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This meeting took place in 2002



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T Lymphocyte Activation, Differentiation and Death (A3)


Organizer(s) Laurie H. Glimcher, Gerald R. Crabtree and Harvey I. Cantor
January 16—22, 2002
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Oct 1, 2001
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Nov 16, 2001

Sponsored by Berlex Biosciences

Summary of Meeting:
There have been substantial advances in molecular and cellular biology that have provided new insight into the biochemical and genetic basis of lymphocyte recognition, activation and expression of distinct functional phenotypes. It has now become evident that for both T and B cells, stimuli delivered through their receptors can result in either clonal expansion or apoptosis. In the case of T cells, clonal expansion of helper cells is accompanied by differentiation into two major functional subsets which regulate the immune response. The pathways between the membrane and the nucleus and their molecular components are an area of very active investigation. This meeting will draw together scientists working on diverse aspects of this problem, including receptor ligand interactions, intracellular pathways that transmit receptor mediated signals and the effect of such signal transduction pathways on gene regulation. The implications and applicability of these processes for human disease will be considered as well. The aim of this meeting is to integrate the information from these various experimental approaches into a new synthesis and molecular explanation of T cell activation, differentiation and death.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


WEDNESDAY, JANUARY 16

16:00—19:00
Registration

Quandary Peak Foyer
18:15—19:15
Welcome

Quandary Peak Foyer
19:15—19:30
Orientation

Quandary Peak 1-3
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Quandary Peak 1-3
Emil R. Unanue, Washington University School of Medicine, USA
The Mysteries of Peptide Selection by MHC Molecules


THURSDAY, JANUARY 17

07:00—08:00
Breakfast

Longs Peak
08:00—11:00
Autoimmunity/Tumor Immunity. Session Sponsored by the Juvenile Diabetes Research Foundation.
Meeting has ended...abstracts no longer viewable online.

Quandary Peak 1-3
* Harvey Cantor, Dana Farber Cancer Institute, USA
Autoimune Disease: Too Much Diversity or Too Little Regulation?

Barrett J. Rollins, Dana Farber Cancer Institute, USA
Control of T Helper Cell Polarization by the Chemokine Monocyte Chemoattractant Protein-1 (MCP-1)

Christophe Benoist, Harvard Medical School, USA
Regulation of Autoimmune Damage

Terri M. Laufer, University of Pennsylvania, USA
T Cell Requirements for the Production of Autoantibodies

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Longs Peak
13:00—22:00
Poster Viewing

Longs Peak
14:30—16:30
Workshop 1: Innate Immunity Mechanisms and Disease Pathogenesis

Quandary Peak 1-3
* Barrett J. Rollins, Dana Farber Cancer Institute, USA

* Christophe Benoist, Harvard Medical School, USA

16:30—17:00
Coffee & Snacks Available

Longs Peak Foyer
17:00—19:00
Innate Immunity/Chemokines
Meeting has ended...abstracts no longer viewable online.

Quandary Peaks 1-3
* Jeffrey V. Ravetch, Rockefeller University, USA
Coupling Innate and Adaptive Responses Through Activation/Inhibitory Receptor Pairs

Ruslan Medzhitov, HHMI/Yale University School of Medicine, USA
Short Talk: Role of Toll-Like Receptors in Innate Immune Recognition

Dan R. Littman, HHMI/New York University School of Medicine, USA
Role of Dendritic Cells in Priming of Pathogen-Specific CTL and Gene Regulation during Development of the CTL Lineage

19:00—20:00
Welcome Mixer

Longs Peak
20:00—22:00
Poster Session 1: Autoimmunity/Tumor Immunity/Innate Immunity/Chemokines

Longs Peak

FRIDAY, JANUARY 18

07:00—08:00
Breakfast

Longs Peak
08:00—11:00
Gene Expression
Meeting has ended...abstracts no longer viewable online.

Quandary Peaks 1-3
* Laurie H. Glimcher, Dana-Farber Cancer Institute, USA
T-bet: A Transcription Factor with Key Functions in Both T and B Cells

Dinah S. Singer, National Cancer institute, National Institutes of Health, USA
Regulation of MHC Class I Gene Transcription by the Coactivator, CIITA

Louis M. Staudt, NCI, National Institutes of Health, USA
Gene Expression Profiling of Normal and Malignant Lymphocytes

Matthias Merkenschlager, Imperial College London, UK
Nuclear Organisation, Gene Silencing and Replication Timing in Lymphocytes

M. Frances Shannon, Australian National University, Australia
Short Talk: Directed Chromatin Remodelling at Cytokine Gene Promoters Following T Cell Activation

