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This meeting took place in 2001



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Eicosanoid Lipid Mediators: Biochemistry, Molecular Biology and Pharmacology and Cell-Cell Interactions in Inflammation (E6)


Organizer(s) William L. Smith, Marc Peters-Golden, Bengt Samuelsson, Charles N. Serhan and M. Amin Arnaout
April 7—12, 2001
Snowbird Resort • Snowbird, Utah USA
Abstract Deadline: Dec 7, 2000
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Feb 7, 2001

Sponsored by The American Society of Nephrology

Summary of Meeting:
Eicosanoid Lipid Mediators: Biochemistry, Molecular Biology and Pharmacology: Eicosanoids include the prostanoid, leukotriene and epoxygenase metabolites of arachidonic acid. Regulating the production of prostanoids and leukotrienes has already been shown to have important clinical consequences in the treatment of chronic diseases. Currently, the two major research issues in the prostanoid area include determining why there are two cyclooxygenase isozymes and how these isozymes operate independently when co-expressed in the same cell. Research on these topics focuses on defining how cyclooxygenases-1 and -2 couple biochemically to upstream phospholipase A2s and to downstream PGH metabolizing enzymes and on how different prostanoid receptors may be involved in the actions of the specific PGHS isoforms. Major unresolved issues in the leukotriene area include defining the role of these products in host defense responses, the structural biology of leukotriene biosynthetic enzymes, and the biochemical bases for the mediator actions of leukotrienes. The long term outcome of these studies on prostanoids and leukotrienes is likely to be to extend the clinical usage of available cyclooxygenase and lipoxygenase inhibitors and leukotriene receptor antagonists and to facilitate the development of prostanoid receptor antagonists. The epoxygenase area is less well-developed. Epoxygenase metabolites include epoxy, monohydroxy and dihydroxy polyunsaturated fatty acids that are formed via the actions of P450s. These compounds may play key roles in regulating blood pressure and in local inflammatory responses, and thus, offer potentially important therapeutic targets. Key questions in the epoxygenase field involve defining the P450s relevant to epoxygenase metabolite formation and defining the specific epoxygenase metabolites which are of biological importance. Bringing together investigators studying a broad range of topics in eicosanoid biology and biochemistry is expected to lead to a more comprehensive understanding of the regulation of biosynthesis and mechanisms of actions of this class of lipid mediators. Cell-Cell Interactions in Inflammation: Lipid mediators play a pivotal role in acute and chronic inflammation. These small molecules not only play extracellular roles that govern cell-cell interactions and leukocyte traffic, but also play important roles as intracellular mediators of key signal transduction pathways relevant in inflammation and host defense. It is now clear that cell-cell interactions and adherence molecules on the surface of leukocytes and resident cells govern the transcellular biosynthesis of eicosanoid products including leukotrienes, lipoxins, and related substances. Not only is the biosynthesis of lipid mediators governed via cell-cell interactions, but the products also regulate cell-cell interactions critical in inflammation. Research on these topics focuses on defining the paracrine and autocrine signaling associated with cell trafficking critical in inflammation. Since inflammation is important in a variety of organs and diseases, presentations in this meeting will focus on the importance of novel therapeutic targets in the management of inflammatory responses with special reference to diseases that can impact renal function as well as inflammation in renal tissues. Recently a number of novel lipid mediators have been identified; their receptors and role in cell trafficking will be discussed. Also, development of new nonsteroidal agents that target cyclooxygenase 2-dependent prostanoids and signaling pathways have entered the clinical arena, and a more comprehensive understanding of these new inhibitors of lipid mediators and their impact in renal function and wound healing in human diseases will be discussed. This meeting is interfaced with the biochemistry, molecular biology, and pharmacology of eicosanoids in order to highlight recent advances in the identification of novel components of this important lipid mediator system with a special emphasis on the emergence of potential new therapeutic targets to manage these pathways. Hence, the intertwining of recent advances and research topics from the structural biology, molecular biology, and pharmacology of the eicosanoids with research topics on the vanguard of cell-cell interactions and inflammation should provide an exciting venue for basic scientists and clinician-scientists as well as clinicians who prescribe the use of antiinflammatory agents including traditional nonsteroidals as well as the new regime of COX-2 inhibitors.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SATURDAY, APRIL 7

14:00—19:00
Registration

Ballroom Lobby 3
18:15—19:15
Welcome

Golden Cliff
19:15—19:30
Orientation

Ballroom 3
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
K. Frank Austen, Harvard Medical School, USA
LTC4 Synthase: IL-4 Regulation and Integrated Pathway Function in Mast Cells


SUNDAY, APRIL 8

07:00—08:00
Breakfast

Golden Cliff
08:00—11:00
Biology and Pharmacology of PGHS-1 and PGHS-2
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Peter C. Isakson, Abbott Bioresearch Center, USA
Role of COX-2 in the CNS Assessed Using Transgenic Mice

