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This meeting took place in 2002



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Molecular Biology of the Heart (B6)


Organizer(s) Leslie A. Leinwand and Mark C. Fishman
February 13—18, 2002
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Oct 12, 2001
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Dec 13, 2001

Summary of Meeting:
The focus of this symposium will be on the use of molecular and genetic tools to understand cardiovascular development, function and disease. It is a very exciting time in this field and we will take advantage of the veritable explosion in information that has resulted from the genome projects of multiple organisms. Gene discovery by the time of this meeting will undoubtedly be quite advanced and we should have information about changes in gene expression that accompany cardiovascular disease in mice and men. Another exciting "hot" area of investigation is the potential for stem cells in the heart. We will devote a session to the promise and practice of cardiac stem cells. The use of model organisms has made it possible to develop paradigms for early heart formation and we will use examples of these studies to explore vertebrate and invertebrate heart development. Single gene disorders have contributed a great deal of information about congenital and adult cardiac disease ranging from valve and septal disorders to sudden death in young athletes. We will explore single gene disorders, but also approaches leading to the understanding of complex genetic disorders such as hypertension and predisposition for heart disease. Another emerging area of research is our ability to understand the molecular mechanisms leading to cardiac failure, the most prevalent disease and cause of death in North America. Sessions will be developed that are the essence of "bench-to-bedside" dealing with cardiac failure and how to develop treatment paradigms based on basic research findings. This symposium will bring together people from industry, clinicians and basic scientists in a way that serves the mission of the Keystone symposium. It will be a multidisciplinary meeting that should bring together people who are beginning to have regular dialogues but whose traditions have been somewhat separate.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


WEDNESDAY, FEBRUARY 13

16:00—19:00
Registration

Shavano Peak Foyer
18:15—19:15
Welcome

Shavano Peak Foyer
19:15—19:30
Orientation

Shavano Peak
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
James A. Spudich, Stanford University, USA
Single Molecule Mechanics and the Myosin Family of Molecular Motors


THURSDAY, FEBRUARY 14

07:00—08:00
Breakfast

Red Cloud
08:00—11:00
Genetics of Heart Formation and Function (1)
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* Mark C. Fishman, Novartis Institutes for BioMedical Research, USA
Preparing for the First Heartbeat

Rolf Bodmer, Sanford-Burnham Medical Research Institute, USA
Genetics of Cardiac Positioning and Cell-Type Specification

Glenn I. Fishman, New York University School of Medicine, USA
Murine Cardiac Conduction: Molecular and Functional Characterization

Mark T. Keating, Novartis Institutes for BioMedical Research, USA
Channelopathies and Heart Disease

09:20—09:40
Coffee Break

Shavano Peak Foyer
11:00—13:00
Poster Setup

Torreys Peak 1-4
13:00—22:00
Poster Viewing

Torreys Peak 1-4
16:30—17:00
Coffee & Snacks Available

Shavano Peak Foyer
17:00—19:00
Genetics of Heart Formation and Function (2)
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* Nadia A. Rosenthal, The Jackson Laboratory, USA

Kenneth R. Chien, Karolinska Institutet, Sweden
Molecular Interventions into Hypertrophic Pathways

Jonathan A. Epstein, University of Pennsylvania, USA
Neural Crest and Cardiac Development

Martina Brueckner, Yale University School of Medicine, USA
Cilia, Dynein and the Development of Left-Right Asymmetry

Didier Stainier, Max Planck Institute for Heart and Lung Research, Germany
Cardiac Valve Formation

19:00—20:00
Welcome Mixer

Torreys Peak 1-4
20:00—22:00
Poster Session 1: Genetics of Heart Formation and Function

Torreys Peak 1-4

FRIDAY, FEBRUARY 15

07:00—08:00
Breakfast

Red Cloud
08:00—11:00
Stem Cells Hopes
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
Fabio M.V. Rossi, University of British Columbia, Canada
From Blood to Brain and Brawn

* Charles E. Murry, University of Washington, USA
Cellular Therapy for Cardiac Injury

Giulio Cossu, Stem Cell Research Institute, Italy
Pluripotent Progenitors Associated with Fetal Vasculature

