Sheraton Steamboat Resort Floorplan

Registered Attendees


Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:

  • Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting (You can edit your own abstract from My Account page as well)

    NOTE: Abstract authors/submitters may choose to not have their abstract available online and in the secure mobile app until a week before the meeting.

  • Full participant list, including joint meeting participants
  • Printable Invoices and Invitation Letters
  • Scholarship Information
  • Lodging Information

Login to My Account page

This meeting took place in 2002



For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Molecular Mechanisms of Leukocyte Trafficking (X6)


Organizer(s) Steven D. Rosen, Geoffrey S. Kansas, Elisabetta Dejana and Samuel C. Silverstein
April 9—14, 2002
Sheraton Steamboat Resort • Steamboat Springs, Colorado USA
Abstract Deadline: Dec 10, 2001
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Feb 8, 2002

Sponsored by ICOS Corporation and The Director's Sponsor Fund


Summary of Meeting:
The Keystone meeting on ‘Molecular Mechanisms of Leukocyte Trafficking’ will be a comprehensive gathering of the world's foremost scientists working in a cutting-edge basic science area with important ramifications for human disease. This meeting is a reprise of a highly successful joint meeting on "Molecular Mechanisms of Leukocyte Trafficking" and "Endothelium," held in March 1998. The past few years have seen continued advances in the understanding of how leukocytes extravasate and migrate within tissues. There has been further elucidation of the participation of selectins and their ligands; chemokines and their receptors; integrins; and Ig superfamily molecules. A number of novel strategies for anti-inflammatory therapeutics have already emerged from these disciplines and more are likely to follow. The meeting will bring together scientists working in a diverse range of topics in leukocyte and vascular biology. The resulting interactions are likely to stimulate new approaches to the critical remaining problems in trafficking research.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, APRIL 9

16:00—19:00
Registration

Foyer
18:15—19:15
Welcome

Foyer
19:15—19:30
Orientation

Sunshine
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Sunshine
Eugene C. Butcher, Stanford University, USA
Chemokines and the Systemic Organization of the Immune System

19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Storm Peak
Michael Karin, University of California, San Diego, USA
IKK – A Master Regulator of Innate and Adaptive Immune Responses


WEDNESDAY, APRIL 10

07:00—08:00
Breakfast

3 Saddles/Sevens
08:00—11:00
Different Views of Cell-Cell Interactions
Meeting has ended...abstracts no longer viewable online.

Sunshine
* Michael L. Dustin, University of Oxford, UK
The Structure of the Immunological Synapse

Timothy A. Springer, Immune Disease Institute, Harvard University, USA
Conformational Regulation of Integrin Structure and Function

Paul S. Frenette, Albert Einstein College of Medicine, USA
Adhesion Mechanisms of Sickle Cells and Progenitor Cells in the Microvasculature

E. Yvonne Jones, Wellcome Trust Centre for Human Genetics, UK
Three-Dimensional Structure of Cell Adhesion Molecules

08:00—11:00
Stress Responses and the Vasculature I
Meeting has ended...abstracts no longer viewable online.

Storm Peak
* Momtaz K. Wassef, National Institutes of Health, USA

Tucker Collins, Children's Hospital Boston, USA
Transcriptional Regulation of Vascular Stress Responses

Judith A. Berliner, University of California, Los Angeles, USA
Novel Lipid Mediators of Atherogenesis

David M. Stern, Columbia University College of Physicians & Surgeons, USA
Amyloid Angiopathy and the RAGE: Interactions of Amyloid-beta with the Blood Brain Barrier and Neurons

Richard O. Hynes, Massachusetts Institute of Technology, USA
Roles of Vascular Adhesion Receptors in Tumor Progression

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Twilight/Mt. Werner
13:00—22:00
Poster Viewing

Twilight/Mt. Werner
14:30—16:30
Workshop 1: Vascular Complications of Diabetes: The Clinical Perspective

Storm Peak
* Steven P. Marso, Mid-America Heart Institute, USA
Type 2 Diabetes Mellitus and Cardiovascular Disease: Framing the Clinical Issues

Charles Kunsch, Abbott Laboratories, USA
Laminar Shear Stress Induction of the Antioxidant Response Element (ARE) in Endothelial Cells: Role of ARE-Mediated Gene Expression in Vascular Protection

