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This meeting took place in 2003



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Transposition and Other Genome Rearrangements (C1)


Organizer(s) Tania A. Baker, Ronald Plasterk, Daniel F. Voytas
February 8—14, 2003
Hilton Santa Fe Historic Plaza Hotel • Santa Fe, New Mexico USA
Abstract Deadline: Oct 8, 2002
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Dec 9, 2002

Sponsored in part by The Director's Sponsor Fund

Summary of Meeting:
Transposons are a powerful creative force. The recent sequence of the human genome reveals that 45% of the DNA and about 50 genes appear to be transposon-derived. Transposition and related recombination reactions are responsible for generating antibody diversity, altering antigen expression, integration of retroviruses, and the horizontal transmission of virulence factors. Current research is aimed at understanding: (1) recombination mechanisms, using biochemical and structural approaches; (2) their regulation by the environment and during development; and (3) how these events affect cellular function and organism evolution. In this post-genomic era, transposition and site-specific recombination have also been embraced as tools for genome analysis and manipulation. This meeting will bring together researchers interested in all aspects of specialized recombination, from the biological to the structural and mechanistic. Research probing recombination in diverse organisms--including microbes, plants, and animals--will be presented to facilitate exchange of information and ideas, and encourage participants to reach out in new directions.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SATURDAY, FEBRUARY 8

15:00—19:00
Registration

Promenade
18:15—19:15
Welcome

Promenade
19:15—19:30
Orientation

Mesa A-B
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
Jef D. Boeke, New York University Langone Medical Center, USA
The Host-Retrotransposon Interface


SUNDAY, FEBRUARY 9

07:00—08:00
Breakfast

Chamisa
08:00—11:15
Classical Transposons: Mechanism and Control
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
Patrick A. Pribil, University of Maryland, USA
Target DNA Modifications that Enhance Target Capture and Strand Transfer in Tn10 Transposition

Kiyoshi Mizuuchi, NIDDK, National Institutes of Health, USA
Mu Transposition Complex Assembly Dynamics and Target Site Selection

Tai Kong Au, University of Texas at Austin, USA
Short Talk: Disintegration of Mu Strand Transfer Complexes: Implications for Target Site Conformation

Tania A. Baker, Massachusetts Institute of Technology, USA
Alternative Pathways of Mu Transposition

* Nancy L. Craig, Johns Hopkins University School of Medicine, USA
Tn7

Donald R. Ronning, University of Toledo, USA
Short Talk: TnsA/TnsC C-Terminal Tail Structure: The Glue that Binds Tn7

09:20—09:40
Coffee Break

Promenade
11:00—13:00
Poster Setup

Mesa C
13:00—22:00
Poster Viewing

Mesa C
16:30—17:00
Coffee & Snacks Available

Promenade
17:00—19:00
Conservative Site Specific Recombination
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Reid C. Johnson, University of California, Los Angeles, USA
Inversion by the Hin-Fis Protein Complex

Nigel D. F. Grindley, Yale University, USA
Site-Specific Recombination by Gamma-Delta Resolvase: Assessing the 'Filament' Model for the Synaptic Complex

David J. Sherratt, University of Oxford, UK
Chromosome Dimer Resolution by FtsK-Dependent XerCD Recombination at dif

Kerren Swinger, University of Chicago, USA
Short Talk: Flexible DNA Bending in HU-DNA Cocrystal Structures

19:00—20:00
Social Hour

Mesa C
20:00—22:00
Poster Session 1: Classical Elements, Recombinase Mechanism and Structure

Mesa C

MONDAY, FEBRUARY 10

07:00—08:00
Breakfast

Chamisa
08:00—11:15
Retrotransposition
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Thomas H. Eickbush, University of Rochester, USA
Retrotransposons that Propagate in the Nucleolus

Suzanne B. Sandmeyer, University of California, Irvine, USA
Host Genes Supporting Ty3 Retrotransposition

