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This meeting took place in 2002



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Epigenetics in Development and Disease (J5)


Organizer(s) Alan P. Wolffe, Stephen B. Baylin and Trevor K. Archer
February 21—26, 2002
Taos Convention Center (meeting only) • Taos, New Mexico USA
Abstract Deadline: Oct 22, 2001
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Dec 20, 2001


Summary of Meeting:
Remarkable progress is being made in appreciation and the role of epigenetics in topics as diverse as somatic gene therapy, cloning and transgenic strategies in plants and animals, aspects of cancer biology, the study of viral latency, the activity of mobile elements, genomic imprinting, and developmental abnormalities in animals and plants. Epigenetics presents a wonderful fusion of sciences relevant to human medicine, animal and plant biotech, and basic science. The excitement in this research area comes from the realization that diverse organisms have common molecular mechanisms that contribute to epigenetic control. This Keystone Symposium on 'Epigenetics in Development and Disease' will review the enormous progress and opportunities in this fast moving field. The meeting will have substantial representation from academic, medical and biotechnology perspectives. Therapeutic and commercial applications of epigenetics will be considered in depth.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


THURSDAY, FEBRUARY 21

16:00—19:00
Registration

Rio Grande D
18:15—19:15
Welcome

Rio Grande A-C
19:15—19:30
Orientation

Bataan
19:30—21:30
Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online.

Bataan
Peter A. Jones, Van Andel Research Institute, USA
Epigenetics of Cancer

Phillip A. Sharp, Massachusetts Institute of Technology, USA
RNA Biology and the Genome


FRIDAY, FEBRUARY 22

07:00—08:00
Breakfast

Bataan
08:00—11:15
DNA Methylation and Human Disease
Meeting has ended...abstracts no longer viewable online.

Rio Grande A-B
Brian D. Hendrich, University of Edinburgh, UK
Methyl-CpG Binding Proteins in Development and Disease

* Stephen B. Baylin, Johns Hopkins University School of Medicine, USA
Promoter Hypermethylation and Silencing of Genes in Cancer

En Li, China Novartis Institutes for BioMedical Research, China
Functions of Dnmt3a, Dnmt3b, and Dnmt3L in Mammalian Development

Kirk B. Jensen, Rockefeller University, USA
The Consequences of Loss of Function of the FMRP and Nova RNA Binding Proteins in Neurons and in Neurologic Disease

Gerd P. Pfeifer, Beckman Research Institute, USA
Short Talk: MBD3L, a Gene Homologous to the Methyl-CpG-Binding Domain Protein Genes MBD3 and MBD2, is Expressed Specifically in Postmeiotic Cells of the Testis

David C. Schultz, Case Western Reserve University, USA
Short Talk: SETDB1: A Novel SET Domain Protein that Contains Histone H3-Lysine 9 Specific Methylase Activity, and Recruits HP1 to Endogenous, Euchromatic Targets

08:00—11:00
RNAi and Cosuppression in Different Organisms I
Meeting has ended...abstracts no longer viewable online.

Rio Grande C-D
* Richard W. Carthew, Northwestern University, USA
RNAi in Drosophila

Jan M. Kooter, Free University, Netherlands
RNA Interference and DNA Methylation in Plants

Lisa Timmons, University of Kansas, USA
RNAi in Caenorhabditis elegans: The Spreading Effect

Elisabetta Ullu, Yale University, USA
In vivo Analysis of RNA Interference in Trypanosoma brucei

09:20—09:40
Coffee Break

Bataan
11:00—13:00
Poster Setup

Bataan
13:00—22:00
Poster Viewing

Bataan
14:30—16:30
Workshop Sponsored by Rett Syndrome Research Foundation. This Workshop will include a dedication to Dr. Alan Wolff.

