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This meeting took place in 2002



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Nuclear Receptor Superfamily (D4)


Organizer(s) Pierre H. Chambon, David J. Mangelsdorf and Benita S. Katzenellenbogen
April 13—19, 2002
Snowbird Resort • Snowbird, Utah USA
Abstract Deadline: Dec 13, 2001
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Feb 13, 2002

Sponsored by Bristol-Meyers Squibb Pharmaceutical Research Institute

Summary of Meeting:
Nuclear receptors are ligand-dependent transcriptional regulators that govern virtually every aspect of fetal and adult life in metazoans. In addition to the well-characterized receptors that respond to steroid and thyroid hormones, retinoids, and other lipophilic metabolites, this family includes a number of orphan receptors whose ligands and physiologic functions are under intense investigation. Nuclear receptors are also important therapeutic targets, because of their involvement in reproduction, metabolic and endocrine diseases, and cancer. Major questions in this field are focused on elucidating the molecular mechanisms underlying transcriptional activation and repression of target genes, and the translation of these processes into physiological responses at the organismal level. This meeting will bring together leading experts in structural and molecular biology, functional genomics and engineered mouse genetics, as well as younger investigators and trainees, from both academia and industry, to present their current research and discuss new approaches that can address these key issues.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SATURDAY, APRIL 13

16:00—19:00
Registration

Ballroom Lobby 3
18:15—19:15
Welcome

Ballroom Mezzanine/Atrium Overlook
19:15—19:30
Orientation

Ballroom
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Ballroom
* Pierre H. Chambon, Institut de Génétique Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), France

Richard Axel, Columbia University, USA
Representation of Olfactory Information in the Brain


SUNDAY, APRIL 14

06:30—08:00
Breakfast

Aries, Golden Cliff, Magpie
08:00—11:00
Structure/Function of NRs, NR Coregulators and Transcription Factors
Meeting has ended...abstracts no longer viewable online.

Ballroom
* Robert G. Roeder, Rockefeller University, USA

Gary Felsenfeld, NIDDK, National Institutes of Health, USA
Chromatin Boundaries and the Developmental Regulation of Gene Expression

Roderick E. Hubbard, University of York, UK
What Can Structure Tell Us About Function in the Estrogen Receptors?

Dino Moras, Institute of Genetics, Molecular and Cellular Biology, France
Chasing Effective Ligands for Orphan Nuclear Receptors

Timothy M. Willson, GlaxoSmithKline, USA
Structure and Function of Orphan Nuclear Receptors

09:20—09:40
Coffee Break

Ballroom Mezzanine
11:00—13:00
Poster Setup

Wasatch, Maybird, Superior & Superior Lobby
13:00—21:30
Poster Viewing

Wasatch, Maybird, Superior & Superior Lobby
14:00—16:00
Workshop 1: Hot Topics and/or Presentations by Young Investigators

Ballroom
Matthew R. Redinbo†, University of North Carolina at Chapel Hill, USA
Structural Insights into the Promiscuity and Function of the Human Xenobiotic Nuclear Receptor PXR

Ashley C.W. Pike, University of York, UK
Structural Snapshots of Agonist-Bound ERbeta-LBD

Robert Gampe, GlaxoSmithKline, USA
Molecular Specificity of New Rexinoids Bound to the PPARgamma/RXRalpha Ligand Binding Domain Heterodimer

Matthias Becker, National Cancer Institute, National Institutes of Health, USA
Dynamic Behavior of Transcription Factors on a Natural Promoter in Living Cells

Anobel Tamrazi, Johns Hopkins University, USA
Functional Fluorescent Estrogen Receptors (ER): Homo- and Heterodimerization, Coregulator Recruitment and Site-Specific Regional Dynamics of ER-Ligand Binding Domain (LBD) Subtypes

Frederick J. Schaufele, University of California, San Francisco, USA
Cellular Imaging of Nuclear Receptor Action

* Debu Chakravarti, Northwestern University, Feinberg School of Medicine, USA
Hormones, HATs & INHAT: Regulation of Transcription and Circadian Timing

16:00—16:30
Coffee & Snacks Available

Ballroom Mezzanine
16:30—18:30
Coactivators, Corepressors and Transcription I
Meeting has ended...abstracts no longer viewable online.

