in Allergic Diseases

Dale T. Umetsu, Genentech, Inc., USA
Modulation of IgE in Atopic Diseases Reveals the Critical Role of IgE

George D. Yancopoulos, Regeneron Pharmaceuticals, Inc., USA
IL-4R Modulation in Atopic Dermatitis and Asthma

Rajita Pappu, Genentech, Inc., USA
Short Talk: Combined Blockade of IL13 or IL5 with IL33 Leads to a Greater Inhibition of Type-2 Inflammation Over Inhibition of Either Pathway Alone

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
19:00—20:00
Dinner

Granhall
19:00—20:00
Social Hour
No registration fees are used to fund alcohol served at this function.

Granhall
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Granhall

THURSDAY, MARCH 28

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI143062-01

Funding for this conference was made possible (in part) by 1R13AI143062-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Regeneron Pharmaceuticals, Inc.


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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Phone:+1 970-262-1179