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This meeting took place in 2002
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JAKs and STATs: Activation and Biologic Impact (A2)
Organizer(s) George R. Stark, Ian M. Kerr and James E. Darnell, Jr.
January 13—18, 2002
Snowbird Resort • Snowbird, Utah USA
Abstract Deadline: Oct 1, 2001
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Nov 13, 2001
Sponsored in part by The Director's Sponsor Fund
Summary of Meeting:
The JAK tyrosine kinases and STAT transcription factors are now appreciated to be essential for the function of many pathways that regulate gene expression and biological function. Exciting current research has revealed, for example, family members in slime molds and insects, both positive and negative regulation of gene expression, cross-responses to pathways that use serine phosphorylation, and that Stat3 is an oncogene and Stat1 a tumor suppressor. Future issues: determine more protein structures, mechanisms and significance of serine phosphorylation, details of pivotal protein-protein interactions, basis of ligand-specific signals. Meeting goals: to cross-fertilize a very large range of research projects in an exciting and rapidly evolving field.
View Scholarships/Awards
The JAK tyrosine kinases and STAT transcription factors are now appreciated to be essential for the function of many pathways that regulate gene expression and biological function. Exciting current research has revealed, for example, family members in slime molds and insects, both positive and negative regulation of gene expression, cross-responses to pathways that use serine phosphorylation, and that Stat3 is an oncogene and Stat1 a tumor suppressor. Future issues: determine more protein structures, mechanisms and significance of serine phosphorylation, details of pivotal protein-protein interactions, basis of ligand-specific signals. Meeting goals: to cross-fertilize a very large range of research projects in an exciting and rapidly evolving field.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SUNDAY, JANUARY 13
MONDAY, JANUARY 14
TUESDAY, JANUARY 15
WEDNESDAY, JANUARY 16
THURSDAY, JANUARY 17
FRIDAY, JANUARY 18
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, JANUARY 13
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.
C. David Allis,
Rockefeller University, USA
The Histone Modification Circus: Balancing Acts Fundamental to Human Biology and Disease
The Histone Modification Circus: Balancing Acts Fundamental to Human Biology and Disease
08:00—12:00
Receptor/JAK Complexes, Receptor Cross-Talk, Modular Signaling/STATs
Meeting has ended...abstracts no longer viewable online.
*
Ian M. Kerr,
Cancer Research UK, UK
JAK/STAT Signaling
JAK/STAT Signaling
Pipsa I. Saharinen,
Haartman Institute, University of Helsinki, Finland
Short Talk: The Pseudokinase Domain in the Regulation of JAK2 and JAK3 Tyrosine Kinases
Short Talk: The Pseudokinase Domain in the Regulation of JAK2 and JAK3 Tyrosine Kinases
K. Christopher Garcia,
Stanford University School of Medicine, USA
Short Talk: The Interaction between gp130 and Viral Interleukin-6: A Paradigm for the Architecture of gp130-Cytokine Signaling Assemblies
Short Talk: The Interaction between gp130 and Viral Interleukin-6: A Paradigm for the Architecture of gp130-Cytokine Signaling Assemblies
Nicholas K. Tonks,
Cold Spring Harbor Laboratory, USA
Tadatsugu Taniguchi,
University of Tokyo, Japan
STATs and IRFs in the Regulation of Immunity and Bone Remodeling
STATs and IRFs in the Regulation of Immunity and Bone Remodeling
Stephen Brown,
University of Cambridge, UK
Short Talk: Characterisation of Domeless, the Drosophila JAK/STAT Receptor
Short Talk: Characterisation of Domeless, the Drosophila JAK/STAT Receptor
14:00—16:00
Workshop 1
Athanasia D. Panopoulos,
University of Texas MD Anderson Cancer Center, USA
Cytokine-Inducible Expression of the Myeloid-Specific Integrin alphaMbeta2 (CD11b/CD18) is Regulated by STAT3-Dependent Activation of PU.1
Cytokine-Inducible Expression of the Myeloid-Specific Integrin alphaMbeta2 (CD11b/CD18) is Regulated by STAT3-Dependent Activation of PU.1
*
Nancy C. Reich,
Stony Brook University, USA
Regulated Cellular Localization of STATs and Influence of Small GTPases
Regulated Cellular Localization of STATs and Influence of Small GTPases
Pravin B. Sehgal,
New York Medical College, USA
STATs in Membrane Rafts
STATs in Membrane Rafts
Erika A. Bach,
New York University School of Medicine, USA
A Genetic Screen to Identify New Components of the Drosophila JAK-STAT Pathway
A Genetic Screen to Identify New Components of the Drosophila JAK-STAT Pathway
Antonis E. Koromilas,
Lady Davis Institute, McGill University, Canada
The Interferon-Inducible Protein Kinase PKR is a Mediator of JAK-STAT Activation and Translational Control
The Interferon-Inducible Protein Kinase PKR is a Mediator of JAK-STAT Activation and Translational Control
Joe F. Lau,
Mount Sinai School of Medicine, USA
A Hybrid IRF9-STAT2 Transcription Factor Recapitulates Gene Expression and Biological Responses
A Hybrid IRF9-STAT2 Transcription Factor Recapitulates Gene Expression and Biological Responses
16:30—18:30
Transcription Mechanisms 1
Meeting has ended...abstracts no longer viewable online.