Rio Grande A-B
Jeffrey J. Hayes, University of Rochester, USA
Nucleosomes are Substrates for hFEN1 Endonuclease and hDNA Ligase I

Mona D. Shahbazian, Baylor College of Medicine, USA
Short Talk: Characterization of a Mouse Model for Rett Syndrome

Paul A. Wade, NIEHS, National Institutes of Health, USA
Mutational Analysis of MBD Proteins: Insights into Structure and Function

Karine Monier, Ecole Normale Superieure de Lyon, France
Short Talk: Nuclear Architecture Remodeling during in vitro Neuronal Differntiation

Fyodor D. Urnov, Altius Institute for Biomedical Sciences, USA
Chromatin and the Epigenome

16:30—17:00
Coffee & Snacks Available

Bataan
17:00—19:00
DNA Methylation and Development
Meeting has ended...abstracts no longer viewable online.

Rio Grande A-B
David J. Katz, Princeton University, USA
Epigenetic Regulation of Mammalian Growth

* Wolf Reik, Babraham Institute, UK
Function and Mechanisms of Imprinting and Epigenetic Reprogramming

F. Alex Feltus, Emory University School of Medicine, USA
Short Talk: Large Scale Mapping of DNMT1-Induced Hypermethylated CpG Island Loci

Fumitoshi Ishino, Medical Research Institute, Tokyo Medical and Dental University, Japan
Short Talk: Epigenetic Regulation of Cloned Mice Produced from Somatic Cells and Primordial Germ Cells

17:00—19:00
RNAi and Cosuppression in Different Organisms II
Meeting has ended...abstracts no longer viewable online.

Rio Grande C-D
* Giuseppe Macino, Universita' la Sapienza, Italy
Quelling and Questing in Neurospora crassa

James A. Birchler, University of Missouri, USA
Transcriptional and Post-Transcriptional Transgene Silencing in Drosophila

David C. Baulcombe, University of Cambridge, UK
RNA Polymerase and Other Factors Involved in Maintenance of Cosuppression in Arabidopsis

19:00—20:00
Welcome Mixer

Bataan
20:00—22:00
Poster Session 1: DNA Methylation and Human Disease/DNA Methylation and Development

Bataan

SATURDAY, FEBRUARY 23

07:00—08:00
Breakfast

Rio Grande
08:00—11:00
DNA Methylation/Epigenetics (Joint)
Meeting has ended...abstracts no longer viewable online.

Bataan
Herve Vaucheret, Institut National de la Recherche Agronomique, France
DNA Methylation and Gene Silencing in Plants

* Timothy H. Bestor, Columbia University College of Physicians and Surgeons, USA
Disruption of Dnmt3L Prevents Establishment of Maternal Genomic Imprints

Marjori Ann Matzke, Institute of Plant and Microbial Biology, Academy Sinica, Taiwan
RNA-Directed Methylation of Promoter Sequences

Rudolf Jaenisch, Whitehead Institute for Biomedical Research, USA
Mammalian Cloning and Epigenetic Reprogramming

09:20—09:40
Coffee Break

Rio Grande
13:00
Poster Setup

Bataan
14:00—22:00
Poster Viewing

Bataan
14:30—16:30
Oral Abstract Presentations

Rio Grande C-D
György Hutvágner, , USA
How Distinct are RNAi and stRNA Pathways?

Eugene Aleksandrovich Glazov, FMI for Biomedical Research, Switzerland
A Gene Encoding an Exonuclease-Like Protein is Required for Postranscriptional Silencing in Arabidopsis.

Nelson C. Lau, Boston University School of Medicine, USA
An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans

Alexei A. Aravin, California Institute of Technology, USA
Double Stranded RNA-Mediated Silencing of Genomic Tandem Repeats and Transposable Elements in Drosophila melanogaster Germline

Petr Svoboda, , Switzerland
RNAi in Preimplantation Embryos: dsRNA Processing and Suppression of Transposable Elements.

16:30—17:00
Coffee & Snacks Available

Bataan
17:00—19:00
Epigenetic Mechanisms in Tumorigenesis 1
Meeting has ended...abstracts no longer viewable online.

Rio Grande A-B
Ina Rhee, ,
DNMT1 and DNMT3B Cooperate to Silence Genes in Human Cancer Cells

Ulrike Hardeland, Institute of Medical Radiobiology, Switzerland
Mechanisms Coordinating the Repair of G•T Mispairs Arising through 5-Methylcytosine Deamination

* Trevor K. Archer, NIEHS, National Institutes of Health, USA
Chromatin Structure Regulates Promoter Function

Christian Seiser, University of Vienna, Austria
Short Talk: Essential Function of Histone Deacetylase 1in Proliferation Control and CDK Inhibitor Repression

17:00—19:00
Regulatory RNA
Meeting has ended...abstracts no longer viewable online.

