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This meeting took place in 2002



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Molecular Mechanisms of DNA Replication and Recombination (A1)


Organizer(s) Kenneth J. Marians and Rodney J. Rothstein
January 7—13, 2002
Snowbird Resort • Snowbird, Utah USA
Abstract Deadline: Sep 17, 2001
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Nov 7, 2001

Sponsored by The Director's Sponsor Fund

Summary of Meeting:
The Keystone Symposium on DNA Replication and Recombination is the only meeting of its type that draws large numbers of participants from both fields. The meeting has been designed to have comprehensive coverage of central aspects of the fields, including the traditional studies of biochemical mechanisms, how structural biology is informing studies of biochemical mechanisms, how understanding biochemical mechanisms is informing our understanding of the biology of the systems, and how the molecular genetics of the maintenance of genome integrity is revealing new targets and directing studies of biochemical mechanisms. The last meeting of this type was held in February 1999. Since then there have been many significant developments that should make the 2002 meeting both a timely and exciting one.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


MONDAY, JANUARY 7

16:00—19:00
Registration

Ballroom Lobby 3
18:15—19:15
Welcome

Ballroom Lobby
19:15—19:30
Orientation

Ballroom 2-3
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
Bruce W. Stillman, Cold Spring Harbor Laboratory, USA
Inheritance of DNA and Chromatin


TUESDAY, JANUARY 8

07:00—08:00
Breakfast

Golden Cliff/Magpie/Superior/Eagles Nest
08:00—11:00
Replication Fork Mechanisms
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Dale B. Wigley, Institute of Cancer Research, UK
Relating Structure to Mechanism in Helicases

Michael E. O'Donnell, Rockefeller University, USA
Clamps and Clamp Loaders - Structure and Mechanism

Jerard Hurwitz, Memorial Sloan-Kettering Cancer Center, USA
Studies on the Function of the MCM Complex

Charles S. McHenry, University of Colorado Boulder, USA
Assembly, Interactions and Function of the Clamp Loader of an Asymmetric Replicase

Nancy G. Nossal, National Institutes of Health, USA
Protein-DNA Interactions at the T4 DNA Replication Fork

09:20—09:40
Coffee Break

Ballroom Lobby/Mezzanine
11:00—13:00
Poster Setup

Superior/Maybird & Wasatch
13:00—23:00
Poster Viewing

Superior/Maybird & Wasatch
13:30—15:30
Workshop 1: Enzymology of Homologous Recombination

Ballroom 2
* Douglas A. Julin, University of Maryland, USA

13:30—15:30
Workshop 2: Initiation of DNA Replication

Ballroom 3
* John W. Newport, University of California, San Diego, USA

15:30—16:30
Coffee & Snacks Available

Ballroom Lobby/Mezzanine
16:30—18:30
Mechanisms of Recombination
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Stephen C. Kowalczykowski, University of California, Davis, USA
Mechanism and Visualization of Recombination Processes

Patrick M. Sung, Yale University, USA
Role of the Saccharomyces cerevisiae Rad50-Mre11-Xrs2 Complex in DNA Recombination and Repair

Martin Gellert, NIDDK, National Institutes of Health, USA
Specific and Non-Specific Aspects of V(D)J Recombination

Roland Kanaar, Erasmus MC, Netherlands
Homologous Recombination Protein: Architecture and Dynamics

Steven Brill, Rutgers University, USA
Short Talk: Identification and Characterization of the Mms4-Mus81 Endonuclease from S. cerevisiae

20:00—21:00
Welcome Mixer

Superior/Maybird & Wasatch
20:00—23:00
Poster Session 1: Replication Mechanisms

Superior/Maybird & Wasatch

WEDNESDAY, JANUARY 9

07:00—08:00
Breakfast

Golden Cliff/Magpie/Superior/Eagles Nest
08:00—11:00
Genome Stability I
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Ian D. Hickson, University of Copenhagen, Denmark
Role of RecQ Helicases in Maintenance of Genome Stability

Virginia A. Zakian, Princeton University, USA
The Pif1-Subfamily of DNA Helicases: Effects at Telomeres and Elsewhere

Leonard P. Guarente, Massachusetts Institute of Technology, USA
Genetic Mechanisms of Aging