Henry L. Levin, National Institutes of Health, USA
The Retrotransposon Tf1 of Schizosaccharomyces pombe as a Model for the Study of Particle Formation, Reverse Transcription and Integration

John V. Moran, University of Michigan Medical School, USA
Studies of a Human Retrotransposon

Abram Gabriel, Rutgers University, USA
Short Talk: Biochemical Analysis of a Ty1 RT Active Site Mutant that Retains Polymerase Activity

Sandra L. Martin, University of Colorado Denver, Anschutz Medical Campus, USA
Short Talk: Structural and Functional Analyses of the ORF1 Protein from Mouse LINE-1: Implications for Retrotransposition

09:20—09:40
Coffee Break

Promenade
11:00—13:00
Poster Setup

Mesa C
13:00—22:00
Poster Viewing

Mesa C
16:30—17:00
Coffee & Snacks Available

Promenade
17:00—19:00
Recombinase Structure and Function
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Gregory D. Van Duyne, University of Pennsylvania School of Medicine, USA
Cre-loxP Recombination: Synapsis of loxP Sites

William S. Reznikoff, Marine Biological Laboratory, USA
Relating Structure to Mechanism for Tn5 Transposition

Alison Burgess Hickman, National Institutes of Health, USA
The Nuclease Domain of AAV Rep: A Role in Site-Specific Integration

Isaac Wong, Oregon State University, USA
Short Talk: Functional Oligomeric State of ASV Integrase

19:00—20:00
Social Hour

Mesa C
20:00—22:00
Poster Session 2: Retrotransposition

Mesa C

TUESDAY, FEBRUARY 11

07:00—08:00
Breakfast

Chamisa
08:00—11:00
Transposition Silencing and RNAi
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Ronald H. Plasterk, Ministry of Education, Culture and Science, Netherlands
Transposon Silencing and RNAi in C. elegans

Robert A. Martienssen, Cold Spring Harbor Laboratory, USA
Transposons and Related Repeats Mediate Heterochromatin Formation via RNA Interference

Heriberto D. Cerutti, University of Nebraska, USA
Epigenetic Silencing of Transposable Elements in Chlamydomonas

David J. Garfinkel, National Cancer Institute, National Institutes of Health, USA
Short Talk: Copy Number Control of Ty1 Retrotransposition

Jean-Marc Deragon, Universite Blaise Pascal, France
Short Talk: Expression of a SINE Founder Locus Results in the Accumulation of Stable PolyA-Ending RNAs

Damon R. Lisch, University of California, Berkeley, USA
Short Talk: Epigenetic Silencing and Reactivation of the Maize Transposon MuDR

09:20—09:40
Coffee Break

Promenade
11:00—13:00
Poster Setup

Mesa C
13:00—22:00
Poster Viewing

Mesa C
16:30—17:00
Coffee & Snacks Available

Promenade
17:00—19:00
Unusual Elements and Reactions
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* George Chaconas, University of Calgary, Canada
Telomere Resolution in the Lyme Disease Spirochete: Mechanistic Similarities to Site-Specific Recombination and DNA Transposition

Alan M. Lambowitz, University of Texas at Austin, USA
Group II Intron Mobility by Reverse Splicing into DNA and its Applications in Targeted Gene Disruption and Site-Specific DNA Insertion

Marlene Belfort, University of Albany, SUNY, USA
Mobile Introns: Function and Evolution

Russell T.M. Poulter, University of Otago, New Zealand
Short Talk: A Mini-Intein in Cryptococcus

19:00—20:00
Social Hour

Mesa C
20:00—22:00
Poster Session 3: Recombination in Development, Homing and Unusual Reactions

Mesa C

WEDNESDAY, FEBRUARY 12

07:00—08:00
Breakfast

Chamisa
08:00—11:00
Developmentally Programmed Rearrangements
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Martin Gellert, NIDDK, National Institutes of Health, USA
Multiple Roles of the Rag Proteins in Recombination and Transposition

