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This meeting took place in 2001
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Eicosanoid Lipid Mediators: Biochemistry, Molecular Biology and Pharmacology and Cell-Cell Interactions in Inflammation (E6)
Organizer(s) William L. Smith, Marc Peters-Golden, Bengt Samuelsson, Charles N. Serhan and M. Amin Arnaout
April 7—12, 2001
Snowbird Resort • Snowbird, Utah USA
Abstract Deadline: Dec 7, 2000
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Feb 7, 2001
Sponsored by The American Society of Nephrology
Summary of Meeting:
Eicosanoid Lipid Mediators: Biochemistry, Molecular Biology and Pharmacology: Eicosanoids include the prostanoid, leukotriene and epoxygenase metabolites of arachidonic acid. Regulating the production of prostanoids and leukotrienes has already been shown to have important clinical consequences in the treatment of chronic diseases. Currently, the two major research issues in the prostanoid area include determining why there are two cyclooxygenase isozymes and how these isozymes operate independently when co-expressed in the same cell. Research on these topics focuses on defining how cyclooxygenases-1 and -2 couple biochemically to upstream phospholipase A2s and to downstream PGH metabolizing enzymes and on how different prostanoid receptors may be involved in the actions of the specific PGHS isoforms. Major unresolved issues in the leukotriene area include defining the role of these products in host defense responses, the structural biology of leukotriene biosynthetic enzymes, and the biochemical bases for the mediator actions of leukotrienes. The long term outcome of these studies on prostanoids and leukotrienes is likely to be to extend the clinical usage of available cyclooxygenase and lipoxygenase inhibitors and leukotriene receptor antagonists and to facilitate the development of prostanoid receptor antagonists. The epoxygenase area is less well-developed. Epoxygenase metabolites include epoxy, monohydroxy and dihydroxy polyunsaturated fatty acids that are formed via the actions of P450s. These compounds may play key roles in regulating blood pressure and in local inflammatory responses, and thus, offer potentially important therapeutic targets. Key questions in the epoxygenase field involve defining the P450s relevant to epoxygenase metabolite formation and defining the specific epoxygenase metabolites which are of biological importance. Bringing together investigators studying a broad range of topics in eicosanoid biology and biochemistry is expected to lead to a more comprehensive understanding of the regulation of biosynthesis and mechanisms of actions of this class of lipid mediators. Cell-Cell Interactions in Inflammation: Lipid mediators play a pivotal role in acute and chronic inflammation. These small molecules not only play extracellular roles that govern cell-cell interactions and leukocyte traffic, but also play important roles as intracellular mediators of key signal transduction pathways relevant in inflammation and host defense. It is now clear that cell-cell interactions and adherence molecules on the surface of leukocytes and resident cells govern the transcellular biosynthesis of eicosanoid products including leukotrienes, lipoxins, and related substances. Not only is the biosynthesis of lipid mediators governed via cell-cell interactions, but the products also regulate cell-cell interactions critical in inflammation. Research on these topics focuses on defining the paracrine and autocrine signaling associated with cell trafficking critical in inflammation. Since inflammation is important in a variety of organs and diseases, presentations in this meeting will focus on the importance of novel therapeutic targets in the management of inflammatory responses with special reference to diseases that can impact renal function as well as inflammation in renal tissues. Recently a number of novel lipid mediators have been identified; their receptors and role in cell trafficking will be discussed. Also, development of new nonsteroidal agents that target cyclooxygenase 2-dependent prostanoids and signaling pathways have entered the clinical arena, and a more comprehensive understanding of these new inhibitors of lipid mediators and their impact in renal function and wound healing in human diseases will be discussed. This meeting is interfaced with the biochemistry, molecular biology, and pharmacology of eicosanoids in order to highlight recent advances in the identification of novel components of this important lipid mediator system with a special emphasis on the emergence of potential new therapeutic targets to manage these pathways. Hence, the intertwining of recent advances and research topics from the structural biology, molecular biology, and pharmacology of the eicosanoids with research topics on the vanguard of cell-cell interactions and inflammation should provide an exciting venue for basic scientists and clinician-scientists as well as clinicians who prescribe the use of antiinflammatory agents including traditional nonsteroidals as well as the new regime of COX-2 inhibitors.
