Fairmont Banff Springs Floorplan

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This meeting took place in 2003



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Molecular Targets for Cancer Therapy (E1)


Organizer(s) Karen H. Vousden and William G. Kaelin, Jr.
March 19—24, 2003
Fairmont Banff Springs • Banff, Alberta Canada
Abstract Deadline: Nov 19, 2002
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Jan 21, 2003

Sponsored by DNAX Research, Inc. and Novartis Pharmaceuticals Corporation

Summary of Meeting:
Enormous advances have been made in our understanding of the molecular mechanism that regulate cell proliferation and cell death, and this knowledge is now being applied to the development of drugs designed to target key components of these pathways. Small molecules that function in this way will be useful as both experimental tools and potential therapeutics for human disease, particularly cancer. The aim of this meeting is to explore the progress, and potential for progress, in the translation of several areas of basic cell biology to drug development. Sessions will concentrate on the regulation of cell proliferation, cell death and tumor progression, with speakers ranging from basic academic scientists to industrial scientists who are in the process of developing screens and testing lead compounds. By integrating the basic and applied science in each session we hope to stimulate interactions and discussion to help identify and develop new molecular targets.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


WEDNESDAY, MARCH 19

15:00—19:00
Registration

Van Horne Foyer
18:15—19:15
Welcome

Van Horne Foyer
19:15—19:30
Orientation

VH Ballroom AB
19:30—21:30
Keynote Addresses
Meeting has ended...abstracts no longer viewable online.

VH Ballroom AB
* William G. Kaelin, Jr., Dana-Farber Cancer Institute, USA

Alex Matter, Novartis Institute for Tropical Diseases, Singapore
Molecular Targets: From Pathways to Drugs

David P. Lane, Agency for Science, Technology and Research, Singapore
Small Molecule Activators of Tumor Suppressor Proteins


THURSDAY, MARCH 20

07:00—08:00
Breakfast

Cascade/Conservatory
08:00—11:00
Proliferation I
Meeting has ended...abstracts no longer viewable online.

VH Ballroom AB
* Erich A. Nigg, Max Planck Institute for Biochemistry, Germany
Mitotic Kinases and Chromosomal Instability

Paul L. Hallenbeck, Premier Research, USA
Oncolytic Adenoviruses Dependent upon Two Prevalent Alterations in Human Cancer; Disregulation of the Rb-Pathway and Telomerase

Robert J. White, University of Glasgow, UK
Control of RNA Polymerase III Transcription by Tumor Suppressors and Oncogene Products

09:20—09:40
Coffee Break

Van Horne Foyer
11:00—13:00
Poster Setup

Alberta/New Brunswick
13:00—22:00
Poster Viewing

Alberta/New Brunswick
16:30—17:00
Coffee & Snacks Available

Van Horne Foyer
17:00—19:00
Telomerase/Angiogenesis
Meeting has ended...abstracts no longer viewable online.

VH Ballroom AB
* Lea Harrington, Ontario Cancer Institute, Canada
Telomerase, Telomere Recruitment and Cancer

William G. Kaelin, Jr., Dana-Farber Cancer Institute, USA
Hypoxia and the von Hipple-Lindau Tumor Suppressor

19:15—20:15
Social Hour

Alberta/New Brunswick
20:00—22:00
Poster Session 1

Alberta/New Brunswick

FRIDAY, MARCH 21

07:00—08:00
Breakfast

Cascade/Conservatory
08:00—11:00
Apoptosis
Meeting has ended...abstracts no longer viewable online.

VH Ballroom AB
* Eileen P. White, Rutgers University, USA
Role of Apoptosis in Mediating p53-Independent Suppression of Tumorigenesis

Joan Massagué, Memorial Sloan Kettering Cancer Center, USA
The TGFbeta Program in Cancer

Karen H. Vousden, Crick Institute, UK
Apoptotic Activity of p53 in Tumor Suppression

David A. Tuveson, Cold Spring Harbor Laboratory, USA
B-Raf as a Potential Therapeutic Target in Malignancy

09:20—09:40
Coffee Break

Van Horne Foyer
11:00—13:00
Poster Setup

Alberta/New Brunswick
13:00—22:00
Poster Viewing

Alberta/New Brunswick
16:30—17:00
Coffee & Snacks Available

Van Horne Foyer
17:00—19:00
Transcription
Meeting has ended...abstracts no longer viewable online.

