Beaver Run Resort Floorplan

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This meeting took place in 2001



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Control of Viral Latency and Persistence (D6)


Organizer(s) Bernard Roizman, Peter M. Howley, Flossie Wong-Staal and Richard J. Whitley
March 24—29, 2001
Beaver Run Resort • Breckenridge, Colorado USA
Abstract Deadline: Nov 22, 2000
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Jan 24, 2001

Sponsored by Roche Diagnostics GmbH

Summary of Meeting:
Members of several families of viruses (e.g., adenoviruses, parvoviruses, papillomaviruses, papovaviruses, herpesviruses, retroviruses, etc.) persist in human cells principally, but not exclusively, by establishing latent infections. In the course of latent infections, viral genomes are retained in an episomal state or become integrated in cellular chromosomes, but retain the capacity to replicate and to cause significant morbidity. In recent years there have been significant advances in the understanding of the diversity of mechanisms by which viruses establish latency. Among many key findings are identification of viral and cellular functions involved in the establishment of latency and reactivation from latent state. Equally important is the current research on suppression of reactivation and on deliberate reactivation of latent viruses in the presence of antiviral drugs. The intent of the Keystone conference is to bring together key investigators working on fundamental aspects of viral persistence and on the efforts to control and ultimately eradicate latent viruses.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SATURDAY, MARCH 24

14:00—19:00
Registration

Third Floor Lobby
18:15—19:15
Welcome

Third Floor Lobby
19:15—19:30
Orientation

Peak 5

SUNDAY, MARCH 25

07:00—08:00
Breakfast

Peaks 1 - 3
08:00—11:00
Herpesviruses I
Meeting has ended...abstracts no longer viewable online.

Peak 5
Lawrence A. Feldman, University of California, Los Angeles, USA
Herpes Simplex Virus Latent Functions

* James R. Smiley, University of Alberta, Canada
Herpes Simplex Virus Triggers and Disarms a Host Antiviral Response: Mechanisms and Implications

Edward S. Mocarski, Emory University, USA
Latent Gene Products of Cytomegalovirus

Philip E. Pellett, Wayne State University Medical School, USA
Roseolovirus Persistence and Latency

Lori D. Frappier, University of Toronto, Canada
Short Communication: Reconstitution of Epstein-Barr Nuclear Antigen 1 (EBNA1)-Mediated Plasmid Partitioning in Budding Yeast Requires Human EBP2

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Peak 4
15:00—16:00
Workshop 1

Peak 5
* Edward S. Mocarski, Emory University, USA

Stijn Heessen, Karolinska Institute, Sweden
Analysis of the Inhibition of Proteasomal Degradation by the EBNA1 Gly-Ala Repeat

Liudmila V. Matskova, Karolinska Institute, Sweden
Latent Membrane Protein 2A of Epstein-Barr Virus Binds WW Domain E3 Protein-Ubiquitin Ligase that Ubiquitinate B-Cell Tyrosine Kinases

Dirk Peter Dittmer, University of Oklahoma Health Sciences Center, USA
Overlapping Latent and Lytic Promoters in Kaposi's Sarcoma-Associated Herpesvirus (KSHV/HHV-8)

Eric T. Clambey, University of Colorado Denver, USA
Genetic Analysis of the M1 ORF and 9.4 Kilobases of Murine Gammaherpesvirus 68 Previously Identified as a Transcriptionally Active Region During Latency

16:00—18:00
Poster Session 1: Herpesviruses

Peak 4
17:00—18:00
Social Hour

Peak 4
20:00—21:00
Coffee Available

Foyer
20:00—22:00
Herpesviruses II
Meeting has ended...abstracts no longer viewable online.

Peak 5
Jeffrey I. Cohen, National Institutes of Health, USA
Varicella-Zoster Virus Latency

* Nancy J. Raab-Traub, University of North Carolina at Chapel Hill, USA
Epstein Barr Virus Latent Infection in Epithelial Cells

Donald E. Ganem, Novartis Institutes for BioMedical Research, USA
Latent and Lytic Herpesviral Functions in the Pathogenesis of Kapusi's Sarcoma


MONDAY, MARCH 26

07:00—08:00
Breakfast

Peaks 1 - 3
08:00—11:00
Papillomaviruses
Meeting has ended...abstracts no longer viewable online.

Peak 5
* Peter M. Howley, Harvard University Medical School, USA
Papillomavirus Transformation Functions

Denise A. Galloway, Fred Hutchinson Cancer Research Center, USA
The Role of the HPV 16 E6 Oncoprotein in Cellular Immortalization

Laimonis A. Laimins, Northwestern University, USA
A Genetic Analysis of the Human Papillomavirus Life Cycle

Alison A. McBride, NIAID, National Institutes of Health, USA
Regulation of the Papillomavirus Lifecycle by the E2 Regulatory Proteins

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Peak 4
15:00—16:00
Workshop 2

Peak 5
* Laimonis A. Laimins, Northwestern University, USA

Dennis John McCance, University of Rochester, USA
The E6 Protein from Human Papillomavirus Type 16 (HPV-16) Inhibits Transcription of IL-6 and IL-8

Toni Cathomen, University Medical Center Freiburg, Germany
Identification of Cellular Proteins that Regulate the Life Cycle of Adeno-Associated Virus (AAV)

Simo Pekka Nikkari, Stanford University, USA
Presence of Parvovirus B19 DNA in Human Skin - A New Site for B19 Persistence?

