Sheraton Tamarron Resort Floorplan

Registered Attendees


Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:

  • Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting (You can edit your own abstract from My Account page as well)

    NOTE: Abstract authors/submitters may choose to not have their abstract available online and in the secure mobile app until a week before the meeting.

  • Full participant list, including joint meeting participants
  • Printable Invoices and Invitation Letters
  • Scholarship Information
  • Lodging Information

Login to My Account page

This meeting took place in 2001



For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Neuronal and Vascular Stress: A New Window on Alzheimer's Disease (A3)


Organizer(s) David M. Stern, Samuel C. Silverstein, Michael L. Shelanski, Richard Mayeux, Lennart Mucke, Alex Roher, Berislav Zlokovic and Perry B. Molinoff
January 15—21, 2001
Sheraton Tamarron Resort • Durango, Colorado USA
Abstract Deadline: Sep 15, 2000
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Nov 30, 2000

Sponsored in part by the Director's Sponsor Fund

Summary of Meeting:
Recent findings have focused attention on amyloid beta-peptide (Abeta) as a key element in the pathogenicity of cell stress and, ultimately, cytotoxicity to neurons and the vasculature in Alzheimer’s disease and cerebrovascular amyloid angiopathy. Although dense, extracellular plaque-like deposits of Abeta are abundant late in the course of Alzheimer’s disease, it has become evident that much earlier events in the generation and toxicity of Abeta, especially within the endoplasmic reticulum, will be critical to fully understand in order to design therapies that block the disease at a stage when cellular dysfunction is still reversible. Biology of the presenilins, cell surface and intracellular targets of Abeta converge on microglial-neuronal interactions and the vasculature to create a milieu of sustained and destructive inflammation, as well as an exaggerated and adverse response to ischemic stress. Insights from new animal models and clinical studies will be described, and related to an emerging cell biology of Alzheimer’s disease and cerebrovascular amyloid angiopathy; namely, that of cellular dysfunction is driven by Abeta-induced engagement of specific molecular targets, rather than the previously held notion of passive cellular disruption by massive fibrils nonspecifically and inexorably destabilizing cell membranes. This altered view of the pathogenesis of Alzheimer’s disease suggests multiple sites for future therapeutic interventions.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


MONDAY, JANUARY 15

14:00—19:00
Registration

Alcove
18:15—19:15
Welcome

Windom Peak
19:15—19:30
Orientation

Silverton
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Silverton
Konrad Beyreuther, University of Heidelberg, Germany
Alzheimer's Disease - Does Neuronal Transport Hold the Key?


TUESDAY, JANUARY 16

07:00—08:00
Breakfast

Antlers
08:00—11:00
The Presenilins
Meeting has ended...abstracts no longer viewable online.

Silverton
* Peter St. George-Hyslop, Cambridge Institute for Medical Research, UK
Presenilin and Protein Trafficking

Raphael Kopan, University of Cincinnati College of Medicine, USA
Notch Signaling: A New Paradigm for Signal Transduction

Christian Haass, Ludwig-Maximilians University Munich, Germany
The Cell Biology of beta- and gamma-Secretase

Hui Zheng, Baylor College of Medicine, USA
Presenilins in CNS Function and Skin Tumorigenesis

09:20—09:40
Coffee Break

Windom Peak
11:00—13:00
Poster Setup

Innisbrook/Animas
15:00—16:00
Workshop 1: Molecular Markers of AD

Silverton
* Joseph D. Buxbaum, Mount Sinai School of Medicine, USA
Alpha Beta in Early Dementia

Elaine R. Peskind, University of Washington, USA
Increased Cerbrospinal Fluid Cortisol in Alzheimer's Disease is a Function of Apolipoprotien E. Genotype

Elizabeth H. Corder, Duke University, USA
Brain Weight at Ages 80+ is Predicted by the Regional Brain Distribuition of Abeta and NFT Density: Two Profiles of Early Clinical Alzheimer Disease

Fiona Caroline Crawford, Roskamp Institute, USA
The Cystatin C Gene as A Novel Genetic Risk Factor for Late Onset Alzheimer's Disease

16:00—18:00
Poster Session 1: Presenilin and Other Genes Associated with AD Pathology

Innisbrook/Animas
17:00—18:00
Social Hour

Windom Peak
20:00—21:00
Coffee Available

Windom Peak
20:00—22:30
Estrogen, Genetics, and Alzheimer's Disease
Meeting has ended...abstracts no longer viewable online.

