Beaver Run Resort Floorplan

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This meeting took place in 2002



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Structural Genomics: From Gene Sequence to Function (J1)


Organizer(s) Gaetano T. Montelione, Barry Honig and Wayne A. Hendrickson
January 5—11, 2002
Beaver Run Resort • Breckenridge, Colorado USA
Abstract Deadline: Sep 17, 2001
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Nov 5, 2001

Sponsored by Pfizer Global Research and Development


Summary of Meeting:
Structural Genomics represents a new area at the interface between structural biology and genomic sciences. The various genome sequencing projects provide new opportunities and challenges to the field of structural biology, as many synergies exist between the information provided by the expanding database of linear sequences and three-dimensional structures of proteins. The goals of structural genomics include: (1) Coverage of sequence space in terms of protein structure by determination of a representative three-dimensional (3D) structure from each of 10,000 - 30,000 sequence clusters and homology modeling of all the corresponding proteins; (2) Analysis of the 3D structures of all the proteins coded by entire genomes; and (3) Structure-based Functional Genomics in which the biochemical functions of proteins are identified using clues provided by 3D structure analysis. The field of Structural Genomics is driven by developments in the areas of bioinformatics, molecular biology and protein production, X-ray crystallography, NMR spectroscopy, and homology modeling. Major challenges involve developing a sound scientific basis for target selection, high throughput protein production and crystallization, rapid X-ray crystallographic and NMR data collection, automated methods for generating 3D structures from these data, organization of these data into databases, and retrospective analysis of the data to develop broad understanding of protein evolution and structure / function relationships. Structural Genomics provides a new paradigm for structural biology and pharmaceutical development. This Keystone meeting will bring together key players in the international community to: (1) assess the feasibility and value of high throughput structure determination as a key component of an International Structural Genomics Initiative, (2) assess the scientific validity of various target selection strategies, and (3) foster international cooperation in this nascent field.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SATURDAY, JANUARY 5

16:00—19:00
Registration

Third Floor Foyer
18:15—19:15
Welcome

Third Floor Foyer
19:15—19:30
Orientation

Peaks 4-5
19:30—21:30
Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Gaetano Thomas Montelione, Rutgers University, USA

David Eisenberg, University of California, Los Angeles, USA
Protein Interactions

* John Kuriyan, University of California, Berkeley, USA

Thomas A. Steitz, HHMI/Yale University, USA
The Marvelous Macromolecular Machines of Gene Expression


SUNDAY, JANUARY 6

07:00—08:00
Breakfast

Peaks 6-12
08:00—11:00
Structural Bioinformatics I - Target Selection
Meeting has ended...abstracts no longer viewable online.

Peak 4
* Barry Honig, Columbia University / HHMI, USA

Chris Sander, Memorial Sloan-Kettering Cancer Center, USA
Mapping the Protein Structure Universe

Alexey G. Murzin, Medical Research Council, UK
Extension of Structural Superfamilies to Sequence Families of Unknown Structure

Burkhard Rost, Columbia University, USA
Target Space for Structural Genomics Revisited

Peer Bork, European Molecular Biology Laboratory, Germany
Prioritising Targets for Structural Genomics


Following Session is for Frontiers of Structural Biology (J2)

08:00—11:00
RNA and the Ribosome
Meeting has ended...abstracts no longer viewable online.

Peaks 5
* Michael F. Summers, HHMI/University of Maryland, Baltimore County, USA

Jennifer A. Doudna, HHMI/University of California, Berkeley, USA
Structure and Mechanism of the Hepatitis C IRES RNA

Venki Ramakrishnan, MRC Laboratory of Molecular Biology, UK
The Atomic Structure of the 30S Ribosomal Subunit: Insights into Antibiotic Function and the Decoding Mechanism

Juli Feigon, University of California, Los Angeles, USA
Interaction of Nucleolin with Pre-Ribosomal RNA

James R. Williamson, The Scripps Research Institute, USA
RNA-Protein Interactions in the Assembling Ribosome

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Peak 1-3
13:00—21:30
Poster Viewing

Peak 1-3
16:00—17:00
Coffee & Snacks Available

Foyer
16:00—18:30
Structural Genomics Initiatives I (20-Minute Talks, 5-Minute Questions). Sponsored in part by Bruker Biospin Corporation.
Meeting has ended...abstracts no longer viewable online.

