Banff Centre Floorplan

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This meeting took place in 2003



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Antibody-Based Therapeutics for Cancer (B4)


Organizer(s) Louis M. Weiner and Paul Carter
February 4—9, 2003
Banff Centre • Banff, Alberta Canada
Abstract Deadline: Oct 3, 2002
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Dec 4, 2002

Sponsored by Amgen Inc.

Summary of Meeting:
Monoclonal antibodies have emerged as increasingly important therapeutic vehicles for the treatment of cancer and other human diseases. Selected unconjugated antibodies can exert clinically meaningful anti-tumor effects in important cancers such as breast cancer and lymphomas. The mechanisms underlying these exciting results remain to be elucidated, but most likely include the induction of host immune responses and the perturbation of signaling through growth factor receptors. Antibody conjugates have been used to deliver toxic principles such as radioactive particles, chemotherapy agents and catalytic toxins with increasing success in defined clinical settings. Advances in antibody engineering have permitted the systematic evaluation of structural manipulation on targeting and efficacy. Antibodies with novel specificities can be isolated with increasing ease from naive and immunized phage display libraries. Major challenges in this rapidly evolving field include the development of improved means for identifying new targets, including structurally-defined (e.g., through proteomic or genomic screening) and functionally-defined approaches. New approaches are needed to harness the ability of antibodies to initiate and sustain innate and adaptive immune responses. For immunoconjugate strategies to consistently succeed without undue host toxicity, new strategies must be developed to dissociate the process of antibody distribution from the effects of antibody-directed tumor targeting. This meeting will address these challenges in distinct sessions devoted to antibody structure and function, immunoconjugates, antibodies as tools for target discovery, antibodies as signaling agents and immune effectors, and in a session that highlights clinical advances in the field. Leaders in each of these areas will present their work and discussion periods will be used to highlight areas felt to have particular promise.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, FEBRUARY 4

15:00—19:00
Registration

Max Bell Foyer
18:15—19:15
Welcome

Max Bell Foyer
19:15—19:30
Orientation

Max Bell Auditorium
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Max Bell Auditorium
Sir Greg Winter, Trinity College Cambridge, UK
Evolution and the Antibody Binding Site


WEDNESDAY, FEBRUARY 5

07:00—08:00
Breakfast

Donald Cameron Hall
08:00—11:00
Antibody Structure and Function I
Meeting has ended...abstracts no longer viewable online.

Max Bell Auditorium
* Paul Carter, Genentech, Inc., USA

Leonard Presta, DNAX Research Institute, USA
Engineering Therapeutic Antibodies for Improved Function

Raphael Clynes, Xencor, Inc., USA
Fc Receptors: Contributions to Antibody-Mediated Tumor Immunity

Peter J. Hudson, Aviper, Pty., Ltd., Australia
Design and Characterization of Multivalent Antibody Molecules

Andreas G. Plückthun, University of Zürich, Switzerland
Biophysical Properties of Antibody Fragments: Importance for Applications

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Max Bell 252, 253
13:00—22:00
Poster Viewing

Max Bell 252, 253
16:30—17:00
Coffee & Snacks Available

Foyer
17:00—17:35
Antibody Structure and Function II
Meeting has ended...abstracts no longer viewable online.

Max Bell Auditorium
Ian M. Tomlinson, GlaxoSmithKline, UK
Fully Human Domain Antibodies as Therapeutics

17:35—19:00
Antibodies as Tools for Target Discovery
Meeting has ended...abstracts no longer viewable online.

Max Bell Auditorium
* James D. Marks, University of California, San Francisco, USA
Tumor Cell Binding and Internalizing Antibodies from Phage Libraries

Brian B. Haab, Van Andel Institute, USA
Analysis of Blood Proteins from Prostate and Pancreatic Cancer Patients using Antibody Microarrays

19:00—20:00
Social Hour

Max Bell 252, 253
20:00—22:00
Poster Session 1

Max Bell 252, 253

THURSDAY, FEBRUARY 6

07:00—08:00
Breakfast

Donald Cameron Hall
08:00—11:00
Immunoconjugates I
Meeting has ended...abstracts no longer viewable online.

Max Bell Auditorium
Peter D. Senter, Seattle Genetics Inc., USA
Highly Potent Immunoconjugates for the Treatment of Cancer

Ralph A. Reisfeld, The Scripps Research Institute, USA
Immunoctyokines for Cancer Immunotherapy

* Richard H.J. Begent, University College London, UK
Antibody-Directed Enzyme Prodrug Therapy: Preclinical and Clinical Development with an Engineered Fusion Protein

Carlos F. Barbas III, The Scripps Research Institute, USA
Chemical Approaches to Cancer Immunotherapy

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Max Bell 252, 253
13:00—22:00
Poster Viewing

Max Bell 252, 253
16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
Immunoconjugates II
Meeting has ended...abstracts no longer viewable online.

