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This meeting took place in 2002
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Molecular and Cellular Biology of Leukocyte Regulatory Receptors (C3)
Organizer(s) John R. Ortaldo and Lewis L. Lanier
March 17—22, 2002
Granlibakken Tahoe • Tahoe City, California USA
Abstract Deadline: Nov 16, 2001
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Jan 17, 2002
Sponsored by DNAX Research, Inc. and The Director's Sponsor Fund
Summary of Meeting:
The goal of this conference is to highlight progress in both molecular and cellular biology for a novel class of Leukocyte Regulatory Receptors (LRR) that are involved in positive and negative regulation of immune cell function. LRR contain either ITIM- or ITAM-sequences in the cytoplasmic domains and include membrane receptors of the Ig- and C-type lectin superfamily. Their expression is broad since family members are found on a variety of leukocytes (LAIR), including natural killer and T cells (KIR, Ly-49, CD94, gp49, NKG2), B (PIR) cells, mast cells (gp49, MAFA) and monocyte-macrophage-dendritic cells (ILT, LIR, PIR). This meeting will bring together leaders whose studies include expression, structure, signal transduction and biological functions of LRR, and their interactions with ligands, including tumor cells, viral and bacterial pathogens.
View Scholarships/Awards
The goal of this conference is to highlight progress in both molecular and cellular biology for a novel class of Leukocyte Regulatory Receptors (LRR) that are involved in positive and negative regulation of immune cell function. LRR contain either ITIM- or ITAM-sequences in the cytoplasmic domains and include membrane receptors of the Ig- and C-type lectin superfamily. Their expression is broad since family members are found on a variety of leukocytes (LAIR), including natural killer and T cells (KIR, Ly-49, CD94, gp49, NKG2), B (PIR) cells, mast cells (gp49, MAFA) and monocyte-macrophage-dendritic cells (ILT, LIR, PIR). This meeting will bring together leaders whose studies include expression, structure, signal transduction and biological functions of LRR, and their interactions with ligands, including tumor cells, viral and bacterial pathogens.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SUNDAY, MARCH 17
MONDAY, MARCH 18
TUESDAY, MARCH 19
WEDNESDAY, MARCH 20
THURSDAY, MARCH 21
FRIDAY, MARCH 22
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, MARCH 17
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.
Jeffrey V. Ravetch,
Rockefeller University, USA
Inhibitory Signaling: Lessons in Self-Control
Inhibitory Signaling: Lessons in Self-Control
08:00—11:00
Classical Signaling Receptors
Meeting has ended...abstracts no longer viewable online.
*
John R. Ortaldo,
National Cancer Institute, USA
Lawrence E. Samelson,
National Institutes of Health, USA
Lymphocyte Signaling and the Role of the LAT Molecule
Lymphocyte Signaling and the Role of the LAT Molecule
John C. Cambier,
University of Colorado, USA
SHIPs and their Doks: Feedback and Transregulators of Immune Cell Signaling
SHIPs and their Doks: Feedback and Transregulators of Immune Cell Signaling
Jean-Pierre Kinet,
Beth Israel Deaconess Medical Center and Harvard Medical School, USA
Role of Lipid Kinases in Antigen Receptor Signaling
Role of Lipid Kinases in Antigen Receptor Signaling
John J. O'Shea,
NIAMS, National Institutes of Health, USA
Cytokine Signaling and Lymphoid Development, Differentiation and Immunoregulation
Cytokine Signaling and Lymphoid Development, Differentiation and Immunoregulation
16:30—18:30
Regulatory Receptors in Autoimmunity
Meeting has ended...abstracts no longer viewable online.
