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This meeting took place in 2003



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Chromatin: Organizing the Genome for Patterns of Gene Expression in Health and Disease (A4)


Organizer(s) Stephen B. Baylin, Susan M. Gasser and Tony Kouzarides
January 10—15, 2003
Big Sky Resort • Big Sky, Montana USA
Abstract Deadline: Sep 16, 2002
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Nov 11, 2002

Sponsored in part by The Director's Sponsor Fund

Summary of Meeting:
Exciting recent advances in biology stem from our growing appreciation of how chromatin dynamically modulates the genome to program the repertoire of gene expression. To accomplish this process, which is fundamental to embryonic development and mature cell renewal and differentiation, chromatin assembly must be intimately coordinated with cell cycle control, timing of DNA replication, positioning of genes within nuclear domains, and signal transduction events guiding essential post-translational modifications of the proteins involved. Failure of any step can contribute to diseases ranging from inherited disorders to cancer. Despite the importance of the above arena, we are just beginning to understand the molecular players and their co-ordination during cell fate decisions. This meeting will bring together a diverse range of experts in developmental biology, gene transcription, chromatin modeling complexes, nuclear structure, cell cycle regulation and DNA replication, and study of these processes in disease states, to discuss the current and future status of this key cell biology arena

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


FRIDAY, JANUARY 10

15:00—19:00
Registration

Lower Atrium
18:15—19:15
Welcome

Upper Atrium
19:15—19:30
Orientation

Jefferson
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Jefferson
Gary Felsenfeld, NIDDK, National Institutes of Health, USA
Chromatin Boundaries and the Regulation of Gene Expression


SATURDAY, JANUARY 11

07:00—08:00
Breakfast

Gallatin/Lake-Canyon
08:00—11:00
Histone Modification. Session Sponsored in part by Abcam, Ltd.
Meeting has ended...abstracts no longer viewable online.

Jefferson
* Shelley L. Berger, University of Pennsylvania, USA
Covalent Modifications of Histones in Gene Activation

Yi Zhang, HHMI/Harvard Medical School, Children's Hospital Boston, USA
Histone Methylation and Polycomb Group Gene Silencing

Tony Kouzarides, University of Cambridge, UK
Histone Modification in Transcriptional Control

Paolo Sassone-Corsi, University of California, Irvine, USA
Signaling to Chromatin - Coupled Histone Modifications

Neil Brockdorff, University of Oxford, UK
Short Talk: Polycomb Proteins in X Chromosome Inactivation

09:20—09:40
Coffee Break

Lower Atrium
11:00—13:00
Poster Setup

Gallatin
13:00—22:00
Poster Viewing

Gallatin
14:30—16:30
Workshop 1: Modifying and Remodeling Enzymes

Jefferson
* Tony Kouzarides, University of Cambridge, UK

Orr G. Barak, Wistar Institute, USA
Identification and Characterization of a Novel Human SNF2L Containing Chromatin Remodeling Complex

Vincent Géli, Centre National de la Recherche Scientifique, France
The Many Faces of Set1p

Jill A. Fahrner, Johns Hopkins School of Medicine, USA
Inhibition of DNA Methyltransferases but not Histone Deacetylases Reverses the Distinct Histone Code that Marks a Hypermethylated hMLH1 Promoter in Cancer

David G. Skalnik, Indiana University, USA
Defects in Cytosine Methylation and Histone Modification in Embryonic Stem Cells Lacking CpG Binding Protein

François Fuks, Université libre de Bruxelles, Belgium
Dnmt3a Associates with the Myc Oncoprotein

Matthew C. Lorincz, University of British Columbia, Canada
DNA Methylation Density Defines the Stability of an Epigenetic Mark and Dnmt3a/b Independent de novo Methylation

Gregory David, New York University School of Medicine, USA
Mammalian SDS3 is an Essential Component of the mSIN3/HDAC Corepressor Complex

16:30—17:00
Coffee & Snacks Available

Lower Atrium
17:00—19:00
Chromatin Remodeling
Meeting has ended...abstracts no longer viewable online.

