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This meeting took place in 2001



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The Molecular Basis of Neurodegenerative Disease (E1)


Organizer(s) Sangram S. Sisodia, Huda Y. Zoghbi, Paul F. Worley and Donald L. Price
March 29—April 3, 2001
Sheraton Steamboat Resort • Steamboat Springs, Colorado USA
Abstract Deadline: Nov 29, 2000
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Jan 29, 2001

Sponsored in part by the Director's Sponsor Fund

Summary of Meeting:
The neurodegenerative disorders, a heterogeneous group of chronic progressive diseases, arise via complex etiologies. Fortunately, the discovery of pathogenic gene mutations that cause familial, autosomal dominant forms of several of these disorders have offered extraordinary opportunities to clarify the relationship of genetic lesions to the pathogenesis of these puzzling illnesses. Indeed, cell culture and transgenic animal models have been developed to address the cellular and molecular consequences of expressing mutant genes that cause familial forms of several disorders, including Alzheimer’s disease, prion diseases, trinucleotide expansion diseases and amytrophic lateral sclerosis. Despite these advances, the biochemical, physiological and clinical consequences of expressing mutant proteins in vivo and the underlying molecular bases for selective vulnerability of specific subsets of neurons in each of these disorders is poorly understood. Sadly, neither treatments, nor effective therapies have been developed for these devastating illnesses. Our program is intended to develop a conceptual framework that addresses these critical issues. The speakers will provide a synthesis of diverse areas that are highly pertinent to the topic, including brain development, synaptic plasticity, neurodegeneration, genetics, and models of neurodegenerative diseases. Finally, investigators will discuss the potential of neuroprotective and regenerative strategies for neurodegenerative disorders.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


THURSDAY, MARCH 29

14:00—19:00
Registration

Foyer
18:15—19:15
Welcome

Foyer
19:15—19:30
Orientation

Sunshine/Mt. Werner
19:30—20:30
Opening Address
Meeting has ended...abstracts no longer viewable online.

Sunshine/Mt. Werner
Donald L. Price, Johns Hopkins University, USA
Overview of Neurodegenerative Diseases


FRIDAY, MARCH 30

07:00—08:00
Breakfast

3 Saddles
08:00—11:00
Neural Development
Meeting has ended...abstracts no longer viewable online.

Sunshine/ Mt. Werner
Hollis T. Cline, The Scripps Research Institute, USA
Activity-regulated Mechanisms Controlling Brain Development

Stephen T. Warren, Emory University School of Medicine, USA
The Molecular Basis of Fragile X Syndrome

* Judith Melki, INSERM, France
Degenerative Process in Spinal Muscular Atrophy

Joachim Herz, University of Texas Southwestern Medical Center, USA
Roles of Neuronal Apolipoprotein E Receptors in Brain Development and Neurodegeneration

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Twilight/ Rainbow
16:00—18:00
Poster Session 1: Neural Development/Synaptic Interactions

Twilight/ Rainbow
17:00—18:00
Social Hour

Foyer
20:00—21:00
Coffee Available

Foyer
20:00—22:00
Synaptic Interactions
Meeting has ended...abstracts no longer viewable online.

Sunshine/ Mt. Werner
* Thomas C. Südhof, Stanford School of Medicine, USA
Molecular Mechansims of Presynaptic Plasticity

Paul F. Worley, Johns Hopkins School of Medicine, USA
Activity-Dependent Synaptic Plasticity

Roberto Malinow, University of California, San Diego, USA
AMPA Receptor Trafficking During Synaptic Plasticity


SATURDAY, MARCH 31

07:00—08:00
Breakfast

3 Saddles
08:00—11:00
Mechanisms of Neurodegeneration
Meeting has ended...abstracts no longer viewable online.

Sunshine/ Mt. Werner
* Michael E. Greenberg, Harvard Medical School, USA
Signal Transduction Pathways that Prevent Neurodegeneration

Dale E. Bredesen, Buck Institute for Research on Aging, USA
An Alternative, Non-apoptotic Form of Programmed Cell Death

Jeffrey H. Kordower, Rush Presbyterian St. Lukes Medical College, USA
Lentiviral Delivery of GDNF in Nonhuman Primate Models of Parkinson's Disease

Mahlon Delong, Emory University School of Medicine, USA
Pathophysiology of Parkinson's Disease

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Twilight/ Rainbow
16:00—18:00
Poster Session 2: Mechanisms of Neurodegeneration/Genetics of Neurodegenerative Diseases

Twilight/ Rainbow
17:00—18:00
Social Hour

Foyer
20:00—21:00
Coffee Available

Foyer
20:00—22:00
Genetics of Neurodegenerative Diseases
Meeting has ended...abstracts no longer viewable online.