Rio Grande C-D
* Craig C. Mello, University of Massachusetts Medical School, USA
Target-Dependent Accumulations of RNA Species Define Genetically Distinct Events During RNAi in C. elegans

Bruce M. Paterson, National Cancer Institute, National Institutes of Health, USA
RNAi as Random Degradative PCR

Victor R. Ambros, University of Massachusetts, USA
Eukaryotic Genes Encoding Small Regulatory RNAs

19:00—20:00
Welcome Mixer

Bataan
20:00—22:00
Poster Session 2: DNA Methylation/Epigenetics/Epigenetic Mechanisms in Tumorigenesis

Bataan

SUNDAY, FEBRUARY 24

07:00—08:00
Breakfast

Bataan
08:00—11:00
Epigenetic Mechanisms in Tumorigenesis 2
Meeting has ended...abstracts no longer viewable online.

Rio Grande A-B
* Pier Paolo Pandolfi, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Oncogenesis and Developmental Control

Pier Giuseppe Pelicci, European Institute of Oncology, Italy
Histone Deacetylases: a Common Molecular Target for Differentiation Treatment of Acute Myeloid Leukemias

Henk G. Stunnenberg, Radboud University, Netherlands
HDAC and Leukemia

Maarten Van Lohuizen, Netherlands Cancer Institute, Netherlands
Functional Analysis of Mouse Polycomb-Repression: Implications for Development and Cancer

Yi-Ching Wang, National Taiwan Normal University, Taiwan
Short Talk: Inactivation of hMLH1 by Genetic and Epigenetic Alterations, A Novel Mechanism Causing Non-Small Cell Lung Cancer

08:00—11:00
Genome Defense
Meeting has ended...abstracts no longer viewable online.

Rio Grande C-D
Thierry Heidmann, Institut Gustave Roussy, France
Taming of Transposable Elements in Drosophila by Homology-Dependent Gene Silencing/Cosuppression

* Ronald H. Plasterk, Ministry of Education, Culture and Science, Netherlands
Transposon Silencing and RNAi in C. elegans

Virginia Walbot, Stanford University, USA
Control of Mutator Activity and Mu Transposons in Maize

Heriberto D. Cerutti, University of Nebraska, USA
Epigenetic Control of Transposon Mobility in Chlamydomonas

09:20—09:40
Coffee Break

Bataan
11:00—13:00
Poster Setup

Bataan
13:00—22:00
Poster Viewing

Bataan
14:30—16:30
Workshop on Chromosomal Domains

Rio Grande A-B
Dirk Schübeler, Friedrich Miescher Institute for Biomedical Research, Switzerland
Gene Activation and Repression in Red Cells

Adam G. West, National Institutes of Health, USA
Organisation of Gene Expression by Chromatin Insulators

* Wendy A. Bickmore, University of Edinburgh, UK
Chromosomal Domains and Nuclear Compartments in the Human Genome

Frank Weissmann, German Cancer Research Center (DKFZ), Germany
Short Talk: Hypermethylation of the Drosophila Genome Results in Chromosome Condensation Defects and Aberrant Histone Modification

14:30—16:30
Oral Abstract Presentations

Rio Grande C-D
Shou-Wei Ding, University of California, Riverside, USA
An Animal RNA Virus Encodes a Potent Suppressor of Post-Transcriptional Gene Silencing

Jozsef Burgyán, Plant Virology Institute-CNR, Italy
P19 Protein of Tombusviruses Can Specifically Bind 21-25 nt Double-Stranded RNAs Generated by Posttranscriptional Gene Silencing and Prevent the Development of Local and Systemic Silencing

Alla Grishok, Columbia University Medical Center, USA
Target Dependent Accumulation of siRNAs During RNAi in C. elegans

Anke Geick, Alnylam Europe AG, Germany
Specific Inhibition of Cancer-Related Target Gene Expression by Short Double-Stranded RNA

David L. Lewis, Arrowhead Research Corporation, USA
Specific Inhibition of Gene Expression in Post-Natal Mammals Using Small Interfering RNAs

Alexandra Boutla, European Molecular Biology Laboratory, Germany
Induction of Silencing in Invertebrates by Synthetic and Natural RNAs

16:30—17:00
Coffee & Snacks Available

Bataan
17:00—19:15
Functional Specialization of Chromatin
Meeting has ended...abstracts no longer viewable online.

