Granlibakken Tahoe Floorplan

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This meeting took place in 2001



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Cell Migration and Invasion (D3)


Organizer(s) Alan Rick Horwitz, Douglas A. Lauffenburger and Arthur M. Mercurio
March 11—16, 2001
Granlibakken Tahoe • Tahoe City, California USA
Abstract Deadline: Nov 10, 2000
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Jan 11, 2001

Sponsored in part by the Director's Sponsor Fund

Summary of Meeting:
Cell invasion plays a central role in important physiological and pathological phenomena including embryonic development, inflammation, cellular transplantation and tumor metastasis. For this reason, invasion is emerging as a key therapeutic target for cancer and other diseases. Cell migration provides an accessible model of understanding how individual cells function as integrated systems and interpret multiple, complex signals in their environment. Substantial progress is being made in understanding the molecular basis of cell migration and invasion. Examples include: elucidation of the receptors and signal transduction pathways involved, identification of the pathways that regulate the formation and release of adhesions, development of technologies for observing cellular and molecular dynamics in vivo, and elucidation of the mechanisms that regulate action polymerization and organization. The goal of this meeting is to bring together investigators studying basic mechanisms of migration with those interested in the role of migration and invasion in specific diseases and in developing therapeutic strategies.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MARCH 11

14:00—19:00
Registration

Lobby
19:15—19:30
Orientation

Mountain Ballroom
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Mountain Ballroom
Thomas P. Stossel, Brigham and Women's Hospital, USA
The Centrality of Actin Remodeling in Cell Migration and Invasion: Coping with Complexity


MONDAY, MARCH 12

07:00—08:00
Breakfast

Granhall
08:00—11:00
Formation and Dynamics of Adhesions
Meeting has ended...abstracts no longer viewable online.

Mountain Ballroom
Kenneth M. Yamada, NIDCR, National Institutes of Health, USA
Integrin Complexes in Matrix Interactions, Migration and Signaling

J. Victor Small, Austrian Academy of Sciences, Austria
Regulating the Actin Cytoskeleton for Cell Motility

* Benjamin Geiger, Weizmann Institute of Science, Israel
The Molecular Dynamics of Cell-Matrix Adhesions: Cross-Talk with the Signal Transduction System

Laura M. Machesky, Beatson Institute for Cancer Research, Scotland
Signaling to Cell Motility via the WASP-Family Proteins and the Arp2/3 Complex

Gareth E. Jones, King's College London, UK
Short Talk: Human Dendritic Cell Motility is Controlled by Rho GTPases through WASp-Arp2/3

09:20—09:40
Coffee Break

Prefunction
11:00—13:00
Poster Setup

Mountain Ballroom
16:00—17:00
Coffee & Snacks Available

Prefunction
16:30—18:30
Motors, Contraction and Forces
Meeting has ended...abstracts no longer viewable online.

Mountain Ballroom
* Douglas A. Lauffenburger, Massachusetts Institute of Technology, USA

Kozo Kaibuchi, Nagoya University Graduate School of Medicine, Japan
Involvement of IQGAP1, an Effector of Cdc42 and Rac1 GTPases, in Cell-Cell Dissociation during Cell Scattering

Michael P. Sheetz, Mechanobiology Institute, National University of Singapore, Singapore
Integrin Force-Sensing by Tyrosine Phosphatases and Kinases

Erik A. Sahai, Cancer Research UK London Research Institute, UK
Short Talk: Ras-Map Kinase Signalling Promotes Cell Motility by Uncoupling Rho-GTP from Formation of Actin Stress Fibres

Keow Lin Goh, Massachusetts Institute of Technology, USA
Short Talk: Role of Ena/VASP Proteins in Cortical Neuronal Migration

Sandrine Etienne-Manneville, Institut Pasteur, France
Short Talk: Polarization of Migrating Astrocytes Involves Cdc42, Par6 and PKCzeta

18:30—19:30
Dinner

Granhall
19:30—21:30
Poster Session 1: Formation and Dynamics of Adhesions/Motors, Contraction and Forces

Mountain Ballroom
19:30—20:30
Social Hour

Mountain Ballroom

TUESDAY, MARCH 13

07:00—08:00
Breakfast

Granhall
08:00—11:00
Signal Transduction Pathways
Meeting has ended...abstracts no longer viewable online.

Mountain Ballroom
* J. Thomas Parsons, University of Virginia Health Science Center, USA
Focal Adhesion Signaling and Migration

Alan H. Wells, University of Pittsburgh, USA
EGF Signaling of Cell Migration

Martin Schwartz, Yale School of Medicine, USA
Integrin Regulation of Rac and Cdc42 Membrane Targeting and Effector Coupling

Peter N. Devreotes, Johns Hopkins University, USA
Chemoattractant Gradient Sensing by Eucaryotic Cells

Ivan de Curtis, San Raffaele Scientific Institute, Italy
Short Talk: Rac-Mediated Cell Motility: p95-APP1 Links Membrane Traffic to Reorganization of Actin

09:20—09:40
Coffee Break

Prefunction
11:00—13:00
Poster Setup

Mountain Ballroom
16:00—17:00
Coffee & Snacks Available

Prefunction
16:30—18:30
Imaging Invasion
Meeting has ended...abstracts no longer viewable online.