*
Arthur Weiss,
University of California, San Francisco, USA
Dimerization of CD45 Negatively Regulates its Function
Dimerization of CD45 Negatively Regulates its Function
Jeffrey A. Bluestone,
University of California, San Francisco, USA
CTLA-4 Control of Autoimmunity and Tolerance
CTLA-4 Control of Autoimmunity and Tolerance
Arlene H. Sharpe,
Harvard Medical School, USA
B7-CD28 Superfamily
B7-CD28 Superfamily
19:15—21:15
Workshop 1: Regulatory Receptors - Identification, Structure, and in Vitro Function
*
Veronique Braud,
Institut de Pharmacologie Moleculaire et Cellulaire, France
*
Benjamin G. Neel,
Ontario Cancer Institute, Canada
Jonathan W. Heusel,
Washington University School of Medicine, USA
Ly-49H-Mediated Activation by Murine Cytomegalovirus in vitro: Analysis of a Unique Host-Pathogen Interaction
Ly-49H-Mediated Activation by Murine Cytomegalovirus in vitro: Analysis of a Unique Host-Pathogen Interaction
Brian Rabinovich,
University of Texas MD Anderson Cancer Center, USA
T Cell Activation Induces Sensitivity to NK-Mediated Lysis: Insights into Receptor/Ligand Pairs
T Cell Activation Induces Sensitivity to NK-Mediated Lysis: Insights into Receptor/Ligand Pairs
Kevin B. Urdahl,
University of Washington, USA
MHC Class I Molecules Expressed on Bone-Marrow-Derived Cells Regulate Granuloma Formation and Containment of Mycobacterium tuberculosis Infection by a Mechanism Independent of CD8+ T Cells
MHC Class I Molecules Expressed on Bone-Marrow-Derived Cells Regulate Granuloma Formation and Containment of Mycobacterium tuberculosis Infection by a Mechanism Independent of CD8+ T Cells
Robert Marc Hoek,
Amsterdam Medical Centre, Netherlands
OX2 (CD200) Provides an Essential Down-Regulatory Checkpoint for the Macrophage Lineage
OX2 (CD200) Provides an Essential Down-Regulatory Checkpoint for the Macrophage Lineage
Claus-Peter Danzer,
Novartis Institutes for BioMedical Research, Switzerland
Unmasking of CD22 and the Development of Marginal Zone B Cells in CD22-/- Mice
Unmasking of CD22 and the Development of Marginal Zone B Cells in CD22-/- Mice
Hiroshi Furukawa,
Washington University School of Medicine, USA
Recognition of Chinese Hamster MHC Class I by the Murine Natural Killer (NK) Cell Activation Receptor Ly49D
Recognition of Chinese Hamster MHC Class I by the Murine Natural Killer (NK) Cell Activation Receptor Ly49D
Elma Z. Tchilian,
Pirbright Institute, UK
The Human CD45R0 Isoform Can Restore Immune Function in CD45 Deficient Mice
The Human CD45R0 Isoform Can Restore Immune Function in CD45 Deficient Mice
08:00—11:00
Signaling of Regulatory Receptors
Meeting has ended...abstracts no longer viewable online.
*
Clifford A. Lowell,
University of California, San Francisco, USA
Control of Leukocyte Signaling by Src-Family and Syk Tyrosine Kinases
Control of Leukocyte Signaling by Src-Family and Syk Tyrosine Kinases
Deborah N. Burshtyn,
University of Alberta, Canada
KIR Dynamics at the Effector - Target Cell Interface
KIR Dynamics at the Effector - Target Cell Interface
Daniel W. McVicar,
National Institutes of Health, USA
Altered Signaling from the Dap12-Coupled, Stimulatory Ly49s of 129/J mice.
Altered Signaling from the Dap12-Coupled, Stimulatory Ly49s of 129/J mice.
Benjamin G. Neel,
Ontario Cancer Institute, Canada
SIRP and SIRP-Associated Proteins in Myeloid Cell Adhesion
SIRP and SIRP-Associated Proteins in Myeloid Cell Adhesion
16:30—18:30
Regulatory Receptors in Cancer and Disease
Meeting has ended...abstracts no longer viewable online.