Jean B. Regard, Johns Hopkins University, USA
L119: A Novel Endothelial Immediate Early Gene

Justin C. Mason, Imperial College School of Medicine, UK
Complement-Mediated Vascular Endothelial Injury is Inhibited by Statins Through Upregulation of Expression of Complement Inhibitory Proteins

Craig M. Stolen, University of Turku, Finland
Genetic Manipulation of Semicarbazide-Sensitive Amine Oxidation in Mice

Deborah Stroka, University of Bern, Switzerland
HIF-1 Mediated Responses to Hypoxia and Inflammation in the Vasculature

Anna M. Randi, Imperial College London, UK
Anti-Inflammatory Effect of Peroxisome-Proliferator Activated Receptor (PPAR) gamma Agonist GW347845 in TNF-Stimulated HUVECs

Jonathan E. Shelton, University of Alabama at Birmingham, USA
Effects of Lipid Lowering Therapy on the Vascular Response to Injury in a Model of Type 2 Diabetes

16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
Selectins and Their Ligands
Meeting has ended...abstracts no longer viewable online.

Sunshine
* Rodger P. McEver, Oklahoma Medical Research Foundation, USA
Interactions of Selectins with PSGL-1

Bruce Furie, Beth Israel Deaconess Medical Center, USA
In vivo Real Time Imaging Of Arterial Thrombus Formation Reveals P-Selectin and Psgl-1-Mediated Tissue Factor Accumulation as a Mechanism for Fibrin Clot Generation

Raymond T. Camphausen, Wyeth Pharmaceuticals, USA
Structural Studies of the Interactions of the Selectins with Their Physiological Ligands

17:00—19:00
Angiotensin
Meeting has ended...abstracts no longer viewable online.

Storm Peak
* R. Wayne Alexander, Emory University Hospital, USA
Renin Angiotensin System and Vascular Disease

Bradford C. Berk, University of Rochester Medical Center, USA
Angiotensin II, Oxidative Stress and Signal Transduction Events: Role of PDE1A1

W. Robert Taylor, Emory University School of Medicine, USA
Atherosclerosis and Angiotensin II

19:00—20:00
Welcome Mixer

Foyer
20:00—22:00
Poster Session 1

Twilight/Mt. Werner

THURSDAY, APRIL 11

07:00—08:00
Breakfast

3 Saddles/Sevens
08:00—11:00
Molecular Glycobiology of Selectin Ligands
Meeting has ended...abstracts no longer viewable online.

Sunshine
* Steven D. Rosen, University of California, San Francisco, USA
Sulfotransferases and L-Selectin Ligands

John B. Lowe, Genentech, Inc., USA
Glycan Fucosylation in Leukocyte Biology

Jamey D. Marth, Sanford-Burnham Medical Research Institute, USA
Biology of Sialyltransferases in Leukocyte Traffic, Immunity, Apoptosis and Hemostasis

Minoru Fukuda, Sanford-Burnham Medical Research Institute, USA
Structural Diversity of Oligosaccharides that Provides Functional Diversity

08:00—11:00
Chemokines and Receptors
Meeting has ended...abstracts no longer viewable online.

Storm Peak
Christian W. Schindler, Columbia University, USA
IL-6 in a Murine Model of Atherosclerosis

Michael Farzan, The Scripps Research Institute, USA
Chemokine Receptors for HIV-1 and P. Vivax Malaria

* Israel F. Charo, ChemoCentryx, Inc., USA
Chemokine Control of Trafficking in Atherosclerosis

Mark B. Taubman, Mount Sinai School of Medicine, USA
Chemokine Receptors as Activators of Vascular Smooth Muscle

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Twilight/Mt. Werner
13:00—22:00
Poster Viewing

Twilight/Mt. Werner
14:30—16:30
Workshop 2: Chemokines, Leukocyte-Endothelial Interactions and Atherosclerosis

Storm Peak
* Martha K. Cathcart, Cleveland Clinic Foundation, USA
Lipid Regulation of Monocyte Chemotaxis to MCP1

Ronen Alon, Weizmann Institute of Science, Israel
The CD81 Tetraspanin Upregulates Leukocyte Integrin Clustering at Subsecond Contacts and Promotes Chemokine-Triggered Adhesion Under Shear Flow

Marschall S. Runge, University of North Carolina at Chapel Hill, USA
Oxidative Signals in Atherosclerosis

Peter Gough, GlaxoSmithKline, USA
Macrophage-Specific Retroviral Expression Vectors as Tools for Studying Macrophage Function in vivo.

