Taos Convention Center (meeting only) Floorplan

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This meeting took place in 2001



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Chemokines and Chemokine Receptors (C3)


Organizer(s) Gregory J. LaRosa, Steven L. Kunkel, Alberto Mantovani and Barrett J. Rollins
February 16—21, 2001
Taos Convention Center (meeting only) • Taos, New Mexico USA
Abstract Deadline: Oct 16, 2000
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Dec 15, 2000

Sponsored by ICOS Corporation and Millennium Pharmaceuticals, Inc.

Summary of Meeting:
Chemokines are members of a superfamily of proteins whose primary function is to control leukocyte trafficking through lymphoid organs and other tissues. Their expression is associated with inflammatory disorders, allergic disease, infectious diseases (including HIV), atherosclerosis, and cancer. Recently, genetically modified animal models have provided in vivo proof of the pathogenetic role played by chemokines in disease, and thereby validated chemokines and their receptors as pharmacological targets. Finally, chemokine receptors have been found on a number of non-hematopoietic cells and may be important for the positioning of these cells (e.g., vascular and brain cells). Critical problems in the field include: difficulty in discovering small molecule chemokine inhibitors, indicating an incomplete understanding of chemokine ligand-receptor interactions; gaps in connecting chemokine receptor activation with the molecular machinery of cell migration; and an unclear vision of the physiology of chemokines in non-hematopoietic cells. This meeting will bring together scientists working on the molecular basis of chemokine responses with those working at the organismal level on problems of disease and the immune response. The goal is to stimulate new approaches to critical problems in chemokine research that may ultimately result in chemokine-directed therapeutics.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


FRIDAY, FEBRUARY 16

14:00—19:00
Registration

Rio Grande D
18:15—19:15
Welcome

Rio Grande ABC
19:15—19:30
Orientation

Bataan
19:30—21:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Bataan
Timothy A. Springer, Immune Disease Institute, Harvard University, USA
Structural Rearrangements in Integrins that Regulate Leukocyte Adhesion and Trafficking

Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland
Chemokine Receptors in Primary and Secondary Immune Responses


SATURDAY, FEBRUARY 17

07:00—08:00
Breakfast

Rio Grande
08:00—11:00
Chemokines, Receptorology and Novel Activities I
Meeting has ended...abstracts no longer viewable online.

Bataan
* Amanda E.I. Proudfoot Fichard, Merck Serono Geneva Research Centre, Switzerland

Carlos Martinez-A, National Center of Biotechnology-Madrid, Spain
Ligand-Mediated Chemokine Receptor Oligomerization and Its Implications

Tracy M. Handel, University of California, San Diego, USA
Structure-Function Studies of Chemokine- Receptor Interactions

Michael Briskin, CSO Xios Pharmaceuticals, USA
Short Talk: The Bonzo Ligand CXCL16 is a Novel Transmembrane Chemokine with Multiple Potential Functions

Knut Biber, Universitätsklinikum, Germany
Short Talk: Characterization and mRNA Expression of a Novel MCP Chemokine Receptor (CCR12) in Mouse Glial Cells

R. William Hipkin, Schering-Plough Research Institute, USA
Short Talk: Human Interferon-Inducible Protein 10 (hIP-10) and Human Interferon-Inducible T Cell alpha Chemoattractant (hI-TAC) are Allotopic Ligands for Human CXCR3: Differential Binding to Receptor States

09:20—09:40
Coffee Break

Rio Grande
11:00—13:00
Poster Setup

Rio Grande
16:30—18:30
POSTER SESSION 1: Chemokines, Receptorology and Novel Activities

Rio Grande
17:30—18:30
Social Hour

Rio Grande
18:30—19:30
Coffee Available

Hallway
18:30—20:30
Chemokines, Receptorology and Novel Activities II
Meeting has ended...abstracts no longer viewable online.

Bataan
* Amanda E.I. Proudfoot Fichard, Merck Serono Geneva Research Centre, Switzerland
Differential Activation of Chemokine Receptors - More to Specificity than Meets the Eye

Eugene C. Butcher, Stanford University, USA
Chemokines and the Systemic Organization of the Immune System

Philip M. Murphy, NIAID, National Institutes of Health, USA
Chemokine Receptors in Disease


SUNDAY, FEBRUARY 18

07:00—08:00
Breakfast

Rio Grande
08:00—11:00
Biology of Chemokines in Disease I. Cardiovascular and Rheumatological Disease.
Meeting has ended...abstracts no longer viewable online.

Bataan
Campbell D.K. Rogers, Brigham and Women's Hospital, USA
Restenosis and Cardiovascular Disease: Involvement of Leukocyte Adhesion and Chemokine Activity

* Israel F. Charo, ChemoCentryx, Inc., USA
The Role of Monocytes in Atherosclerosis and the Immune Response: Insights from the CCR2 Knockout Mouse

Pieter H.E. Groot, SmithKline Beecham Pharmaceuticals, UK
Short Talk: A Val6-4Ile Mutation in CCR2B is Associated with Reduced Atherosclerosis and Decreased Signalling

Daniel N. Streblow, Oregon Health & Science University, USA
Short Talk: The Human Cytomegalovirus Chemokine Receptor US28 Mediates Vascular Smooth Muscle Cell Migration

Alison D. Schecter, Novartis Institute for Biomedical Research, USA
Short Talk:

Katrine R. Shadidi, ,
Short Talk: The Specificity of the T Cell Correlates with Its Capacity to Migrate Towards Chemokines Produced in the Inflamed Synovial Tissue

Joel Steven Pachter, University of Connecticut Health Center, USA
Short Talk: Functional Expression of CCR2 by Human Astrocytes

09:20—09:40
Coffee Break

Rio Grande
11:00—13:00
Poster Setup

Rio Grande
16:30—18:30
POSTER SESSION 2: Biology of Chemokines in Disease, Cardiovascular and Rheumatological Disease/Neurological Disease and Transplantation

Rio Grande
17:30—18:30
Social Hour

Rio Grande
18:30—19:30
Coffee Available

Hallway
18:30—20:30
Biology of Chemokines in Disease I. Neurological Disease and Transplantation.
Meeting has ended...abstracts no longer viewable online.