Peak 4
* Wayne A. Hendrickson, Columbia University, USA

John C. Norvell, NIGMS, National Institutes of Health, USA
NIGMS Programs in Structural Genomics

Stephen K. Burley, Rutgers University, USA
Structural Genomics: An X-ray Crystallographic Approach by the NYSGRC

Sung-Hou Kim, University of California, Berkeley, USA
Structural Genomics of Minimal Organisms

* Gaetano Thomas Montelione, Rutgers University, USA
Structural Proteomics of Eukaryotic Protein Families

Ian A. Wilson, The Scripps Research Institute, USA
A High Throughput Automated Pipeline for Structural Genomics


Following Session is for Frontiers of Structural Biology (J2)

16:30—18:30
Macromolecular Machines
Meeting has ended...abstracts no longer viewable online.

Peak 5
* William I. Weis, Stanford University, USA

Carlos J. Bustamante, HHMI/University of California, Berkeley, USA
Recent Advances in Single Molecule Biophysics: Reversible Unfolding of a Single RNA Molecule by Force

Wolfgang P. Baumeister, Max Planck Institute of Biochemistry, Germany
Electron Tomography: Towards Visualizing Supramolecular Architecture Inside Cells

Ada Yonath, Weizmann Institute of Science, Israel
High Resolution Studies on the Two Ribosomal Subunits: Flexibility, Conformation Variability and Disorder

17:20—17:40
Coffee Break

Foyer
18:30—19:30
Welcome Mixer

Foyer/Peak 1-3
19:30—21:30
Poster Session 1

Peak 1-3

MONDAY, JANUARY 7

07:00—08:00
Breakfast

Peak 6-12
08:00—11:00
Structural Genomics Initiatives II (20-Minute Talks, 5-Minute Questions)
Meeting has ended...abstracts no longer viewable online.

Peak 4
* John L. Markley, University of Wisconsin-Madison, USA

Andrzej Joachimiak, Argonne National Laboratory, USA
High-Throughput Structure Determination Using 3rd Generation Synchrotrons

Bi-Cheng Wang, University of Georgia, USA
Direct Crystallography and the Southeast Collaboratory for Structural Genomics

Thomas C. Terwilliger, Los Alamos National Laboratory, USA
Structural Genomics of M. tuberculosis

Shigeyuki Yokoyama, RIKEN, Japan
Structural Genomics of Thermus thermophilus HB8 and Higher Eukaryotes

Cheryl Arrowsmith, University of Toronto, Canada
Comparative Structural Proteomics

Udo Heinemann, Freie Universitat Berlin, Germany
Progress Report from the Berlin Protein Structure Factory


Following Session is for Frontiers of Structural Biology (J2)

08:00—11:00
Proteins and Nucleic Acids
Meeting has ended...abstracts no longer viewable online.

Peaks 5
* Jennifer A. Doudna, HHMI/University of California, Berkeley, USA

Wei Yang, NIDDK, National Institutes of Health, USA
Crystal Structure of a Y-Family DNA Polymerase in Action: A Mechanism for Error-Prone and Lesion-Bypass Replication

Cynthia Wolberger, Johns Hopkins University School of Medicine, USA
Structural Studies of the ETS-1/PAX5 Complex Bound to DNA

Menachem Shoham, Case Western Reserve University, USA
Crystal Structure of Colicin E3: Implications for Cell Entry and Ribosome Inactivation

Ad Bax, NIDDK, National Institutes of Health, USA
Weak Alignment Offers New Opportunities in NMR Structure Determination

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Peak 1-3
13:00—21:30
Poster Viewing

Peak 1-3
16:00—16:30
Coffee & Snacks Available

Foyer
16:30—18:30
Automation and Robotics in Structural Genomics
Meeting has ended...abstracts no longer viewable online.

Peak 4
* Christopher D. Lima, Memorial Sloan Kettering Cancer Center, USA

George T. DeTitta, Hauptman-Woodward Medical Research Institute, USA
Microbatch Crystallization at High Throughput

Janice A. Culpepper, , USA
Building a High-Throughput Platform for Structure Determination

F. Raymond Salemme, Imiplex, LLC., USA
ThermoFluor Protein Stability Screens: A Key Element for Effective Integration of High-Throughput Crystallography and Computationally Optimized Combinatorial Chemistry for Drug Discovery

Wladek Minor, University of Virginia, USA
Short Talk: Data Acquisition and Analysis in Structural Genomics Era Automatic or Remotely Controlled Expert System


Following Session is for Frontiers of Structural Biology (J2)

16:30—18:30
Membrane Proteins
Meeting has ended...abstracts no longer viewable online.

