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This meeting took place in 2002



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Regulation of Cellular Responses by Lipid Mediators (B2)


Organizer(s) Philip W. Majerus and Stephen M. Prescott
February 1—6, 2002
Sagebrush Inn & Suites • Taos, New Mexico USA
Abstract Deadline: Oct 1, 2001
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Nov 30, 2001

Sponsored by ICOS Corporation and The Director's Sponsor Fund

Summary of Meeting:
This symposium will consider intracellular lipid messengers that evoke cell responses following activation by agonists. We will emphasize how these messengers interact with other signaling pathways. For example activation of phosphatidylinositol signaling to yield inositol phosphates and DAG interact with many cellular effector molecules including those with FYVE and PH domains. For example PDK-I, AKT, p70S6K, GSK-3 and a number of guanine nucleotide exchange factors. Receptors also activate PI kinases and phosphatases and the functions of many of the products of these reactions have recently been shown to have signaling roles. InsP5 and InsP6 have recently been shown to be required for mRNA export and some transcription reactions in yeast. The tumor suppressor gene PTEN is an inositol phosphatase as is SopB a Salmonella virulence factor that is essential for pathogenesis. Additional defects in these lipid-signaling pathways are associated with diseases including an inositol phosphatase in LOWE syndrome and a PLC in drosophila NORPA which cause blindness. Other signals are initiated by PLA-2 and PLD. These sessions will emphasize downstream events such as the targets for phosphatidic acid and the mechanisms whereby COX-2 products are tumorigenic (e.g., their role in activating PPARs and their alteration of NFkB and p53-dependent transcription).

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


FRIDAY, FEBRUARY 1

16:00—19:00
Registration

Chamisa Lobby
18:15—19:15
Welcome

Chamisa Lobby
19:15—19:30
Orientation

Chamisa Ballroom 2
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 2
* Philip W. Majerus, Washington University School of Medicine, USA

Jack E. Dixon, University of California, San Diego, USA
Phosphatidylinositol Phosphatases and Phospholipase D Superfamily Members.


SATURDAY, FEBRUARY 2

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Cellular Events Regulated by PI Kinases
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 2
Lewis C. Cantley, Weill Cornell Medicine, USA
Signaling via Phosphoinositide Kinases

* James H. Hurley, University of California, Berkeley, USA
Structural Basis for Signal Attenuation through Inositol Polyphosphate 5-Phosphatases

Len R. Stephens, Babraham Institute, UK
Signaling via PI3Ks

Richard A. Anderson, University of Wisconsin Medical School, USA
Spatial and Temporal Phosphoinositide Signaling

Aaron J. Marshall, University of Manitoba, Canada
Short Talk: Bam32, TAPP1 and TAPP2 are Novel Targets of Phosphatidylinositol 3-Kinase Signaling: Regulation by SHIP and FcgammaRII in B Lymphocytes

09:20—09:40
Coffee Break

Chamisa Lobby
11:00—13:00
Poster Setup

Chamisa Ballroom 1
13:00—22:00
Poster Viewing

Chamisa Ballroom 1
16:30—17:00
Coffee & Snacks Available

Chamisa Lobby
17:00—19:00
Intracellular Targets of Diacylglycerol and Phorbol Esters
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 2
* Stephen M. Prescott, Oklahoma Medical Research Foundation, USA

Marcelo G. Kazanietz, University of Pennsylvania, USA
Chimaerins as Intracellular Targets of Diacylglycerol and Phorbol Esters

Matthew K. Topham, University of Utah, USA
Regulation of Cellular Processes by Diacylglycerol Kinases

James C. Stone, University of Alberta, Canada
RasGRP Links Diacylglycerol to Ras Signaling in T cells

19:00—20:00
Welcome Mixer

Chamisa Ballroom 1
20:00—22:00
Poster Session 1

Chamisa Ballroom 1

SUNDAY, FEBRUARY 3

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Role of Lipids in Physiology and Disease
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 2
* Christina Anne Mitchell, Monash University, Australia
Inositol Polyphosphate 5-Phosphatases are Relatives of the Base Excision Repair Endonucleases

Philip W. Majerus, Washington University School of Medicine, USA
The Role of Phosphatases and Kinases in Inositol Signaling Reactions

Gerald Krystal, British Columbia Cancer Research Centre, Canada
The Role of SHIP in Hematopoietic Cell Functions

Garret A. FitzGerald, University of Pennsylvania, USA
Nuclear Receptor Activation and Bioactive Lipids