View Scholarships/Awards
Eicosanoid Lipid Mediators: Biochemistry, Molecular Biology and Pharmacology: Eicosanoids include the prostanoid, leukotriene and epoxygenase metabolites of arachidonic acid. Regulating the production of prostanoids and leukotrienes has already been shown to have important clinical consequences in the treatment of chronic diseases. Currently, the two major research issues in the prostanoid area include determining why there are two cyclooxygenase isozymes and how these isozymes operate independently when co-expressed in the same cell. Research on these topics focuses on defining how cyclooxygenases-1 and -2 couple biochemically to upstream phospholipase A2s and to downstream PGH metabolizing enzymes and on how different prostanoid receptors may be involved in the actions of the specific PGHS isoforms. Major unresolved issues in the leukotriene area include defining the role of these products in host defense responses, the structural biology of leukotriene biosynthetic enzymes, and the biochemical bases for the mediator actions of leukotrienes. The long term outcome of these studies on prostanoids and leukotrienes is likely to be to extend the clinical usage of available cyclooxygenase and lipoxygenase inhibitors and leukotriene receptor antagonists and to facilitate the development of prostanoid receptor antagonists. The epoxygenase area is less well-developed. Epoxygenase metabolites include epoxy, monohydroxy and dihydroxy polyunsaturated fatty acids that are formed via the actions of P450s. These compounds may play key roles in regulating blood pressure and in local inflammatory responses, and thus, offer potentially important therapeutic targets. Key questions in the epoxygenase field involve defining the P450s relevant to epoxygenase metabolite formation and defining the specific epoxygenase metabolites which are of biological importance. Bringing together investigators studying a broad range of topics in eicosanoid biology and biochemistry is expected to lead to a more comprehensive understanding of the regulation of biosynthesis and mechanisms of actions of this class of lipid mediators. Cell-Cell Interactions in Inflammation: Lipid mediators play a pivotal role in acute and chronic inflammation. These small molecules not only play extracellular roles that govern cell-cell interactions and leukocyte traffic, but also play important roles as intracellular mediators of key signal transduction pathways relevant in inflammation and host defense. It is now clear that cell-cell interactions and adherence molecules on the surface of leukocytes and resident cells govern the transcellular biosynthesis of eicosanoid products including leukotrienes, lipoxins, and related substances. Not only is the biosynthesis of lipid mediators governed via cell-cell interactions, but the products also regulate cell-cell interactions critical in inflammation. Research on these topics focuses on defining the paracrine and autocrine signaling associated with cell trafficking critical in inflammation. Since inflammation is important in a variety of organs and diseases, presentations in this meeting will focus on the importance of novel therapeutic targets in the management of inflammatory responses with special reference to diseases that can impact renal function as well as inflammation in renal tissues. Recently a number of novel lipid mediators have been identified; their receptors and role in cell trafficking will be discussed. Also, development of new nonsteroidal agents that target cyclooxygenase 2-dependent prostanoids and signaling pathways have entered the clinical arena, and a more comprehensive understanding of these new inhibitors of lipid mediators and their impact in renal function and wound healing in human diseases will be discussed. This meeting is interfaced with the biochemistry, molecular biology, and pharmacology of eicosanoids in order to highlight recent advances in the identification of novel components of this important lipid mediator system with a special emphasis on the emergence of potential new therapeutic targets to manage these pathways. Hence, the intertwining of recent advances and research topics from the structural biology, molecular biology, and pharmacology of the eicosanoids with research topics on the vanguard of cell-cell interactions and inflammation should provide an exciting venue for basic scientists and clinician-scientists as well as clinicians who prescribe the use of antiinflammatory agents including traditional nonsteroidals as well as the new regime of COX-2 inhibitors.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SATURDAY, APRIL 7
SUNDAY, APRIL 8
MONDAY, APRIL 9
TUESDAY, APRIL 10
WEDNESDAY, APRIL 11
THURSDAY, APRIL 12
Conference Program Print | View meeting in 12 hr (am/pm) time
SATURDAY, APRIL 7
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.