Ballroom
* Gary Felsenfeld, NIDDK, National Institutes of Health, USA

Leonard P. Freedman, Thomas Jefferson University, USA
Mediating Transcriptional Activation by Nuclear Receptors

Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA
Nuclear Hormone Receptor Corepressors

Malcolm G. Parker, Imperial College London, UK
Role of NRIP1 Corepressor in Reproduction

18:30—19:30
Welcome Mixer

Maybird/Superior/Superior Lobby
19:30—21:30
Poster Session 1: Nuclear Receptor and Cofactors, Structure/Function and Transcription

Wasatch, Maybird, Superior & Superior Lobby

MONDAY, APRIL 15

06:30—08:00
Breakfast

Aries, Golden Cliff, Magpie
08:00—11:00
Coactivators, Corepressors and Transcription II
Meeting has ended...abstracts no longer viewable online.

Ballroom
* Ronald M. Evans, Howard Hughes Medical Institute, Salk Institute, USA

Vincent Giguère, McGill University, Canada
To ERR in the Estrogen Pathway

Robert G. Roeder, Rockefeller University, USA
Role of the TRAP Complex in the Function of Diverse Nuclear Receptor Pathways

Bert W. O'Malley, Baylor College of Medicine, USA
New Facets of Steroid Receptor Coactivator Action

Myles Brown, Dana-Farber Cancer Institute, USA
SERMS and the Coregulator Hypothesis

09:20—09:40
Coffee Break

Ballroom Mezzanine
11:00—13:00
Poster Setup

Wasatch, Maybird, Superior & Superior Lobby
13:00—21:30
Poster Viewing

Wasatch, Maybird, Superior & Superior Lobby
14:00—16:00
Workshop 2: Hot Topics and/or Presentations by Young Investigators

Ballroom
* Bert W. O'Malley, Baylor College of Medicine, USA

W. Lee Kraus, University of Texas Southwestern Medical Center, USA
Chromatin Exposes Intrinsic Differences in the Transcriptional Activities of Estrogen Receptors Alpha and Beta

Dipali Sharma, University of Maryland, USA
Temporal Assembly and Sequential Promoter Recruitment of Distinct Thyroid Hormone Receptor-Coactivator Complexes in Mammalian Cells

Catherine C. Thompson, Pfizer, USA
Hairless is a Novel Nuclear Receptor Corepressor

Meei-Huey Jeng, Indiana University School of Medicine, USA
Interaction of c-Src with Steroid Receptor Coactivators

Simak Ali, Imperial College London, UK
Regulation of Estrogen Receptor Activity by Phosphorylation

Liang Wang, University of Rochester, USA
Inhibition of the Human Androgen Receptor through a Glycogen Synthase Kinase 3 Beta Signaling Pathway

E. Brad Thompson, University of Texas Medical Branch, USA
Importance on Inter- and Intra-Molecular Signaling in the Structure and Function of the Glucocorticoid Receptor AF1 Domain

Jae In Lee, Amgen Inc., USA

16:00—16:30
Coffee & Snacks Available

Ballroom Mezzanine
16:30—18:30
Post-Translational Modification of NRs and Coregulators - Cross-Talk. Session Sponsored in part by Affinity BioReagents, Inc.
Meeting has ended...abstracts no longer viewable online.

Ballroom
* Walter Wahli, Nanyang Technological University, Singapore

Michael G. Rosenfeld, HHMI/University of California, San Diego, USA
Nuclear Receptor Coregulators in Control of Growth and Development

Michael R. Stallcup, University of Southern California, USA
Synergy Between p160 Coactivators, HATs, and Methyltransferases; and Hormone-Regulated, CARM1-Directed Methylation of Histone H3

Keith R. Yamamoto, University of California, San Francisco, USA
Selective Function and Continuous Recycling of Receptor-Containing Regulatory Complexes

18:30—19:30
Welcome Mixer

Maybird/Superior/Superior Lobby
19:30—21:30
Poster Session 2: Nuclear Receptor Cofactors

Maybird/Superior & Lobby

TUESDAY, APRIL 16

06:30—08:00
Breakfast

Aries, Golden Cliff, Magpie
08:00—11:00
Intermediary Metabolism
Meeting has ended...abstracts no longer viewable online.

