Granlibakken Tahoe Floorplan

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This meeting took place in 2002



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Molecular and Cellular Biology of Leukocyte Regulatory Receptors (C3)


Organizer(s) John R. Ortaldo and Lewis L. Lanier
March 17—22, 2002
Granlibakken Tahoe • Tahoe City, California USA
Abstract Deadline: Nov 16, 2001
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Jan 17, 2002

Sponsored by DNAX Research, Inc. and The Director's Sponsor Fund

Summary of Meeting:
The goal of this conference is to highlight progress in both molecular and cellular biology for a novel class of Leukocyte Regulatory Receptors (LRR) that are involved in positive and negative regulation of immune cell function. LRR contain either ITIM- or ITAM-sequences in the cytoplasmic domains and include membrane receptors of the Ig- and C-type lectin superfamily. Their expression is broad since family members are found on a variety of leukocytes (LAIR), including natural killer and T cells (KIR, Ly-49, CD94, gp49, NKG2), B (PIR) cells, mast cells (gp49, MAFA) and monocyte-macrophage-dendritic cells (ILT, LIR, PIR). This meeting will bring together leaders whose studies include expression, structure, signal transduction and biological functions of LRR, and their interactions with ligands, including tumor cells, viral and bacterial pathogens.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MARCH 17

16:00—19:00
Registration

Prefunction
19:15—19:30
Orientation

Granhall
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Granhall
Jeffrey V. Ravetch, Rockefeller University, USA
Inhibitory Signaling: Lessons in Self-Control


MONDAY, MARCH 18

07:00—08:00
Breakfast

Granhall
08:00—11:00
Classical Signaling Receptors
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Room
* John R. Ortaldo, National Cancer Institute, USA

Lawrence E. Samelson, National Institutes of Health, USA
Lymphocyte Signaling and the Role of the LAT Molecule

John C. Cambier, University of Colorado, USA
SHIPs and their Doks: Feedback and Transregulators of Immune Cell Signaling

Jean-Pierre Kinet, Beth Israel Deaconess Medical Center and Harvard Medical School, USA
Role of Lipid Kinases in Antigen Receptor Signaling

John J. O'Shea, NIAMS, National Institutes of Health, USA
Cytokine Signaling and Lymphoid Development, Differentiation and Immunoregulation

09:20—09:40
Coffee Break

Prefunction
11:00—13:00
Poster Setup

Bay Room
13:00—22:00
Poster Viewing

Bay Room
16:30—17:00
Coffee & Snacks Available

Mountain/Lake Room
16:30—18:30
Regulatory Receptors in Autoimmunity
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Room
* Arthur Weiss, University of California, San Francisco, USA
Dimerization of CD45 Negatively Regulates its Function

Jeffrey A. Bluestone, University of California, San Francisco, USA
CTLA-4 Control of Autoimmunity and Tolerance

Arlene H. Sharpe, Harvard Medical School, USA
B7-CD28 Superfamily

18:30—19:15
Dinner

Granhall
19:15—21:15
Workshop 1: Regulatory Receptors - Identification, Structure, and in Vitro Function

Mountain/Lake Room
* Veronique Braud, Institut de Pharmacologie Moleculaire et Cellulaire, France

* Benjamin G. Neel, Ontario Cancer Institute, Canada

Jonathan W. Heusel, Washington University School of Medicine, USA
Ly-49H-Mediated Activation by Murine Cytomegalovirus in vitro: Analysis of a Unique Host-Pathogen Interaction

Brian Rabinovich, University of Texas MD Anderson Cancer Center, USA
T Cell Activation Induces Sensitivity to NK-Mediated Lysis: Insights into Receptor/Ligand Pairs

Kevin B. Urdahl, University of Washington, USA
MHC Class I Molecules Expressed on Bone-Marrow-Derived Cells Regulate Granuloma Formation and Containment of Mycobacterium tuberculosis Infection by a Mechanism Independent of CD8+ T Cells

Robert Marc Hoek, Amsterdam Medical Centre, Netherlands
OX2 (CD200) Provides an Essential Down-Regulatory Checkpoint for the Macrophage Lineage

Claus-Peter Danzer, Novartis Institutes for BioMedical Research, Switzerland
Unmasking of CD22 and the Development of Marginal Zone B Cells in CD22-/- Mice