Maria Jasin, Memorial Sloan Kettering Cancer Center, USA
Double-Strand Break Repair and Genomic Integrity in Mammalian Cells

Jonathan Goldberg, Memorial Sloan-Kettering Cancer Center, USA
Structural Study of Ku Heterodimer Bound to DNA

09:20—09:40
Coffee Break

Ballroom Lobby/Mezzanine
11:00—13:00
Poster Setup

Superior/Maybird & Wasatch
13:00—23:00
Poster Viewing

Superior/Maybird & Wasatch
13:30—15:30
Workshop 3: Site Specific Recombination

Ballroom 2
* Tania A. Baker, Massachusetts Institute of Technology, USA

13:30—15:30
Workshop 4: Structural Insights to DNA Replication, Recombination and Repair

Ballroom 3
* Gregory D. Van Duyne, University of Pennsylvania School of Medicine, USA

15:30—16:30
Coffee & Snacks Available

Ballroom Lobby/Mezzanine
16:30—18:30
Checkpoints
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Theodore Weinert, University of Arizona, USA
Mechanisms of Cell Cycle Checkpoints

Susan M. Gasser, Friedrich Miescher Institute for Biomedical Research, Switzerland
Defects in Orc2p Compromise the S-Phase Checkpoint: A Threshold Model for Rad53p Activation

Graham C. Walker, Massachusetts Institute of Technology, USA
Response to Damage in E. coli: From Molecular Structure to Subcellular Localization

Jean J. Gautier, Columbia University, College of Physicians and Surgeons, USA
Responses to DNA Double-Strand Breaks: Linking Recombination-Dependent Repair to DNA Replication

20:00—21:00
Welcome Mixer

Superior/Maybird & Wasatch
20:00—23:00
Poster Session 2: Recombination/Genome Stability

Superior/Maybird & Wasatch

THURSDAY, JANUARY 10

07:00—08:00
Breakfast

Golden Cliff/Magpie/Superior/Eagles Nest
08:00—11:00
Genome Stability II
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* John H.J. Petrini, Memorial Sloan-Kettering Cancer Center, USA
The MRE11 Complex: Linking DSB Repair to Cell Cycle Checkpoints During DNA Replication

James E. Haber, Brandeis University, USA
Mechanisms of Gene Conversion and Break-Induced Replication

Rodney J. Rothstein, Columbia University Medical Center, USA
Genome Response to DNA Damage

Stephen C. West, Francis Crick Institute, UK
Protein-Protein Interactions in Double-Strand Break Repair

John A. Tainer, The Scripps Research Institute, USA
Coordination of DNA Base Excision and Double Strand Break Repair Processes

09:20—09:40
Coffee Break

Ballroom Lobby/Mezzanine
11:00—13:00
Poster Setup

Superior/Maybird & Wasatch
13:00—23:00
Poster Viewing

Superior/Maybird & Wasatch
13:30—15:30
Workshop 5: Topoisomerases and Helicases

Ballroom 2
* Stewart H. Shuman, Memorial Sloan-Kettering Institute, USA

13:30—15:30
Workshop 6: Dealing with Ends

Ballroom 3
* Carolyn M. Price, University of Cincinnati, USA

15:30—16:30
Coffee & Snacks Available

Ballroom Lobby/Mezzanine
16:30—18:30
Initiation of DNA Replication
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Stephen P. Bell, Massachusetts Institute of Technology, USA
The Architecture and Differential Subunit Function of the MCM Complex

John F.X. Diffley, Francis Crick Institute, UK
Checkpoints and DNA Replication

Kenneth N. Kreuzer, Duke University, USA
Initiation of DNA Replication at Phage T4 Origins

James M. Berger, Johns Hopkins University School of Medicine, USA
Structure of the Cdc6/Orc1 Protein from the Archaeon Pyrobaculum aerophilum

20:00—21:00
Welcome Mixer

Superior/Maybird & Wasatch
20:00—23:00
Poster Session 3: Response to Damage

Superior/Maybird & Wasatch

FRIDAY, JANUARY 11

07:00—08:00
Breakfast

Golden Cliff/Magpie/Superior/Eagles Nest
08:00—11:00
Chromosome Dynamics I
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Nicholas R. Cozzarelli, University of California, Berkeley, USA
Effects of the Folding of the Bacterial Chromosome on its Replication