Ballroom
* Günther Schütz, German Cancer Research Center, Germany

Ronald M. Evans, Howard Hughes Medical Institute, Salk Institute, USA
Orphan Receptors in Lipid Metabolism

David J. Mangelsdorf, University of Texas Southwestern Medical Center, USA
Nuclear Receptors as The Body’s Lipid Sensors

Walter Wahli, Nanyang Technological University, Singapore
Regulation of the Adaptive Response to Fasting by PPAR alpha

Johan Auwerx, École Polytechnique Fédérale de Lausanne – EPFL, Switzerland
Control of Metabolism by PPARgamma and its Cofactors

09:20—09:40
Coffee Break

Ballroom Mezzanine
11:00—13:00
Poster Setup

Wasatch, Maybird, Superior & Superior Lobby
13:00—21:30
Wasatch, Maybird, Superior & Superior Lobby

14:00—16:00
Workshop 3: Hot Topics and/or Presentations by Young Investigators

Ballroom
* Frank J. Gonzalez, National Institutes of Health, USA
Role of Hepatic PPARgamma in Lipid Homeostasis

Bryan A. Laffitte, Genomics Institute of the Novartis Research Foundation, USA
LXR-Dependent Effects of Oxidized Lipids on Macrophage Gene Expression

Joyce J. Repa, University of Texas Southwestern Medical Center, USA
Regulation of ATP-Binding Cassette Sterol Transporters, ABCG5 and ABCG8, by the Oxysterol Receptors, LXRalpha and LXRbeta

Mercedes Ricote, Centro Nacional de Investigaciones Cardiovasculares, Spain
Regulation of Machrophage Gene Expression by RXR Heterodimers

Wen Xie, University of Pittsburgh, USA
Activation of Phase II Detoxicificating UDP-Glucuronosyltransferase (UGTs) by Nuclear Receptors SXR/PXR and its Implication in Hormonal Homeostasis

Henry M. Sucov, University of Southern California, USA
Developmental Roles of Retinoid Receptors

Anton M. Jetten, NIEHS, National Institutes of Health, USA
Absence of Lymph Nodes and High Incidence of T-Cell Lymphomas in Mice Deficient in the Retinoid-Related Orphan Receptor RORgamma

Frances M. Sladek, University of California, Riverside, USA

16:00—16:30
Coffee & Snacks Available

Ballroom Mezzanine
16:30—18:30
Orphan Receptors
Meeting has ended...abstracts no longer viewable online.

Ballroom
* David J. Mangelsdorf, University of Texas Southwestern Medical Center, USA

Thomas Perlmann, Karolinska Institutet, Ludwig Institute for Cancer Research, Sweden
Role of Nuclear Receptors in Neuron Development and Survival

Carl S. Thummel, University of Utah School of Medicine, USA
Molecular Mechanisms of Hormone Action in Drosophila

Steven A. Kliewer, University of Texas Southwestern Medical Center, USA
Regulation of Xenobiotic and Lipid Metabolism by Nuclear Receptors

18:30—19:30
Welcome Mixer

Maybird/Superior/Superior Lobby
19:30—21:30
Poster Session 3: Nuclear Receptor Orphan Potpourri

Wasatch, Maybird, Superior & Superior Lobby

WEDNESDAY, APRIL 17

06:30—08:00
Breakfast

Aries, Golden Cliff, Magpie
08:00—11:00
Development and Integrated Functions I
Meeting has ended...abstracts no longer viewable online.

Ballroom
* Michael G. Rosenfeld, HHMI/University of California, San Diego, USA

Pierre H. Chambon, Institut de Génétique Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), France
Genetic Dissection of the Retinoid Signaling Pathway in the Mouse

Orla M. Conneely, Baylor College of Medicine, USA
Reproductive Functions of Progesterone Receptor Isoforms

Günther Schütz, German Cancer Research Center, Germany
Molecular Genetic Analysis of Glucocorticoid Receptor Function in Mice

Sophia Y. Tsai, Baylor College of Medicine, USA
The Role of COUP-TFII in Organogenesis

09:20—09:40
Coffee Break

Ballroom Mezzanine
11:00—13:00
Poster Setup

Wasatch, Maybird, Superior & Superior Lobby
13:00—21:30
Poster Viewing

Wasatch, Maybird, Superior & Superior Lobby
14:00—16:00
Workshop 4: Hot Topics and/or Presentations by Young Investigators