Guy Chisolm, Cleveland Clinic Foundation, USA
Regulation of Tissue Factor in Vascular Smooth Muscle Cells: Role of Lipoprotein-Borne Bioactive Phospholipids

Min Peter Kim, National Institutes of Health, USA
Angiotensin II Increases Matrix Metalloproteinase -1 and -9 by Monocytes Stimulated with TNF-alpha and GM-CSF

16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
Selectins and Their Ligands II
Meeting has ended...abstracts no longer viewable online.

Sunshine
* Geoffrey S. Kansas, Northwestern University Medical School, USA
Control of Selectin Ligand Biosynthesis in Th1 Cells

Thomas F. Tedder, Duke University Medical Center, USA
L-Selectin Endoproteolytic Release: Dogma, Data and Reality

Denisa D. Wagner, Harvard Medical School, USA
Selectins and Other Leukocyte Adhesion Receptors

17:00—19:00
Candidate Genes in the Regulation of Chronic Vasculopathies
Meeting has ended...abstracts no longer viewable online.

Storm Peak
* David M. Stern, Columbia University College of Physicians & Surgeons, USA

Jerry L. Nadler, Eastern Virginia Medical School, USA
12-Lipoxygenase, Atherosclerosis and Restenosis

Margarete Mehrabian, University of California, Los Angeles, USA
The Role of 5-Lipoxygenase and Atherosclerosis

Ann Marie Schmidt, New York University Langone Medical Center, USA
RAGE: Insights into Proinflammatory Mechanisms in Diabetes and Immune/Inflammatory Disorders

19:00—20:00
Welcome Mixer

Foyer
20:00—22:00
Poster Session 2

Twilight/Mt. Werner

FRIDAY, APRIL 12

07:00—08:00
Breakfast

3 Saddles/Sevens
08:00—11:00
Chemokines, Cytokines and Immune Responses
Meeting has ended...abstracts no longer viewable online.

Sunshine
* Jason G. Cyster, HHMI/University of California, San Francisco, USA
Role of Homeostatic Chemokines in Immunity

Michael D. Gunn, Duke University Medical Center, USA
Chemokines, Dendritic Cell Migration, and the Regulation of Immune Response

Martin Lipp, Max-Delbrueck-Center, MDC, Germany
Systemic Regulatory Immune Functions of Homeostatic Chemokine Receptors

Nancy H. Ruddle, Yale University School of Medicine, USA
Lymphoid Organ Neogenesis and Leukocyte Trafficking

08:00—11:00
Leukocyte-Vessel Wall Interactions: What's New?
Meeting has ended...abstracts no longer viewable online.

Storm Peak
* John M. Harlan, Harbor View Medical Center, USA

Victor Kotelianski, Promedior, USA
Atherosclerotic Plaque Plasticity: Importance of alpha1beta1 Integrin and TGF-beta

Donald E. Staunton, ICOS Corporation, USA
Regulation of Leukocyte Integrin Affinity and Function at the IDAS

Claire M. Doerschuk, Case Western Reserve University, USA
Neutrophil-Endothelial Cell Adhesion and Signaling

Antonin de Fougerolles, Ablynx NV, Belgium
Role of Collagen-Binding Integrin alpha1beta1 in Leukocyte Trafficking

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Twilight/Mt. Werner
13:00—22:00
Poster Viewing

Twilight/Mt.Werner
14:30—16:30
Workshop 3: Vascular Smooth Muscle Cell Biology and Restenosis

Storm Peak
* Gary H. Gibbons, NHLBI, National Institutes of Health, USA
Preventing Restenosis: Translating Mechanistic Insights into Novel Therapeutics

John F. Schmedtje, COEURative, USA
Cardiovascular Cyclooxygenase-2 in Hypoxia

Uwe Schonbeck, Brigham and Women's Hospital, USA
CD40 Signaling and Atherosclerosis

Mario B. Marrero, Georgia Regents University, USA
S100B Augments the Angiotensin II-Induced Activation of JAK2 in Vascular Smooth Muscle Cells Via Activation Of PLD2.