Jefferson
* Jerry L. Workman, Stowers Institute for Medical Research, USA
Recruitment and Interactions of Chromatin Modifying Complexes

Steven Henikoff, Fred Hutchinson Cancer Research Center, USA
Chromatin States Distinguished by Variant H3 Histones

Peter B. Becker, University of Munich, Germany
Regulation of Nucleosome Mobility

Jane Mellor, University of Oxford, UK
Short Talk: The Isw1p Chromatin Remodeling ATPase Configures a Promoter Proximal Nucleosome and Regulates Elongating RNA Polymesase II

19:00—20:00
Social Hour

Lower Atrium/Gallatin
20:00—22:00
Poster Session 1

Gallatin

SUNDAY, JANUARY 12

07:00—08:00
Breakfast

Gallatin/Lake-Canyon
08:00—11:00
Heterochromatin
Meeting has ended...abstracts no longer viewable online.

Jefferson
* Thomas Jenuwein, Max Planck Institute of Immunobiology and Epigenetics, Germany
Epigenetic Control by Histone Methylation

Sarah C.R. Elgin, Washington University, USA
HP1, HP2 and the Organization of Heterochromatin

Jef D. Boeke, New York University Langone Medical Center, USA
Chromatin Modification in Yeast and Beyond

David C. Schultz, Case Western Reserve University, USA
Short Talk: Purification and Characterization of a Core HP1-CAF1 Complex: Implications for Maintenance of Heterochromatin Domains

Huawei Xin, Baylor College of Medicine, USA
Short Talk: Involvements of DMAP1 and p33ING1 in Heterochromatin Duplication

09:20—09:40
Coffee Break

Lower Atrium
11:00—13:00
Poster Setup

Gallatin
13:00—22:00
Poster Viewing

Gallatin
14:30—16:30
Workshop 2: Heterochromatin, Nuclear Organization, Replication and DNA Repair

Jefferson
* Susan M. Gasser, Friedrich Miescher Institute for Biomedical Research, Switzerland

Brian Burke, University of Florida, USA
A-Type Lamins and Nuclear Organization

Philippe Louis Clerc, Pasteur Institut, France
Functional Analysis of the Mouse X Inactivation Center through Targeted Deletions and Site Specific Transgenesis

Emmanuel Käs, Centre National de la Recherche Scientifique, France
A Model for the Initiation of Heterochromatin Assembly by the D1 Multi-A•T Hook Protein of Drosophila melanogaster

Bas van Steensel, Netherlands Cancer Institute, Netherlands
Heterochromatin Genomics in Drosophila

Colin L. Stewart, Institute of Medical Biology, Singapore
The Nuclear Envelope in Development and Disease

Hiten D. Madhani, University of California, San Francisco, USA
Inhibition of Heterochromatin Formation by an Intrinsic Component of Euchromatin

Amy K. Csink, Carnegie Mellon University, USA
Using Interspecific Introgression to Demonstrate the Sequence Independence of Heterochromatic Self-Association

Catherine A. Fox, University of Wisconsin-Madison, USA
Specifying Function of the Origin Recognition Complex in Heterochromatin by Differential DNA Affinity

16:30—17:00
Coffee & Snacks Available

Lower Atrium
17:00—19:00
Chromatin in Replication and Repair
Meeting has ended...abstracts no longer viewable online.

Jefferson
* Stephen B. Baylin, Johns Hopkins University School of Medicine, USA

David M. Gilbert, Florida State University, USA
Early G1-Phase Establishment of Late-Replication

Xuetong Shen, University of Texas MD Anderson Cancer Center, USA
Involvement of INO80 ATP-Dependent Chromatin Remodeling Complex in Nuclear Functions

Christopher J. Ramey, University of Colorado Health Sciences Center, USA
Short Talk: Alterations to Chromatin Structure are Sufficient to Activate the DNA Damage Checkpoint

Leon H.F. Mullenders, Leiden University Medical Center, Netherlands
Short Talk: CHIP Analysis of Transcription Coupled Repair Complexes in UV-Irradiated Normal and NER Deficient Human Cells

19:00—20:00
Social Hour

Lower Atrium/Gallatin
20:00—22:00
Poster Session 2

Gallatin

MONDAY, JANUARY 13

07:00—08:00
Breakfast

Gallatin/Lake-Canyon
08:00—11:00
Chromatin and Chromosomes
Meeting has ended...abstracts no longer viewable online.

