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This meeting took place in 2001



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Molecular Mechanisms of Apoptosis (A4)


Organizer(s) Douglas R. Green and Gerard I. Evan
January 16—22, 2001
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Sep 18, 2000
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Nov 16, 2000

Sponsored by Yamanouchi USA Foundation

Summary of Meeting:
The process of apoptotic cell death is central to our understanding of normal development, homeostasis, and aging, as well as diseases such as cancer, neurodegeneration, ischemic injury, and AIDS. A variety of agents and conditions can initiate events that engage the central mechanisms of apoptosis, which are regulated to either result in cellular survival or orchestrate the execution of the cell. Through analysis and comparison of model systems in nematodes, insects, and vertebrates, some of the pathways of initiation, regulation and execution of the apoptotic program are becoming understood. Others remain to be discovered. The goal of this meeting is to bring together leading authorities and young scientists to discuss and debate the mechanisms of apoptosis in diverse organisms and the role of this process in human health and disease.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, JANUARY 16

14:00—19:00
Registration

Shavano Foyer
18:15—19:15
Welcome

Shavano Foyer
19:15—19:30
Orientation

Crestone/Redcloud
19:30—20:30
Chairs Tag-Team Presentations
Meeting has ended...abstracts no longer viewable online.

Crestone/Redcloud
Douglas R. Green, St. Jude Children's Research Hospital, USA
and

Gerard I. Evan, University of Cambridge, UK


WEDNESDAY, JANUARY 17

07:00—08:00
Breakfast

Shavano /Torreys
08:00—11:30
Transcriptional Activation/Regulation of Apoptosis. Session Sponsored by The March of Dimes Birth Defects Foundation.
Meeting has ended...abstracts no longer viewable online.

Crestone/Redcloud
* Sally A. Kornbluth, Duke University Medical Center, USA

Andreas E. Strasser, Walter and Eliza Hall Institute of Medical Research, Australia
BH3-Only Members of the Bcl-2 Family Are Critical Inducers of Apoptosis and Preclude Autoimmunity

Michael E. Greenberg, Harvard Medical School, USA
Signal Transduction Pathways that Promote Neuronal Survival

Michael Karin, University of California, San Diego, USA
Regulation of Apoptotic Responses by NF-kappaB, AP-1 and their Signaling Pathways

Randal J. Kaufman, Sanford-Burnham Medical Research Institute, USA
Stress Signaling from the Endoplasmic Reticulum

Markus G. Seidel, Dana Farber Cancer Institute, USA
Short Talk: Mice Lacking Slug, a Ces-1-Related Leukemogenic Zinc Finger Transcription Factor, Develop Bone Marrow Failure and Overexpress Bax After Radiation

Ross L. Cagan, Mount Sinai School of Medicine, USA
Short Talk: Regulating PCD in the Developing Drosophila Retina

09:20—09:40
Coffee Break

Shavano Foyer
11:00—13:00
Poster Setup

Shavano /Torreys
16:00—18:00
POSTER SESSION 1: A - D

Shavano /Torreys
17:00—18:00
Social Hour

Shavano /Torreys
20:00—21:00
Coffee Available

Shavano Foyer
20:00—22:30
Signaling Pathways
Meeting has ended...abstracts no longer viewable online.

Crestone/Redcloud
* George C. Prendergast, Lankenau Institute for Medical Research, USA

Barbara A. Osborne, University of Massachusetts, USA
Notch as a Regulator of Cell Death in T cells and Drosophila

John M. Abrams, University of Texas Southwestern Medical Center, USA
Activators and Effectors of Cell Death in Drosophila

Sally A. Kornbluth, Duke University Medical Center, USA
Scythe/Reaper-Mediated Pathways of Apoptosis

Cristina Claveria, Centro Nacional de Biotecnologia, Spain
Short Talk: Mapping and Characterization of Novel Pro-Apoptotic Domains in Drosophila Grim

Atsushi Matsuzawa, Tokyo Medical and Dental University, Japan
Short Talk: Establishment and Analysis of Apoptosis Signal-Regulating Kinase 1 (ASK1) -Deficient Mice


THURSDAY, JANUARY 18

07:00—08:00
Breakfast

Shavano /Torreys
08:00—11:30
p53
Meeting has ended...abstracts no longer viewable online.

