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This meeting took place in 2003



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Tuberculosis: Integrating Host and Pathogen Biology (B3)


Organizer(s) Gilla Kaplan, Clifton E. Barry III and Stewart Cole
January 25—30, 2003
Sagebrush Inn & Suites • Taos, New Mexico USA
Abstract Deadline: Sep 25, 2002
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Nov 25, 2002

Supported by Keystone Symposia

Summary of Meeting:
With the completion of the genome sequence for both Mycobacterium tuberculosis and Homo sapiens the complexities of pathogen host interaction are now accessible for study. The aims of this meeting are: to review the latest insights obtained from analysis of the genome sequence of M. tuberculosis; to dissect the cell biology of the interaction between M. tuberculosis and host cells; to understand the physiology of the pathogen and identify novel targets for drug development; to discuss the molecular basis of M. tuberculosis strain differences and the implications for transmission and immunity; to explore mechanisms of pathogenesis; to learn how the host develops protective immunity against the pathogen; and to develop strategies for manipulation of the host response to tuberculosis through vaccine development. The stimulating discussion among epidemiologists, cell biologists, immunologists, microbial geneticists, and biotechnologists will define the direction of research and accelerate the development of new therapies, diagnostics, and vaccines and promote the forging of new collaborative efforts.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SATURDAY, JANUARY 25

15:00—19:00
Registration

Chamisa Lobby
18:15—19:15
Welcome

Chamisa Lobby
19:15—19:30
Orientation

Chamisa 1
19:30—20:30
Opening Remarks
Meeting has ended...abstracts no longer viewable online.

Chamisa 1
Clifton E. Barry III, NIAID, National Institutes of Health, USA
Opening Remarks


SUNDAY, JANUARY 26

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Exploratory Genomics - Prokaryotic (Genomes, Proteomes, Structural Genomics)
Meeting has ended...abstracts no longer viewable online.

Chamisa 1
* Stewart T. Cole, Institut Pasteur, France
Evolutionary and Comparative Genomics of the M. tuberculosis Complex

William R. Jacobs, Jr., HHMI/Albert Einstein College of Medicine, USA
Unmasking the Intracellular Lifestyles of Mycobacterium tuberculosis

John T. Belisle, Colorado State University, USA
Proteomics for the Study of Tuberculosis

Peter M. Small, Bill & Melinda Gates Foundation, USA
Comparing Genomes within the Species M. tuberculosis

09:20—09:40
Coffee Break

Chamisa 2
11:00—13:00
Poster Setup

Chamisa 2
13:00—22:00
Poster Viewing

Chamisa 2
16:30—17:00
Coffee & Snacks Available

Chamisa 2
17:00—19:00
Mycobacterial Lipids and Lipid Metabolism in TB Pathogenesis
Meeting has ended...abstracts no longer viewable online.

Chamisa 1
* Clifton E. Barry III, NIAID, National Institutes of Health, USA
The Role of Polyketides in MTB Virulence

Helen Billman-Jacobe, University of Melbourne, Australia
Glycopeptidolipid Biosynthesis in Mycobacteria

Gilla Kaplan, Bill & Melinda Gates Foundation, USA
The Role of MTB Lipids in Immunity and Virulence of Clinical Isolates

19:00—20:00
Social Hour

Los Vaqueros
20:00—22:00
Poster Session 1: Bacterial Physiology and Genomics

Chamisa 2

MONDAY, JANUARY 27

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Regulation and Genetics. Session Sponsored by The Ellison Medical Foundation.
Meeting has ended...abstracts no longer viewable online.

Chamisa 1
James C. Sacchettini, Texas A & M University, USA
The Structural Genomics Consortium

Harvey Rubin, University of Pennsylvania School of Medicine, USA
Regulatory Enzymes in MTB

* William R. Bishai, Johns Hopkins School of Medicine and K-RITH, USA
Sigma Factors and Regulation of Gene Expression in M. tuberculosis

Neil G. Stoker, Royal Veterinary College, UK
Two-Component Systems

09:20—09:40
Coffee Break

Chamisa 2
11:00—13:00
Poster Setup

Chamisa 2
13:00—22:00
Poster Viewing

Chamisa 2
16:30—17:00
Coffee & Snacks Available

Chamisa 2
17:00—19:00
Adaptation of the Host and Pathogen to Coexistance
Meeting has ended...abstracts no longer viewable online.

