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This meeting took place in 2002
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Regulation of Cellular Responses by Lipid Mediators (B2)
Organizer(s) Philip W. Majerus and Stephen M. Prescott
February 1—6, 2002
Sagebrush Inn & Suites • Taos, New Mexico USA
Abstract Deadline: Oct 1, 2001
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Nov 30, 2001
Sponsored by ICOS Corporation and The Director's Sponsor Fund
Summary of Meeting:
This symposium will consider intracellular lipid messengers that evoke cell responses following activation by agonists. We will emphasize how these messengers interact with other signaling pathways. For example activation of phosphatidylinositol signaling to yield inositol phosphates and DAG interact with many cellular effector molecules including those with FYVE and PH domains. For example PDK-I, AKT, p70S6K, GSK-3 and a number of guanine nucleotide exchange factors. Receptors also activate PI kinases and phosphatases and the functions of many of the products of these reactions have recently been shown to have signaling roles. InsP5 and InsP6 have recently been shown to be required for mRNA export and some transcription reactions in yeast. The tumor suppressor gene PTEN is an inositol phosphatase as is SopB a Salmonella virulence factor that is essential for pathogenesis. Additional defects in these lipid-signaling pathways are associated with diseases including an inositol phosphatase in LOWE syndrome and a PLC in drosophila NORPA which cause blindness. Other signals are initiated by PLA-2 and PLD. These sessions will emphasize downstream events such as the targets for phosphatidic acid and the mechanisms whereby COX-2 products are tumorigenic (e.g., their role in activating PPARs and their alteration of NFkB and p53-dependent transcription).
View Scholarships/Awards
This symposium will consider intracellular lipid messengers that evoke cell responses following activation by agonists. We will emphasize how these messengers interact with other signaling pathways. For example activation of phosphatidylinositol signaling to yield inositol phosphates and DAG interact with many cellular effector molecules including those with FYVE and PH domains. For example PDK-I, AKT, p70S6K, GSK-3 and a number of guanine nucleotide exchange factors. Receptors also activate PI kinases and phosphatases and the functions of many of the products of these reactions have recently been shown to have signaling roles. InsP5 and InsP6 have recently been shown to be required for mRNA export and some transcription reactions in yeast. The tumor suppressor gene PTEN is an inositol phosphatase as is SopB a Salmonella virulence factor that is essential for pathogenesis. Additional defects in these lipid-signaling pathways are associated with diseases including an inositol phosphatase in LOWE syndrome and a PLC in drosophila NORPA which cause blindness. Other signals are initiated by PLA-2 and PLD. These sessions will emphasize downstream events such as the targets for phosphatidic acid and the mechanisms whereby COX-2 products are tumorigenic (e.g., their role in activating PPARs and their alteration of NFkB and p53-dependent transcription).
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
FRIDAY, FEBRUARY 1
SATURDAY, FEBRUARY 2
SUNDAY, FEBRUARY 3
MONDAY, FEBRUARY 4
TUESDAY, FEBRUARY 5
WEDNESDAY, FEBRUARY 6
Conference Program Print | View meeting in 12 hr (am/pm) time
FRIDAY, FEBRUARY 1
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.
*
Philip W. Majerus,
Washington University School of Medicine, USA
Jack E. Dixon,
University of California, San Diego, USA
Phosphatidylinositol Phosphatases and Phospholipase D Superfamily Members.
Phosphatidylinositol Phosphatases and Phospholipase D Superfamily Members.
08:00—11:00
Cellular Events Regulated by PI Kinases
Meeting has ended...abstracts no longer viewable online.