Hiroshi Furukawa, Washington University School of Medicine, USA
Recognition of Chinese Hamster MHC Class I by the Murine Natural Killer (NK) Cell Activation Receptor Ly49D

Elma Z. Tchilian, Pirbright Institute, UK
The Human CD45R0 Isoform Can Restore Immune Function in CD45 Deficient Mice

19:15—22:30
Poster Session 1: Receptors in Immunity

Bay Room

TUESDAY, MARCH 19

07:00—08:00
Breakfast

Granhall
08:00—11:00
Signaling of Regulatory Receptors
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Room
* Clifford A. Lowell, University of California, San Francisco, USA
Control of Leukocyte Signaling by Src-Family and Syk Tyrosine Kinases

Deborah N. Burshtyn, University of Alberta, Canada
KIR Dynamics at the Effector - Target Cell Interface

Daniel W. McVicar, National Institutes of Health, USA
Altered Signaling from the Dap12-Coupled, Stimulatory Ly49s of 129/J mice.

Benjamin G. Neel, Ontario Cancer Institute, Canada
SIRP and SIRP-Associated Proteins in Myeloid Cell Adhesion

09:20—09:40
Coffee Break

Prefunction
11:00—13:00
Poster Setup

Bay Room
13:00—22:00
Poster Viewing

Bay Room
16:30—17:00
Coffee & Snacks Available

Mountain/Lake Room
16:30—18:30
Regulatory Receptors in Cancer and Disease
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Room
* Eric Vivier, Centre d'Immunologie de Marseille-Luminy / Innate Pharma, France

Roberto Biassoni, Istituto Scientifico Tumori, Italy
Triggering and Inhibitory Receptors Regulating the Human NK Cell Function

Christine A. Biron, Brown University, USA
Interferon Signaling and Immunoregulatory Responses during Viral Infections

Andrea Velardi, University of Perugia, Italy
Donor Alloreactive NK Cells Prevent Rejection and GVHD, and Ablate Leukemia in Hematopoietic Transplantation

18:30—19:15
Dinner

Granhall
19:15—21:15
Workshop 2: Regulatory Receptors - Signaling and Recognition

Mountain/Lake Room
* Daniel W. McVicar, National Institutes of Health, USA

* Deborah N. Burshtyn, University of Alberta, Canada

Judith Gerlach, University of Würzburg, Germany
The Ligand-Binding Domain of CD22 is Needed for Inhibition of the BCR Signal, as Demonstrated by a Novel Human CD22-Specific Inhibitor Compound

Thomas M. Yankee, University of Washington, USA
GrpL/Gads Expression in B Cells Regulates the Signaling Threshold Through the B Cell Antigen Receptor

Anne M. Brauweiler, National Jewish Medical and Research Center, USA
Cross-Talk Mediated by Inhibitory Receptors Attenuates Chemokine Signaling in Murine B Cells

Jacqueline Alblas, VU Medical Center, Netherlands
SIRPalpha Signals Towards a Low Affinity State of Adhesion Molecules

Yatin M. Vyas, Memorial Sloan-Kettering Institute for Cancer Research, USA
Visualization and Quantitation of Distinct and Sequential Events that Regulate the Natural Killer Cell Immune Synapse.

Christopher C. Stebbins, National Institutes of Health, USA
Engagement of NK Cell Inhibitory Receptors by Target Cells Prevents Cytotoxicity by Inducing vav Dephosphorylation

Francisco Borrego, NIAID, National Institutes of Health, USA
CD94/NKG2A Recycling and Transmission of the Inhibitory Signal are Independent Processes

Melissa R. Snyder, Mayo Foundation, USA
Activation of the JNK Signaling Pathway by KIR2DS2 in CD4+CD28null T cells

19:15—22:30
Poster Session 2: Receptor Signaling

Bay Room

WEDNESDAY, MARCH 20

07:00—08:00
Breakfast

Granhall
08:00—11:00
Receptors that Recognize MHC Class I
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Room
* Wayne M. Yokoyama, Washington University School of Medicine, USA

Peter D. Sun, NIAID, National Institutes of Health, USA
Structural Basis for the Function of the Activating (NKG2D) and Inhibitory KIR Receptors

Eric Vivier, Centre d'Immunologie de Marseille-Luminy / Innate Pharma, France
Biology of T Cells Expressing MHC Class I-Specific Receptors

