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This meeting took place in 2003



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Proteomics: Technologies and Applications (E2)


Organizer(s) Ruedi Aebersold and Stanley Fields
March 25—30, 2003
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Nov 25, 2002
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Jan 27, 2003

Supported by Keystone Symposia

Summary of Meeting:
The completion of the genomic sequences of a number of prokaryotic and eukaryotic species has catalyzed new research approaches to study the structure, function, and control of biological processes. They are characterized by the systematic and, in many cases, quantitative analysis of all the molecules of a particular type expressed by a cell or tissue. The systematic analysis of proteins has been termed "proteomics." In an initial phase, most of the proteomics efforts were focused on large-scale protein identification. More recently, the objectives and technologies of proteomics have diversified and expanded. Current proteomics research attempts to systematically and, where applicable, quantitatively determine the many properties of proteins that determine their biological function. These include protein abundance, state of modification, specific activity, interaction with other biomolecules, half-life, subcellular location, structure, and more. Significant current challenges include the development of suitable technologies to determine these properties on a proteome-wide scale, the interpretation of the large amounts of data obtained, the development of computational approaches to infer biological function, and the integration of different types of data into a coherent model describing a biological process. The goal of the meeting is to bring together leading experts from the different areas of proteomics research to discuss emerging technologies and their applications to biological and clinical research.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, MARCH 25

15:00—19:00
Registration

Shavano Peak Foyer
18:15—19:15
Welcome

Shavano Peak Foyer
19:15—19:30
Orientation

Shavano Peak
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* Rudolf H. Aebersold, Institute of Molecular Systems Biology, ETH Zürich, Switzerland

Tony Pawson, Samuel Lunenfeld Research Institute, Canada
Modular Protein Interactions and Signaling Networks


WEDNESDAY, MARCH 26

07:00—08:00
Breakfast

Torreys Peak
08:00—11:00
Identification and Quantification of Proteins on a Proteome-Wide Scale
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* Pavel A. Pevzner, University of California, San Diego, USA

Rudolf H. Aebersold, Institute of Molecular Systems Biology, ETH Zürich, Switzerland
Toward a High Throughput Quantitative Proteomics Platform

Marvin Vestal, Applied Biosystems, USA
Trends in Mass Spectrometry Instrumentation for Proteomics

John R. Yates III, The Scripps Research Institute, USA
Proteomic View of Malaria Parasite Life Cycle

Scott L. Diamond, University of Pennsylvania, USA
Short Talk: Printing Chemical Libraries on Microarray for Nanoliter Fluid Phase Reactions

09:20—09:40
Coffee Break

Shavano Peak Foyer
11:00—13:00
Poster Setup

Torreys Peak
13:00—22:00
Poster Viewing

Torreys Peak
16:00—16:30
Special Lecture
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
Gregory Milman, National Institutes of Health, USA
Over $1 Billion in Biodefense Research Opportunities

16:30—17:00
Coffee & Snacks Available

Shavano Peak Foyer
17:00—19:00
Analysis, Interpretation and Management of Proteomics Data
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* John R. Yates III, The Scripps Research Institute, USA

Benno Schwikowski, Institute for Systems Biology, USA
Computational Tools and Challenges for Integrating Proteomic Data

Pavel A. Pevzner, University of California, San Diego, USA
New Algorithmic Approaches for the Analysis of Peptide Mass Spectral Data

Bruno Domon, Celera Genomics, Inc., USA
Generation and Analysis of Data for Target Discovery

19:00—20:00
Social Hour

Torreys Peak
20:00—22:00
Poster Session 1: Identification and Quantification of Proteins/Management of Proteomics Data

Torreys Peak

THURSDAY, MARCH 27

07:00—08:00
Breakfast

Torreys Peak
08:00—11:30
Protein Interactions and Protein Linkage Maps
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* Elizabeth J. Grayhack, University of Rochester School of Medicine, USA

Joachim Frank, Columbia University, USA
Single-Particle Reconstruction of Molecular Machines Using Cryo-Electron Microscopy

Stanley Fields, University of Washington, USA
Genetic and Genomic Approaches to Protein Interaction

Marc Vidal, Dana-Farber Cancer Institute, USA
Toward a Proteome Atlas for C. elegans

Bertrand Séraphin, Universite Paris 6, France
Large Scale Protein Linkage Maps via Purification of Protein Complexes and Mass Spectrometric Analysis

Amy L. Hitchcock, Dana Farber Cancer Institute, USA
Short Talk: Identification of Ubiquitinated ER Proteins

Ole N. Jensen, University of Southern Denmark, Denmark
Short Talk: Proteomic Strategy for Identification of GPI-Anchored Proteins in H. sapiens and A. thaliana Cell Membranes

09:20—09:40
Coffee Break

Shavano Peak Foyer
11:30—13:00
Poster Setup

Torreys Peak
13:00—22:00
Poster Viewing

Torreys Peak
16:00—16:30
Special Lecture
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
Gregory Milman, National Institutes of Health, USA
Whom to Contact at NIH and When?