Tatsuya Hirano, RIKEN, Japan
Chromosome Condensation and Cohesion in Mitosis

Titia de Lange, Rockefeller University, USA
Protection of Human Telomeres

Nancy E. Kleckner, Harvard University, USA
Chromosome Breathing

Kerry S. Bloom, University of North Carolina at Chapel Hill, USA
Dynamics of a DNA Double-Strand Break and the Repair Protein Rad52-CFP in Living Saccharomyces cerevisiae Cells

09:20—09:40
Coffee Break

Ballroom Lobby/Mezzanine
11:00—13:00
Poster Setup

Superior/Maybird & Wasatch
13:00—23:00
Poster Viewing

Superior/Maybird & Wasatch
13:30—15:30
Workshop 7: Repairosomes

Ballroom 2
* Myron F. Goodman, University of Southern California, USA

13:30—15:30
Workshop 8: Replication Fork Progression

Ballroom 3
* Robert A. Bambara, University of Rochester Medical Center, USA

15:30—16:30
Coffee & Snacks Available

Ballroom Lobby/Mezzanine
16:30—18:30
Meiosis
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Maria Jasin, Memorial Sloan Kettering Cancer Center, USA

Scott Keeney, HHMI/Memorial Sloan Kettering Cancer Center, USA
Chromosome Structures and Sexually Dimorphic Checkpoint Responses in Mouse Meiotic Recombination Mutants

Michael J. Lichten, National Cancer Institute, National Institutes of Health, USA
Starting and Finishing Meiotic Recombination

Alain G. Nicolas, Institut Curie, France
Links Between Replication and the Intitiation of Meiotic Recombination in Saccharomyces cerevisiae, Targeting of DSBs to Novel Sites

Douglas K. Bishop, University of Chicago, USA
The Role of Dmc1 and Tid1 in Homologous Strand Invasion and Crossover Interference

20:00—21:00
Welcome Mixer

Superior/Maybird & Wasatch
20:00—23:00
Poster Session 4: Site Specific Recombination/Chromosome Dynamics

Superior/Maybird & Wasatch

SATURDAY, JANUARY 12

07:00—08:00
Breakfast

Golden Cliff/Magpie/Superior/Eagles Nest
08:00—11:00
The Intersection of Replication and Recombination
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Michael M. Cox, University of Wisconsin-Madison, USA
RecA as a Motor Protein in the Repair of Stalled Replication Forks

Bénédicte Michel, Institut National de la Recherche Agronomique, France
Rescue of Arrested Replication Forks by Homologous Recombination

Steven J. Sandler, University of Massachusetts, USA
Starting and Restarting Replication Forks in vivo: Different Substrates - Different Pathways

Richard D. Kolodner, Ludwig Institute for Cancer Research, USA
Identification of Pathways that Prevent Genome Instability

Marco F. Foiani, Instituto FIRC di Oncologia Molecolare, Italy
Control of Replication Fork Integrity in Response to DNA Damage and Replication Pausing

09:20—09:40
Coffee Break

Ballroom Lobby/Mezzanine
15:30—16:30
Coffee & Snacks Available

Ballroom Lobby/Mezzanine
16:30—18:00
Chromosome Dynamics II
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* David J. Sherratt, University of Oxford, UK
The DNA Motor Protein FtsK Directs Chromosome Dimer Resolution by XerCD Recombinase at Dif in vitro

Kenneth J. Marians, Memorial Sloan Kettering Cancer Center, USA
Spatial and Temporal Regulation of Topoisomerase IV Localization in E. coli

Andrew Chess, Massachusetts General Hospital, USA
Coordination of Asynchronous Replication in Mammals

18:00—19:00
Meeting Summary
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
Richard D. Wood, University of Pittsburgh Cancer Institute, USA
Where We Are in 2002

19:00—20:00
Welcome Mixer

Mezzanine
20:00—22:00
Banquet

Ballroom
21:00—00:00
Entertainment

Ballroom

SUNDAY, JANUARY 13

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 CA94232-01




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Phone:+1 970-262-2676