Max Bell Auditorium
* Ellen S. Vitetta, University of Texas Southwestern Medical Center, USA
Engineering Toxins to Avoid VLS

Richard J. Youle, NINDS, National Institutes of Health, USA
Targeting of Bcl-2 Family Proteins to Regulate Apoptosis

Martin J. Glennie, University of Southampton, UK
Selecting CD20 Antibodies for Optimal Effector Function

19:00—20:00
Social Hour

Max Bell 252, 253
20:00—22:00
Poster Session 2

Max Bell 252, 253

FRIDAY, FEBRUARY 7

07:00—08:00
Breakfast

Donald Cameron Hall
08:00—11:00
Advances in Antibody Engineering
Meeting has ended...abstracts no longer viewable online.

Max Bell Auditorium
* Hennie R. Hoogenboom, Ablynx, Belgium
Exploiting Phage Display Libraries for Cancer Diagnosis and Therapy

Kathrin Tissot, ESBA Tech AG, Switzerland
Intracellularly Stable Antibodies for Therapy and Target Validation

Terence H. Rabbitts, MRC Laboratory of Molecular Biology, UK
Intracellular Antibody Capture (IAC): The Second Generation

Quan Karen Zhu, Dana Farber Cancer Institute, USA
Intrabodies as Tools to Mediate Protein Function

09:20—09:40
Coffee Break

Foyer
16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
Applications of Antibody Engineering
Meeting has ended...abstracts no longer viewable online.

Max Bell Auditorium
Gregory P. Adams, Fox Chase Cancer Center, USA
Targeting the Epidermal Growth Factor Receptor Family with Heterodimeric Single-Chain FV Molecules

Jan van de Winkel, Genmab, Netherlands
Novel Antibody Therapeutics for Cancer

* Anna M. Wu, University of California, Los Angeles, USA
Engineering Antibody Fragments for Targeting and Pharmacokinetic Properties

19:00—20:00
Social Hour

Foyer
20:00—21:00
Workshop 1

Max Bell Auditorium
* Anna M. Wu, University of California, Los Angeles, USA

Bryan Edwards, , UK
Isolation of Agonistic Human Monoclonal Antibodies to TRAIL-R2 that Display Potent in vitro and in vivo Anti-Tumour Activities

Mark S. Dennis, Denali Therapeutics, USA
Improved Tumor Targeting Using an Fab with a Prolonged Half-Life

Marielle A. Otten, UMC-Utrecht, Netherlands
Immunoglobulin A Receptor (FcaRI) as Target for Antibody Immunotherapy

Pablo Umaña, Roche Innovation Center Zürich, Switzerland
Cell Line Engineering for Production of Therapeutic Antibody Glycoforms with Increased Biological Activity

Robert M. Sharkey, Garden State Cancer Center, USA
Development of a Bispecific Antibody (bsMAb) Pretargeting System for the Treatment of CEA-Expressing Tumors: Clinical Studies to Define the Optimal Conditions for Delivering an 131I-Peptide


SATURDAY, FEBRUARY 8

07:00—08:00
Breakfast

Donald Cameron Hall
08:00—10:30
Antibodies as Effector Molecules
Meeting has ended...abstracts no longer viewable online.

Max Bell Auditorium
Mark X. Sliwkowski, Genentech, Inc., USA
Therapeutic Approaches to Targeting ErbB2/HER2 in Solid Tumors

* Louis M. Weiner, Georgetown University Medical Center, USA
Selective Manipulation of Immune Response Using Antibody-Based Fusion Proteins

Dario Neri, ETH Zürich, Switzerland
Antibody-Promoted Tumor Blood Vessels Thrombosis

09:20—09:40
Coffee Break

Foyer
16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
Clinical Updates
Meeting has ended...abstracts no longer viewable online.

Max Bell Auditorium
Mark D. Pegram, Stanford Cancer Institute, USA
Antibodies Targeting HER2

* George J. Weiner, University of Iowa, USA
Monoclonal Antibody Therapy of B Cell Lymphoma: What's Next?

Gisela Schwab, Exelixis, Inc., USA
ABX-EGF, a Fully Anti-Epidermal Growth Factor Receptor (EGFr) Monoclonal Antibody (MAb)

David A. Reardon, Duke University Medical Center, USA
Short Talk: Radiolabeled Anti-Tenascin Monoclonal Antibody 81C6 Administered into Surgical Resection Cavities in the Treatment of Patients with Malignant Brain Tumors

19:30—20:30
Social Hour

Donald Cameron Hall
20:30—23:30
Entertainment

Donald Cameron Hall

SUNDAY, FEBRUARY 9

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 CA098899-01




We gratefully acknowledge additional support for this conference from:

Educational donation provided by Amgen Janssen Research & Development LLC

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