Wang Min, University of Rochester, USA
Role of ASK1 in Endothelial Cell Function

Dominique P.V. de Kleijn, University Medical Center Utrecht, Netherlands
Activation of Toll-Like Receptor 4 in Adventitial Cells Induces Neointima Formation; The Adventitial Fibroblast as Local Immunoregulatory Cell

Russell M. Medford, AtheroGenics, Inc., USA
Inflammatory Mediators in Restenosis: New Therapeutic Strategies

16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
In vivo Analysis of Leukocyte-Endothelial Interactions
Meeting has ended...abstracts no longer viewable online.

Sunshine
* Ulrich H. Von Andrian, Harvard Medical School, USA
Homing And Cellular Traffic In Lymphoid Tissues

Klaus Ley, La Jolla Institute for Allergy and Immunology, USA
Integration of Signals from G-Protein Coupled Receptors, Selectin and Integrin Engagement by Rolling Neutrophils

Paul Kubes, University of Calgary, Canada
Complexities of the Leukocyte Recruitment Cascade In Vivo

17:00—19:00
Nitric Oxide-Vessel Wall Interactions
Meeting has ended...abstracts no longer viewable online.

Storm Peak
Eric J. Smart, University of Kentucky, USA
High-Density Lipoprotein Binding to Scavenger Receptor Class B, Type I Activates Endothelial Nitric Oxide Synthase in a Ceramide-Dependent Manner

* Joseph Loscalzo, Brigham and Women's Hospital, Harvard Medical School, USA
Thiol and S-Nitrosothiol Homeostasis in Vasculature

Timothy R. Billiar, University of Pittsburgh Medical Center Presbyterian Hospital, USA
iNOS Regulation of the Vascular Injury Response

19:00—20:00
Welcome Mixer

Foyer
20:00—22:00
Poster Session 3

Twilight/Mt. Werner

SATURDAY, APRIL 13

07:00—08:00
Breakfast

3 Saddles/Sevens
08:00—11:00
Mechanisms of Transendothelial Migration
Meeting has ended...abstracts no longer viewable online.

Sunshine
* Sonia A. Cunningham, Texas Biotechnology Corporation, USA
JAM2 Interactions with Integrin

Beat A. Imhof, Centre Médical Universitaire, Switzerland
Facilitation of Leukocyte Transmigration by JAM-2

Samuel C. Silverstein, Columbia University College of Physicians & Surgeons, USA
How Many Neutrophils are Enough? A Biophysical Explanation for the Association Between Neutropenia and Bacterial Infection

Anne J. Ridley, King's College London, UK
Rho GTPase Signaling in Endothelial Cells

08:00—11:00
Immunologic Injury
Meeting has ended...abstracts no longer viewable online.

Storm Peak
* Jeffrey L. Platt, University of Michigan, USA
Complement Mediated Blood Vessel Injury

Jordan S. Pober, Yale University School of Medicine, USA
T Lymphocyte-Mediated Blood Vessel Injury

Wayne W. Hancock, Children's Hospital of Philadelphia, USA
The Role of Antibody in Accelerated Arteriosclerosis

Thomas M. Coffman, NUS Duke Singapore, Singapore
Pro-Inflammatory Actions of Angiotensin II in Vascular Disease

09:20—09:40
Coffee Break

Foyer
16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
Novel Models of Leukocyte Trafficking
Meeting has ended...abstracts no longer viewable online.

Sunshine/Mt. Werner
* Paul R. Crocker, University of Dundee, UK
Siglecs in Adhesion and Signaling

Mark H. Siegelman, University of Texas Southwestern Medical Center, USA
Defining a New Activation Marker for T Cells on the Path to Extravasation: Hyaluronan Interactions with Activated CD44

Masayuki Miyasaka, Osaka University, Japan
Genetic Profiling of High Endothelial Venule Cells – Search for Novel HEV Molecules Involved in Lymphocyte Homing

19:00—20:00
Welcome Mixer

Foyer
20:00—23:00
Entertainment

Storm Peak

SUNDAY, APRIL 14

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 AI51316-01




We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676