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This meeting took place in 2001



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Integration of Signaling Pathways in Development (B3)


Organizer(s) Anita B. Roberts and Roeland Nusse
January 27—February 1, 2001
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Sep 27, 2000
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Nov 27, 2000

Sponsored in part by the Director's Sponsor Fund

Summary of Meeting:
Key insights into signaling pathways have been gained from study of control of spatial and temporal patterning and morphogenesis in both invertebrate and vertebrate models, and from study of dysregulation of these pathways in disease. Given that nearly one-quarter of the genome is predicted to encode signaling proteins and that many pathways use common intermediates, it is likely that many of the proteins will be involved in regulation and integration of these signals. Recent findings suggest that development is guided by multiple levels of cooperation between different signaling pathways, which govern competence of cells to respond to a second signal, with both direct and indirect cross-talk providing additional levels of control. This meeting will focus on the latest advances in understanding developmental pathways involving Notch, Hedgehog, Wnt, members of the TGF-beta superfamily, FGF and EGF, with emphasis on new levels of signal integration between these pathways.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SATURDAY, JANUARY 27

14:00—19:00
Registration

Shavano Foyer
18:15—19:15
Welcome

Shavano Foyer
19:15—19:30
Orientation

Red Cloud
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Red Cloud
Cliff Tabin, Harvard Medical School, USA
Patterning and Signaling in the Vertebrate Embryo


SUNDAY, JANUARY 28

07:00—08:00
Breakfast

Shavano
08:00—11:00
Hedgehog Pathways
Meeting has ended...abstracts no longer viewable online.

Red Cloud
* Philip A. Beachy, HHMI/Stanford University, USA
Regulation of Hedgehog Signaling

Raphael Rousset, Institut de Biologie Valrose, France
Putting Limits on Wnt Signaling

Joan E. Hooper, University of Colorado Health Sciences Center, USA
Hedgehog Signal Transduction in Drosophila

Konrad Basler, University of Zurich, Switzerland
Precision of Hedgehog Signalling

09:20—09:40
Coffee Break

Shavano Foyer
11:00—13:00
Poster Setup

Torreys
16:00—18:00
Poster Session 1: Hedgehog Pathways/Notch Pathways

Torreys
17:00—18:00
Social Hour

Torreys
20:00—21:00
Coffee Available

Shavano Foyer
20:00—22:00
Notch Pathways
Meeting has ended...abstracts no longer viewable online.

Red Cloud
Robert Lake, Massachusetts General Hospital, USA
Elucidating the Role of Mastermind in Notch Signaling

* Raphael Kopan, University of Cincinnati College of Medicine, USA
Notch Signaling: A New Paradigm for Signal Transduction

Kenneth Irvine, Rutgers University, USA
Modulation of Notch Signaling by the Glycosyltransferase Fringe


MONDAY, JANUARY 29

07:00—08:00
Breakfast

Shavano
08:00—11:00
Wnt Signaling in Vertebrates
Meeting has ended...abstracts no longer viewable online.

Red Cloud
* Randall T. Moon, University of Washington School of Medicine, USA
Multiple Wnt Signaling Pathways in Vertebrates

Hans C. Clevers, Hubrecht Institute, Netherlands
TCF Factors, Mediators of Wnt Signaling

Mariann Bienz, MRC Laboratory of Molecular Biology, UK
APC Tumor Suppressor Signaling

William I. Weis, Stanford University, USA
Biochemical and Structural Analysis of Wnt Signaling Pathway Components

09:20—09:40
Coffee Break

Shavano Foyer
11:00—13:00
Poster Setup

Torreys
16:00—18:00
Poster Session 2: Wnt Signaling/MAPK

Torreys
17:00—18:00
Social Hour

Torreys
20:00—21:00
Coffee Available

Shavano Foyer
20:00—22:00
Wnt Pathways in Invertebrates
Meeting has ended...abstracts no longer viewable online.

