Taos Convention Center (meeting only) Floorplan

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This meeting took place in 2004



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G-Protein-Coupled Receptors: Evolving Concepts and Drug Discovery (C1)


Organizer(s) Paul A. Insel and Graeme Milligan
February 17—22, 2004
Taos Convention Center (meeting only) • Taos, New Mexico USA
Abstract Deadline: Oct 16, 2003
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Dec 17, 2003

Sponsored by Aventis Pharmaceuticals, Inc.

Summary of Meeting:
G-protein-coupled receptors (GPCRs), which comprise one of the largest gene families identified in the human genome, also represent the largest number of currently used targets of therapeutic drugs. Recent work has indicated a number of intriguing observations in terms of GPCR structure, function and regulation, including existence of receptor homodimers and heterodimers, genetic identification of orphan GPCRs, novel receptor interacting proteins, clinically important polymorphisms and receptor mutations, mechanisms involved in receptor deactivation/desensitization, and receptor targeting/action in signaling microdomains. Definitive information about each of these topics is still being developed. This symposium will focus on these and related topics with an emphasis on use of new tools, e.g., bioinformatic approaches to evaluate GPCR family members, novel strategies to identify ligands active at GPCRs, and insights from non-mammalian/lower eukaryotic systems. Attendees will thus have the chance to learn and discuss new cutting-edge topics regarding GPCRs.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, FEBRUARY 17

15:00—19:00
Registration

Rio Grande Hall D
18:15—19:15
Refreshments

Rio Grande A/B/C
19:15—19:30
Orientation

Bataan
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Bataan
Robert J. Lefkowitz, HHMI/Duke University Medical Center, USA
A Brief History of Seven Membrane Spanning Receptors


WEDNESDAY, FEBRUARY 18

07:00—08:00
Breakfast

Rio Grande A/B/C
08:00—11:15
GPCR Structure and Oligomerization
Meeting has ended...abstracts no longer viewable online.

Bataan
* Dianne M. Perez, Cleveland Clinic Foundation, USA

Krzysztof Palczewski, Case Western Reserve University, USA
Rhodopsin Structure and Activation

Michel Bouvier, University of Montreal, Canada
Functional Role of 7TM Receptor Dimerization in Transport

Kendall J. Blumer, Washington University School of Medicine, USA
Yeast GPCR Oligomerization

Graeme Milligan, University of Glasgow, UK
Receptor Dimerization

Jakob S. Hansen, Novo Nordisk A/S, Denmark
Short Talk: Oligomerization of Wild Type and Non-Functional Mutant Angiotensin II Type I (AT1) Receptors Inhibits Galphaq Signaling but Not ERK Activation

Nagarajan Vaidehi, City of Hope National Medical Center, USA
Short Talk: First Principles Structure and Function Prediction for G Protein-Coupled Receptors

09:20—09:40
Coffee Break

Rio Grande C/D
11:15—13:00
Poster Setup

Rio Grande
13:00—22:00
Poster Viewing

Rio Grande
16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
GPCR Interacting Proteins
Meeting has ended...abstracts no longer viewable online.

Bataan
* Michael P. Lisanti, University of Manchester, UK

Stephen M. Lanier, Louisiana State University Health Science Center, USA
AGS Proteins, GPR Motifs and the Signals Processed by Heterotrimeric G Proteins

Marilyn Gist Farquhar, University of California, San Diego, USA
RGS-PX1 Connects Gs to EGF Receptor Trafficking and Down-Regulation: From Cell Biology to Mouse Genetics

Hyeseon Cho, National Institutes of Health, USA
Short Talk: RGS14, A Centrosomal and Nuclear-Cytoplasmic Shuttling Protein Regulates Cell Cycle Progression

Thue W. Schwartz, University of Copenhagen, Denmark
Molecular Mechanisms of Activation of 7TM Receptors

19:00—20:00
Social Hour

Rio Grande
19:30—22:00
Poster Session 1

Rio Grande

THURSDAY, FEBRUARY 19

07:00—08:00
Breakfast

Rio Grande A/B/C
08:00—11:00
GPCR Trafficking and Regulation
Meeting has ended...abstracts no longer viewable online.

Bataan
* Robert J. Lefkowitz, HHMI/Duke University Medical Center, USA
Regulation of Seven Membrane Spanning Receptor Trafficking by Ubiquitination

Mark von Zastrow, University of California, San Francisco, USA
Regulation of G Protein-Coupled Receptors by Membrane Trafficking in the Endocytic Pathway

Andrew B. Tobin, University of Glasgow, Scotland
GPCR Phosphorylation Offers a "Flexible" Adaptive Mechanism of Regulation

JoAnn Trejo, University of California, San Diego, USA
Regulation of Protease-Activated Receptor-1 Signaling and Trafficking

Patrick M. Sexton, Monash University, Australia
Short Talk: Molecular Characterization of Receptor Activity Modifying Proteins (RAMPs)

Sarah H. Cant, University College London, UK
Short Talk: Ezrin Represents a Novel Substrate of GRK2 with a Potential Role in Regulating GPCR Internalization and Cytoskeletal Reorganization

09:20—09:40
Coffee Break

Rio Grande C/D
11:00—13:00
Poster Setup

Rio Grande
13:00—22:00
Poster Viewing

Rio Grande
16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
GPCR Signaling Microdomains
Meeting has ended...abstracts no longer viewable online.