*
James E. Darnell,
Rockefeller University, USA
Transcriptional Activation by STATs and Biologic Impact
Transcriptional Activation by STATs and Biologic Impact
Joo Yeon Yoo,
POSTECH, South Korea
Short Talk: Specific Ablation of STAT3beta Distorts the Pattern of STAT3-Responsive Gene Expression and Impairs Recovery from Endotoxic Shock
Short Talk: Specific Ablation of STAT3beta Distorts the Pattern of STAT3-Responsive Gene Expression and Impairs Recovery from Endotoxic Shock
J. Jillian Zhang,
Cornell Medical School, USA
Short Talk: Analysis of Trancription Co-Activators of STAT1 in IFN-gamma Signaling
Short Talk: Analysis of Trancription Co-Activators of STAT1 in IFN-gamma Signaling
Jan H. Tavernier,
Ghent University, Belgium
Short Talk: Design and Application of a Cytokine Receptor-Based Interaction Trap
Short Talk: Design and Application of a Cytokine Receptor-Based Interaction Trap
Carmen Herrero,
Hospital for Special Surgery, USA
Short Talk: Modulation of IL-10 Activity and Signaling during Macrophage Activation
Short Talk: Modulation of IL-10 Activity and Signaling during Macrophage Activation
08:00—12:00
Negative Regulation
Meeting has ended...abstracts no longer viewable online.
*
Douglas J. Hilton,
Walter and Eliza Hall Institute of Medical Research, Australia
SOCS Proteins - Negative Regulations of Cytokine Signal Transduction
SOCS Proteins - Negative Regulations of Cytokine Signal Transduction
Ann L. Cornish,
University of Melbourne, Australia
Short Talk: SOCS-1 is Important in the Negative Regulation of T Cell Activation
Short Talk: SOCS-1 is Important in the Negative Regulation of T Cell Activation
Alexander H. Dalpke,
University Heidelberg, Germany
Short Talk: Toll-Like Receptor-Dependent Microbial Stimuli Modulate Cytokine Responses in Antigen Presenting Cells by Inducing Suppressors of Cytokine Signaling
Short Talk: Toll-Like Receptor-Dependent Microbial Stimuli Modulate Cytokine Responses in Antigen Presenting Cells by Inducing Suppressors of Cytokine Signaling
Thomas A.F. Decker,
Vienna Biocenter, University of Vienna, Austria
Short Talk: The STAT1 Binding Motif of the IFN-gamma Receptor is Sufficient to Mediate STAT5 Activation and Its Repression by SOCS3
Short Talk: The STAT1 Binding Motif of the IFN-gamma Receptor is Sufficient to Mediate STAT5 Activation and Its Repression by SOCS3
Christin Carter-Su,
University of Michigan Medical School, USA
Regulation of JAK Activity and Cytokine Signaling by Members of the SH2-B Family of Adapter Proteins
Regulation of JAK Activity and Cytokine Signaling by Members of the SH2-B Family of Adapter Proteins
Ke Shuai,
University of California, Los Angeles, USA
Inactivation of STAT Signaling in the Nucleus
Inactivation of STAT Signaling in the Nucleus
Yi Eve Sun,
University of California, Los Angeles, USA
Short Talk: Neurogenin1 Inhibits the JAK-STAT Pathway Via Multiple Routes
Short Talk: Neurogenin1 Inhibits the JAK-STAT Pathway Via Multiple Routes
16:30—18:30
Transcription Mechanisms 2
Meeting has ended...abstracts no longer viewable online.
