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This meeting took place in 2003



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Signaling via Cell-Cell Interactions (D6)


Organizer(s) Rudy L. Juliano and Keith W.T. Burridge
March 18—23, 2003
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Nov 18, 2002
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Jan 21, 2003

Supported by Keystone Symposia

Summary of Meeting:
Over the last decade it has become clear that many key signal transduction processes are strongly influenced by transmembrane cell adhesion molecules and by their associated cytoskeletal partners. In particular there has been a great deal of progress in understanding how integrin-mediated adhesion to the extracellular matrix leads to the organization of supramolecular complexes of structural and signaling proteins, and how these complexes then regulate the efficiency of signaling pathways. More recently, evidence is beginning to emerge that cell-cell adhesion molecules, including cadherins and immunoglobulin-superfamily proteins, also have strong impacts on signal transduction. Cell-cell adhesion molecule (CAM) mediated signaling seems to be particularly important in the context of the nervous system, and in the context of the organization of polarized epithelia. Thus this proposed Keystone Symposia intends to address several key aspects of the emerging research theme of CAMs and their role in signaling pathways affecting mitogenesis, cell survival, and cell differentiation.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, MARCH 18

15:00—19:00
Registration

Shavano Peak Foyer
18:15—19:15
Welcome

Shavano Peak Foyer
19:15—19:30
Orientation

Shavano Peak

WEDNESDAY, MARCH 19

08:30—09:30
Breakfast

Red Cloud
11:00—13:00
Poster Setup

Torreys Peak
13:00—22:00
Poster Viewing

Torreys Peak
16:30—17:00
Coffee & Snacks Available

Shavano Peak Foyer
17:00—18:45
Epithelial Cell Junctions, Rho GTPases and Signaling I
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* Yoshimi Takai, Osaka University Graduate School of Medicine, Japan
Roles and Modes of Action of Nectin and Afadin in Formation of Intercellular Junctions

Vania M.M. Braga, Imperial College, Faculty of Medicine, UK
Rho Proteins and Cadherin Receptors

Celeste M. Nelson, Princeton University, USA
Short Talk: VE-Cadherin, Focal Adhesions and Mechanotransduction

18:45—19:00
Integrins and Signal Transduction
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
Valerie G. Brunton, CR-UK Beatson Institute for Cancer Research, UK
Short Talk: Src Tyrosine Kinase-Dependent Adhesion Changes in A Model of Colon Cancer Metastasis

19:00—20:00
Social Hour

Torreys Peak
20:00—22:00
Poster Session

Torreys Peak

THURSDAY, MARCH 20

07:00—08:00
Breakfast

Red Cloud
08:00—08:40
Epithelial Cell Junctions, Rho GTPases and Signaling II
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
Shoichiro Tsukita, Kyoto University, Japan
Cancelled Due to Weather

* Keith W.T. Burridge, University of North Carolina at Chapel Hill, USA
Signaling from Cadherins to RhoA

08:40—09:20
CAMs and Nucleocytoplasmic Trafficking
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
Charles Streuli, University of Manchester, UK
Adhesion Signals for Differentiation and Survival in Mammary Epithelium

09:20—09:40
Coffee Break

Shavano Peak Foyer
09:40—10:45
Epithelial Cell Junctions, Rho GTPases and Signaling II
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
Yasuyuki M. Fujita, University College London, UK
Short Talk

Alec E. Vaezi, Rockefeller University, USA
Short Talk: Actin Cable Dynamics and Rho/Rock Orchestrate a Polarized Cytoskeletal Architecture in Early Steps of Assembling a Stratified Epithelium

Estelle Sontag, University of Texas Southwestern Medical Center, USA
Short Talk: PP2A Critically Regulates the Actin Cytoskeleton and Assembly of Epithelial Tight Junctions

10:45—11:00
Integrins and Signal Transduction
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
Kerstin Danker, Charite - Universitaetsmedizin Berlin, Germany
Short Talk: Alpha1Beta1 Integrin-Mediated Post-Ligand Events Require the Cytoplasmic Sequence of the Alpha1 Integrin Subunit

11:00—13:00
Poster Setup

Torreys Peak
13:00—22:00
Poster Viewing

Torreys Peak
16:30—17:00
Coffee & Snacks Available

Shavano Peak Foyer
17:00—17:45
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
W. James Nelson, Stanford University, USA
How Simple Epithelial Cells Form Cell-Cell Adhesions

17:45—19:00
PAR Genes and Epithelial Polarity
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
Daniel St Johnston, University of Cambridge, UK
The Roles of Drosophila PAR-1, LKB1 and 14-3-3 in Anterior-Posterior Axis Formation and Epithelial Polarity

* Dietmar Vestweber, Max Planck Institute for Molecular Biomedicine, Germany
Regulation of Endothelial Cell Contacts

19:00—20:00
Social Hour

Torreys Peak
20:00—22:00
Poster Session

Torreys Peak

FRIDAY, MARCH 21

07:00—08:00
Breakfast

Red Cloud
08:00—08:40
Leukocyte Interactions
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
Elisabetta Dejana, Uppsala University, Sweden
Signaling through Endothelial Junctions

