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This meeting took place in 2002
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Angiogenesis in Cancer and Other Diseases: From Genes to Function to Therapy (Z2)
Organizer(s) Rakesh K. Jain, Peter M. Carmeliet and James M. Pluda
February 8—13, 2002
Banff Centre • Banff, Alberta Canada
Abstract Deadline: Oct 8, 2001
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Dec 7, 2001
Sponsored by Novartis Pharmaceuticals Corporation
Joint Meeting:
Biological Response to the Extracellular Matrix (Z1)
Summary of Meeting:
Pathological angiogenesis is a hallmark of cancer and various ischemic and inflammatory diseases. Concerted efforts in this area of research are leading to the discovery of a growing number of pro- and anti-angiogenic molecules, some of which are already in clinical trials. The complex interactions among these molecules and their effect on vascular structure and function in different environments are beginning to be elucidated. This integrated understanding is leading to the development of a number of exciting and bold approaches to treat cancer and other diseases. However, there are several outstanding questions that must be addressed for successful translation of discoveries from the bench to the bedside. With advances in molecular genetics and the availability of molecular probes, imaging technologies, and therapeutic opportunities, we are now beginning to answer these questions. In this meeting, we discuss how normal and abnormal blood vessels form, how they function, what molecules (genes) are involved, how they are used for therapy, why caution is warranted and what key questions remain unanswered. We will first discuss tumor angiogenesis since it is most widely studied, and then, the emerging role of angiogenesis and vascular remodeling in non-neoplastic disorders resulting from ischemia, inflammation, obesity and vascular malformations.
View Scholarships/Awards
Pathological angiogenesis is a hallmark of cancer and various ischemic and inflammatory diseases. Concerted efforts in this area of research are leading to the discovery of a growing number of pro- and anti-angiogenic molecules, some of which are already in clinical trials. The complex interactions among these molecules and their effect on vascular structure and function in different environments are beginning to be elucidated. This integrated understanding is leading to the development of a number of exciting and bold approaches to treat cancer and other diseases. However, there are several outstanding questions that must be addressed for successful translation of discoveries from the bench to the bedside. With advances in molecular genetics and the availability of molecular probes, imaging technologies, and therapeutic opportunities, we are now beginning to answer these questions. In this meeting, we discuss how normal and abnormal blood vessels form, how they function, what molecules (genes) are involved, how they are used for therapy, why caution is warranted and what key questions remain unanswered. We will first discuss tumor angiogenesis since it is most widely studied, and then, the emerging role of angiogenesis and vascular remodeling in non-neoplastic disorders resulting from ischemia, inflammation, obesity and vascular malformations.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
FRIDAY, FEBRUARY 8
SATURDAY, FEBRUARY 9
SUNDAY, FEBRUARY 10
MONDAY, FEBRUARY 11
TUESDAY, FEBRUARY 12
WEDNESDAY, FEBRUARY 13
Conference Program Print | View meeting in 12 hr (am/pm) time
FRIDAY, FEBRUARY 8
19:30—22:00
Keynote Addresses (Joint) Sponsored in part by OSI Pharmaceuticals, Inc.
Meeting has ended...abstracts no longer viewable online.
*
David A. Cheresh,
University of California, San Diego, USA
*
Rakesh K. Jain,
Massachusetts General Hospital and Harvard Medical School, USA
Bjorn Reino Olsen,
Harvard Medical School, USA
Molecular Mechanisms of Endostatin: Lessons from Collagen XVIII Knock-Out Mice
Molecular Mechanisms of Endostatin: Lessons from Collagen XVIII Knock-Out Mice
M. Amin Arnaout,
Massachusetts General Hospital, USA
Crystal Structure of Heterodimeric Integrin aVb3.
Crystal Structure of Heterodimeric Integrin aVb3.