Silverton
* Richard Mayeux, Columbia University, USA
Estrogen and Alzheimer's Disease

Michael Hutton, Eli Lilly Research Center, UK
The Molecular Genetics and Transgenic Modeling of Tauopathy

Rudolph E. Tanzi, Massachusetts General Hospital, USA
The Search for Novel AD Genes

Sam Gandy, Mount Sinai Medical Center, USA
Gonadal Hormones Control Brain Beta-Amyloid Levels in Animal Models and Circulating Beta-Amyloid Levels in Humans


WEDNESDAY, JANUARY 17

07:00—08:00
Breakfast

Antlers
08:00—11:00
Amyloid beta-Peptide Cellular Interactions
Meeting has ended...abstracts no longer viewable online.

Silverton
G. William Rebeck, Massachusetts General Hospital, USA
Role of LDL-Receptor Related Protein (LRP) in AD Neuropathological Processes

David M. Stern, Columbia University College of Physicians & Surgeons, USA
Receptor for Advanced Glycation Endproducts (RAGE): A Signal Transduction Receptor for beta-Sheet Fibrils that Activates Pathways Leading to Chronic Cellular Perturbation

Paul A. Hyslop, Eli Lilly and Company, USA
Secondary Structure of Amyloid-beta Peptide Determines the Ability of ApoE to Inhibit Abeta Proteolysis in vitro: A Model for Studying the Role of ApoE in Amyloid-beta Clearance.

* Carl W. Cotman, University of California, Irvine, USA
Neuronal and Vascular Stress: The Pivotal Role of Beta-Amyloid in Disease Propagation

09:20—09:40
Coffee Break

Windom Peak
11:00—13:00
Poster Setup

Innisbrook/Animas
14:00—16:00
Workshop 2: Animal Models

Silverton
* Lennart Mucke, Gladstone Institutes and University of California, San Francisco, USA
Overview and Discussion Leader

Giulio M. Pasinetti, Mount Sinai School of Medicine, USA
COX-2 Dependent Cell Cycle Activities in Brain. Implications in the Clinical Progression of Alzheimer's Disease Dementia

Ottavio Arancio, Columbia University Medical Center, USA
Age-Dependent Impairment of Hippocampal Long-Term Potentiation in Double Transgenic Mice Overexpression ABAD and mutAPP(V717F,K670M,N671L)

Thomas A. Bayer, University of Saarland, Germany
Alpha-Synucleinin Alzheimer's Disease: Analysis of Postmortem Brains and APP/PS1 Transgenic Mice

Miguel A. Pappolla, University of South Alabama, USA

Tony Wyss-Coray, Stanford University School of Medicine, USA

16:00—18:00
Poster Session 2: Biology of Amyloid beta Peptide

Innisbrook/Animas
17:00—18:00
Social Hour

Windom Peak
20:00—21:00
Coffee Available

Windom Peak
20:00—21:30
Imaging for the Diagnosis and Monitoring of Treatment of AD
Meeting has ended...abstracts no longer viewable online.

Silverton
Michael W. Weiner, Veterans Affairs Medical Center, USA
MRI and MR Spectroscopic Imaging (MRSI) Studies of Alzheimer's Disease (AD) and Other Dementias

* Clifford R. Jack, Mayo Clinic, USA
Prediction of AD with MRI-Based Hippocampal Volume and Mild Cognitive Impairment

Daniel Skovronsky, University of Pennsylvania School of Medicine, USA
Development of Radioligands for in vivo Imaging of Brain Amyloid


THURSDAY, JANUARY 18

07:00—08:00
Breakfast

Antlers
08:00—11:30
Interactions of Amyloid with the Vasculature and Microglia
Meeting has ended...abstracts no longer viewable online.

Silverton
* Alex E. Roher, Sun Health Research Institute, USA
Interactions of Amyloid with the Vasculature and Microglia

Shi Du Yan, Columbia University, USA
Amyloid-beta Binding Alcohol Dehydrogenase (ABAD): An Intracellular Target of Amyloid beta (Abeta)

Mark R. Emmerling, Pfizer Global Research & Development, USA
Oligomeric Abeta and Neuronal Stress

Jorge Ghiso, New York University School of Medicine, USA
Familial British Dementia: An Alternative Model of Neurodegeneration

Berislav Zlokovic, University of Southern California, USA
Vascular Interaction of Abeta

09:20—09:40
Coffee Break

Windom Peak
17:00—18:00
Social Hour

Windom Peak
20:00—21:00
Coffee Available

Windom Peak
20:00—22:00
Clinical Development of Amyloid beta-Lowering Agents
Meeting has ended...abstracts no longer viewable online.