Sunshine/ Mt. Werner
Kenneth H. Fischbeck, National Institutes of Health, USA
Kennedy's Disease

* Rudolph E. Tanzi, Massachusetts General Hospital, USA
The Genetics of Alzheimer's Disease

Short Talk(s) Chosen from Abstracts


SUNDAY, APRIL 1

07:00—08:00
Breakfast

3 Saddles
08:00—11:00
Mutant Proteins in Neurodegenerative Diseases
Meeting has ended...abstracts no longer viewable online.

Sunshine/ Mt. Werner
Sangram S. Sisodia, University of Chicago, USA
Molecular Mechanisms of Familial Alzheimer's Disease

Huda Y. Zoghbi, HHMI/Baylor College of Medicine, USA
Genetic Studies to Unravel the Pathogenesis of Spinocerebellar Ataxia Type 1

Virginia M. Y. Lee, University of Pennsylvania School of Medicine, USA
Pathobiology of Mutant Tau Proteins in Neurodegenerative Diseases

* Jeffrey D. Rothstein, Johns Hopkins University, USA
Amytrophic Lateral Sclerosis - Multiple Proteins Responsible for Motor Neuron Degeneration

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Twilight/ Rainbow
16:00—18:00
Poster Session 3: Mutant Proteins in Neurodegenerative Diseases/Animal Models/Molecular Mechanisms/Regeneration and Repair

Twilight/ Rainbow
17:00—18:00
Social Hour

Foyer
20:00—21:00
Coffee Available

Foyer
20:00—22:00
Animal Models
Meeting has ended...abstracts no longer viewable online.

Sunshine/ Mt. Werner
Donald L. Price, Johns Hopkins University, USA
The Value of Transgenic Models for Studies of Neurodegenerative Disease

* Don W. Cleveland, University of California, San Diego, USA
SOD1 Mutants, Neurofilaments and Lou Gehrig’s Disease

Harry T. Orr, University of Minnesota, USA
The Molecular Basis of a Polyglutamine-Induced Neurodegenerative Disease, SCA1


MONDAY, APRIL 2

07:00—08:00
Breakfast

3 Saddles
08:00—11:00
Molecular Mechanisms
Meeting has ended...abstracts no longer viewable online.

Sunshine/ Mt. Werner
Patrick Tremblay, University of California, San Francisco, USA
Transgenic Models to Study the Development of Prion Diseases

* Ted M. Dawson, Johns Hopkins University School of Medicine, USA
Molecular Mechanisms of Selective Vulnerability in Parkinson's Disease

David R. Borchelt, Johns Hopkins School of Medicine, USA
Transgenic Mouse Models of Polyglutamine Disorders

Mirella Gonzalez-Zulueta, AGY Therapeutics, USA
Mechanistic Pathways of Neurological Disease Models Based on Gene Expression Analysis

09:20—09:40
Coffee Break

Foyer
16:00—17:00
Coffee Available

Foyer
16:00—18:00
Regeneration and Repair
Meeting has ended...abstracts no longer viewable online.

Sunshine/ Mt. Werner
Evan Snyder, Sanford-Burnham Medical Research Institute, USA
Neural Stem Cells May be Ideally Suited for Gene Therapy and Cell Replacement in the Degenerating CNS

Steven Goldman, University of Rochester Medical Center, USA
Isolation and Induction of A Neural Progenitors of the Adult Human Brain

* Ronald D. McKay, Lieber Institute for Brain Development, USA
From Stem Cells to Synapses

19:00—20:00
Social Hour

Foyer
20:00—22:00
Banquet

Storm Peak/Mt. Werner
21:00—00:00
Entertainment

Storm Peak/Mt. Werner

TUESDAY, APRIL 3

 
Departure


*Session Chair †Invited, not yet responded.



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