*
Christin Carter-Su,
University of Michigan Medical School, USA
Peter C. Heinrich,
Universitätsklinikum Aachen, Germany
Modulation of IL-6-Type Cytokine Signaling
Modulation of IL-6-Type Cytokine Signaling
Heather A. Bruns,
Indiana University School of Medicine, USA
Short Talk: A Constitutively Active STAT6 is not Sufficient to Alter B Cell Gene Expression and Function in the Absence of IL-4
Short Talk: A Constitutively Active STAT6 is not Sufficient to Alter B Cell Gene Expression and Function in the Absence of IL-4
Edith B. Pfitzner,
Institute for Biomedical Research, Germany
Short Talk: Transciptional Activation by STAT6 Requires the Direct Interaction with NCoA-1
Short Talk: Transciptional Activation by STAT6 Requires the Direct Interaction with NCoA-1
08:00—12:00
Oncogenesis, Immune Regulation, Tissue-Specific Effects 1
Meeting has ended...abstracts no longer viewable online.
John J. O'Shea,
NIAMS, National Institutes of Health, USA
Cytokine Signaling and Lymphoid Development, Differentiation and Immunoregulation
Cytokine Signaling and Lymphoid Development, Differentiation and Immunoregulation
Kenneth M. Murphy,
HHMI/Washington University School of Medicine, USA
Mechanisms of STAT4 in Th1 Development
Mechanisms of STAT4 in Th1 Development
*
Robert D. Schreiber,
Washington University School of Medicine, USA
STAT1 and Lymphocytes: Tumor Suppression and Tumor Editing
STAT1 and Lymphocytes: Tumor Suppression and Tumor Editing
David E. Levy,
New York University School of Medicine, USA
STAT Transcriptional Mechanisms in Host Defense and Cancer
STAT Transcriptional Mechanisms in Host Defense and Cancer
George R. Stark,
Cleveland Clinic, USA
Stat1-Independent Responses to IFNgamma and Stat 1,3-Dependent Transcription Without Tyrosine Phosphorylation
Stat1-Independent Responses to IFNgamma and Stat 1,3-Dependent Transcription Without Tyrosine Phosphorylation
14:00—16:00
Workshop 2
*
Peter C. Heinrich,
Universitätsklinikum Aachen, Germany
Markus H. Heim,
University Hospital Basel, Switzerland
Inhibition of Interferon Alpha Signaling Through the JAK-STAT Pathway in HVC Transgenic Mice
Inhibition of Interferon Alpha Signaling Through the JAK-STAT Pathway in HVC Transgenic Mice
Simone Radtke,
Medical School RWTH Aachen, Germany
Short Talk: Novel Role of Janus Kinase 1 in the Regulation of Oncostatin M Receptor Surface Expression
Short Talk: Novel Role of Janus Kinase 1 in the Regulation of Oncostatin M Receptor Surface Expression
Lily Huang,
University of Texas Southwestern Medical Center at Dallas, USA
Short Talk: The N-Terminal Domain of Janus Kinase 2 is Required for Golgi Processing and Cell Surface Expression of Erythropoietin Receptor
Short Talk: The N-Terminal Domain of Janus Kinase 2 is Required for Golgi Processing and Cell Surface Expression of Erythropoietin Receptor
Jennifer Rubin Grandis,
University of Pittsburgh Eye & Ear Institute, USA
STATs in Head and Neck Cancer
STATs in Head and Neck Cancer
June H. Lee,
University of California, San Francisco, USA
IL-13 and IL-4 Induce Differential Gene Expression in Bronchial Smooth Muscle Cells and Lung Fibroblasts
IL-13 and IL-4 Induce Differential Gene Expression in Bronchial Smooth Muscle Cells and Lung Fibroblasts
Thomas Kay,
St. Vincent's Institute of Medical Research, Australia
Hypersensitivity to TNF-alpha-Induced Cell Death in Pancreatic beta Cells with SOCS-1 Deficiency
Hypersensitivity to TNF-alpha-Induced Cell Death in Pancreatic beta Cells with SOCS-1 Deficiency
Bao Q. Vuong,
City College of New York, CUNY, USA
Pim Serine/Theronine Kinases Regulate the Stability of SOCS-1 Protein
Pim Serine/Theronine Kinases Regulate the Stability of SOCS-1 Protein
16:30—18:30
Oncogenesis, Immune Regulation, Tissue-Specific Effects 2
Meeting has ended...abstracts no longer viewable online.