K. Frank Austen,
Harvard Medical School, USA
LTC4 Synthase: IL-4 Regulation and Integrated Pathway Function in Mast Cells
LTC4 Synthase: IL-4 Regulation and Integrated Pathway Function in Mast Cells
08:00—11:00
Biology and Pharmacology of PGHS-1 and PGHS-2
Meeting has ended...abstracts no longer viewable online.
*
Peter C. Isakson,
Abbott Bioresearch Center, USA
Role of COX-2 in the CNS Assessed Using Transgenic Mice
Role of COX-2 in the CNS Assessed Using Transgenic Mice
Jonathan P. Arm,
Bill & Melinda Gates Foundation, USA
Phospholipase A2 and the Regulation of Eicosanoid Biosynthesis in Mouse Mast Cells
Phospholipase A2 and the Regulation of Eicosanoid Biosynthesis in Mouse Mast Cells
William L. Smith,
University of Michigan, USA
Interaction of Substrate Fatty Acids with Cyclooxygenases
Interaction of Substrate Fatty Acids with Cyclooxygenases
Per-Johan Jakobsson,
Karolinska Institutet, Sweden
Prostaglandin E Synthase: An Inducible Member of the MAPEG Family
Prostaglandin E Synthase: An Inducible Member of the MAPEG Family
Victor Leonard Schuster,
Albert Einstein College of Medicine, USA
Short Talk: A Neurotransmitter Model of Eiscosanoid Release & Reuptake Utilizing the Prostanoid Transporter PGT
Short Talk: A Neurotransmitter Model of Eiscosanoid Release & Reuptake Utilizing the Prostanoid Transporter PGT
16:00—18:00
POSTER SESSION 1: Biology and Pharmacology of PGHS-1 and PGHS-2/Eicosanoid Actions and Eicosanoid Receptors
20:00—22:00
Eicosanoid Actions and Eicosanoid Receptors
Meeting has ended...abstracts no longer viewable online.
Raymond N. DuBois,
Arizona State University, USA
Prostaglandins Enhance the Malignant Potential of Cultured Cells
Prostaglandins Enhance the Malignant Potential of Cultured Cells
*
Shuh Narumiya,
Kyoto University, Japan
Roles of Prostanoids Examined Using Receptor-Gene Knockout Mice
Roles of Prostanoids Examined Using Receptor-Gene Knockout Mice
Takehiko Yokomizo,
Juntendo University School of Medicine, Japan
Regulation and Signaling of Leukotriene Receptors
Regulation and Signaling of Leukotriene Receptors
William S. Powell,
McGill University, Canada
Short Talk: PGD2 is a Potent Eosinophil Chemoattractant that Acts via a Novel DP2 Receptor
Short Talk: PGD2 is a Potent Eosinophil Chemoattractant that Acts via a Novel DP2 Receptor
08:00—11:00
Leukotriene Biosynthesis and Mechanisms of Action
Meeting has ended...abstracts no longer viewable online.
Jesper Z. Haeggström,
Karolinska Institute, Sweden
Leukotriene A4 Hydrolase, Structure and Function
Leukotriene A4 Hydrolase, Structure and Function
Marc Peters-Golden,
University of Michigan, USA
Leukotrienes and Antimicrobial Defenses
Leukotrienes and Antimicrobial Defenses
Maikel Peppelenbosch,
Erasmus Medical Center, Netherlands
5-Lipoxygenase Signal Transduction
5-Lipoxygenase Signal Transduction
Joseph A. Hankin,
National Jewish Medical and Research Center, USA
Short Talk: Covalent Binding of LTA4 to Oligonucleotides
Short Talk: Covalent Binding of LTA4 to Oligonucleotides
16:00—18:00
POSTER SESSION 2: Leukotriene Biosynthesis and Mechanisms of Action/Isoprostanes, Cyclooxygenases, Leukotrienes
20:00—22:00
Isoprostanes, Cyclooxygenases, Leukotrienes
Meeting has ended...abstracts no longer viewable online.