Piero Anversa, Brigham and Women's Hospital, USA
Myocardial Damage and Repair

09:20—09:40
Coffee Break

Shavano Peak Foyer
11:00—13:00
Poster Setup

Torreys Peak 1-4
13:00—22:00
Poster Viewing

Torreys Peak 1-4
16:30—17:00
Coffee & Snacks Available

Shavano Peak Foyer
17:00—19:00
Genetics of Cardiomyopathy
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* Jonathan G. Seidman, Harvard Medical School, USA
Genetics of Hypertrophic and Dilated Cardiomyopathy in Mouse and Man

Elizabeth M. McNally, Northwestern University, USA
Genetics of Cardiomyopathy and Muscle Disease

Neal D. Epstein, National Institutes of Health, USA
The Overall Pattern of Cardiac Contraction Depends on a Spatial Gradient of Myosin Regulatory Light Chain Phosphorylation

19:00—20:00
Welcome Mixer

Torreys Peak 1-4
20:00—22:00
Poster Session 2: Stem Cells Hopes/Genetics of Cardiomyopathy

Torreys Peak 1-4

SATURDAY, FEBRUARY 16

07:00—08:00
Breakfast

Red Cloud
08:00—11:00
Molecular Mechanisms of Cardiac Function and Failure (1)
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* Leslie A. Leinwand, University of Colorado Boulder, USA
Molecular Mechanisms of Cardiac Failure

Eric N. Olson, University of Texas Southwestern Medical Center, USA
The Role of HDACs and Transcriptional Pathways of Hypertrophy

* Nadia A. Rosenthal, The Jackson Laboratory, USA
How to Become a Muscle Cell

Julie R. McMullen, Baker Heart and Diabetes Institute, Australia
Signal Transduction in Cardiac Hypertrophy in vivo

09:20—09:40
Coffee Break

Shavano Peak Foyer
11:00—13:00
Poster Setup

Torreys Peak 1-4
13:00—22:00
Poster Viewing

Torreys Peak 1-4
16:30—17:00
Coffee & Snacks Available

Shavano Peak Foyer
17:00—19:00
Molecular Mechanisms of Cardiac Function and Failure (2)
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* Stephen C. Mockrin, NHLBI, National Institutes of Health, USA

Paul Rosenberg, Duke University, USA
Calcium Signals that Regulate Calcineurin/NFAT Signaling in Muscle

Andrew R. Marks, Columbia University College of Physicians and Surgeons, USA
Defective Calcium Signaling in Failing Hearts: Why Beta Blockers Work

Michael R. Bristow, University of Colorado Anschutz Medical Campus, USA
Adrenergic Mechanisms in Human Myocardial Failure

Michael D. Schneider, Imperial College London, UK
Genetic Dissection of Cardiac Growth Cascades

19:00—20:00
Welcome Mixer

Torreys Peak 1-4
20:00—22:00
Poster Session 3: Molecular Mechanisms of Cardiac Function and Failure/Large Scale Genomics/Proteomics/Late Breaking Science

Torreys Peak 1-4

SUNDAY, FEBRUARY 17

07:00—08:00
Breakfast

Red Cloud
08:00—11:00
Large Scale Genomics/Proteomics
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* Susan E. Old, NHLBI, National Institutes of Health, USA

Edward M. Rubin, Lawrence Berkeley National Laboratory, USA
Comparative Analysis to Identify Functional Mouse Sequences

Larry Gold, SomaLogic Inc., USA
Proteomics and Heart Disease

James D. Bristow, University of California, San Francisco, USA
Expression Profiling of Cardiac Hypertrophy

09:20—09:40
Coffee Break

Shavano Peak Foyer
16:30—17:00
Coffee & Snacks Available

Shavano Peak Foyer
17:00—19:00
Late Breaking Science
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* Robert J. Schwartz, Texas A&M University, USA
Molecular Induced Specification of Early Cardiovascular Lineages

Robert A. Schulz, University of Texas MD Anderson Cancer Center, USA
Cardioblast Specification and Diversification During Heart Development

Bernardo Nadal-Ginard, New York Medical College, USA
Stem Cells in Myocardial Maintenance and Regeneration. Clinical Implications

19:00—20:00
Welcome Mixer

Torreys Peak 1-4
20:00—23:00
Entertainment

Torreys Peak 1-4

MONDAY, FEBRUARY 18

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 HL69887-01




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