Jefferson
Jeffrey C. Hansen, Colorado State University, USA
Architectural Proteins that Convert Chromatin Fibers into Supramolecular Secondary and Tertiary Chromatin Structures

Dirk Schübeler, Friedrich Miescher Institute for Biomedical Research, Switzerland
A Genome-Wide Map of Chromatin Structure and Replication Timing Links Transcriptional Activity, DNA Replication and Histone Modifications

Susan M. Gasser, Friedrich Miescher Institute for Biomedical Research, Switzerland
Tethering and Dynamics of Chromosomes in the Nucleus

* Katherine L. Wilson, Johns Hopkins School of Medicine, USA
Chromatin Attachment to the Nuclear Envelope and emerin-Lamin Complexes

09:20—09:40
Coffee Break

Lower Atrium
11:00—13:00
Poster Setup

Gallatin
13:00—22:00
Poster Viewing

Gallatin
16:30—17:00
Coffee & Snacks Available

Lower Atrium
17:00—19:00
Heritable Silenced States
Meeting has ended...abstracts no longer viewable online.

Jefferson
Andrew P. Feinberg, Johns Hopkins University School of Medicine, USA
Epigenetic Alterations in Human Cancer

Amanda G. Fisher, MRC Clinical Sciences Centre, Imperial College London, UK
Replication Timing as an Indicator of Lineage Restriction in Development

* En Li, China Novartis Institutes for BioMedical Research, China
DNA Methylation in Mammalian Development and Diseases

Zhenghan Xin, University of Virginia, USA
Short Talk: Role of G9a Histone H3 Lys9/Lys27 Methyltransferase in CpG Methylation of Imprinting Centers

19:00—20:00
Social Hour

Lower Atrium/Gallatin
20:00—22:00
Poster Session 3

Gallatin

TUESDAY, JANUARY 14

07:00—08:00
Breakfast

Gallatin/Lake-Canyon
08:00—11:00
Transcriptional Control During Cell Fate Decisions
Meeting has ended...abstracts no longer viewable online.

Jefferson
Vincenzo Pirrotta, Rutgers University, USA
Polycomb Silencing Mechanisms

Philip A. Beachy, HHMI/Stanford University, USA
Downstream Events in the Control of Cell Patterning by the Sonic Hedgehog Pathway

* Victor G. Corces, Emory University, USA
Chromatin Insulators and Nuclear Organization

Richard A. Young, Whitehead Institute for Biomedical Research, USA
Chromatin and Eukaryotic Transcriptional Regulatory Circuitry

Victoria Lunyak, University of California, San Diego, USA
Short Talk: Corepressor-Dependent Silencing of the Chromosomal Regions Encoding Neuronal Genes

09:20—09:40
Coffee Break

Lower Atrium
16:30—17:00
Coffee & Snacks Available

Lower Atrium
17:00—19:00
Chromatin Dysfunction and Disease
Meeting has ended...abstracts no longer viewable online.

Jefferson
Jennifer Berger, University of Edinburgh, The King's Buildings, UK
Role of MBD2 in Gene Regulation and Tumourigenesis

Stephen B. Baylin, Johns Hopkins University School of Medicine, USA
Gene Silencing in Cancer – Viewing the Process as a Consequence of Altered Chromatin Organization

* Peter A. Jones, Van Andel Research Institute, USA
Reversing DNA Methylation Changes in Human Cancers

Pier Giuseppe Pelicci, European Institute of Oncology, Italy
Epigenetic Changes Induced by Leukemia- Associated Fusion Proteins

20:00—21:00
Social Hour

Lower Atrium
21:00—00:00
Entertainment

Jefferson/Madison

WEDNESDAY, JANUARY 15

 
Departure


*Session Chair †Invited, not yet responded.



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Abcam plc

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