Peaks 5
* Wei Yang, NIDDK, National Institutes of Health, USA

Donald M. Engelman, Yale University, USA
Stability and Specificity in Membrane Protein Folding

Robert M. Stroud, University of California, San Francisco, USA
Encoding Selectivity of a Transmembrane Channel

Benoit Roux, University of Chicago, USA
Computational Studies of the Potassium Channel

18:30—19:30
Welcome Mixer

Foyer/Peak 1-3
19:30—21:30
Poster Session 2

Peak 1-3

TUESDAY, JANUARY 8

07:00—08:00
Breakfast

Peaks 6-12
08:00—11:00
Protein Structure Prediction and Design (Joint)
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Robert M. Stroud, University of California, San Francisco, USA

David Baker, University of Washington, USA
Progress in ab Intio Protein Structure Prediction

Stephen L. Mayo, California Institute of Technology, USA

Homme Hellinga, Duke University Medical Center, USA
Rational Design of Receptors and Sensors

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Peak 1-3
13:00—21:30
Poster Viewing

Peak 1-3
14:00—16:00
Workshop: International Coordination of Structural Genomics

Peak 4
Thomas C. Terwilliger, Los Alamos National Laboratory, USA

Udo Heinemann, Freie Universitat Berlin, Germany

Shigeyuki Yokoyama, RIKEN, Japan
Report from the International Structural Genomics Organization (ISCO)

John C. Norvell, NIGMS, National Institutes of Health, USA
International Aspects of the NIH Funded Protein Structure Initiative

* Helen M. Berman, Rutgers University, Center for Proteomics Research, USA
The Protein Data Bank and the International Structural Genomics Community

16:00—16:30
Coffee & Snacks Available

Foyer
16:30—18:30
Structural Genomics of Integral Membrane Proteins
Meeting has ended...abstracts no longer viewable online.

Peak 4
* Gaetano Thomas Montelione, Rutgers University, USA

Kurt Wüthrich, ETH Zürich, Switzerland
Solution NMR Studies of Integral Membrane Proteins Reconstituted in Detergent Micelles

Stanley J. Opella, University of California, San Diego, USA
Structure Determination of Membrane Proteins by NMR Spectroscopy


Following Session is for Frontiers of Structural Biology (J2)

16:30—18:30
Protein Folding and Misfolding
Meeting has ended...abstracts no longer viewable online.

Peaks 5
* Michael K. Rosen, University of Texas Southwestern Medical Center, USA

Christopher M. Dobson, University of Cambridge, UK
Protein Folding, Misfolding and Disease

Susan Lindquist, HHMI/Whitehead Institute for Biomedical Research, USA
Prion Assembly and Disassembly

Arthur L. Horwich, Yale University, USA
GroEL-GroES-Mediated Protein Folding

18:30—19:30
Welcome Mixer

Foyer/Peak 1-3
19:30—21:30
Poster Session 3

Peak 1-3

WEDNESDAY, JANUARY 9

07:00—08:00
Breakfast

Peaks 6-12
08:00—11:00
Structural Bioinformatics II - Combining Sequence and Structure to Understand Protein Relationships
Meeting has ended...abstracts no longer viewable online.

Peak 4
* Jane S. Richardson, Duke University, USA

Julian Gough, University of Bristol, UK
Hidden Markov Models in Structural Genomics

Michal Linial, University of Washington, USA
In Search of New Structures - Comprehensive Sequence-Based Ranking

Mark Gerstein, Yale University, USA
Integrative Structural Genomics

Barry Honig, Columbia University / HHMI, USA
Combining Bioinformatics and Biophysics to Understand Protein Structure and Function


Following Session is for Frontiers of Structural Biology (J2)

08:00—11:00
Signaling and Targeting - I
Meeting has ended...abstracts no longer viewable online.

