Granlibakken Tahoe Floorplan

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This meeting took place in 2001



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Membrane Protein Structure/Function Relationships (D1)


Organizer(s) H. Ronald Kaback and Ernest M. Wright
March 5—11, 2001
Granlibakken Tahoe • Tahoe City, California USA
Abstract Deadline: Nov 6, 2000
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Jan 5, 2001

Sponsored in part by the Director's Sponsor Fund

Summary of Meeting:
Of the genomes sequenced thus far, about 30% of the gene products are predicted to be polytopic transmembrane proteins. These hydrophobic proteins catalyze a multitude of essential functions, from oxidative phosphorylation and electron transfer, to transport of molecules into and out of cells and intracellular organelles, to signal transduction across membranes, and many are important with regard to human disease. Although advances in molecular biology and biochemistry over the past 15 years have led to the characterization, purification and modification of this class of proteins, only a handful of these proteins have been crystallized in a form that allows structure determination at atomic resolution, which is essential for understanding mechanism of action. Furthermore, many membrane proteins require conformation flexibility in order to function, making it imperative to obtain dynamic information as well in order to fully understand function. Thus, a major problem in this area is the difficulty inherent in obtaining structural information at a relevant level of resolution. The purpose of this symposium is to bring together key investigators studying structure/function relationships at the molecular level in polytopic membrane proteins involved in a variety of functions from as many different perspectives as possible. It is expected that by bringing such individuals together, discussions will focus the field on the importance of high resolution,structure-function studies in order to understand this important class of biological molecules.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


MONDAY, MARCH 5

14:00—19:00
Registration

Lobby
19:15—19:30
Orientation

Granhall
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Granhall
* Douglas C. Rees, California Institute of Technology, USA
Structural Aspects of Membrane Protein Function and Stability


TUESDAY, MARCH 6

07:00—08:00
Breakfast

Granhall
08:00—11:00
General Approaches
Meeting has ended...abstracts no longer viewable online.

Mtn/Lake Room
* Stephen H. White, University of California, Irvine, USA
Folding Proteins into Membranes

James U. Bowie, University of California, Los Angeles, USA
Stabilizing Membrane Proteins

Wayne L. Hubbell, University of California, Los Angeles, USA
A New Spin on Structure/Function Relationships in Membrane Proteins

Karen G. Fleming, Johns Hopkins University, USA
Energetics of Helix-Helix Interactions

09:20—09:40
Coffee Break

Prefunction
11:00—13:00
Poster Setup

Bay Room
16:00—18:00
POSTER SESSION 1: General Approaches/Membrane Protein Structure

Bay Room
17:00—18:00
Social Hour

Bay Room
18:00—19:00
Dinner

Granhall
19:00—20:00
Coffee Available

Prefunction
19:00—20:30
Membrane Protein Structure 1
Meeting has ended...abstracts no longer viewable online.

Mtn/Lake Room
* Douglas C. Rees, California Institute of Technology, USA

Ehud M. Landau, University of Texas Medical Branch, USA
Structure-Function Relationships in Retinal Proteins

Ronald E. Stenkamp, University of Washington, USA
Structural Studies of Rhodopsin, a G-Protein Coupled Receptor


WEDNESDAY, MARCH 7

07:00—08:00
Breakfast

Granhall
08:00—11:00
Membrane Protein Structure 2
Meeting has ended...abstracts no longer viewable online.

Mtn/Lake Room
Shinya Yoshikawa, University of Hyogo, Japan
X-ray Structure and Reaction Mechanism of Bovine Heart Cytochrome c Oxidase

So Iwata, Imperial College London, UK
Structural Studies on the Bacterial Terminal Oxydases

Andreas Engel, University of Basel, Switzerland
Structure and Function of Water Channel Proteins

* Robert M. Stroud, University of California, San Francisco, USA
What Does the Structure of a Glycerol Channel Tell Us About Selectivity, Conductivity and Regulation?

09:20—09:40
Coffee Break

Prefunction
16:00—18:00
Workshop 1: Emerging Techniques

Mtn/Lake Room
17:00—18:00
Social Hour

Bay Room
18:00—19:00
Dinner

Granhall
19:00—20:00
Coffee Available

Prefunction
19:00—21:00
Membrane Protein Structure 3
Meeting has ended...abstracts no longer viewable online.

Mtn/Lake Room
* Gene A. Scarborough, University of North Carolina at Chapel Hill, USA
Structure and Conformational Dynamics of the P-Type ATPases

Chikashi Toyoshima, University of Tokyo, Japan
Crystal Structure of the Calcium Pump of Sarcoplasmic Reticulum

Eduardo A. Perozo, University of Chicago, USA
Structural Basis for Activation Gating in Channels


THURSDAY, MARCH 8

07:00—08:00
Breakfast

Granhall
08:00—11:00
Ion Channels
Meeting has ended...abstracts no longer viewable online.