M. Judah Folkman,
Children's Hospital Boston, USA
Anti-Angiogenic Therapy of Cancer: Lessons from the Clinical Trials
Anti-Angiogenic Therapy of Cancer: Lessons from the Clinical Trials
08:00—11:00
Endothelial Stem Cells and Vascular Development
Meeting has ended...abstracts no longer viewable online.
*
Shahin Rafii,
Weill Cornell Medical College, USA
Co-Recruitment of Marrow-Derived VEGFR1 (+)Hematopoietic and VEGFR2+ Vasculogenic Progenitors Cells by Angiogenic Factors is Essential for Angiogenesis.
Co-Recruitment of Marrow-Derived VEGFR1 (+)Hematopoietic and VEGFR2+ Vasculogenic Progenitors Cells by Angiogenic Factors is Essential for Angiogenesis.
Jun Yamashita,
Kyoto University Graduate School of Medicine, Japan
Vascular Progenitor Cells Common to Endothelial and Mural Cells
Vascular Progenitor Cells Common to Endothelial and Mural Cells
Patrick H. Maxwell,
Rayne Institute, UK
Cellular Oxygen Sensing - A Key Regulator of Angiogenesis
Cellular Oxygen Sensing - A Key Regulator of Angiogenesis
Sarah J. Childs,
University of Calgary, Canada
Short Talk: Patterning Angiogenesis in the Zebrafish Embryo
Short Talk: Patterning Angiogenesis in the Zebrafish Embryo
08:00—11:00
The Matrix in Development
Meeting has ended...abstracts no longer viewable online.
*
Elaine V. Fuchs,
HHMI/Rockefeller University, USA
Beauty is Skin Deep: Differentiation and Development in the Skin
Beauty is Skin Deep: Differentiation and Development in the Skin
Robert Benezra,
Memorial Sloan-Kettering Cancer Center, USA
The Id Proteins are Required for Tumor Angiogenesis
The Id Proteins are Required for Tumor Angiogenesis
Mina J. Bissell,
Lawrence Berkeley National Laboratory, USA
The Structural Basis of Tissue-Specific Signaling in Normal and Malignant Breast
The Structural Basis of Tissue-Specific Signaling in Normal and Malignant Breast
17:00—19:00
Endothelial Specification: Arteries, Veins, Lymphatics
Meeting has ended...abstracts no longer viewable online.
Jan K. Kitajewski,
Columbia University, USA
Notch Function in Vascular Specification
Notch Function in Vascular Specification
*
Harold F. Dvorak,
Beth Israel Deaconess Medical Center, USA
Structure and Function of Cytokine Induced Vessels: Tumor Vessel Surrogates?
Structure and Function of Cytokine Induced Vessels: Tumor Vessel Surrogates?
Rüdiger Klein,
Max Planck Institute of Neurobiology, Germany
Requirements for Bi-Directional Eph/Ephrin Signaling in vivo
Requirements for Bi-Directional Eph/Ephrin Signaling in vivo
17:00—19:00
Matrix Structure and Assembly
Meeting has ended...abstracts no longer viewable online.
*
Peter D. Yurchenco,
UMDNJ RW Johnson Medical School, USA
Matrix Assembly, Regulatory and Survival Functions of Laminin and its Receptors in Embryonic Stem Cell Differentiation
Matrix Assembly, Regulatory and Survival Functions of Laminin and its Receptors in Embryonic Stem Cell Differentiation
Harold P. Erickson,
Duke University Medical Center, USA
Stretching Fibronectin Matrix Fibrils and Single Molecules
Stretching Fibronectin Matrix Fibrils and Single Molecules
Bianca Tomasini-Johansson,
University of Wisconsin-Madison, USA
Cellular Control of Fibronectin Assembly
Cellular Control of Fibronectin Assembly
08:00—11:00
Angiogenesis and Neurogenesis
Meeting has ended...abstracts no longer viewable online.