Red Cloud
* Roeland Nusse, HHMI/Stanford University, USA
Growth Factor Signaling During Animal Development and Cancer

Bruce A. Bowerman, University of Oregon, USA
Wnt Signaling and SGG-1/GSK-3beta in C. elegans Embryos: Cell Fate Patterning and Mitotic Spindle Orientation

Stephen DiNardo, University of Pennsylvania, USA
Arrow and Lines: Two New Genes Implicated in Wingless Signaling


TUESDAY, JANUARY 30

07:00—08:00
Breakfast

Shavano
08:00—11:00
TGF-beta Superfamily Signaling Pathways
Meeting has ended...abstracts no longer viewable online.

Red Cloud
* Anita B. Roberts, National Institutes of Health, USA
Emerging Complexities in a Simple Signal Transduction Pathway - Smad Signaling from TGF-beta

Richard W. Padgett, Rutgers University, USA
Defining New Components of TGFbeta Signaling Pathways in C. elegans and Drosophila

Jeffrey L. Wrana, Mount Sinai Hospital, Canada
Smad Signaling and the Ubiquitin-Proteasome System

Caroline S. Hill, Francis Crick Institute, UK
Signaling by the TGF-beta Superfamily and Regulation of Transcription in Early Xenopus Development

09:20—09:40
Coffee Break

Shavano Foyer
11:00—13:00
Poster Setup

Torreys
16:00—18:00
Poster Session 3: TGF-beta Superfamily Pathways/EGF/FGF/Cross-Talk

Torreys
17:00—18:00
Social Hour

Torreys
20:00—21:00
Coffee Available

Shavano Foyer
20:00—22:00
Bone Morphogenetic Proteins
Meeting has ended...abstracts no longer viewable online.

Red Cloud
* Brigid L. M. Hogan, Duke University Medical Center, USA
BMP Proteins in Mouse Development

Mary C. Mullins, University of Pennsylvania, USA
The BMP's of Dorsoventral Axis Development

John F. Fallon, University of Wisconsin-Madison, USA
Anterior-Posterior Limb Patterning: Beyond the ZPA


WEDNESDAY, JANUARY 31

07:00—08:00
Breakfast

Shavano
08:00—11:00
Signaling Cross-Talk in Development
Meeting has ended...abstracts no longer viewable online.

Red Cloud
Juan Carlos Izpisua-Belmonte, The Salk Institute for Biological Studies, USA
Wnt Signals Control FGF-Dependent Limb Initiation and AER Induction in the Chick Embryo

Alan M. Michelson, Brigham and Women's Hospital, USA
Developmental Specificity and Integration of Ras, Wnt, BMP and Notch Pathways

* Andrew P. McMahon, Harvard University, USA
Hedgehog Signaling; Cholesterol Modification and Negative Feedback in Patterning

Alexander F. Schier, Harvard University, USA
Nodal Signaling and Gastrulation

09:20—09:40
Coffee Break

Shavano Foyer
16:00—17:00
Coffee Available

Shavano Foyer
16:00—18:00
EFG/FGF in Development
Meeting has ended...abstracts no longer viewable online.

Red Cloud
* Gail R. Martin, University of California, San Francisco, USA
FGF Signaling in Brain and Limb Development

Matthew Freeman, Medical Research Council, UK
Control of EGF Receptor Signaling in Drosophila

David M. Ornitz, Washington University School of Medicine, USA
Short Talk: Essential Roles for FGF Receptor 2 Signaling in Skeletal Development and the Pathogenesis of Apert Syndrome

Sara Ivy Wilson, Umea University, Sweden
Short Talk: Neural Versus Epidermal Cell Specification in Chick

19:00—20:00
Social Hour

Shavano Foyer
20:00—22:00
Banquet

Torreys/Shavano
21:00—00:00
Entertainment

Torreys/Shavano

THURSDAY, FEBRUARY 1

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 HD39938-01




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