08:40—09:20
Integrins and Signal Transduction
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* Joan S. Brugge, Harvard Medical School, USA
VAV - A Critical Regulator of Rho GTPases

09:40—11:00
Epithelial Cell Junctions, Rho GTPases and Signaling
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
Andrea I. McClatchey, Massachusetts General Hospital, USA
Short Talk: NF2-Deficiency Promotes Tumorigenesis and Metastasis by Destabilizing Adherens Junctions

Pierre D. McCrea, University of Texas MD Anderson Cancer Center, USA
Short Talk: Vertebrate Development Requires Interplay of p120- and ARVCF-Catenins with Rho-Family GTPases

Cara J. Gottardi, Northwestern University, USA
Short Talk: Distinct Biochemical Pools of b-Catenin Exhibit Differential Binding to Cadherin and TCF: Implications for wnt Signaling and Adhesion

09:20—09:40
Coffee Break

Shavano Peak Foyer
13:00—22:00
Poster Viewing

Torreys Peak
16:30—17:00
Coffee & Snacks Available

Shavano Peak Foyer
17:00—19:00
CAMs, Signaling and Neuronal Guidance
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* Louis F. Reichardt, University of California, San Francisco, USA
Adhesive Signaling in Neural Development

Morgan H. Sheng, Genentech, Inc., USA
The Dynamic Organization of Synaptic Junctions

Spyros Artavanis-Tsakonas, Harvard Medical School and Biogen Idec, USA
Notch Signaling

19:00—19:30
Scaffolds, the Cytoskeleton and Signaling
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
Mark L. Dell'Acqua, University of Colorado, USA
Short Talk: AKAP79 Binding to Cadherins: Polarized Targeting of a Kinase-Phosphatase Signaling Scaffold to Cell-Cell Contacts in Neurons and Epithelial Cells

19:30—20:30
Social Hour

Torreys Peak
20:00—22:00
Poster Session

Torreys Peak

SATURDAY, MARCH 22

07:00—08:00
Breakfast

Red Cloud
08:00—09:20
Scaffolds, the Cytoskeleton and Signaling
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* Rudy L. Juliano, University of North Carolina at Chapel Hill, USA
Regulation of Signal Transduction by Integrins and the Cytoskeleton

Filippo G. Giancotti, Memorial Sloan-Kettering Cancer Center, USA
Genetic Analysis of Integrin Alpha-6 Beta-4 Signaling

09:20—09:40
Coffee Break

Shavano Peak Foyer
09:20—10:15
CAMs and Nucleocytoplasmic Trafficking
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
Ruggero Pardi, San Raffaele University School of Medicine, Italy
Cancelled Due to Weather

* Mary C. Beckerle, Huntsman Cancer Institute, USA
LIM Proteins that Modulate Integrin Function

Donald M. Black, Beatson Institute, UK
Short Talk: TES is a Focal Adhesion LIM Domain Protein that Interacts with ZYXIN, MENA and TALIN

10:15—11:30
Potential Therapeutic Targets Based on Cell Interactions
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* David R. Phillips, Portola Pharmaceuticals Inc., USA
Therapeutic Regulation of alphaIIbbeta3: Surprising Effect on CD40L and Inflammation

Diane Baronas-Lowell, Florida Atlantic University, USA
Short Talk: Endothelial Cell Activation Induced by ECM "Mini-Proteins"

Mario M. Müller, Institute of Molecular Biology and Biochemistry, Germany
Short Talk: CEACAM1 (CD66a) A Potent Regulator of Endothelial Differentiation

11:00—22:00
Poster Viewing

Torreys Peak
16:00—16:30
Coffee & Snacks Available

Shavano Peak Foyer
16:45—17:30
Leukocyte Interactions
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
John D. Scott, University of Washington, USA
Cancelled Due to Weather

* Peter J. Newman, Blood Center of Wisconsin, USA
Novel Roles for PECAM-1 in the Biology of Blood and Vascular Cells

Michael L. Dustin, University of Oxford, UK
The Immunological Synapse: A Signaling Paradox Resolved

17:30—18:30
PAR Genes and Epithelial Polarity
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
Shigeo Ohno, Yokohama City University School of Medicine, Japan
Cancelled Due to Weather

Christopher E. Rudd, University of Montreal, Canada
Short Talk: Adaptors ADAP and SKAP-55 Regulate Integrin Adhesion and T Cell/APC Conjugate Formation

18:30—19:30
Potential Therapeutic Targets Based on Cell Interactions
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
Frank Struyf, Northwestern University, USA
Short Talk: Constitutive Upregulation of an Interferon Response Pathway in Fibroblasts Lacking Full-Length Nectin-1

Carlos Rosales, Instituto de Investigaciones Biomedicas - UNAM, Mexico
Short Talk: Beta1 and Beta2 Integrins Activate Different Signaling Pathways in Monocytes

John P. O'Bryan, University of Illinois at Chicago, USA
Short Talk: Intersectin Activates Ras and c-Jun N-Terminal Kinase and is Negatively Regulated by Src and p38 MAPK

19:30—20:30
Social Hour

Torreys Peak
20:30—23:30
Entertainment

Torreys Peak

SUNDAY, MARCH 23

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 CA099389-01




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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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