Roberto Biassoni,
Istituto Scientifico Tumori, Italy
Triggering and Inhibitory Receptors Regulating the Human NK Cell Function
Triggering and Inhibitory Receptors Regulating the Human NK Cell Function
Christine A. Biron,
Brown University, USA
Interferon Signaling and Immunoregulatory Responses during Viral Infections
Interferon Signaling and Immunoregulatory Responses during Viral Infections
Andrea Velardi,
University of Perugia, Italy
Donor Alloreactive NK Cells Prevent Rejection and GVHD, and Ablate Leukemia in Hematopoietic Transplantation
Donor Alloreactive NK Cells Prevent Rejection and GVHD, and Ablate Leukemia in Hematopoietic Transplantation
19:15—21:15
Workshop 2: Regulatory Receptors - Signaling and Recognition
*
Daniel W. McVicar,
National Institutes of Health, USA
*
Deborah N. Burshtyn,
University of Alberta, Canada
Judith Gerlach,
University of Würzburg, Germany
The Ligand-Binding Domain of CD22 is Needed for Inhibition of the BCR Signal, as Demonstrated by a Novel Human CD22-Specific Inhibitor Compound
The Ligand-Binding Domain of CD22 is Needed for Inhibition of the BCR Signal, as Demonstrated by a Novel Human CD22-Specific Inhibitor Compound
Thomas M. Yankee,
University of Washington, USA
GrpL/Gads Expression in B Cells Regulates the Signaling Threshold Through the B Cell Antigen Receptor
GrpL/Gads Expression in B Cells Regulates the Signaling Threshold Through the B Cell Antigen Receptor
Anne M. Brauweiler,
National Jewish Medical and Research Center, USA
Cross-Talk Mediated by Inhibitory Receptors Attenuates Chemokine Signaling in Murine B Cells
Cross-Talk Mediated by Inhibitory Receptors Attenuates Chemokine Signaling in Murine B Cells
Jacqueline Alblas,
VU Medical Center, Netherlands
SIRPalpha Signals Towards a Low Affinity State of Adhesion Molecules
SIRPalpha Signals Towards a Low Affinity State of Adhesion Molecules
Yatin M. Vyas,
Memorial Sloan-Kettering Institute for Cancer Research, USA
Visualization and Quantitation of Distinct and Sequential Events that Regulate the Natural Killer Cell Immune Synapse.
Visualization and Quantitation of Distinct and Sequential Events that Regulate the Natural Killer Cell Immune Synapse.
Christopher C. Stebbins,
National Institutes of Health, USA
Engagement of NK Cell Inhibitory Receptors by Target Cells Prevents Cytotoxicity by Inducing vav Dephosphorylation
Engagement of NK Cell Inhibitory Receptors by Target Cells Prevents Cytotoxicity by Inducing vav Dephosphorylation
Francisco Borrego,
NIAID, National Institutes of Health, USA
CD94/NKG2A Recycling and Transmission of the Inhibitory Signal are Independent Processes
CD94/NKG2A Recycling and Transmission of the Inhibitory Signal are Independent Processes
Melissa R. Snyder,
Mayo Foundation, USA
Activation of the JNK Signaling Pathway by KIR2DS2 in CD4+CD28null T cells
Activation of the JNK Signaling Pathway by KIR2DS2 in CD4+CD28null T cells
08:00—11:00
Receptors that Recognize MHC Class I
Meeting has ended...abstracts no longer viewable online.
*
Wayne M. Yokoyama,
Washington University School of Medicine, USA
Peter D. Sun,
NIAID, National Institutes of Health, USA
Structural Basis for the Function of the Activating (NKG2D) and Inhibitory KIR Receptors
Structural Basis for the Function of the Activating (NKG2D) and Inhibitory KIR Receptors
Eric Vivier,
Centre d'Immunologie de Marseille-Luminy / Innate Pharma, France
Biology of T Cells Expressing MHC Class I-Specific Receptors
Biology of T Cells Expressing MHC Class I-Specific Receptors
Peter Parham,
Stanford University, USA
Evolution and Diversity of the KIR Gene Family
Evolution and Diversity of the KIR Gene Family
16:30—18:30
Receptors in the Innate Immune System
Meeting has ended...abstracts no longer viewable online.