Ballroom
* Michael B. Sporn, Dartmouth Medical School, USA
Cancer Prevention: Rexinoids, Deltanoids, SERMs and SPARMs

Adriana Maggi, University of Milan, Italy
In vivo Imaging of Estrogen Receptor Activity in Transgenic Mice

Jean-Francois Arnal, INSERM, France
Estrogen Receptors and Vascular Physiology and Pathophysiology

Barry Marc Forman, City of Hope, USA
Orphan Nuclear Receptors and Lipid Homeostasis

Daniel Metzger, Institut de Génétique et de Biologie Molécullaire et Cellulaire, Strasbourg, France
Impaired Adipogenesis, Lipolysis and Glucose Homeostasis in the Mouse Upon Selective Ablation of RXRalpha in Adipocytes

Martin Petkovich, Queen's University, Canada
The Murine RARgamma-Null Mutation is a Suppressor of the CYP26A1-Null Embryonic- Lethal Phenotype

Carole R. Mendelson, University of Texas Southwestern Medical Center, USA
Coactivators in Lung Development and Surfactant Protein Gene Expression

16:00—16:30
Coffee & Snacks Available

Ballroom Mezzanine
16:30—18:30
NRs and Cancer
Meeting has ended...abstracts no longer viewable online.

Ballroom
* Kenneth S. Korach, NIEHS, National Institutes of Health, USA

Shigeaki Kato, University of Tokyo, Japan
Function of Androgen Receptor

Kathryn B. Horwitz, University of Colorado Health Sciences Center, USA
N-Terminal Structure and Function in Breast Cancers of the Progesterone Receptor (PR)-A and PR-B Isoforms

Benita S. Katzenellenbogen, University of Illinois at Urbana-Champaign, USA
Estrogen Receptors, SERMs and Breast Cancer

18:30—19:30
Welcome Mixer

Maybird/Superior/Superior Lobby
19:30—21:30
Poster Session 4: Nuclear Receptor in Development and Physiology

Wasatch, Maybird, Superior & Superior Lobby

THURSDAY, APRIL 18

06:30—08:00
Breakfast

Aries, Golden Cliff, Magpie
08:00—11:00
Development and Integrated Functions II
Meeting has ended...abstracts no longer viewable online.

Ballroom
* Benita S. Katzenellenbogen, University of Illinois at Urbana-Champaign, USA

Kenneth S. Korach, NIEHS, National Institutes of Health, USA
Analyzing Differential Receptor Function Using Gene Targeting

David D. Moore, Baylor College of Medicine, USA
CAR Integrates Responses to Exogenous and Endogenous Toxic Compounds

Jan-Åke Gustafsson, University of Houston, USA
On the Role of ERbeta in the CNS

Jacques Samarut, Centre National de la Recherche Scientifique, France
Genetic Dissection of the Function of Thyroid Hormone Receptor Isoforms in the Development of the Mouse

09:20—09:40
Coffee Break

Ballroom Mezzanine
11:00—13:00
Poster Setup

Wasatch, Maybird, Superior & Superior Lobby
13:00—21:30
Poster Viewing

Wasatch, Maybird, Superior & Superior Lobby
16:00—16:30
Coffee & Snacks Available

Ballroom Mezzanine
16:30—18:30
Impact of Functional Genomics and Novel Technologies on Drug Discovery
Meeting has ended...abstracts no longer viewable online.

Ballroom
* Keith R. Yamamoto, University of California, San Francisco, USA

Richard A. Heyman, ORIC Pharmaceuticals, USA
Vertical Integration of Orphan Nuclear Receptors as Drug Discovery Targets

Donald P. McDonnell, Duke University School of Medicine, USA
The Molecular Determinants of Estrogen Receptor Pharmacology

Hinrich Gronemeyer, Institut de Génétique et de Biologie Molécullaire et Cellulaire, Strasbourg, France
Regulation of Life and Death by Retinoid Receptors

18:30—19:30
Welcome Mixer

Maybird/Superior/Superior Lobby
19:30—21:30
Poster Session 5: Late Breaking Topics in Nuclear Receptor Action

Wasatch, Maybird, Superior & Superior Lobby
20:30—00:30
Entertainment

Ballroom

FRIDAY, APRIL 19

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 DK61302-01




We gratefully acknowledge additional support for this conference from:

Bristol-Myers Squibb Company

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