Christopher D. Meiering, Fred Hutchinson Cancer Research Center, USA
Differential Regulation of the Two Foamy Virus Promoters in Lytic and Persistent Infection

Toshiki Watanabe, University of Tokyo, Japan
Roles of CpG Methylation in HTLV-1 Latency and Malignant Transformation

16:00—18:00
Poster Session 2: Papillomaviruses/Papovaviruses, Adenoviruses and Parvoviruses/Lentiviruses/Oncornaviruses and Lentiviruses/Hepatitis Viruses B and C/Control of Viral Latency

Peak 4
17:00—18:00
Social Hour

Peak 4
20:00—21:00
Coffee Available

Foyer
20:00—22:00
Papovaviruses, Adenoviruses and Parvoviruses
Meeting has ended...abstracts no longer viewable online.

Peak 5
* Luis P. Villarreal, University of California, Irvine, USA
Persistence of Polyomavirus and Its Link to Host Cell Differentiation

Nicholas Muzyczka, University of Florida, USA
Parvovirus Replication Functions

Philip E. Branton, McGill University, Canada
Human Adenovirus E4ORF6 and E1B55K Proteins are Subunits of a Cullin-Containing E3 Ubiquitin Ligase that Targets p53


TUESDAY, MARCH 27

07:00—08:00
Breakfast

Peaks 1 - 3
08:00—11:00
Lentiviruses
Meeting has ended...abstracts no longer viewable online.

Peak 5
Robert F. Siliciano, Johns Hopkins University School of Medicine, USA
Latent Infection of Resting CD4+ T Cells: A Mechanism for Lifetime Persistence of HIV-1

* Janice E. Clements, Johns Hopkins University, USA
Role of the CNS as a Reservoir in Lentivirus Infections

Eric M. Verdin, University of California, San Francisco, USA
Molecular Basis of HIV Latency

09:20—09:40
Coffee Break

Foyer
15:00—16:00
Workshop 3

Peak 5
* Janice E. Clements, Johns Hopkins University, USA

Emily D. Overholser, Johns Hopkins School of Medicine, USA
Differential Replication of SIV in Primary Rhesus Astrocytes

Takaomi Ishida, University of Tokyo, Japan
Cell Cycle Dependent Reactivation of Latent HIV-1 Associated with Demethylation of CpG Sites in LTR

Fiona J. Davidson, University of Edinburgh, UK
Hepatitis B Virus Mutants and Clinical Implications

16:00—18:00
Poster Sessions 1, 2, 3: Open Viewing

Peak 4
17:00—18:00
Social Hour

Peak 4
20:00—21:00
Coffee Available

Foyer
20:00—22:00
Oncornaviruses and Lentiviruses
Meeting has ended...abstracts no longer viewable online.

Peak 5
* Denise A. Galloway, Fred Hutchinson Cancer Research Center, USA

Julie M. Overbaugh, Fred Hutchinson Cancer Research Center, USA
Infection of T-Cell-Tropic FeLV Requires a Two Component Receptor

Kuan-Teh Jeang, National Institutes of Health, USA
HTLV-I Tax and Dysregulation of Cell Cycle Controls

Maxine L. Linial, Fred Hutchinson Cancer Research Center, USA
Foamy Virus Replication and Persistence


WEDNESDAY, MARCH 28

07:00—08:00
Breakfast

Peaks 1 - 3
08:00—11:00
Hepatitis Viruses B and C
Meeting has ended...abstracts no longer viewable online.

Peak 5
* Carlos V. Paya, Immune Design, USA

David R. Milich, Vaccine Research Institute of San Diego, USA
Mechanisms of Persistence of Hepatitis B Infection

Charles M. Rice, Rockefeller University, USA
Molecular Characterization of Hepatitis C Virus

Francis V. Chisari, The Scripps Research Institute, USA
Hepatitis B Virus Purging, Persistence and Pathogenesis

Jesse W. Summers, University of New Mexico, USA
Viral Competition and Replication Space During Hepadnavirus Infection

09:20—09:40
Coffee Break

Foyer
16:00—17:00
Coffee Available

Foyer
16:00—18:00
Control of Viral Latency
Meeting has ended...abstracts no longer viewable online.

Peak 5
Anna Wald, University of Washington, USA
Herpes Simplex Virus Reactivation in Humans

* Carlos V. Paya, Immune Design, USA
Role of NF-kappaB in Regulating HIV Latency and Persistence in Immune Cells

19:00—20:00
Social Hour

Coppertop
20:00—22:00
Banquet

Coppertop
21:00—00:00
Entertainment

Tiffany's

THURSDAY, MARCH 29

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 AI48841-01




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