Darryl C. Zeldin,
NIEHS, National Institutes of Health, USA
Roles of PGHS-1 and PGHS-2 in Respiration and Cardiac Function as Examined in Gene Knockout Mice
Roles of PGHS-1 and PGHS-2 in Respiration and Cardiac Function as Examined in Gene Knockout Mice
*
Robert C. Murphy,
University of Colorado Denver, USA
FOG(7): A Chemotactic Eicosanoid and Glutathione Adduct of 5-oxo-ETE
FOG(7): A Chemotactic Eicosanoid and Glutathione Adduct of 5-oxo-ETE
Yang (Cindy) Cao,
Aventis Pharmaceutical, Inc., USA
Short Talk: Reduction of the Intracellular Level of Free Arachidonic Acid Prevents Apoptosis
Short Talk: Reduction of the Intracellular Level of Free Arachidonic Acid Prevents Apoptosis
Gwendalyn J. Randolph,
Washington University, USA
Short Talk: The Leukotriene C4 Transporter MRP1 Regulates CCL19-Dependent Mobilization of Dendritic Cells from Skin
Short Talk: The Leukotriene C4 Transporter MRP1 Regulates CCL19-Dependent Mobilization of Dendritic Cells from Skin
08:00—11:00
Coupling of Phospholipases to Eicosanoid Biosynthesis
Meeting has ended...abstracts no longer viewable online.
Makoto Murakami,
Tokyo Metropolitan Institute of Medical Science, Japan
Roles of Different PLA2s in Eicosanoid Production and Other Cellular Functions
Roles of Different PLA2s in Eicosanoid Production and Other Cellular Functions
Edward A. Dennis,
University of California, San Diego, USA
Regulation of Phospholipase A2 and Cyclooxygenase in Eicosanoid Production in Macrophages
Regulation of Phospholipase A2 and Cyclooxygenase in Eicosanoid Production in Macrophages
*
Michael H. Gelb,
University of Washington, USA
Structure, Function, and Regulation of Mammalian Secreted Phospholipases A2
Structure, Function, and Regulation of Mammalian Secreted Phospholipases A2
Patricia K. Tithof,
University of Tennessee, USA
Activation of iPLA2 by Xenobiotics and Its Effects on Cellular Functions
Activation of iPLA2 by Xenobiotics and Its Effects on Cellular Functions
Krystyna E. Rys-Sikora,
University of Rochester, USA
Short Talk: Assessing the Role of Secretory Phospholipase A2 and Cycloxygenase-2 in the Motility of Activated Primary Keratinocytes
Short Talk: Assessing the Role of Secretory Phospholipase A2 and Cycloxygenase-2 in the Motility of Activated Primary Keratinocytes
08:00—11:00
Cell-Cell Interactions in Inflammation
Meeting has ended...abstracts no longer viewable online.
Andrew T. Gewirtz,
Georgia State University, USA
Pro-Anti-Inflammatory Signals at Epithelial Surfaces
Pro-Anti-Inflammatory Signals at Epithelial Surfaces
M. Amin Arnaout,
Massachusetts General Hospital, USA
A Structural Basis for Allosteric Regulation of Integrin Affinity
A Structural Basis for Allosteric Regulation of Integrin Affinity
Nicolas Flamand,
Université Laval - Centre de recherche de l'Hôpital Laval, CANADA
Mechanisms of the Inhibition of Lipid Mediator Biosynthesis in Human Neutrophils by Autacoids
Mechanisms of the Inhibition of Lipid Mediator Biosynthesis in Human Neutrophils by Autacoids
Timothy T. Hla,
Boston Children's Hospital/Harvard Medical School, USA
Lipid Mediators and Angiogenesis
Lipid Mediators and Angiogenesis
Hugh Brady,
University College Dublin, Ireland
Lipoxins and Aspirin-Triggered 15-epi-Lipoxins: Novel Anti-Inflammatory Bioactions in Renal Disease
Lipoxins and Aspirin-Triggered 15-epi-Lipoxins: Novel Anti-Inflammatory Bioactions in Renal Disease
16:00—18:00
POSTER SESSION 3: Coupling of Phospholipases to Eicosanoid Biosynthesis/Cell-Cell Interactions in Inflammation/Eicosanoid Biosynthetic Enzymes/P450 and Lipoxygenase Metabolites/Differential Expression and Substrate Utilization by PGHS-1 and PGHS-2
20:00—22:00
Eicosanoid Biosynthetic Enzymes
Meeting has ended...abstracts no longer viewable online.
