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This meeting took place in 2002



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NF-kappaB: Bench to Bedside (B8)


Organizer(s) Inder M. Verma and David Baltimore
February 25—March 3, 2002
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Oct 25, 2001
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Dec 27, 2001

Sponsored by Aventis Pharmaceuticals, Inc. and The Director's Sponsor Fund

Summary of Meeting:
NF-kappaB (NF-kB) is a transcription factor which is involved in the transcription of many genes involved in growth differentiation and development. In addition, the transcription of many lymphokines and cytokines involved in inflammation, rheumatoid arthritis, cancer, and other metabolic diseases is also regulated by NF-kB. NF-kB resides in the cytoplasm, and following induction with a wide variety of agents, is translocated to the nucleus. The translocation to the nucleus, however, is dependent on the degradation of IkB which is associated with NF-kB in the cytoplasm. There is a very complex machinery which leads to the phosphorylation, ubiquitination, and degradation of IkB. This meeting is designed for graduate students, postdoctoral fellows, and scientists working in the field, to understand the molecular mechanisms of activation of NF-kB. There is extensive emphasis on the mechanisms by which NF-kB proteins play a role in disease and identification of therapeutic molecules that may intervene in the biological activity of NF-kB.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


MONDAY, FEBRUARY 25

16:00—19:00
Registration

Longs Peak Foyer
18:15—19:15
Welcome

Longs Peak Foyer
19:15—19:30
Orientation

Quandry 1-3
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Quandry 1-3
Charles A. Dinarello, University of Colorado Health Sciences Center, USA
Anti-Cytokine Therapy Works


TUESDAY, FEBRUARY 26

07:00—08:00
Breakfast

Longs Peak
08:00—11:00
NF-kappaB: Biochemistry and Structure
Meeting has ended...abstracts no longer viewable online.

Quandry 1-3
* Ulrich K. Siebenlist, NIAID, National Institutes of Health, USA

Stephen C. Harrison, Harvard Medical School, USA
Structural Studies of the NF-kappaB Pathway

Gourisankar Ghosh, University of California, San Diego, USA
NF-kappaB regulation by IkappaBalpha and IkappaBbeta

Yinon M. Ben-Neriah, Hebrew University, Hadassah Medical School, Israel
Regulation of IkappaBalpha Ubiquitination

Warner Craig Greene, Gladstone Institute of Virology and Immunology, USA
Reversible Acetylation and the Regulation of NF-kappaB Action

09:20—09:40
Coffee Break

Quandry Peak Foyer
11:00—13:00
Poster Setup

Longs Peak
13:00—22:00
Poster Viewing

Long Peak
16:30—17:00
Coffee & Snacks Available

Quandry Peak Foyer
17:00—19:00
NF-kappaB: Signaling I
Meeting has ended...abstracts no longer viewable online.

Quandry 1-3
* Yinon M. Ben-Neriah, Hebrew University, Hadassah Medical School, Israel

Sankar Ghosh, Columbia University, USA
Phosphorylation Events in the Activation of NF-kappaB

Guoqing Chen, Amgen Inc., USA
Short Talk: TNF Signaling: New Insights into the Composition and Activation of the IKK Complex

David Baltimore, California Institute of Technology, USA
Genetic Analysis of NF-kappaB Function

19:00—20:00
Welcome Mixer

Longs Peak
20:00—22:00
Poster Session 1

Longs Peak

WEDNESDAY, FEBRUARY 27

07:00—08:00
Breakfast

Longs Peak
08:00—11:00
NF-kappaB: Signaling II
Meeting has ended...abstracts no longer viewable online.