Peter Parham, Stanford University, USA
Evolution and Diversity of the KIR Gene Family

Daniel M. Davis, Imperial College London, UK
Short Talk

09:20—09:40
Coffee Break

Prefunction
11:00—13:00
Poster Setup

Bay Room
13:00—22:00
Poster Viewing

Bay Room
16:30—17:00
Coffee & Snacks Available

Mountain/Lake Room
16:30—18:30
Receptors in the Innate Immune System
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Room
* Ruslan Medzhitov, HHMI/Yale University School of Medicine, USA
Role of Toll-Like Receptors in Innate Immune Recognition

Shizuo Akira, Osaka University, Japan
Toll-Like Receptors and Their Signalings; Lessons from Knockout Mice

Gary W. Litman, University of South Florida, USA
Novel Immune-Type Inhibitory Receptor Genes Encoding Diversified Variable Regions

18:30—19:15
Dinner

Granhall
19:15—21:15
Workshop 3: In vivo Functions of Regulatory Receptors

Mountain/Lake Room
* Arlene H. Sharpe, Harvard Medical School, USA

* Wayne M. Yokoyama, Washington University School of Medicine, USA

Linde Meyaard, University Medical Center Utrecht, Netherlands
The Epithelial Cellular Adhesion Molecule (Ep-CAM) is a Ligand for the Leukocyte Associated Ig-Like Receptor (LAIR)

Bana Jabri, University of Chicago, USA
Isotypes of the NKG2 Family of NK Receptors Tightly Regulate the Function of Normal and Celiac Intestinal alphabeta T Lymphocytes

Howard R. Katz, Brigham and Women's Hospital, Harvard Medical School, USA
Regulation of Adaptive and Innate Inflammation by GP49B1

Hanna Sjölin, Karolinska Institute, Sweden
Pivotal Role of KARAP/DAP12 Adaptor Molecule in the Natural Killer Cell-Mediated Resistance to Murine Cytomegalovirus Infection

Seung-Hwan Lee, University of Ottawa, Canada
Study of the Activating Natural Killer Cell Receptor KLRA8 on BAC Transgenic Mice: A New Application to Investigate Host Resistance to Cytomegalovirus Infection

Stipan Jonjic, University of Rijeka, Faculty of Medicine, Croatia
Efficacious Avoidance of Cd8+ and Nk Cell-Mediated Virus Control by Mcmv M152 Gene Product

Mildred Foster-Cuevas, , UK
Viral Homologues of Cell Surface Proteins CD200 and CD47 have Potential to Regulate Myeloid Cell Function

19:15—22:30
Poster Session 3: Structure and Function of Receptors

Bay Room

THURSDAY, MARCH 21

07:00—08:00
Breakfast

Granhall
08:00—11:00
Recognition of Non-Classical MHC
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Room
* Lewis L. Lanier, University of California, San Francisco, USA
Activating NK Cell Receptors

Thomas Spies, Fred Hutchinson Cancer Research Center, USA
T Cell Costimulation by NKG2D

Veronique Braud, Institut de Pharmacologie Moleculaire et Cellulaire, France
Regulation of NK Cell Function: The Molecular Mechanisms that Control HLA-E Expression

Mitchell Kronenberg, La Jolla Institute for Allergy and Immunology, USA
CD1d Reactive NKT Cells: A Unique T cell Subset

Albert S. Bendelac, University of Chicago, USA
Short Talk

09:20—09:40
Coffee Break

Prefunction
16:30—17:00
Coffee & Snacks Available

Mountain/Lake Room
16:30—18:30
Structure and Function of Myeloid Cell Immune Responses
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Room
* David J. Cosman, Aequus BioPharma, Inc., USA
The ULBP Family of Ligands for the NKG2D/DAP10 Receptor

Paul R. Crocker, University of Dundee, UK
Siglecs in the Innate Immune System

Marco Colonna, Washington University School of Medicine, USA
TREM2/DAP12-Mediated Pathway Regulates Maturation of Human Dendritic Cells

Joseph H. Phillips, DNAX Research Institute, USA
Short Talk

18:30—19:30
Welcome Mixer

Bay Room
19:30—20:30
Dinner

Granhall
19:30—22:30
Entertainment

Mountain/Lake Room

FRIDAY, MARCH 22

07:00—08:00
Breakfast

Granhall
 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 AI51933-01




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