Christophe Erneux, Institut de Recherche Interdisciplinaire en Biologie Humaine et Nucleaire, Belgium
Short Talk: The Lipid Phosphatase SHIP2 Controls Insulin Sensitivity

09:20—09:40
Coffee Break

Chamisa Lobby
11:00—13:00
Poster Setup

Chamisa Ballroom 1
13:00—22:00
Poster Viewing

Chamisa Ballroom 1
16:30—17:00
Coffee & Snacks Available

Chamisa Lobby
17:00—19:00
Protein Kinase C as a Central Regulator of Cellular Responses
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 2
Susan Jaken, Eli Lilly and Company, USA
PKC Isozymes: Selective Substrate Phosphorylation and Functions

Peter J. Parker, Cancer Research UK, UK
Cellular Movement and Protein Kinase C Associated Traffic

* Alexandra C. Newton, University of California, San Diego, USA
Coordinated Regulation of Protein Kinase C by Phosphorylation and Lipid Mediators

19:00—20:00
Welcome Mixer

Chamisa Ballroom 1
20:00—22:00
Poster Session 2

Chamisa Ballroom 1

MONDAY, FEBRUARY 4

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Polar Lipids Regulate Cell Growth and Death, Motility and Secretion
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 2
Andrew J. Morris, University of Kentucky, USA
Synthesis and Inactivation of Lysophosphatidic Acid

* Jerold J. Chun, The Scripps Research Institute, USA
Roles for Lysophospholipid Receptors

Thomas M. McIntyre, Cleveland Clinic Foundation, USA
Phospholipid Regulation of Cell Responses by Nuclear Hormone Receptors

Linda C. McPhail, Wake Forest University, USA
Short Talk: Binding of Phosphatidic Acid (PA) to the PX Domain of the NADPH Oxidase Component p47phox

09:20—09:40
Coffee Break

Chamisa Lobby
11:00—13:00
Poster Setup

Chamisa Ballroom 1
13:00—22:00
Poster Viewing

Chamisa Ballroom 1
16:30—17:00
Coffee & Snacks Available

Chamisa Lobby
17:00—19:00
Signaling Functions of Higher Inositol Phosphates
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 2
Susan R. Wente, Vanderbilt University Medical Center, USA
Nuclear Export of mRNA is Regulated by Inositol Hexaphosphate

* John D. York, Vanderbilt University, USA
Inositol Signaling in the Nucleus

Alexis E. Traynor-Kaplan, ISM Therapeutics, USA
Inositol Polyphosphates as Therapeutics

19:00—20:00
Welcome Mixer

Chamisa Ballroom 1
20:00—22:00
Poster Session 3

Chamisa Ballroom 1

TUESDAY, FEBRUARY 5

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Lipids Regulate Vesicle Trafficking
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 2
* Linda J. Pike, Washington University School of Medicine, USA
Cholesterol, Lipid Rafts and Signal Transduction

Scott D. Emr, Cornell University, USA
Phosphoinositide Signaling and the Regulation of Membrane Traffic

Jeremy Thorner, University of California, Berkeley, USA
The Phosphatidylinositol 4-Kinase Isoform, Pik1, Supplies Essential Pools of PtdIns[4]P at the Golgi and in the Nucleus

Pietro V. De Camilli, Yale University School of Medicine, USA
Phosphoinositide Metabolism and Synaptic Vesicle Traffic

Assia Shisheva, Wayne State University School of Medicine, USA
Short Talk: Selective Role of PtdIns 3,5P2 for Endomembrane Homeostasis Revealed by Microinjection and Dissociation of PIKfyve Lipid and Protein Kinase Activity

09:20—09:40
Coffee Break

Chamisa Lobby
16:30—17:00
Coffee & Snacks Available

Chamisa Lobby
17:00—19:00
Lipids Alter Signaling by Covalently Modifying Key Proteins
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 2
* Philip W. Majerus, Washington University School of Medicine, USA

Michael Karin, University of California, San Diego, USA
IKK – A Master Regulator of Innate and Adaptive Immune Responses

Frank A. Fitzpatrick, University of Utah, USA
Cyclopentenone Prostaglandins: Agonists and Antagonists of Apoptosis

L. Jackson Roberts, Vanderbilt University, USA
Reactive Products of the Isoprostane Pathway, Isoketals and Cyclopentenone Isoprostanes, Covalently Modify Key Cellular Proteins that Alter Cellular Function

19:00—20:00
Welcome Mixer

Chamisa Ballroom 1
20:00—23:00
Entertainment

Chamisa Ballroom 2

WEDNESDAY, FEBRUARY 6

 
Departure


*Session Chair †Invited, not yet responded.



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