*
Ruslan Medzhitov,
HHMI/Yale University School of Medicine, USA
Role of Toll-Like Receptors in Innate Immune Recognition
Role of Toll-Like Receptors in Innate Immune Recognition
Shizuo Akira,
Osaka University, Japan
Toll-Like Receptors and Their Signalings; Lessons from Knockout Mice
Toll-Like Receptors and Their Signalings; Lessons from Knockout Mice
Gary W. Litman,
University of South Florida, USA
Novel Immune-Type Inhibitory Receptor Genes Encoding Diversified Variable Regions
Novel Immune-Type Inhibitory Receptor Genes Encoding Diversified Variable Regions
19:15—21:15
Workshop 3: In vivo Functions of Regulatory Receptors
*
Arlene H. Sharpe,
Harvard Medical School, USA
*
Wayne M. Yokoyama,
Washington University School of Medicine, USA
Linde Meyaard,
University Medical Center Utrecht, Netherlands
The Epithelial Cellular Adhesion Molecule (Ep-CAM) is a Ligand for the Leukocyte Associated Ig-Like Receptor (LAIR)
The Epithelial Cellular Adhesion Molecule (Ep-CAM) is a Ligand for the Leukocyte Associated Ig-Like Receptor (LAIR)
Bana Jabri,
University of Chicago, USA
Isotypes of the NKG2 Family of NK Receptors Tightly Regulate the Function of Normal and Celiac Intestinal alphabeta T Lymphocytes
Isotypes of the NKG2 Family of NK Receptors Tightly Regulate the Function of Normal and Celiac Intestinal alphabeta T Lymphocytes
Howard R. Katz,
Brigham and Women's Hospital, Harvard Medical School, USA
Regulation of Adaptive and Innate Inflammation by GP49B1
Regulation of Adaptive and Innate Inflammation by GP49B1
Hanna Sjölin,
Karolinska Institute, Sweden
Pivotal Role of KARAP/DAP12 Adaptor Molecule in the Natural Killer Cell-Mediated Resistance to Murine Cytomegalovirus Infection
Pivotal Role of KARAP/DAP12 Adaptor Molecule in the Natural Killer Cell-Mediated Resistance to Murine Cytomegalovirus Infection
Seung-Hwan Lee,
University of Ottawa, Canada
Study of the Activating Natural Killer Cell Receptor KLRA8 on BAC Transgenic Mice: A New Application to Investigate Host Resistance to Cytomegalovirus Infection
Study of the Activating Natural Killer Cell Receptor KLRA8 on BAC Transgenic Mice: A New Application to Investigate Host Resistance to Cytomegalovirus Infection
Stipan Jonjic,
University of Rijeka, Faculty of Medicine, Croatia
Efficacious Avoidance of Cd8+ and Nk Cell-Mediated Virus Control by Mcmv M152 Gene Product
Efficacious Avoidance of Cd8+ and Nk Cell-Mediated Virus Control by Mcmv M152 Gene Product
Mildred Foster-Cuevas,
, UK
Viral Homologues of Cell Surface Proteins CD200 and CD47 have Potential to Regulate Myeloid Cell Function
Viral Homologues of Cell Surface Proteins CD200 and CD47 have Potential to Regulate Myeloid Cell Function
08:00—11:00
Recognition of Non-Classical MHC
Meeting has ended...abstracts no longer viewable online.
Thomas Spies,
Fred Hutchinson Cancer Research Center, USA
T Cell Costimulation by NKG2D
T Cell Costimulation by NKG2D
Veronique Braud,
Institut de Pharmacologie Moleculaire et Cellulaire, France
Regulation of NK Cell Function: The Molecular Mechanisms that Control HLA-E Expression
Regulation of NK Cell Function: The Molecular Mechanisms that Control HLA-E Expression
Mitchell Kronenberg,
La Jolla Institute for Allergy and Immunology, USA
CD1d Reactive NKT Cells: A Unique T cell Subset
CD1d Reactive NKT Cells: A Unique T cell Subset
Albert S. Bendelac,
University of Chicago, USA
Short Talk
Short Talk
16:30—18:30
Structure and Function of Myeloid Cell Immune Responses
Meeting has ended...abstracts no longer viewable online.
*
David J. Cosman,
Aequus BioPharma, Inc., USA
The ULBP Family of Ligands for the NKG2D/DAP10 Receptor
The ULBP Family of Ligands for the NKG2D/DAP10 Receptor
Paul R. Crocker,
University of Dundee, UK
Siglecs in the Innate Immune System
Siglecs in the Innate Immune System
Marco Colonna,
Washington University School of Medicine, USA
TREM2/DAP12-Mediated Pathway Regulates Maturation of Human Dendritic Cells
TREM2/DAP12-Mediated Pathway Regulates Maturation of Human Dendritic Cells
Joseph H. Phillips,
DNAX Research Institute, USA
Short Talk
Short Talk
*Session Chair †Invited, not yet responded.
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