*
Christina C. Leslie,
National Jewish Health, USA
Differential Regulation of Cytosolic Phospholipase A2 Translocation, Phosphorylation, and Arachidonic Acid Release by Calcium and the ERK pathway
Differential Regulation of Cytosolic Phospholipase A2 Translocation, Phosphorylation, and Arachidonic Acid Release by Calcium and the ERK pathway
Ernst H. Oliw,
Uppsala University, Sweden
Linoleate Diol Synthase, a Fatty Acid Dioxy-genase and Hydroperoxide Isomerase
Linoleate Diol Synthase, a Fatty Acid Dioxy-genase and Hydroperoxide Isomerase
Lawrence J. Marnett,
Vanderbilt University School of Medicine, USA
Oxygenation of the Endocannabinoid, 2-Arachidonylglycerol, by Cyclooxygenase-2
Oxygenation of the Endocannabinoid, 2-Arachidonylglycerol, by Cyclooxygenase-2
Thomas M. McIntyre,
Cleveland Clinic Foundation, USA
Short Talk: Endothelial Cell Angiogenic Response Aided by Cyclooxygenase-2 Induction via PPARgamma
Short Talk: Endothelial Cell Angiogenic Response Aided by Cyclooxygenase-2 Induction via PPARgamma
08:00—11:00
P450 and Lipoxygenase Metabolites
Meeting has ended...abstracts no longer viewable online.
*
William B. Campbell,
Medical College of Wisconsin, USA
New Endothelium-Derived Metabolites of Arachidonic Acid that Mediate Vasodilation
New Endothelium-Derived Metabolites of Arachidonic Acid that Mediate Vasodilation
Jorge H. Capdevila,
Vanderbilt University Medical Center, USA
Experimental and/or Genetically Controlled Alterations of the Renal Arachidonic Acid Monooxygenases Cause Hypertension
Experimental and/or Genetically Controlled Alterations of the Renal Arachidonic Acid Monooxygenases Cause Hypertension
Charles N. Serhan,
Brigham and Women's Hospital, USA
Lipoxins and Mediators in Antiinflammation: A Molecular Rationale for Aspirin and omega-3 Fish Oils
Lipoxins and Mediators in Antiinflammation: A Molecular Rationale for Aspirin and omega-3 Fish Oils
Raymond Harris,
Vanderbilt University, USA
Role of EETs as Intracellular Second Messengers for EGF
Role of EETs as Intracellular Second Messengers for EGF
J. Alyce Bradbury,
NIEHS, National Institutes of Health, USA
Short Talk: Role of Human CYP2J2 in Post-Ischemic Heart Contractile Function and Electrophysiology: Initial Studies with Transgenic Mice
Short Talk: Role of Human CYP2J2 in Post-Ischemic Heart Contractile Function and Electrophysiology: Initial Studies with Transgenic Mice
16:00—18:00
Differential Expression and Substrate Utilization by PGHS-1 and PGHS-2
Meeting has ended...abstracts no longer viewable online.
David L. DeWitt,
Michigan State University, USA
Arachidonic Acid and NSAIDs Induce Conformational Changes in the Human Prostaglandin Endoperoxide H2 Synthase-2 (COX-2)
Arachidonic Acid and NSAIDs Induce Conformational Changes in the Human Prostaglandin Endoperoxide H2 Synthase-2 (COX-2)
Sudhansu K. Dey,
Cincinnati Children's Hospital Medical Center, USA
COX-2-PPARdelta Signaling in Embryo Implantation
COX-2-PPARdelta Signaling in Embryo Implantation
*
Stephen M. Prescott,
Oklahoma Medical Research Foundation, USA
Regulation of COX-2 Expression in Inflammation and Cancer
Regulation of COX-2 Expression in Inflammation and Cancer
Maryse Duquette,
University of Ottawa, Canada
Short Talk: Specific Protein Binding to a Conserved Sequence in the 3'UTR of the Prostaglandin Endoperoxide H Synthase-1 (PGHS-1) mRNA
Short Talk: Specific Protein Binding to a Conserved Sequence in the 3'UTR of the Prostaglandin Endoperoxide H Synthase-1 (PGHS-1) mRNA
*Session Chair †Invited, not yet responded.
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