Meng-Chao Yao, Fred Hutchinson Cancer Research Center, USA
Programmed Genome Rearrangements in Tetrahymena: An RNA-Guided System of Genome Defense

Zsuzsanna Izsvak, Max-Delbrück Center, Germany
Short Talk: NHEJ Factors and ATM are both Required for Healing the Wounds Inflicted by Sleeping Beauty Transposition in Mammalian Cells

Koichi Kawakami, National Institute of Genetics, Japan
Short Talk: Transposition of the Tol2 Element of the Japanese Medaka Fish Oryzias latipes in Vertebrates

Lindsay Grey Cowell, Duke University Medical Center, USA
Short Talk: Phylogenetic Conservation of Recombination Signals Flanking Rag-1 and Rag-2

09:20—09:40
Coffee Break

Promenade
11:00—13:00
Poster Setup

Mesa C
13:00—22:00
Poster Viewing

Mesa C
16:30—17:00
Coffee & Snacks Available

Promenade
17:00—19:00
Transposon Functions and Consequences
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* William R. Engels, University of Wisconsin-Madison, USA
Double-Strand Break Repair in Drosophila

Mary-Lou Pardue, Massachusetts Institute of Technology, USA
Fitting into the Establishment: The Two Drosophila Telomeric Retrotransposons

Zoltan Ivics, Paul Ehrlich Institute, Germany
Sleeping Beauty: Evolution, Regulation and Genetic Applications in Vertebrates

Thomas Peterson, Iowa State University, USA
Short Talk: Transposition of Reversed Ac Element Ends Shuffles Exons and Rearranges Chromosomes in Maize

19:00—20:00
Social Hour

Mesa C
20:00—22:00
Poster Session 4: Genomes and Evolution

Mesa C

THURSDAY, FEBRUARY 13

07:00—08:00
Breakfast

Chamisa
08:00—11:15
Host-Transposon Communication and Regulation
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Daniel F. Voytas, University of Minnesota, USA
Retrotransposition and Heterochromatin in Baker’s Yeast

Reinhard Kunze, University of Cologne, Germany
The Maize Ac/Ds Transposable Elements: Regulation and Manipulation of Transposition Activity

Donald Rio, University of California, Berkeley, USA
Mechanism and Regulation of Drosophila P Element Transposition

M. Joan Curcio, Wadsworth Center, USA
Activation of LTR-Retrotransposons in Telomerase-Negative Yeast Mutants

Scott E. Devine, Emory University School of Medicine, USA
Short Talk: Functional Genomics Reveals Relationships between the Retrovirus-Like Ty1 Element and its Host

Ping Zhang, University of Connecticut, USA
Short Talk: Timing and Targeting of P-Element Local Transposition in the Male Germ Line Cells of Drosophila melanogaster

09:20—09:40
Coffee Break

Promenade
16:30—17:00
Coffee & Snacks Available

Promenade
17:00—19:00
Transposons and Genome Organization
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Haig H. Kazazian, Johns Hopkins University School of Medicine, USA
Further Estimates of the Frequency of Retrotransposition Events in Humans

Susan R. Wessler, University of California, Riverside, USA
Rice as a Model System to Understand the Origin and Spread of MITEs

Dixie L. Mager, British Columbia Cancer Agency, Canada
Short Talk: ETn Retrotransposons and Related Type D Endogenous Retroviral Elements in the Mouse

Hugh M. Robertson, University of Illinois at Urbana-Champaign, USA
Short Talk: Molecular Evolution of Eeyore/TIGD1 and Nine Other Human Genes Derived from Tigger/pogo DNA Transposons

Zhijian (Jake) Tu, Virginia Polytechnic Institute and State University, USA
Short Talk: Mosquito Transposable Elements: A Genomic and Evolutionary Perspective

19:00—20:00
Social Hour

Mesa C
20:00—23:00
Entertainment

Mesa C

FRIDAY, FEBRUARY 14

 
Departure


*Session Chair †Invited, not yet responded.



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