Bataan
William J. Karpus, Northwestern University, USA
Chemokines and Chemokine Receptors in Autoimmune Demyelinating Disease

Wayne W. Hancock, Children's Hospital of Philadelphia, USA
Chemokine Receptors and Transplant Rejection vs. Tolerance

* Richard M. Ransohoff, Third Rock Ventures, LLC, USA
Short Talk: CXCL1/CXCR2 Signaling in Developmental Oligodendrogliogenesis

Lisa A. Robinson, University of Toronto, Canada
Short Talk: Anti-CX3CR1 Antibody Blockade Prolongs Cardiac Allograft Survival


MONDAY, FEBRUARY 19

07:00—08:00
Breakfast

Rio Grande
08:00—11:00
Biology of Chemokines in Disease II. Pulmonary and Oncological Disease.
Meeting has ended...abstracts no longer viewable online.

Bataan
Timothy J. Williams, Imperial College Faculty of Medicine, UK
Role of Chemokines in Asthma and Allergy

Robert M. Strieter, University of Virginia School of Medicine, USA
Chemokine Regulation of Angiogenesis in Cancer and Chronic Fibroproliferative Disorders

* Frances R. Balkwill, Barts Cancer Institute, Queen Mary University of London, UK
The Chemokine Network in Ovarian Cancer

Timothy R. Traynor, University of Michigan Medical Center, USA
Short Talk: MCP-1 is Required for the Development of T1-Type Immunity to Pulmonary Cryptococcus neoformans Infection

Anja D. Müller, Heinrich-Heine University, Germany
Short Talk: Specific Expression of Chemokine Receptors in Breast Cancer: Implications for Organ-Specific Metastasis

09:20—09:40
Coffee Break

Rio Grande
11:00—13:00
Poster Setup

Rio Grande
16:30—18:30
POSTER SESSION 3: Biology of Chemokines in Disease. Pulmonary and Oncological Disease/Infectious Disease/Chemokines in Normal Immune Function/Progress Towards Clinical Intervention

Rio Grande
17:30—18:30
Social Hour

Rio Grande
18:30—19:30
Coffee Available

Hallway
18:30—20:30
Biology of Chemokines in Disease I. Infectious Disease.
Meeting has ended...abstracts no longer viewable online.

Bataan
Robert W. Doms, University of Pennsylvania School of Medicine, USA
HIV and Chemokine Receptor Conformation, Density, and Affinity

Thomas J. Schall, ChemoCentryx, Inc., USA
Title to be Determined

* Craig Gerard, Children's Hospital Harvard University, USA
Modulation of Infectious Disease in Chemokine Receptor Knockout Mice


TUESDAY, FEBRUARY 20

07:00—08:00
Breakfast

Rio Grande
08:00—11:00
Chemokines in Normal Immune Function
Meeting has ended...abstracts no longer viewable online.

Bataan
* Alberto Mantovani, Humanitas University, Italy

Massimo Locatti, Istituto Clinico Humanitas IRCCS, Italy

Martin Lipp, Max-Delbrueck-Center, MDC, Germany
Functional Organization of the Immune Response by Homeostatic Chemokines

Barrett J. Rollins, Dana Farber Cancer Institute, USA
MCP-1's Influence on Inflammation and T Helper Cell Polarization

Hideki Nakano, National Institute of Environmental Health Science, USA
Short Talk: Delayed and Enhanced T Cell Response in the plt Mutant Mice

Christophe Caux, Centre Léon Bérard, France
Short Talk: Sequential Involvement of Chemokines for Immature DC Recruitment at Inflamed Epithelial Surfaces

Sergio A. Lira, Mount Sinai School of Medicine, USA
Short Talk: Aberrant in vivo Th2 Cell Response and Impaired Eosinophil Recruitment in CCR8 Knockout Mice

09:20—09:40
Coffee Break

Rio Grande
16:00—17:00
Coffee Available

Hallway
16:00—18:00
Progress Towards Clinical Intervention
Meeting has ended...abstracts no longer viewable online.

Bataan
Joseph E. Hesselgesser, Gilead Sciences, USA
The CCR1 Antagonist BX 471 is Effective in Animal Models of Multiple Sclerosis and Organ Transplant Rejection

Julie M. Strizki, Merck and Co., USA
Development of SCH-C, a Small Molecule Antagonist of CCR5, as a Novel Therapeutic

Louise Anne Conroy, Cambridge Antibody Technology, UK
Short Talk: Therapeutic Human Anti-Cytokine and Anti-Chemokine Antibodies Isolated by Phage Display

Francesco Colotta, Nerviano Medical Sciences, Italy
Short Talk: Small Organic Inhibitors of IL-8 Reduce Tissue Damage in Animal Models of Post-Ischemia Reperfusion Injury

19:00—20:00
Social Hour

Rio Grande
20:00—22:00
Banquet

Bataan
21:00—00:00
Entertainment

Bataan

WEDNESDAY, FEBRUARY 21

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 AI48735-01




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