Quandry 1-3
* Gerald R. Crabtree, Stanford University, USA

Michael Karin, University of California, San Diego, USA
IKK - A Master Regulator of Innate and Adaptive Immune Responses

Ulrich K. Siebenlist, NIAID, National Institutes of Health, USA
Biologic Functions and Modes of Activation of NF-kappaB

Jun-Ichiro Inoue, University of Tokyo, Japan
Regulation of Cytokine Signalings Mediated by TNF Receptor-Associated Factor 6 (TRAF6)

Zhijian 'James' Chen, University of Texas Southwestern Medical Center, USA
Short Talk: Ubiquitin-Mediated Activation of IKK by TRAF6

09:20—09:40
Coffee Break

Quandry Peak Foyer
11:00—13:00
Poster Setup

Longs Peak
13:00—22:00
Poster Viewing

Longs Peak
16:30—17:00
Coffee & Snacks Available

Quandry Peak Foyer
17:00—19:00
Workshop 1. NF-kappaB: Function in Whole Animals
Meeting has ended...abstracts no longer viewable online.

Quandry 1-3
* David Baltimore, California Institute of Technology, USA

Manolis Pasparakis, University of Cologne, Germany
In vivo Analysis of NF-kappaB Function by Conditional Mutagenesis

Tak W. Mak, Campbell Family Institute for Breast Cancer, Canada
Genetic Dissection of the NF-kappaB Pathways

Inder M. Verma, The Salk Institute, USA
Regulation of NF-kappaB Functions

Steve D. Gerondakis, Monash University, Australia
The Roles of Rel/NF-kappaB in Cell Growth and Embryonic Development

19:00—20:00
Welcome Mixer

Longs Peak
20:00—22:00
Poster Session 2

Longs Peak

THURSDAY, FEBRUARY 28

07:00—08:00
Breakfast

Longs Peak
08:00—11:00
NF-kappaB: Cell Growth and Cell Death
Meeting has ended...abstracts no longer viewable online.

Quandry 1-3
* Michael Karin, University of California, San Diego, USA

Albert S. Baldwin Jr., University of North Carolina School of Medicine, USA
Roles for NF-kappaB in Controlling Cell Growth, Differentiation, and Cell Death

Shigeki Miyamoto, University of Wisconsin, Madison, USA
NF-kappaB Activation in Biological Responses to DNA Damage

Douglas R. Green, St. Jude Children's Research Hospital, USA
NF-kappaB and the Mitochondrial Regulation of Apoptosis

Shyamala Maheswaran, Massachusetts General Hospital, USA
Short Talk: Müllerian Inhibiting Substance Regulates NF-kappaB Signaling and Growth of Mammary Epithelial Cells

Mark S. Kindy, Medical University of South Carolina, USA
Short Talk: NF-kappaB and Cerebral Ischemic Injury

09:20—09:40
Coffee Break

Quandry Peak Foyer
11:00—13:00
Poster Setup

Longs Peak
13:00—22:00
Poster Viewing

Longs Peak
16:30—17:00
Coffee & Snacks Available

Quandry Peak Foyer
17:00—19:00
Workshop 2. NF-kappaB in Viruses
Meeting has ended...abstracts no longer viewable online.

Quandry 1-3
* Céline Gélinas, Center for Advanced Biotechnology and Medicine, USA

Thomas D. Gilmore, Boston University, USA
Malignant Transformation of Cells by Rel Proteins

Elliott D. Kieff, Harvard University, USA
NF-kappaB in Lymphocyte Transcription and Survival

Claus Scheidereit, Max Delbrück Center for Molecular Medicine, Germany
NF-kappaB Activation in Tumorigenesis and Epidermal Organogenesis

Amer A. Beg, Moffitt Cancer Center, USA
Short Talk: Regulation of Dendritic Cell Development and Survival by Distinct NF-kappaB Complexes

19:00—20:00
Welcome Mixer

Longs Peak
20:00—22:00
Poster Session 3

Longs Peak

FRIDAY, MARCH 1

07:00—08:00
Breakfast

Longs Peak
08:00—11:00
NF-kappaB and Immunology
Meeting has ended...abstracts no longer viewable online.