Crestone/Redcloud
* Michael Karin, University of California, San Diego, USA

Gerry Melino, University of Rome ‘Tor Vergata’, Italy
Involvement of p73 in Cell Death and Differentiation

Kay F. Macleod, University of Chicago, USA
The Anti-Apoptotic Functions of the RB Tumor Suppressor

Scott W. Lowe, Memorial Sloan Kettering Cancer Center, USA
Modulation of Apoptosis in Tumor Development and Therapy

Tung-Ti Chen, University of California, San Diego, USA
Short Talk: Desensitization to Apoptosis in Mice with Germline Knockin Mutation at the Caspase Cleavage Site of RB

Daniel S. O'Connor, Mount Sinai Medical Center, USA
Short Talk: Regulation of Apoptosis at Cell Division by p34CDC2 Phosphorylation of Survivin

Vishva M. Dixit, Genentech, Inc., USA
New Players in an Old Field - Novel TNF Family Members

09:20—09:40
Coffee Break

Shavano Foyer
11:00—13:00
Poster Setup

Shavano /Torreys
16:00—18:00
POSTER SESSION 2: E - L

Shavano /Torreys
17:00—18:00
Social Hour

Shavano /Torreys
20:00—21:00
Coffee Available

Shavano Foyer
20:00—22:30
Death Receptors. Session Sponsored in part by Genentech, Inc.
Meeting has ended...abstracts no longer viewable online.

Crestone/Redcloud
* Seamus J. Martin, Trinity College Dublin, Ireland

Jürg Tschopp, University of Lausanne, Switzerland
Signals Triggered by Fas

Michael J. Lenardo, NIAID, National Institutes of Health, USA
Molecular Regulation of Fas and TNF Receptor Signaling in the Healthy and Diseased Immune System

Marcus E. Peter, University of Chicago, USA
Novel Functions of Death Effector Domain Containing Proteins in Apoptosis

Bruce Motyka, University of Alberta, Canada
Short Talk: Identification of a Cell Surface Receptor Responsible for the Binding and Uptake of Granzyme B for the Induction of Apoptosis

Henning Walczak, University College London, Cancer Institute, UK
Short Talk: TRAIL-Induced Apoptosis


FRIDAY, JANUARY 19

07:00—08:00
Breakfast

Shavano /Torreys
08:00—11:30
Mitochondria. Session Sponsored in part by DuPont Pharmaceuticals Co.
Meeting has ended...abstracts no longer viewable online.

Crestone/Redcloud
* Gary Fiskum, University of Maryland, USA

Craig B. Thompson, Memorial Sloan Kettering Cancer Center, USA
AKT and Bcl-xl Regulate Two Distinct Mechanisms that Promote Cell Survival

Guido Kroemer, Cordeliers Research Center, France
Mitochondria in Apoptosis. How Pandora's Box Opens

John C. Reed, F. Hoffmann-La Roche AG, Switzerland
Card-Family Proteins Controlling Post-Mitochondrial Steps in Apoptosis

Stanley J. Korsmeyer, Harvard University, USA
Integrating the Cell Death Pathway

Bruno E. Antonsson, Merck Serono, Switzerland
Short Talk: Bax is Present as a High Molecular Weight Oligomer/Complex in the Mitochondrial Membrane of Apoptotic Cells

Luzheng Xue, University of Oxford, UK
Short Talk: Mitochondria are Selectively Eliminated from Eukaryotic Cells After Blockade of Caspases During Apoptosis

09:20—09:40
Coffee Break

Shavano Foyer
11:00—13:00
Poster Setup

Shavano /Torreys
16:00—18:00
POSTER SESSION 3: M - R

Shavano /Torreys
17:00—18:00
Social Hour

Shavano /Torreys
20:00—21:00
Coffee Available

Shavano Foyer
20:00—22:30
Alternative Death Pathways
Meeting has ended...abstracts no longer viewable online.

Crestone/Redcloud
* Barbara A. Osborne, University of Massachusetts, USA

Dale E. Bredesen, Buck Institute for Research on Aging, USA
An Alternative, Non-Apoptotic Cell Death Program

Gordon Shore, Gemin X Pharmaceuticals, Inc., Canada
Regulation of Apoptosis by the BAP31 Complex in the Endoplasmic Reticulum

Junying Yuan, Harvard Medical School, USA
The Peutz-Jegher Gene Product LKB1 is a Mediator of p53-Dependent Cell Death in the Small Intestine

Marja Jäättelä, Danish Cancer Society Research Center, Denmark
Short Talk: Cathepsin B-Like Proteases as Key Mediators in Tumour Cell Apoptosis Induced by Death Receptors

Maria Eugenia Guicciardi, Mayo Clinic, USA
Short Talk: Cathepsin B Contributes to TNF-alpha-Mediated Hepatocyte Apoptosis by Promoting Mitochondrial Release of Cytochrome C


SATURDAY, JANUARY 20

07:00—08:00
Breakfast

Shavano /Torreys
08:00—11:30
Bcl-2 Family. Session Sponsored in part by Idun Pharmaceuticals, Inc.
Meeting has ended...abstracts no longer viewable online.