Bataan
* Marilyn Gist Farquhar, University of California, San Diego, USA

Michael P. Lisanti, University of Manchester, UK
Role of Caveolin-1 in the Modulation of Lipolysis and Lipid Droplet Formation

Jan E. Schnitzer, Proteogenomics Research Institute for Systems Medicine (PRISM), USA
Differential Integration of Signaling and Trafficking in Caveolae and Lipid Rafts by G Proteins and GPCRs

Susan F. Steinberg, Columbia University, USA
Beta-Adrenergic Signaling in Cardiac Membrane Microdomains

Yann Percherancier, Université de Montréal, Canada
Short Talk: Cholesterol Modulation of beta2-Adrenergic Receptor Characteristics by Sequestration of the Adenylyl-Cyclase V/VI in Raft Membranes

19:00—20:00
Social Hour

Rio Grande
19:30—22:00
Poster Session 2

Rio Grande

FRIDAY, FEBRUARY 20

07:00—08:00
Breakfast

Rio Grande A/B/C
08:00—11:15
GPCRs in Olfaction, Infection and Immunity
Meeting has ended...abstracts no longer viewable online.

Bataan
* Thue W. Schwartz, University of Copenhagen, Denmark

Linda B. Buck, Fred Hutchinson Cancer Research Center, USA
Odor Coding in Mammals

Marvin C. Gershengorn, National Institutes of Health, USA
Kaposi's Sarcoma-Associated Herpesvirus GPCR

Marc Parmentier, Universite Libre de Bruxelles, Belgium
Functional Characterization of New Chemoattractant Receptors

Rob Leurs, Vrije Universiteit Amsterdam, Netherlands
Constitutive Signaling of HCMV-Encoded G-Protein Coupled Receptors

Vikas Bhandawat, Duke University, USA
Short Talk: Amplification by a Single GPCR Molecule in the Olfactory Receptor Neuron

Takehiko Yokomizo, Juntendo University School of Medicine, Japan
Short Talk: In vitro and in vivo Roles of Leukotriene B4 Receptors

09:20—09:40
Coffee Break

Rio Grande C/D
11:15—13:00
Poster Setup

Rio Grande
13:00—22:00
Poster Viewing

Rio Grande
16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
Late Breaking Developments
Meeting has ended...abstracts no longer viewable online.

Bataan
* Graeme Milligan, University of Glasgow, UK

Marie Terpager, University of Copenhagen, Denmark
Short Talk: Covalent Dimerization of 7TM Receptors

Douglas P. Gladue, Stony Brook University, USA
Short Talk: Application of a Novel Two Hybrid Assay for Analysis of G Protein Coupled Receptor Interaction in vivo

Annette Gilchrist, Midwestern University, USA
Short Talk: Identification of Small Molecules Targeting Thrombin Receptor – Gq Activation

Xuanmao Jiao, Thomas Jefferson University, USA
Short Talk: Ligand-Induced Dynamic Distribution of CXCR1 and its Signaling Revealed by Living Cell Fluorescence Imaging

Martin J. Stone, Monash University, Australia
Short Talk: Soluble Mimics of Chemokine Receptors

Marcel Hoffmann, Crystallics, Netherlands
Short Talk: Biology Driven Discovery of GPCR Targets Using Arrayed Adenoviral Gain or Loss of Function Libraries

19:00—20:00
Social Hour

Rio Grande
19:30—22:00
Poster Session 3

Rio Grande

SATURDAY, FEBRUARY 21

07:00—08:00
Breakfast

Rio Grande A/B/C
08:00—11:15
New Technologies to Study GPCRs Session Sponsored by Synaptic Pharmaceutical Corporation, a Lundbeck Co.
Meeting has ended...abstracts no longer viewable online.

Bataan
* Susan F. Steinberg, Columbia University, USA

Dianne M. Perez, Cleveland Clinic Foundation, USA
DNA Microarrays to Define Novel alpha1-AR Signaling Networks

Brian K. Kobilka, Stanford University School of Medicine, USA
Spectroscopic Approaches to Study Conformational Changes in GPCRs

Olivier Civelli, University of California, Irvine, USA
Unraveling the Identity of Orphan GPCRs

James Leonard, Janssen Pharmaceuticals, USA
Moving from Genes to Screens at GPCRs

Isabel D. Alves, University of Arizona, USA
Short Talk: Plasmon-Waveguide Resonance Spectroscopy: A Direct Method to Study Signal Transduction Events in GPCRs

Larry A. Sklar, University of New Mexico, USA
Short Talk: Flow Cytometric Analyses of GPCR Assemblies and their Potential Applications in Drug Discovery

09:20—09:40
Coffee Break

Rio Grande C/D
16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
GPCR Genetic Variants in Human Disease
Meeting has ended...abstracts no longer viewable online.

Bataan
* Paul A. Insel, University of California, San Diego, USA

Stephen B. Liggett, USF Health Personalized Medicine Institute, USA
Adrenergic Receptor Polymorphisms: Function and Disease Associations

Mariel Birnbaumer, NIEHS, National Institutes of Health, USA
V2R Mutations and Water Balance

Stephen J. O'Brien, National Cancer Institute, National Institutes of Health, USA
Complex Multifactorial Gene Discovery in Man

Brinda K. Rana, University of California, San Diego, USA
Short Talk: An Approach for Detecting Genetic Epistasis at GPCRs and their Effector Loci in Complex Disease

19:00—20:00
Social Hour

Rio Grande
20:00—23:00
Entertainment

Rio Grande

SUNDAY, FEBRUARY 22

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13DA017912-01




We gratefully acknowledge additional support for this conference from:

Sanofi US
Synaptic Pharmaceutical Corp.

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