Elizabeth Lindsay Illingsworth Baldini,
Texas A&M Health Science Center, USA
Genetic Dissection of the Vascular Defects in DiGeorge Syndrome
Genetic Dissection of the Vascular Defects in DiGeorge Syndrome
*
Peter F. Carmeliet,
University of Leuven, VIB, Belgium
The VEGF Family: Angiogenesis and Beyond
The VEGF Family: Angiogenesis and Beyond
Didier Stainier,
Max Planck Institute for Heart and Lung Research, Germany
Function of VEGF-C in Angiogenesis, Organogenesis and Neurogenesis
Function of VEGF-C in Angiogenesis, Organogenesis and Neurogenesis
08:00—11:00
Biological Consequences of Matrix Turnover
Meeting has ended...abstracts no longer viewable online.
Vito Quaranta,
Vanderbilt University School of Medicine, USA
Laminin Processing by MMPs in Tumor Invasion Across Basement Membranes
Laminin Processing by MMPs in Tumor Invasion Across Basement Membranes
Marsha A. Moses,
Children's Hospital, USA
Matrix Metalloproteinases: Positive and Negative Regulators of Angiogenesis and Tumor Progression
Matrix Metalloproteinases: Positive and Negative Regulators of Angiogenesis and Tumor Progression
Nathalie Ortega,
University of California, San Francisco, USA
Biological Response to ECM Degradation: Insights from Endochondral Ossification and MMPs
Biological Response to ECM Degradation: Insights from Endochondral Ossification and MMPs
*
Raghu Kalluri,
University of Texas MD Anderson Cancer Center, USA
Regulation of Angiogenesis by Vascular Basement Membrane
Regulation of Angiogenesis by Vascular Basement Membrane
17:00—19:00
Angiogenesis and Endothelial Microenvironment (Joint). Session Sponsored by Cell Genesys, Inc.
Meeting has ended...abstracts no longer viewable online.
*
David A. Cheresh,
University of California, San Diego, USA
Differential Raf-ERK Activation by Distinct Integrin/Growth Factor Receptor Pairs During Two Pathways of Angiogenesis: Therapeutic Implications
Differential Raf-ERK Activation by Distinct Integrin/Growth Factor Receptor Pairs During Two Pathways of Angiogenesis: Therapeutic Implications
Rakesh K. Jain,
Massachusetts General Hospital and Harvard Medical School, USA
Functional Heterogeneity in Blood and Lymphatic Vessels in Tumors: Insight from Intravital Microscopy
Functional Heterogeneity in Blood and Lymphatic Vessels in Tumors: Insight from Intravital Microscopy
Erkki Ruoslahti,
Sanford-Burnham Medical Research Institute, USA
Targeting the Endothelium
Targeting the Endothelium
20:00—22:00
Poster Session 2C: Intracellular and Extracellular Mechanisms of Angiogenesis in Pathology
08:00—11:00
Matrix/Growth Factor Dependent Signaling (Joint)
Meeting has ended...abstracts no longer viewable online.
*
Martin Schwartz,
Yale School of Medicine, USA
Integrins and Rho Family GTPases in Mechanotransduction
Integrins and Rho Family GTPases in Mechanotransduction
Anne J. Ridley,
King's College London, UK
Rho GTPase Signaling in Endothelial Cells
Rho GTPase Signaling in Endothelial Cells
Richard K. Assoian,
University of Pennsylvania School of Medicine, USA
Defining the Requirement for Stress Fibers During G1 Phase Cell Cycle Progression
Defining the Requirement for Stress Fibers During G1 Phase Cell Cycle Progression
Anthony R. Hunter,
The Salk Institute for Biological Sciences, USA
Signaling by Tyrosine Phosphorylation
Signaling by Tyrosine Phosphorylation
17:00—19:00
Tumor and Pathological Angiogenesis. Session Sponsored by Enzon, Inc.
Meeting has ended...abstracts no longer viewable online.