Crestone/Redcloud
* John C. Reed, F. Hoffmann-La Roche AG, Switzerland

Eileen P. White, Rutgers University, USA
Regulation of Apoptosis by Viral Transforming Proteins

J. Marie Hardwick, Johns Hopkins University Schools of Public Health and Medicine, USA
Reversing the Functions of Apoptosis Regulators

Gabriel Nuñez, University of Michigan, USA
Regulation of Apoptosis and NF-kappaB Activation by Nod Proteins

Suzanne Cory-Adams, Walter & Eliza Hall Institute of Medical Research, Australia
The Bcl-2 Family: Arbiters of Life and Death

Motoshi Suzuki, National Institutes of Health, USA
Short Talk: Structure of Bax

Tatsushi Igaki, Kyoto University Graduate School of Biostudies, Japan
Short Talk: Drob-1, a Drosophila Proapoptotic Member of the Bcl-2/CED-9 Family: Genetic Studies for Caspase-Independent Cell Death

09:20—09:40
Coffee Break

Shavano Foyer
11:00—13:00
Poster Setup

Shavano /Torreys
14:00—16:00
Apoptosis and Age-Related Disease. Session Sponsored by The Ellison Medical Foundation
Meeting has ended...abstracts no longer viewable online.

Crestone/Redcloud
* Roberta A. Gottlieb, Cedars-Sinai Medical Center, USA

Richard N. Kolesnick, Memorial Sloan-Kettering Cancer Center, USA
Endothelial Cell Apoptosis and Tumor Response to Therapy

Richard N. Kitsis, Albert Einstein College of Medicine, USA
Molecular Regulation of Myocyte Death in Ischemic Heart Disease and Heart Failure

Jonathan L. Tilly, Massachusetts General Hospital, USA
Apoptosis in Mouse and Human Models of Ovarian Failure

Donald W. Nicholson, Nimbus Discovery, Inc., USA
Apoptosis in Neurodegenerative and Infectious Diseases

16:00—18:00
POSTER SESSION 4: S - Z

Shavano /Torreys
17:00—18:00
Social Hour

Shavano /Torreys
20:00—21:00
Coffee Available

Shavano Foyer
20:00—22:30
CARD/Ced4 Proteins and IAPS
Meeting has ended...abstracts no longer viewable online.

Crestone/Redcloud
* Gabriel Nuñez, University of Michigan, USA

Emad Alnemri, Thomas Jefferson University, USA
Regulation of NF-kappaB Activation and Apoptosis by CARD Proteins

David L. Vaux, Walter and Eliza Hall Institute of Medical Research, Australia
BIRps Before Bedtime

Kelvin Cain, MRC Toxicology Unit, University of Leicester, UK
Short Talk: Modulation of Apoptosome Formation and Function

Francesco Cecconi, University of Rome Tor Vergata, Italy
Short Talk: Roles of Apaf1 in Developmental Cell Death


SUNDAY, JANUARY 21

07:00—08:00
Breakfast

Shavano /Torreys
08:00—11:30
Caspases. Session Sponsored by Maxim Pharmaceuticals, Inc.
Meeting has ended...abstracts no longer viewable online.

Crestone/Redcloud
* Sophie Roy, Merck Frosst Canada & Company, Canada

Guy S. Salvesen, Sanford-Burnham Medical Research Institute, USA
Caspase Zymogen Activation

Seamus J. Martin, Trinity College Dublin, Ireland

Richard A. Flavell, HHMI/Yale University School of Medicine, USA
The Role of Caspases and Kinases in Apoptosis in vivo Studied by Gene Targeting

Tak W. Mak, Campbell Family Institute for Breast Cancer, Canada
Genetic Pathways of Apoptosis and Survival Signals

Yoshiaki Shikama, National Children's Medical Research Center, Japan
Short Talk: Subcellular Localizations and Cell Death-Inducing Activities of Eight Apoptosis-Related Caspases

Stephanie Birkey Reffey, National Institutes of Health, USA
Short Talk: XIAP/hILP is a Multi-Functional Protein with Both Signaling and Anti-Apoptotic Properties

09:20—09:40
Coffee Break

Shavano Foyer
14:30—15:30
Coffee Available

Shavano Foyer
14:30—17:00
Execution and Burial
Meeting has ended...abstracts no longer viewable online.

Crestone/Redcloud
Mohanish Deshmukh, University of North Carolina at Chapel Hill, USA
Short Talk: Development of Competence during Sympathetic Neurons Apoptosis is Regulated by an IAP-Like Activity

Patricia J. Gallagher, Indiana University, USA
Short Talk: A Novel Inhibitor of Apoptosis (IAP) Binds Death Associated Protein Kinase

Andreas Bergmann, University of Massachusetts Medical School, USA
Regulation of Cell Number by MAPK-Dependent Control of Apoptosis

Valerie A. Fadok, National Jewish Medical and Research Center, USA
Phosphatidylserine on Apoptotic Cells Mediates Noninflammatory Clearance by Stimulating Macropinocytosis Via the PtdSer Receptor

Xiaodong Wang, BeiGene, China
Biochemical Pathways of Apoptosis

19:00—20:00
Social Hour

Shavano Foyer
20:00—22:00
Banquet

Redcloud/Shav/Torreys
21:00—00:00
Entertainment

Redcloud/Shav/Torreys

MONDAY, JANUARY 22

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 AG19051-01




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