16:30—17:00
Coffee & Snacks Available

Shavano Peak Foyer
17:00—19:00
In vivo Analysis
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* Stanley Fields, University of Washington, USA

Stephen W. Michnick, Université de Montréal, Canada
Mapping and Visualization of Biochemical Networks in Living Cells

Andrew Fraser, Wellcome Trust Sanger Institute, UK
Functional Analysis of the C. elegans Genome by Rna-Mediated Interference

19:00—20:00
Social Hour

Torreys Peak
20:00—22:00
Poster Session 2: In vivo Approaches/Analysis of Protein Activities

Torreys Peak

FRIDAY, MARCH 28

07:00—08:00
Breakfast

Torreys Peak
08:00—11:30
Systematic Analysis of Protein Activities and Protein Arrays
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* Susan S. Taylor, University of California, San Diego, USA

Michael P. Snyder, Stanford University School of Medicine, USA
Global Analysis of the Yeast Proteome

Dolores J. Cahill, Pfizer Inc., Ireland
Protein Arrays: Generation and Recent Applications

Gavin MacBeath, Abpro, USA
Protein Microarrays: From Functional Genomics to Protein Profiling

Larry Gold, SomaLogic Inc., USA
Aptamer Arrays and Proteomics

Alissa Marie Resch, University of California, Los Angeles, USA
Short Talk: Switching Protein Interaction Networks by Alternative Splicing of Protein Interaction Domains

09:20—09:40
Coffee Break

Shavano Peak Foyer
11:30—13:00
Poster Setup

Torreys Peak
13:00—22:00
Poster Viewing

Torreys Peak
16:30—17:00
Coffee & Snacks Available

Shavano Peak Foyer
17:00—19:00
Structural Proteomics
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* Michael P. Snyder, Stanford University School of Medicine, USA

David Baker, University of Washington, USA
Prediction and Design of Protein Structures and Protein-Protein Interactions

Andrej Sali, University of California, San Francisco, USA
Modeling the Structure of Proteins and Macromolecular Assemblies

Susan S. Taylor, University of California, San Diego, USA
Dynamic Integration of Signaling by PKA

19:00—20:00
Social Hour

Torreys Peak
20:00—22:00
Poster Session 3: Structural Proteomics/Control of Protein Abundance and Activity/Computational Methods

Torreys Peak

SATURDAY, MARCH 29

07:00—08:00
Breakfast

Torreys Peak
08:00—11:30
Control and Detection of Protein Abundance and Activity
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* Dolores J. Cahill, Pfizer Inc., Ireland

David R. Morris, University of Washington, USA
Translating the Transcriptome: High Throughput Analysis of mRNA Translation

Brian T. Chait, Rockefeller University, USA
Probes of Protein Interaction and Phosphorylation

Benjamin F. Cravatt III, The Scripps Research Institute, USA
Activity-Based Protein Profiling: Chemical Approaches for Functional Proteomics

Elizabeth J. Grayhack, University of Rochester School of Medicine, USA
Functional Proteomics

Joshua E. Elias, Harvard Medical School, USA
Short Talk: Predicting MS/MS Peptide Fragmentation Patterns: Beyond SEQUEST

Lisa M. Gangi†, National Cancer Institute, National Institutes of Health, USA
Short Talk: Development of Antibody Microarrays for Detection and Quantitation of Specific Proteins

09:20—09:40
Coffee Break

Shavano Peak Foyer
16:30—17:00
Coffee & Snacks Available

Shavano Peak Foyer
17:00—19:00
Methods to Explore Function
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* Brian T. Chait, Rockefeller University, USA

Tom W. Muir, Princeton University, USA
From Protein Semisynthesis to Chemical Genetics: The Chemical Biology of Protein Splicing

Edward M. Marcotte, University of Texas at Austin, USA
Global Analysis of Protein Pathways, Systems and Interactions

Peer Bork, European Molecular Biology Laboratory, Germany
Comparative Analysis of Protein Interaction Networks

19:00—20:00
Social Hour

Torreys Peak
20:00—23:00
Entertainment

Torreys Peak

SUNDAY, MARCH 30

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 ES012094-01




National Institutes of Health
Department of Energy Nat'l Nuclear Security Administration (DOE)

Grant No. DE-FO03-03ER63517




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