Jonathan P. Arm, Harvard Medical School, USA
Phospholipase A2 and the Regulation of Eicosanoid Biosynthesis in Mouse Mast Cells

William L. Smith, University of Michigan, USA
Interaction of Substrate Fatty Acids with Cyclooxygenases

Per-Johan Jakobsson, Karolinska Institutet, Sweden
Prostaglandin E Synthase: An Inducible Member of the MAPEG Family

Victor Leonard Schuster, Albert Einstein College of Medicine, USA
Short Talk: A Neurotransmitter Model of Eiscosanoid Release & Reuptake Utilizing the Prostanoid Transporter PGT

09:00—09:20
Coffee Break

Ballroom Lobby 3
11:00—13:00
Poster Setup

Ballroom 2
16:00—18:00
POSTER SESSION 1: Biology and Pharmacology of PGHS-1 and PGHS-2/Eicosanoid Actions and Eicosanoid Receptors

Ballroom 2
17:00—18:00
Social Hour with Lite Bites

Ballroom 2
20:00—21:30
Coffee Available

Ballroom Lobby 3
20:00—22:00
Eicosanoid Actions and Eicosanoid Receptors
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
Raymond N. DuBois, Arizona State University, USA
Prostaglandins Enhance the Malignant Potential of Cultured Cells

* Shuh Narumiya, Kyoto University, Japan
Roles of Prostanoids Examined Using Receptor-Gene Knockout Mice

Takehiko Yokomizo, Juntendo University School of Medicine, Japan
Regulation and Signaling of Leukotriene Receptors

William S. Powell, McGill University, Canada
Short Talk: PGD2 is a Potent Eosinophil Chemoattractant that Acts via a Novel DP2 Receptor


MONDAY, APRIL 9

07:00—08:00
Breakfast

Golden Cliff
08:00—11:00
Leukotriene Biosynthesis and Mechanisms of Action
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
Jesper Z. Haeggstrom, Karolinska Institute, Sweden
Leukotriene A4 Hydrolase, Structure and Function

* Colin D. Funk, Queen's University, Canada
Lipoxygenases and Leukotriene Receptors

Marc Peters-Golden, University of Michigan, USA
Leukotrienes and Antimicrobial Defenses

Maikel Peppelenbosch, Erasmus Medical Center, Netherlands
5-Lipoxygenase Signal Transduction

Joseph A. Hankin, National Jewish Medical and Research Center, USA
Short Talk: Covalent Binding of LTA4 to Oligonucleotides

09:00—09:20
Coffee Break

Ballroom Lobby 3
11:00—13:00
Poster Setup

Ballroom 2
16:00—18:00
POSTER SESSION 2: Leukotriene Biosynthesis and Mechanisms of Action/Isoprostanes, Cyclooxygenases, Leukotrienes

Ballroom 2
17:00—18:00
Social Hour with Lite Bites

Ballroom 2
20:00—21:30
Coffee Available

Ballroom Lobby 3
20:00—22:00
Isoprostanes, Cyclooxygenases, Leukotrienes
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
Garret A. FitzGerald, University of Pennsylvania, USA
Cox Products in Cardiovascular Disease

Darryl C. Zeldin, NIEHS, National Institutes of Health, USA
Roles of PGHS-1 and PGHS-2 in Respiration and Cardiac Function as Examined in Gene Knockout Mice

* Robert C. Murphy, University of Colorado Denver, USA
FOG(7): A Chemotactic Eicosanoid and Glutathione Adduct of 5-oxo-ETE

Yang (Cindy) Cao, Aventis Pharmaceutical, Inc., USA
Short Talk: Reduction of the Intracellular Level of Free Arachidonic Acid Prevents Apoptosis

Gwendalyn J. Randolph, Washington University, USA
Short Talk: The Leukotriene C4 Transporter MRP1 Regulates CCL19-Dependent Mobilization of Dendritic Cells from Skin


TUESDAY, APRIL 10

07:00—08:00
Breakfast

Golden Cliff
08:00—11:00
Coupling of Phospholipases to Eicosanoid Biosynthesis
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
Makoto Murakami, Tokyo Metropolitan Institute of Medical Science, Japan
Roles of Different PLA2s in Eicosanoid Production and Other Cellular Functions

Edward A. Dennis, University of California, San Diego, USA
Regulation of Phospholipase A2 and Cyclooxygenase in Eicosanoid Production in Macrophages

* Michael H. Gelb, University of Washington, USA
Structure, Function, and Regulation of Mammalian Secreted Phospholipases A2

Patricia K. Tithof, University of Tennessee, USA
Activation of iPLA2 by Xenobiotics and Its Effects on Cellular Functions

Krystyna E. Rys-Sikora, University of Rochester, USA
Short Talk: Assessing the Role of Secretory Phospholipase A2 and Cycloxygenase-2 in the Motility of Activated Primary Keratinocytes

08:00—11:00
Cell-Cell Interactions in Inflammation
Meeting has ended...abstracts no longer viewable online.