VH Ballroom AB
* William Sellers, Broad Institute of MIT and Harvard, USA
Forkhead Transcription Factors as Mediators of Tumor Suppression Downstream of PTEN

Jayanta Debnath, University of California, San Francisco, USA
Short Talk: Akt Activation Within Mammary Acini Disrupts Glandular Architecture and Amplifies Oncogene-Driven Proliferation In An mTOR Dependent Manner

Ann M. Winter-Vann, University of North Carolina at Chapel Hill, USA
Short Talk: Targeting Ras Signaling through Inhibition of Carboxyl Methylation: An Unexpected Property of a.ntifolates

Hiroyuki Mano, University of Tokyo, Japan
Short Talk

Erik S. Knudsen, UT Southwestern, USA
Short Talk: RB-Assembled Complexes & Transcriptional Repression

Galina Selivanova, Karolinska Institute, Sweden
Short Talk: Reactivation of Wild Type p53 Function in Tumor Cells by a Small Molecule

19:15—20:15
Social Hour

Alberta/New Brunswick
20:00—22:00
Poster Session 2

Alberta/New Brunswick

SATURDAY, MARCH 22

07:00—08:00
Breakfast

Cascade/Conservatory
08:00—11:00
Proliferation II
Meeting has ended...abstracts no longer viewable online.

VH Ballroom AB
Frank McCormick, University of California, San Francisco, USA
Cancer Therapy Based on the p53 Pathway

* Sara A. Courtneidge, Sanford-Burnham Medical Research Institute, USA
The Role of Src Family Kinases in Cellular Signal Transduction Pathways

Raymond N. DuBois, Arizona State University, USA
Targets for Prevention of Colon Cancer

Pamela A. Silver, Harvard Medical School, USA
Nuclear Transport as a Target for Growth Control

09:20—09:40
Coffee Break

Van Horne Foyer
11:00—13:00
Poster Setup

Alberta/New Brunswick
13:00—22:00
Poster Viewing

Alberta/New Brunswick
16:30—17:00
Coffee & Snacks Available

Van Horne Foyer
17:00—19:00
Protein Stability/Protein Transport
Meeting has ended...abstracts no longer viewable online.

VH Ballroom AB
* Raymond J. Deshaies, Amgen, Inc., USA
Discovery of a New Family of Isopeptidase Enzymes based on the ‘JAMM’ Motif

Lawrence R. Dick, Takeda, USA
Proteasome Inhibitors in the Treatment of Cancer

Susan Demo, Calithera Biosciences, USA
Ubiquitination Pathway Enzymes as Therapeutic Targets

19:15—20:15
Social Hour

Alberta/New Brunswick
20:00—22:00
Poster Session 3

Alberta/New Brunswick

SUNDAY, MARCH 23

07:00—08:00
Breakfast

Cascade/Conservatory
08:00—11:00
Enabling Technologies
Meeting has ended...abstracts no longer viewable online.

VH Ballroom AB
Jonathan Rothbard, CellGate Inc., USA
Transepithelial Delivery of Therapeutics Mediated by Polyguanidyl Compounds

Garry P. Nolan, Stanford University, USA
Polychromatic, Multiparametric Phosphoprotein Analysis by Flow Cytometry for Study of Intracellular Signaling

* René Bernards, Netherlands Cancer Institute, Netherlands
High Throughput Loss-of-Function Phenotypic Screens in Mammalian Cells

Stephen W. Fesik, Vanderbilt University School of Medicine, USA
Cancer Protein Targets in the Cell Death Pathway

09:20—09:40
Coffee Break

Van Horne Foyer
16:30—17:00
Coffee & Snacks Available

Van Horne Foyer
17:00—19:30
Tumor Models
Meeting has ended...abstracts no longer viewable online.

VH Ballroom AB
Gerard I. Evan, University of Cambridge, UK
Building and Demolishing Cancers in vivo

Felix D. Karim, Exelixis Inc., USA
Genetics in a Post-Genome Era: Lessons from Model Systems

* Tyler Jacks, Massachusetts Institute of Technology, USA
Tumor Suppressor Gene Mutations in Mice

Jacqueline A. Lees, Massachusetts Institute of Technology, USA
E2Fs in Cell Cycle Progression and Tumor Development

19:30—20:30
Social Hour

Alberta/New Brunswick
20:30—23:30
Entertainment

Alberta/New Brunswick

MONDAY, MARCH 24

 
Departure


*Session Chair †Invited, not yet responded.



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