Peak 5
* John Kuriyan, University of California, Berkeley, USA

Susan S. Taylor, University of California, San Diego, USA
Dynamics of Signaling by cAMP-Dependent Protein Kinase

Dorothee Kern, Brandeis University, HHMI, USA
A Signaling Protein ‘In Action’- Structure and Dynamics of a Transiently Phosphorylated Switch

Stephen C. Harrison, Harvard Medical School, USA
Assembling a Virus

Michael K. Rosen, University of Texas Southwestern Medical Center, USA
Signaling from Rho GTPases to Actin: Insights from NMR into Biology

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Peak 1-3
13:00—21:30
Poster Viewing

Peak 1-3
16:00—16:30
Coffee & Snacks Available

Foyer
16:30—18:30
Methods for High Throughput Structure Analysis
Meeting has ended...abstracts no longer viewable online.

Peak 4
* Andrzej Joachimiak†, Argonne National Laboratory, USA

Wayne A. Hendrickson, Columbia University, USA
Synchrotron Crystallography

Ad Bax, NIDDK, National Institutes of Health, USA
Towards Faster NMR Structure Determination Using Orientational and Chemical Shift Restraints

James H. Prestegard, University of Georgia, USA
High Throughput NMR Methods for Structural Genomics


Following Session is for Frontiers of Structural Biology (J2)

16:30—18:30
Signaling and Targeting - II
Meeting has ended...abstracts no longer viewable online.

Peak 5
* Arthur G. Palmer, III, Columbia University, USA

Pamela J. Bjorkman, California Institute of Technology, USA
The MHC Family of Proteins in Immune and Non-Immune Recognition

William I. Weis, Stanford University, USA
Biochemical and Structural Analysis of Wnt Signaling Components

James A. Wells, University of California, San Francisco, USA
Site-Directed Ligand Discovery

18:30—19:30
Welcome Mixer

Foyer/Peak 1-3
19:30—21:30
Poster Session 4

Peak 1-3

THURSDAY, JANUARY 10

07:00—08:00
Breakfast

Peaks 6-12
08:00—11:00
Structural Bioinformatics III - Structure to Function
Meeting has ended...abstracts no longer viewable online.

Peak 4
* Jacquelyn S. Fetrow, Wake Forest University, USA

Christine A. Orengo, University College London, UK
From Structure to Function; Perspectives from the CATH Domain Database

Diana Murray, Weill Medical College of Cornell University, USA
Protein-Lipid Interactions in Subcellular Targeting

John Moult, University of Maryland Biotechnology Institute, USA
SNPs, Protein Structure, and Disease

Jeffrey Skolnick, Georgia Institute of Technology, USA
Prediction of Protein Structure and Function on a Genomic Scale


Following Session is for Frontiers of Structural Biology (J2)

08:00—11:00
Protein Dynamics
Meeting has ended...abstracts no longer viewable online.

Peak 5
* Benoit Roux, University of Chicago, USA

Arthur G. Palmer, III, Columbia University, USA
NMR Methods for Characterizing Protein Motions and Folding

Gregory A. Petsko, Brandeis University, USA
The Role of Dynamics in Controlling Enzyme Action

Sharon L. Campbell, University of North Carolina at Chapel Hill, USA
Nitric Oxide Modification of the Ras Protein

Peter E. Wright, The Scripps Research Institute, USA
Protein-DNA and Protein-Protein Interactions in Transcriptional Activation

09:20—09:40
Coffee Break

Foyer
16:00—16:30
Coffee & Snacks Available

Foyer
16:30—18:30
Structural Biology in Drug Design (Joint)
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Gregory A. Petsko, Brandeis University, USA

Giovanna Scapin, Merck Research Laboratories, USA
Selectivity in Homologous Protein Families: Protein Kinases Inhibition

Daniel F. Wyss, Merck Research Laboratories, USA
Structural Evaluation of Drug Targets

Jonathan M. Moore, Vertex Pharmaceuticals Incorporated, USA
NMR-Based Strategies for Drug Discovery

Melissa A. Starovasnik, Genentech, Inc., USA
The IL-17 Cytokine Family: Surprising Parallels with Neurotrophins

18:30—19:30
Welcome Mixer

Foyer/Peak 1-3
19:30—22:30
Entertainment

Peak 1-3

FRIDAY, JANUARY 11

 
Departure


*Session Chair †Invited, not yet responded.



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