Lewis C. Cantley,
Weill Cornell Medicine, USA
Signaling via Phosphoinositide Kinases
Signaling via Phosphoinositide Kinases
*
James H. Hurley,
University of California, Berkeley, USA
Structural Basis for Signal Attenuation through Inositol Polyphosphate 5-Phosphatases
Structural Basis for Signal Attenuation through Inositol Polyphosphate 5-Phosphatases
Len R. Stephens,
Babraham Institute, UK
Signaling via PI3Ks
Signaling via PI3Ks
Richard A. Anderson,
University of Wisconsin Medical School, USA
Spatial and Temporal Phosphoinositide Signaling
Spatial and Temporal Phosphoinositide Signaling
Aaron J. Marshall,
University of Manitoba, Canada
Short Talk: Bam32, TAPP1 and TAPP2 are Novel Targets of Phosphatidylinositol 3-Kinase Signaling: Regulation by SHIP and FcgammaRII in B Lymphocytes
Short Talk: Bam32, TAPP1 and TAPP2 are Novel Targets of Phosphatidylinositol 3-Kinase Signaling: Regulation by SHIP and FcgammaRII in B Lymphocytes
17:00—19:00
Intracellular Targets of Diacylglycerol and Phorbol Esters
Meeting has ended...abstracts no longer viewable online.
*
Stephen M. Prescott,
Oklahoma Medical Research Foundation, USA
Marcelo G. Kazanietz,
University of Pennsylvania, USA
Chimaerins as Intracellular Targets of Diacylglycerol and Phorbol Esters
Chimaerins as Intracellular Targets of Diacylglycerol and Phorbol Esters
Matthew K. Topham,
University of Utah, USA
Regulation of Cellular Processes by Diacylglycerol Kinases
Regulation of Cellular Processes by Diacylglycerol Kinases
James C. Stone,
University of Alberta, Canada
RasGRP Links Diacylglycerol to Ras Signaling in T cells
RasGRP Links Diacylglycerol to Ras Signaling in T cells
08:00—11:00
Role of Lipids in Physiology and Disease
Meeting has ended...abstracts no longer viewable online.
*
Christina Anne Mitchell,
Monash University, Australia
Inositol Polyphosphate 5-Phosphatases are Relatives of the Base Excision Repair Endonucleases
Inositol Polyphosphate 5-Phosphatases are Relatives of the Base Excision Repair Endonucleases
Philip W. Majerus,
Washington University School of Medicine, USA
The Role of Phosphatases and Kinases in Inositol Signaling Reactions
The Role of Phosphatases and Kinases in Inositol Signaling Reactions
Gerald Krystal,
British Columbia Cancer Research Centre, Canada
The Role of SHIP in Hematopoietic Cell Functions
The Role of SHIP in Hematopoietic Cell Functions
Garret A. FitzGerald,
University of Pennsylvania, USA
Nuclear Receptor Activation and Bioactive Lipids
Nuclear Receptor Activation and Bioactive Lipids
Christophe Erneux,
Institut de Recherche Interdisciplinaire en Biologie Humaine et Nucleaire, Belgium
Short Talk: The Lipid Phosphatase SHIP2 Controls Insulin Sensitivity
Short Talk: The Lipid Phosphatase SHIP2 Controls Insulin Sensitivity
17:00—19:00
Protein Kinase C as a Central Regulator of Cellular Responses
Meeting has ended...abstracts no longer viewable online.
Susan Jaken,
Eli Lilly and Company, USA
PKC Isozymes: Selective Substrate Phosphorylation and Functions
PKC Isozymes: Selective Substrate Phosphorylation and Functions
Peter J. Parker,
Cancer Research UK, UK
Cellular Movement and Protein Kinase C Associated Traffic
Cellular Movement and Protein Kinase C Associated Traffic
*
Alexandra C. Newton,
University of California, San Diego, USA
Coordinated Regulation of Protein Kinase C by Phosphorylation and Lipid Mediators
Coordinated Regulation of Protein Kinase C by Phosphorylation and Lipid Mediators
08:00—11:00
Polar Lipids Regulate Cell Growth and Death, Motility and Secretion
Meeting has ended...abstracts no longer viewable online.