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Longs Peak
13:00—22:00
Poster Viewing

Longs Peak
14:30—16:30
Workshop 2: Interface of Signaling and Gene Expression in T Cell Development and Differentiation

Quandary Peaks 1-3
* Pamela L. Schwartzberg, NIAID, NHGRI, USA

* Gary A. Koretzky, University of Pennsylvania School of Medicine, USA

Tomasz Zal, University of Texas MD Anderson Cancer Center, USA
Visualizing TCR Antagonism by Live FRET Imaging of the Immunological Synapse

Jackson G. Egen, University of California, Berkeley, USA
Cytotoxic T Lymphocyte Associated Antigen-4 (CTLA-4) Accumulation in the Immunological Synapse is Regulated by TCR Signal Strength

Quido A. Valent, Netherlands Cancer Institute, Netherlands
Molecular Dissection of the Negative Regulation of T Cell Signalling by CTLA4

Li Zhang, University of Virginia, USA
Role of Shc in Thymic Development

Ihn Kyung Jang, PATH, USA
Altered Development of Thymic T cells in Mice Bearing Targeted Mutant Growth Factor Receptor-bound Protein 2 (Grb2) Gene

Takashi Saito, RIKEN Center for Allergy and Immunology, Japan
Identification of a New ITAM+ Cell Surface Molecule Inducing T Cell Activation by a Novel cDNA Cloning System.

Connie L. Sommers, National Institutes of Health, USA
Mutation of a Single Tyrosine in LAT Knock-In Mice Results in Severe Lymphoproliferative Disease

Andrew Miller, , USA
Defective Activation-Induced Cell Death via TCR-Mediated FasL Expression in Itk-Deficient Mice

16:30—17:00
Coffee & Snacks Available

Longs Peak Foyer
17:00—19:00
Signaling I
Meeting has ended...abstracts no longer viewable online.

Quandary Peaks 1-3
* Arthur Weiss, University of California, San Francisco, USA
Regulating TCR Signal Transduction

Leslie J. Berg, University of Massachusetts Medical Center, USA
Signal Transduction Pathways in T Cell Development and Activation

Michael J. Bevan, HHMI/University of Washington, USA
Notch Signaling during T Cell Development

Hua Gu, National Institutes of Health, USA
Short Talk: Control of T Cell Responsiveness and Intracellular TCR Trafficking by Cbl/Cbl-b

19:00—20:00
Welcome Mixer

Longs Peak
20:00—22:00
Poster Session 2: Gene Expression/Signaling

Longs Peak

SATURDAY, JANUARY 19

07:00—08:00
Breakfast

Longs Peak
08:00—11:00
Signaling II
Meeting has ended...abstracts no longer viewable online.

Quandary Peaks Foyer
* Gerald R. Crabtree, Stanford University, USA
NFAT Signaling in Costimulation and Self Tolerance

Frederick W. Alt, Boston Children's Hospital, USA
The Role of RSSs and Enhancers in the Control of TCR alpha/beta and gamma/delta Gene Rearrangement and Development

Josef M. Penninger, Institute of Molecular Biotechnology GmbH, Austria
Molecular Control of Inside-Out Signaling and Tolerance

Andrey S. Shaw, Genentech, Inc., USA
Immunological Synapse Formation and TCR Signal Transduction

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Longs Peak
13:00—22:00
Poster Viewing

Longs Peak
16:30—17:00
Coffee & Snacks Available

Longs Peak Foyer
17:00—19:00
Apoptosis
Meeting has ended...abstracts no longer viewable online.

Quandary Peaks 1-3
Craig B. Thompson, Memorial Sloan Kettering Cancer Center, USA
Activation - Induces Cell Death

* Stephen M. Hedrick, University of California, San Diego, USA
Coordinant Control of Growth and Death

Michael J. Lenardo, NIAID, National Institutes of Health, USA
Molecular Regulation of Lymphocyte Apoptosis

19:00—20:00
Welcome Mixer

Longs Peak
20:00—22:00
Poster Session 3: Signaling/Apoptosis/Stem Cells and Thymocyte Development

Longs Peak

SUNDAY, JANUARY 20

07:00—08:00
Breakfast

Longs Peak
08:00—11:00
Stem Cells and Thymocyte Development
Meeting has ended...abstracts no longer viewable online.