Quandry 1-3
* Klaus Rajewsky, Max Delbrück Center for Molecular Medicine, Germany

Gerald R. Crabtree, Stanford University, USA
NF-AT Signaling: Choreographing the Social Lives of Cells

Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
NFAT Transcription Factors: Siblings of NFkappaB/Rel Proteins

Tadatsugu Taniguchi, University of Tokyo, Japan
Gene Regulation by NF-kappaB, IRFs and STATs: Immunity and Bone Remodeling

Dan R. Littman, HHMI/New York University School of Medicine, USA
Dissection of TCR Signaling Pathways in T Cells

09:20—09:40
Coffee Break

Quandry Peak Foyer
11:00—13:00
Poster Setup

Longs Peak
13:00—22:00
Poster Viewing

Longs Peak
16:30—17:00
Coffee & Snacks Available

Quandry Peak Foyer
17:00—19:00
NF-kappaB: Model Organisms
Meeting has ended...abstracts no longer viewable online.

Quandry 1-3
* Steve D. Gerondakis, Monash University, Australia

Guy Haegeman, Ghent University, Belgium
Short Talk

Dan Hultmark, Umea University, Sweden
Immune Responses in the Fruit Fly

Ruth Steward, Rutgers University, USA
NF-kappaB/Rel Pathways in Drosophila

19:00—20:00
Welcome Mixer

Longs Peak
20:00—22:00
Poster Session 4

Longs Peak

SATURDAY, MARCH 2

07:00—08:00
Breakfast

Longs Peak
08:00—11:00
NF-kappaB: To the Clinic I. Session Sponsored by Serono International S.A.
Meeting has ended...abstracts no longer viewable online.

Quandry 1-3
* Albert S. Baldwin Jr., University of North Carolina School of Medicine, USA

Julian Adams, Vedantra Pharmaceuticals, Inc., USA
NF-kappaB Inhibition with the Proteasome Inhibitors PS-341

Bharat B. Aggarwal, University of Texas MD Anderson Cancer Center, USA
Transcription Factor NF-kappaB as Potential Target for Chemoprevention and Chemosensitization

James C. Cusack, Massachusetts General Hospital, USA
Short Talk: Ingibition of Nf-kappa B as an Adjuvant Approach for Chemotherapy

Carter Van Waes, NIDCD, National Institutes of Health, USA
Short Talk: Nf-kappaB and Proteasome Inhibition in Therapy of Head and Neck Squamos Cell Carcinoma

Xiao-Hong Sun, Oklahoma Medical Research Foundation, USA
Short Talk: Helix-Loop-Helix Proteins Regulate Pre-TCR and TCR Signaling Through Modulation of Rel/NF-kappaB Activities

Lin Chen, University of Southern California, USA
Short Talk: Structural Connections Between the NFAT and NF-kappaB Families of Transcription Factors

09:20—09:40
Coffee Break

Quandry Peak Foyer
16:30—17:00
Coffee & Snacks Available

Quandry Peak Foyer
17:00—19:00
NF-kappaB: To the Clinic II
Meeting has ended...abstracts no longer viewable online.

Quandry 1-3
* Inder M. Verma, The Salk Institute, USA

Louis M. Staudt, NCI, National Institutes of Health, USA
Validation of NF-kappaB as a Molecular Target in Non-Hodgkin's Lymphoma

Steven E. Shoelson, Harvard Medical School, Joslin Diabetes Center, USA
Relationships Between Inflammation, IKKb, and Insulin Resistance in Type 2 Diabetes

Frank Mercurio, BioTheryX, Inc., USA
NF-kappaB: A Rich Source of Therapeutic Targets in Cancer and Inflammation

19:00—20:00
Welcome Mixer

Longs Peak
20:00—23:00
Entertainment

Longs Peak

SUNDAY, MARCH 3

 
Departure


*Session Chair †Invited, not yet responded.



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