Mountain Ballroom
* Arthur M. Mercurio, University of Massachusetts Medical School, USA

Rakesh K. Jain, Massachusetts General Hospital and Harvard Medical School, USA
Imaging Gene Expression, Angiogenesis and Microcirculation in Tumor: Role of Microenvironment

Paul M. Kulesa, California Institute of Technology, USA

Jeffrey E. Segall, Albert Einstein College of Medicine, USA
In vivo Imaging of Tumor Cell Invasion

Ed Roos, Netherlands Cancer Institute, Netherlands
Short Talk: Interplay of Chemokine and Integrin Signals in Invasion and Metastasis of Lymphomas

18:30—19:30
Dinner

Granhall
19:30—21:30
Poster Session 2: Signal Transduction Pathways/Imaging Invasion

Mountain Ballroom
19:30—20:30
Social Hour

Mountain Ballroom

WEDNESDAY, MARCH 14

07:00—08:00
Breakfast

Granhall
08:00—11:00
Signaling Mechanisms Regulating Migration/Invasion
Meeting has ended...abstracts no longer viewable online.

Mountain Ballroom
* Anne J. Ridley, King's College London, UK
Rho GTPases in Cell Migration

Arthur M. Mercurio, University of Massachusetts Medical School, USA
Integrin alpha6beta4 Function and Carcinoma Progression

David A. Cheresh, University of California, San Diego, USA
Integrin and Growth Factor - Regulation of Migration and Angiogenesis

John G. Collard, Netherlands Cancer Institute, Netherlands
Rho Signaling Networks in Cell-Cell Adhesion and Invasion

Bradford W. Ozanne, Beatson Institute for Cancer Research, UK
Short Talk: The Transcription Factor AP-1 Regulates a Multigenic Invasion Program

09:20—09:40
Coffee Break

Prefunction
11:00—13:00
Poster Setup

Mountain Ballroom
16:00—17:00
Coffee & Snacks Available

Prefunction
16:30—18:30
Adhesive Regulation of Invasion
Meeting has ended...abstracts no longer viewable online.

Mountain Ballroom
* Anna Huttenlocher, University of Wisconsin, USA
Regulation of Cell Migration and Adhesive Complex Dynamics by the Calcium-Dependent Protease Calpain

Martin E. Hemler, Dana Farber Cancer Institute, USA
Phosphorylation of a Conserved Integrin a3 QPSXXE Motif Regulates Signaling, Motility and Cytoskeletal Engagement

Richard L. Klemke, University of California, San Diego Medical Center, USA
Temporal and Spatial Organization of Cytoskeletal-Associated Signals in Leading Pseudopodia and Trailing Rear Compartments of Polarized Cells

Donna Webb, Vanderbilt University, USA
Short Talk: Integrin Endocytosis at the Leading Edge of Protrusions in Migrating Cells

18:30—19:30
Dinner

Granhall
19:30—21:30
Poster Session 3: Signaling Mechanisms Regulating Migration/Invasion/Adhesive Regulation of Invasion/Extracellular Regulators/Engineering Migration

Mountain Ballroom
19:30—20:30
Social Hour

Mountain Ballroom

THURSDAY, MARCH 15

07:00—08:00
Breakfast

Granhall
08:00—11:00
Extracellular Regulators
Meeting has ended...abstracts no longer viewable online.

Mountain Ballroom
Paolo M. Comoglio, University of Torino Medical School, Italy
Plasminogen-Related Growth Factor and Semaphorin Receptors: A Gene Superfamily Controlling Invasive Growth

Walter Birchmeier, Max Delbruck Center for Molecular Medicine, Germany
New Substrates of Receptor Tyrosine Kinases for Biological Responses

* W. James Nelson, Stanford University, USA
Cytomechanics of Cell Adhesion

Denise J. Montell, University of California, Santa Barbara, USA
Hormonal Control of Invasive Cell Behavior in vivo

Michael F. Olson, University of Pennsylvania, USA
Short Talk: Membrane Blebbing During Apoptosis Results from Caspase-Mediated Activation of ROCK I

09:20—09:40
Coffee Break

Prefunction
15:00—16:00
Coffee Available

Prefunction
16:00—18:00
Engineering Migration
Meeting has ended...abstracts no longer viewable online.

Mountain Ballroom
Douglas A. Lauffenburger, Massachusetts Institute of Technology, USA
Autocrine Ligands and Cell Migration

Jeffrey A. Hubbell, University of Chicago, USA
Biologically-Derived and Synthetic Biomimetic Three-Dimensional Cell Ingrowth Matrices

* Linda G. Griffith, Massachusetts Institute of Technology, USA
Nanoscale Spatial Control of Ligand Presentation Controls Cell Migration Response

Frieder Schoeck, McGill University, Canada
Short Talk: Germband Shortening in Drosophila is Mediated by Cell-Matrix Interactions

19:00—20:00
Social Hour

Mountain Ballroom
20:00—22:00
Banquet

Mountain Ballroom
21:00—00:00
Entertainment

Mountain Ballroom

FRIDAY, MARCH 16

07:00—08:00
Breakfast

Granhall
 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 CA88801-01




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