Andrew J. Morris,
University of Kentucky, USA
Synthesis and Inactivation of Lysophosphatidic Acid
Synthesis and Inactivation of Lysophosphatidic Acid
Thomas M. McIntyre,
Cleveland Clinic Foundation, USA
Phospholipid Regulation of Cell Responses by Nuclear Hormone Receptors
Phospholipid Regulation of Cell Responses by Nuclear Hormone Receptors
Linda C. McPhail,
Wake Forest University, USA
Short Talk: Binding of Phosphatidic Acid (PA) to the PX Domain of the NADPH Oxidase Component p47phox
Short Talk: Binding of Phosphatidic Acid (PA) to the PX Domain of the NADPH Oxidase Component p47phox
17:00—19:00
Signaling Functions of Higher Inositol Phosphates
Meeting has ended...abstracts no longer viewable online.
Susan R. Wente,
Vanderbilt University Medical Center, USA
Nuclear Export of mRNA is Regulated by Inositol Hexaphosphate
Nuclear Export of mRNA is Regulated by Inositol Hexaphosphate
Alexis E. Traynor-Kaplan,
ISM Therapeutics, USA
Inositol Polyphosphates as Therapeutics
Inositol Polyphosphates as Therapeutics
08:00—11:00
Lipids Regulate Vesicle Trafficking
Meeting has ended...abstracts no longer viewable online.
*
Linda J. Pike,
Washington University School of Medicine, USA
Cholesterol, Lipid Rafts and Signal Transduction
Cholesterol, Lipid Rafts and Signal Transduction
Scott D. Emr,
Cornell University, USA
Phosphoinositide Signaling and the Regulation of Membrane Traffic
Phosphoinositide Signaling and the Regulation of Membrane Traffic
Jeremy Thorner,
University of California, Berkeley, USA
The Phosphatidylinositol 4-Kinase Isoform, Pik1, Supplies Essential Pools of PtdIns[4]P at the Golgi and in the Nucleus
The Phosphatidylinositol 4-Kinase Isoform, Pik1, Supplies Essential Pools of PtdIns[4]P at the Golgi and in the Nucleus
Pietro V. De Camilli,
Yale University School of Medicine, USA
Phosphoinositide Metabolism and Synaptic Vesicle Traffic
Phosphoinositide Metabolism and Synaptic Vesicle Traffic
Assia Shisheva,
Wayne State University School of Medicine, USA
Short Talk: Selective Role of PtdIns 3,5P2 for Endomembrane Homeostasis Revealed by Microinjection and Dissociation of PIKfyve Lipid and Protein Kinase Activity
Short Talk: Selective Role of PtdIns 3,5P2 for Endomembrane Homeostasis Revealed by Microinjection and Dissociation of PIKfyve Lipid and Protein Kinase Activity
17:00—19:00
Lipids Alter Signaling by Covalently Modifying Key Proteins
Meeting has ended...abstracts no longer viewable online.
*
Philip W. Majerus,
Washington University School of Medicine, USA
Michael Karin,
University of California, San Diego, USA
IKK – A Master Regulator of Innate and Adaptive Immune Responses
IKK – A Master Regulator of Innate and Adaptive Immune Responses
Frank A. Fitzpatrick,
University of Utah, USA
Cyclopentenone Prostaglandins: Agonists and Antagonists of Apoptosis
Cyclopentenone Prostaglandins: Agonists and Antagonists of Apoptosis
L. Jackson Roberts,
Vanderbilt University, USA
Reactive Products of the Isoprostane Pathway, Isoketals and Cyclopentenone Isoprostanes, Covalently Modify Key Cellular Proteins that Alter Cellular Function
Reactive Products of the Isoprostane Pathway, Isoketals and Cyclopentenone Isoprostanes, Covalently Modify Key Cellular Proteins that Alter Cellular Function
*Session Chair †Invited, not yet responded.
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