Rio Grande A-B
* Steven Henikoff, Fred Hutchinson Cancer Research Center, USA
Adaptive Evolution of Centromeric Histone H3-Like Proteins

Robert E. Kingston, Massachusetts General Hospital, USA
Biochemical Analysis of Polycomb - Group Repression

Laura Carrel, Case Western Reserve University, USA
Chromosomal Control of Gene Expression on the Human Inactive X Chromosome

Fang-Lin Sun, Tongji University, China
Short Talk: Chromatin Organization of the Drosophila melanogaster Fourth Chromosome: Interspersed Functional Domains and Inferred Boundaries

17:00—19:00
In Vitro Systems
Meeting has ended...abstracts no longer viewable online.

Rio Grande C-D
* Gregory J. Hannon, University of Cambridge, UK
Mechanism of RNA Interference

Phillip D. Zamore, University of Massachusetts Medical School, USA
RNA Interference: An in vitro Approach to Understanding Mechanism

Thomas Tuschl, HHMI/Rockefeller University, USA
Posttranscriptional Gene Regulation by 21-Nucleotide RNAs

19:00—20:00
Welcome Mixer

Bataan
20:00—22:00
Poster Session 3: Epigenetic Mechanisms in Tumorigenesis/Functional Specialization of Chromatin/Gene Silencing and Development/Overcoming Silencing for Somatic Gene Therapy

Bataan

MONDAY, FEBRUARY 25

07:00—08:00
Breakfast

Bataan
08:00—11:00
Gene Silencing and Development (Joint). Session Sponsored in part by Torrey Mesa Research Institute.
Meeting has ended...abstracts no longer viewable online.

Bataan
* Robert A. Martienssen, Cold Spring Harbor Laboratory, USA
Argonauts in Arabidopsis and Yeast

Steven E. Jacobsen, University of California, Los Angeles, USA
Genetics of DNA Methylation in Arabidopsis

E. Jean Finnegan, CSIRO Plant Industry, Australia
Epigenetic Regulation of Plant Development

Ian Wilmut, University of Edinburgh, UK
Cloning: Overcoming Silencing through Nuclear Transplantation

09:20—09:40
Coffee Break

Rio Grande
16:30—17:00
Coffee & Snacks Available

Bataan
17:00—19:00
Overcoming Silencing for Somatic Gene Therapy
Meeting has ended...abstracts no longer viewable online.

Rio Grande A-B
* Donald B. Kohn, University of California, Los Angeles, USA
Overcoming Gene Silencing in Somatic Gene Therapy

James R. Ellis, Hospital for Sick Children, Canada
Short Talk: Chromatin Marks, Silencer-Blocking Insulators, and Stem Cell Gene Therapy Vectors

17:00—19:15
Applications of RNAi and Cosuppression in Genomics
Meeting has ended...abstracts no longer viewable online.

Rio Grande C-D
* Julie Ahringer, University of Cambridge, UK
Genome Wide RNAi Screening in C. elegans

Peter Waterhouse, Commonwealth Scientific & Industrial Research Organization, Australia
Construct Design for Efficient, Effective and High Throughput Gene Silencing in Plants

Guy della-Cioppa, Large Scale Biology Corporation, USA
Virus Induced Gene Silencing for Functional Genomics in Plants

Christophe J. Echeverri, Cenix BioScience GmbH, Germany
RNAi for Functional Genomics: From Worms to Humans

19:00—20:00
Welcome Mixer

Bataan
20:00—23:00
Entertainment

Bataan

TUESDAY, FEBRUARY 26

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 CA94249-01




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