*
George R. Stark,
Cleveland Clinic, USA
Merav Socolovsky,
University of Massachusetts Medical School, USA
The Roles of EpoR and STAT5 in Red Cell Formation
The Roles of EpoR and STAT5 in Red Cell Formation
James N. Ihle,
St. Jude Children's Research Hospital, USA
JAKs and STATs in Cytokine Signaling
JAKs and STATs in Cytokine Signaling
M. A.Q. Siddiqui,
Downstate Medical Center, State University of New York, USA
JAK/STAT Signaling Mediates Myocardial Dysfunction during Hypertrophy and Ischemia
JAK/STAT Signaling Mediates Myocardial Dysfunction during Hypertrophy and Ischemia
08:00—12:00
Growth Regulation, Constitutive Gene Expression, Alternate Pathways, Apoptosis
Meeting has ended...abstracts no longer viewable online.
Jacqueline F. Bromberg,
Memorial Sloan Kettering Cancer Center, USA
Short Talk: The Role of STAT3 in Breast Cancer Tumorigenesis
Short Talk: The Role of STAT3 in Breast Cancer Tumorigenesis
Keith Syson Chan,
Stem Cells and Regenerative Medicine, USA
Short Talk: Activation of STAT3 during Multistage Skin Tumorigenesis
Short Talk: Activation of STAT3 during Multistage Skin Tumorigenesis
Mariusz A. Wasik,
University of Pennsylvania, USA
Short Talk: Multilevel Dysregulation of STAT3 Activation in T-Cell Lymphomas Expressing Anaplastic Lymphoma Kinase (ALK)
Short Talk: Multilevel Dysregulation of STAT3 Activation in T-Cell Lymphomas Expressing Anaplastic Lymphoma Kinase (ALK)
James L. Watson,
McMaster University, Canada
Short Talk: (-)-Epigallocatechin Gallate (EGCG) Inhibits IFNgamma-Induced STAT1 Activation in Human T84 Epithelia: Implications for the Regulation of Intestinal Barrier Function
Short Talk: (-)-Epigallocatechin Gallate (EGCG) Inhibits IFNgamma-Induced STAT1 Activation in Human T84 Epithelia: Implications for the Regulation of Intestinal Barrier Function
Leonidas C. Platanias,
University of Illinois at Chicago, USA
Role of Map Kinases in Interferon Signaling
Role of Map Kinases in Interferon Signaling
Anna I. Dimberg,
Uppsala University Hospital, Sweden
Short Talk: Serine-727 Phosphorylated STAT1 is Required for ATRA-Induced G0/G1 Arrest of U-937 Cells and the Associated Regulation of Cyclins and p27Kip1
Short Talk: Serine-727 Phosphorylated STAT1 is Required for ATRA-Induced G0/G1 Arrest of U-937 Cells and the Associated Regulation of Cyclins and p27Kip1
Tania C. Benatar,
University of Toronto, Canada
Short Talk: ES Cell Fate is Determined Through a Complex Balance of Intracellular Signaling Pathways
Short Talk: ES Cell Fate is Determined Through a Complex Balance of Intracellular Signaling Pathways
16:30—18:30
Slime Molds to Zebrafish
Meeting has ended...abstracts no longer viewable online.
*
Jeffrey G. Williams,
University of Dundee, School of Biological Sciences, UK
Regulation of the Nuclear Import and Export of Dictyostelium STAT Proteins: Pointers from Ancestral STATs?
Regulation of the Nuclear Import and Export of Dictyostelium STAT Proteins: Pointers from Ancestral STATs?
Leanne Jones,
University of California, Los Angeles, USA
Short Talk: Stem Cell Self-Renewal Specified by JAK-STAT Activation in Response to a Support Cell Cue
Short Talk: Stem Cell Self-Renewal Specified by JAK-STAT Activation in Response to a Support Cell Cue
Toshio Hirano,
Osaka University Graduate School of Medicine, Japan
Roles of JAK/STAT Signaling in Gastrulation
Roles of JAK/STAT Signaling in Gastrulation
*Session Chair †Invited, not yet responded.
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