Napoleone Ferrara,
University of California, San Diego, USA
New Insights into the Regulation of Angiogenesis by VEGF
New Insights into the Regulation of Angiogenesis by VEGF
Richard O. Hynes,
Massachusetts Institute of Technology, USA
Alpha-v Integrins as Negative Regulators of Angiogenesis
Alpha-v Integrins as Negative Regulators of Angiogenesis
*
Robert S. Kerbel,
Sunnybrook Research Institute, Canada
Metronomic Antiangiogenic Chemotherapy: Genetic and Epigenetic Mechanisms Governing Longterm Response and Resistance
Metronomic Antiangiogenic Chemotherapy: Genetic and Epigenetic Mechanisms Governing Longterm Response and Resistance
Dwayne G. Stupack,
The Scripps Research Institute, USA
Short Talk: Intergrin-Mediated Death: Establishing a New Role for alphanu Intergrins in Angiogenesis
Short Talk: Intergrin-Mediated Death: Establishing a New Role for alphanu Intergrins in Angiogenesis
17:00—19:00
Mechanical and Cytoskeletal Responses
Meeting has ended...abstracts no longer viewable online.
*
Keith W.T. Burridge,
University of North Carolina at Chapel Hill, USA
Signaling from Adhesion to Rho Family GTPases
Signaling from Adhesion to Rho Family GTPases
Paul A. Janmey,
University of Pennsylvania, USA
The Cytoskeleton and Signal Transduction
The Cytoskeleton and Signal Transduction
Christopher S. Chen,
Boston University, USA
Short Talk: New Microengineered Microenvironments to Study Cell Adhesion and Mechanics
Short Talk: New Microengineered Microenvironments to Study Cell Adhesion and Mechanics
Peter F. Davies,
University of Pennsylvania, USA
Title to be Determined
Title to be Determined
08:00—11:00
Structural Factors in Cell and Vessel Regulation (Joint)
Meeting has ended...abstracts no longer viewable online.
*
Donald E. Ingber,
Wyss Institute for Biologically Inspired Engineering at Harvard, USA
Mechanochemical Signaling and Control of Angiogenesis
Mechanochemical Signaling and Control of Angiogenesis
Donald M. McDonald,
University of California, San Francisco, USA
Structural Heterogeneity of Angiogenic Blood Vessels
Structural Heterogeneity of Angiogenic Blood Vessels
Michael P. Sheetz,
Mechanobiology Institute, National University of Singapore, Singapore
Force-Dependent Signals in Cell Motility
Force-Dependent Signals in Cell Motility
Elisabetta Dejana,
Uppsala University, Sweden
Role of Adherence Junctions in Endothelial Cell Proliferation and Angiogenesis
Role of Adherence Junctions in Endothelial Cell Proliferation and Angiogenesis
17:00—19:00
Therapeutic Angiogenesis/Inhibition. Session Sponsored by the Juvenile Diabetes Research Foundation.
Meeting has ended...abstracts no longer viewable online.
Katherine W. Ferrara,
University of California, Davis, USA
Imaging of Angiogenesis
Imaging of Angiogenesis
*
James M. Pluda,
MedImmune, Inc., USA
Lessons from Anti-Angiogenesis Clinical Trials
Lessons from Anti-Angiogenesis Clinical Trials
17:00—19:00
Disruption of ECM Interactions: Therapeutic Implications
Meeting has ended...abstracts no longer viewable online.
*
Judith A. Varner,
University of California, San Diego, USA
Role of Fibronectin and its Receptors in Angiogenesis
Role of Fibronectin and its Receptors in Angiogenesis
Peter C. Brooks,
New York University School of Medicine, USA
Cryptic ECM Elements and the Regulation of Angiogenesis and Tumor Invasion
Cryptic ECM Elements and the Regulation of Angiogenesis and Tumor Invasion
Mark D. Bednarski,
Targesome, Inc., USA
Integrin Targeted Nanoparticles for Imaging and Therapeutics
Integrin Targeted Nanoparticles for Imaging and Therapeutics
*Session Chair †Invited, not yet responded.
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