Silverton
* Perry B. Molinoff, University of Pennsylvania, USA
Abeta-Modulation: The Next Generation of AD Therapeutics

Frederique Bard, Janssen Alzheimer Immunotherapy, USA
Beta Amyloid Based Immunotherapeutic Approach to Alzheimer's Disease Treatment

Harry F. Dovey, Elan Pharmaceuticals, Inc., USA
Functional gamma-Secretase Inhibitors Reduce Abeta Levels in PDAPP Mouse Brain


FRIDAY, JANUARY 19

07:00—08:00
Breakfast

Antlers
08:00—11:00
Amyloid beta, apoE Biology and Lipoprotein Receptors
Meeting has ended...abstracts no longer viewable online.

Silverton
* David M. Stern, Columbia University College of Physicians & Surgeons, USA

Paul Edward Fraser, University of Toronto, Canada
Examining the Molecular Structure of Alzheimer's Amyloid-beta Protein

Charles G. Glabe, University of California, Irvine, USA
Mechanisms of Amyloid Accumulation and Pathogenesis in Alzheimer's Disease

Robert W. Mahley, J. David Gladstone Institutes, USA
Differential Effects of Cytosolic Apolipoprotein (Apo) E3 and ApoE4 on Neurite Outgrowth and the Cytoskeleton

Joachim Herz, University of Texas Southwestern Medical Center, USA
Roles of Neuronal Apolipoprotein E Receptors in Brain Development and Neurodegeneration

09:20—09:40
Coffee Break

Windom Peak
11:00—13:00
Poster Setup

15:00—17:00
Workshop 4: Amyloid Angiopathy

Silverton
* Robert Kisilevsky, Queen's University, Canada

* Berislav Zlokovic, University of Southern California, USA
The Blood-Brain Barrier: Akey to Neurovascular Asynchron, Brain Senescence and Pathology Associated with Alzheimer's Disease

William E. Van Nostrand, Stony Brook University, USA
Pathogenic Mechanisms of the Amyloid Beta Protein in Cerebral Amyloid Angiopathy

Paula Grammas, University of Oklahoma Health Sciences Center, USA
Brain Endothelial Cells are Key Participants in teh Pathogenesis of Neuronal Cell Death in Alzheimer's Disease

16:00—18:00
Poster Session 3: Amyloid Angiopathy

17:00—18:00
Social Hour

Windom Peak
20:00—21:00
Coffee Available

Windom Peak
20:00—22:30
Mechanisms of Neuronal Repair
Meeting has ended...abstracts no longer viewable online.

Silverton
* Melitta Schachner, Nelson Biological Laboratories, USA
Cell Adhesion Molecules and Neuroprotection

Ann Marie Schmidt, New York University Langone Medical Center, USA
RAGE and Peripheral Nerve Repair

Valerie M.K. Verge, University of Saskatchewan, Canada
Role of Neurotrophins in Adult Sensory Neuron Responses to Injury


SATURDAY, JANUARY 20

07:00—08:00
Breakfast

Antlers
08:00—11:00
Approaches to Treatment of AD and Other Amyloidoses
Meeting has ended...abstracts no longer viewable online.

Silverton
* Berislav Zlokovic, University of Southern California, USA

M. Kerry O'Banion, University of Rochester School of Medicine & Densitstry, USA
Cyclooxygenases as Targets in Neuroinflammation and Neurodegeneration

Robert Kisilevsky, Queen's University, Canada
Of Starch and Silk: In vivo Amyloid Formation and Strategies for Its Prevention

Daniel H. Paris, Oxford University, Thailand
Pro-Inflammatory Induction by Abeta in the Cerebrovasculature

Costantino Iadecola, Weill Cornell Medicine, USA
Amyloid Beta: Roles in Cerebrovascular Regulation and Ischemic Damage

09:20—09:40
Coffee Break

Windom Peak
15:00—16:00
Coffee Available

Windom Peak
15:00—17:00
Transgenic Models: Amyloid beta-Induced Stress in vivo
Meeting has ended...abstracts no longer viewable online.

Silverton
* Lennart Mucke, Gladstone Institutes and University of California, San Francisco, USA
Abeta-Induced Neuronal Deficits and Their Modulation by ApoE Isoforms in vivo

Karen Hsiao Ashe, University of Minnesota, USA
Spatial Reference Memory in Transgenic Mice Overexpressing Mutant and Wild-Type APP

Karen Duff, Columbia University, USA
Cellular Responses to Amyloid and Tau

19:00—20:00
Social Hour

Windom Peak
20:00—22:00
Banquet

Silverton
21:00—00:00
Entertainment

Windom Peak

SUNDAY, JANUARY 21

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 AG18868-01




We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676