Mtn/Lake Room
* Christopher Miller, Brandeis University, USA
CLC-Type Chloride Channels

Francisco Bezanilla, University of Chicago, USA
Movements of the Voltage-sensor in Voltage-dependent Channels

Peter C. Agre, Johns Hopkins Malaria Research Institute, USA
Aquaporin Water Channels

Lise Heginbotham, Yale University, USA
Probing the Dimensions of the KscA K+ Channel in the Open State

09:20—09:40
Coffee Break

Prefunction
11:00—13:00
Poster Setup

Bay Room
16:00—18:00
POSTER SESSION 2: Ion Channels/Transporters A - Primary/Transporters B - Secondary/ABC Transporters/Ligand-Gated Ion Channels/Non-Channel Receptors

Bay Room
17:00—18:00
Social Hour

Bay Room
18:00—19:00
Dinner

Granhall
19:00—20:00
Coffee Available

Prefunction
19:00—21:00
Transporters A - Primary
Meeting has ended...abstracts no longer viewable online.

Mtn/Lake Room
* Robert H. Fillingame, University of Wisconsin-Madison, USA
Transmembrane Fo Sector of Rotary ATP Synthase: Structure and Mechanism

Peter Dimroth, ETH Zentrum, Switzerland
Operation Principles of the Propionigenium modestum Fo Motor

Steven Karlish, Weizmann Institute of Science, Israel
The Energy Transduction Mechanism of Na,K-ATPase


FRIDAY, MARCH 9

07:00—08:00
Breakfast

Granhall
08:00—11:00
Transporters B - Secondary
Meeting has ended...abstracts no longer viewable online.

Mtn/Lake Room
* Ernest M. Wright, University of California, Los Angeles, USA
Sodium-Coupled Glucose Transporters

Shimon Schuldiner, Hebrew University of Jerusalem, Israel
A Common Binding Site for Substrates and Protons in EmrE, an Ion-Coupled Multidrug Transporter

Etana Padan, Hebrew University of Jerusalem, Israel
Structure and Function of NhaA Na+/H+ Antiporter

H. Ronald Kaback, University of California, Los Angeles, USA
Lac Permease Structure and Function: So Close, Yet So Far

09:20—09:40
Coffee Break

Prefunction
17:00—18:00
Social Hour

Bay Room
18:00—19:00
Dinner

Granhall
19:00—20:00
Coffee Available

Prefunction
19:00—21:00
ABC Transporters
Meeting has ended...abstracts no longer viewable online.

Mtn/Lake Room
* Wil N. Konings, University of Groningen, Netherlands
LmrA, A P-Glycoprotein Homologue in Lactococcus lactis, Confers Resistance to a Broad Spectrum of Antibiotics

Philippe Gros, McGill University, Canada
Functional Analyses of the Nucleotide Binding Sites of P-Glycoprotein and Their Role in the Catalytic Cycle and Drug Transport

Barry P. Rosen, Florida International University, USA
Structure of the ArsA ATPase


SATURDAY, MARCH 10

07:00—08:00
Breakfast

Granhall
08:00—11:00
Ligand-Gated Ion Channels
Meeting has ended...abstracts no longer viewable online.

Mtn/Lake Room
* Arthur Karlin, Columbia University, USA
Structures and States of the Acetylcholine Receptor

Paul A. Slesinger, The Salk Institute, USA
Structural Features of the Serotonin-Gated Ion Channel

Steven A. Siegelbaum, Columbia University, USA
Structural Changes upon Opening of Cyclic Nucleotide-Gated Channels

Katjusa Brejc, Netherlands Cancer Institute, Netherlands
Crystal Structure of AChBP, a Homologue of the Ligand-Binding Domain of the Acetylcholine Receptor

09:20—09:40
Coffee Break

Prefunction
16:00—17:00
Coffee Available

Prefunction
16:00—18:00
Non-Channel Receptors
Meeting has ended...abstracts no longer viewable online.

Mtn/Lake Room
Jonathan A. Javitch, Columbia University, USA
Mapping the Binding-Site Crevice of G-Protein-Coupled Receptors

Daniel D. Oprian, Brandeis University, USA
Structure and Function of Rhodepsin

* Joseph J. Falke, University of Colorado, USA
The Aspartate Receptor: Mechanisms of Covalent Adaptation and Kinase Regulation

19:00—20:00
Social Hour

Bay Room
20:00—22:00
Banquet

Granhall
21:00—00:00
Entertainment

Granhall

SUNDAY, MARCH 11

07:00—08:00
Breakfast

Granhall
 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 DK58527-01




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