Chamisa 1
Maria Laura Gennaro, Public Health Research Institute (PHRI), USA
Antigen Specificity of the Host Immune Response and Pathogen Biology

John D. McKinney, Swiss Federal Institute of Technology (EPFL), Switzerland
MTB Persistence

* Douglas B. Young, Imperial College London, UK
Pathogen Adaptations to the Host Immune Response

19:00—20:00
Social Hour

Los Vaqueros
20:00—22:00
Poster Session 2: Pathogenesis and Virulence

Chamisa 2

TUESDAY, JANUARY 28

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Macrophage MTB Interaction
Meeting has ended...abstracts no longer viewable online.

Chamisa 1
* David G. Russell, Cornell University, USA
Mycobacterium tuberculosis: The Indigestible Microbe

Jean Pieters, University of Basel, Switzerland
Evasion of Host Cell Defense Mechanisms by Pathogenic Mycobacteria

Carl F. Nathan, Weill Cornell Medical College, USA
Targeting Defenses of M. tuberculosis Against Reactive Nitrogen Intermediates (RNI)

Alan Aderem, Center for Infectious Disease Research, USA
The Role of Toll-Like Receptors in Orchestrating the Innate Immune Response

09:20—09:40
Coffee Break

Chamisa 2
11:00—13:00
Poster Setup

Chamisa 2
13:00—22:00
Poster Viewing

Chamisa 2
16:30—17:00
Coffee & Snacks Available

Chamisa 2
17:00—19:00
Immune Responses and Vaccine Development
Meeting has ended...abstracts no longer viewable online.

Chamisa 1
Robert A. Seder, NIAID, National Institutes of Health, USA
Vaccine Strategies to Induce Sustained Cellular Immune Responses in vivo Against Intracellular Infections

* Peter L. Andersen, Statens Serum Institut, Denmark
Tuberculosis Subunit Vaccines – Recent Progress Based on Proteomics, Genomics and Studies in Animal Models

M. Joseph Colston, Medical Research Council,
Dendritic Cells and Their Role in Priming Immune Responses to Mycobacteria

19:00—20:00
Social Hour

Los Vaqueros
20:00—22:00
Poster Session 3: Immunology and Vaccines

Chamisa 2

WEDNESDAY, JANUARY 29

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Host Immune Responses to MTB Infection
Meeting has ended...abstracts no longer viewable online.

Chamisa 1
Jan A.M. Langermans, Biomedical Primate Research Centre, Netherlands
The Immune Response to Tuberculosis: Non-Human Primate Models

Warwick J. Britton, Centenary Institute, Australia
Regulation of the Granulomatous Response to Mycobacterium tuberculosis

Anne E. Goldfeld, Children's Hospital Boston, Harvard Medical School, USA
Variations in Host Immune Response to TB Infection

* Stefan H. E. Kaufmann, Max Planck Institute for Infection Biology, Berlin, Germany
The T Cell Response to Mycobacterium tuberculosis

09:20—09:40
Coffee Break

Chamisa 2
11:00—11:30
Poster Setup

11:30—12:30
Lunch

Los Vaqueros
12:30—14:30
Poster Session 4: Diagnostics, Therapeutics and Vaccines

15:30—16:00
Coffee & Snacks Available

Chamisa 2
16:00—18:00
Exploratory Genomics - Eukaryotic (The Host Genomics, Proteomics, Genetics)
Meeting has ended...abstracts no longer viewable online.

Chamisa 1
* Alan Sher, NIAID, National Institutes of Health, USA
A Novel Gene Family which Controls Acute Host Resistance to Mycobacteria and Other Intracellular Pathogens

Jean-Laurent Casanova, Rockefeller University, USA
Genetic Dissection of Immunity to Mycobacteria: The Human Model

* Richard A. Young, Whitehead Institute for Biomedical Research, USA
Exploring the Host Response to Pathogens Using Microarray Technologies

19:00—20:00
Social Hour

Chamisa 2
20:00—23:00
Entertainment

Chamisa 2

THURSDAY, JANUARY 30

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 AI053720-01




We gratefully acknowledge additional support for this conference from:

AstraZeneca R&D

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