Superior
* Charles N. Serhan, Brigham and Women's Hospital, USA

Andrew T. Gewirtz, Georgia State University, USA
Pro-Anti-Inflammatory Signals at Epithelial Surfaces

M. Amin Arnaout, Massachusetts General Hospital, USA
A Structural Basis for Allosteric Regulation of Integrin Affinity

Nicolas Flamand, Université Laval - Centre de recherche de l'Hôpital Laval, CANADA
Mechanisms of the Inhibition of Lipid Mediator Biosynthesis in Human Neutrophils by Autacoids

Timothy T. Hla, Boston Children's Hospital/Harvard Medical School, USA
Lipid Mediators and Angiogenesis

Hugh Brady, University College Dublin, Ireland
Lipoxins and Aspirin-Triggered 15-epi-Lipoxins: Novel Anti-Inflammatory Bioactions in Renal Disease

09:00—09:20
Coffee Break

Ballroom Lobby 3
11:00—13:00
Poster Setup

Ballroom 2
16:00—18:00
POSTER SESSION 3: Coupling of Phospholipases to Eicosanoid Biosynthesis/Cell-Cell Interactions in Inflammation/Eicosanoid Biosynthetic Enzymes/P450 and Lipoxygenase Metabolites/Differential Expression and Substrate Utilization by PGHS-1 and PGHS-2

Ballroom 2
17:00—18:00
Social Hour with Lite Bites

Ballroom 2
20:00—21:30
Coffee Available

Ballroom Lobby 3
20:00—22:00
Eicosanoid Biosynthetic Enzymes
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Christina C. Leslie, National Jewish Health, USA
Differential Regulation of Cytosolic Phospholipase A2 Translocation, Phosphorylation, and Arachidonic Acid Release by Calcium and the ERK pathway

Ernst H. Oliw, Uppsala University, Sweden
Linoleate Diol Synthase, a Fatty Acid Dioxy-genase and Hydroperoxide Isomerase

Lawrence J. Marnett, Vanderbilt University School of Medicine, USA
Oxygenation of the Endocannabinoid, 2-Arachidonylglycerol, by Cyclooxygenase-2

Thomas M. McIntyre, Cleveland Clinic Foundation, USA
Short Talk: Endothelial Cell Angiogenic Response Aided by Cyclooxygenase-2 Induction via PPARgamma


WEDNESDAY, APRIL 11

07:00—08:00
Breakfast

Magpie
08:00—11:00
P450 and Lipoxygenase Metabolites
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* William B. Campbell, Medical College of Wisconsin, USA
New Endothelium-Derived Metabolites of Arachidonic Acid that Mediate Vasodilation

Jorge H. Capdevila, Vanderbilt University Medical Center, USA
Experimental and/or Genetically Controlled Alterations of the Renal Arachidonic Acid Monooxygenases Cause Hypertension

Charles N. Serhan, Brigham and Women's Hospital, USA
Lipoxins and Mediators in Antiinflammation: A Molecular Rationale for Aspirin and omega-3 Fish Oils

Raymond Harris, Vanderbilt University, USA
Role of EETs as Intracellular Second Messengers for EGF

J. Alyce Bradbury, NIEHS, National Institutes of Health, USA
Short Talk: Role of Human CYP2J2 in Post-Ischemic Heart Contractile Function and Electrophysiology: Initial Studies with Transgenic Mice

09:00—09:20
Coffee Break

Ballroom Lobby 3
16:00—17:00
Coffee Available

Ballroom Lobby 3
16:00—18:00
Differential Expression and Substrate Utilization by PGHS-1 and PGHS-2
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
David L. DeWitt, Michigan State University, USA
Arachidonic Acid and NSAIDs Induce Conformational Changes in the Human Prostaglandin Endoperoxide H2 Synthase-2 (COX-2)

Sudhansu K. Dey, Cincinnati Children's Hospital Medical Center, USA
COX-2-PPARdelta Signaling in Embryo Implantation

* Stephen M. Prescott, Oklahoma Medical Research Foundation, USA
Regulation of COX-2 Expression in Inflammation and Cancer

Maryse Duquette, University of Ottawa, Canada
Short Talk: Specific Protein Binding to a Conserved Sequence in the 3'UTR of the Prostaglandin Endoperoxide H Synthase-1 (PGHS-1) mRNA

19:00—20:00
Social Hour

Aerie Lounge
20:00—22:00
Banquet Sponsored by the American Society of Nephrology

Aerie Restaurant
21:00—00:00
Entertainment

Aerie Restaurant

THURSDAY, APRIL 12

 
Departure


*Session Chair †Invited, not yet responded.



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