Quandary Peaks 1-3
Irving L. Weissman, Stanford University, USA
From Stem Cells to T Cells

Meinrad Busslinger, Research Institute of Molecular Pathology, Austria
Lineage Skewing by Precocious Pax5 Expression in Hematopoietic Stem Cells

* Alfred Singer, National Institutes of Health, USA
The CD4/CD8 Lineage Decision: Old Dilemmas and New Solutions

Nikolaus S. Trede, Children's Hospital Boston, USA
Forward Genetic Approach to Lymphoid Development in Zebrafish

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Longs Peak
13:00—22:00
Poster Viewing

Longs Peak
14:30—16:30
Workshop 3: Relationship of Membrane Surface Receptors to T Cell Activation and Death

Quandary Peaks 1-3
* Paul M. Allen, Washington University School of Medicine, USA

* Arlene H. Sharpe, Harvard Medical School, USA

James L. Riley†, University of Pennsylvania, USA
Gene Expression Profiles Reveal Modulation of TCR Signaling by Costimulatory Receptors that is Prevented by CTLA-4 Engagement

Stanley G. Nathenson, Albert Einstein College of Medicine, USA
Structural Basis for Co-stimulation by the Human CTLA-4/B7-2 Complex

Jing Wang, University of Chicago, USA
The Regulation of T Cell Homeostasis and Autoimmunity by T Cell Derived LIGHT.

Rebecca A. Shilling, Indiana University School of Medicine, USA
The Role of CD28 and IOCS Costimultion in the Induction of TH2 Responses in a Murine Model of Allergic Airway Disease

Lauren I. Richie, Stanford University, USA
Imaging Synapse Formation During Thymocyte Selection: Recruitment of p56lck and CD3z During Negative Selection

Eric Hailman, ARIAD Pharmaceuticals, Inc., USA
Multifocal Immunological Synapses in Immature CD4+ CD8+ Thymocytes

Fran Balamuth, Yale University, USA
Distinct Pattern of Membrane Microdomain Organization in Th1 and Th2 Cells

Elizabeth M. Hiltbold, Wake Forest University School of Medicine, USA
Lipid Microdomains Facilitate Antigen-Specific Conjugate Formation

16:30—17:00
Coffee & Snacks Available

Longs Peak Foyer
17:00—19:00
T Cell Activation. Session Sponsored in part by Xcyte Therapies, Inc.
Meeting has ended...abstracts no longer viewable online.

Quandary Peaks 1-3
* Ronald N. Germain, NIAID, National Institutes of Health, USA
Influence of Self-Recognition on T Cell Activation

Kim Bottomly, Yale University School of Medicine, USA
Regulation of CD4+ T Cell Activation

James P. Allison, University of Texas MD Anderson Cancer Center, USA
More is Less: New Insights Into the Mechanisms of Negative Costimulation by CTLA4

Susan L. Swain, University of Massachusetts Medical School, USA
Regulation of CD4 Memory T Cell Generation and Persistence

19:00—20:00
Welcome Mixer

Longs Peak
20:00—22:00
Poster Session 4: T Cell Activation/T Cell/APC Membrane Structure and Activation/T Cell Differentiation

Longs Peak

MONDAY, JANUARY 21

07:00—08:00
Breakfast

Longs Peak
08:00—11:00
T Cell/APC Membrane Structure and Interaction
Meeting has ended...abstracts no longer viewable online.

Quandary Peaks 1-3
* Kenneth L. Rock, University of Massachusetts Medical School, USA
Immune Surveillance of Viral Infections

Mark M. Davis, Stanford University School of Medicine, USA
Coordinated Movement of Cell Surface and Internal Molecules during T Cell Recognition

Michael L. Dustin, University of Oxford, UK
The Immunological Synapse in vivo

Anne I. Sperling, University of Chicago, USA

09:20—09:40
Coffee Break

Longs Peak Foyer
16:30—17:00
Coffee & Snacks Available

Longs Peak Foyer
17:00—19:00
T Cell Differentiation
Meeting has ended...abstracts no longer viewable online.

Quandary Peaks 1-3
Richard A. Flavell, HHMI/Yale University School of Medicine, USA
Mechanisms of T Cell Differentiation

Kenneth M. Murphy, HHMI/Washington University School of Medicine, USA
Commitment Mechanisms among T Helper Cell Subsets

Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School, USA
Short Talk: Function of TIM-3, a Novel Cell Surface Molecule Expressed on Th1 Cells

19:00—20:00
Welcome Mixer

Longs Peak
20:00—23:00
Entertainment

Longs Peak

TUESDAY, JANUARY 22

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 AI51295-01




We gratefully acknowledge additional support for this conference from:

Berlex Biosciences

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Phone:+1 970-262-2690

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